Patents Assigned to Advanced Cardiovascular Systems
  • Publication number: 20100047315
    Abstract: Stents and a method of using the stents to increase blood flow to ischemic tissues in a patient are disclosed.
    Type: Application
    Filed: October 23, 2009
    Publication date: February 25, 2010
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Evgenia Mandrusov, Paul Consigny, Syed Faiyaz Ahmed Hossainy, Dary Mirzaee
  • Patent number: 7666223
    Abstract: Coatings for stents that include a polymer and a drug are provided. The stent's struts are generally linear segments interrupted by a curved or bent segment that contain a drug/polymer coating wherein the concentration of the drug in the coating is greater in at least a portion of the curved or bent segment as compared to the linear segments.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: February 23, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Veronica J. Santos, Santosh Prabhu
  • Patent number: 7662130
    Abstract: One aspect of the invention is directed to a balloon catheter with a multilayered polymeric sleeve at the rapid exchange intermediate section, having an outer layer formed of a polymer with a relatively low processing temperature (i.e., melting temperature for semi-crystalline polymers or glass transition temperature for amorphous polymers), and having an inner layer.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: February 16, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Jeong S. Lee
  • Patent number: 7662326
    Abstract: Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: February 16, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: David C. Gale, Klaus Kleine, Anthony J. Abbate, Svava Maria Atladottir, Stephen D. Pacetti
  • Patent number: 7658880
    Abstract: A method and apparatus for simultaneously polishing the inner and outer surfaces of an unpolished polymeric stent using a heat process. The unpolished stent can be mounted, for example, on a “spiral-mandrel,” a tubular helical structure with gaps in between a series of coils of the structure. Heat from a heat source can then applied to the spiral-mandrel at a range between the glass transition temperature and melting temperature of the polymer of the stent.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: February 9, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Patrick P. Wu
  • Patent number: 7658966
    Abstract: A drug delivery device for delivering therapeutic agents and a method of making such a device is disclosed. The device includes an inflatable balloon having a plurality of holes formed in the wall of the balloon. A microporous coating covers a portion of the outer surface of the wall of the balloon. The thickness of the coating and the size of the micropores can permit controlled delivery of a substance from the micropores of the coating and into the tissue of a patient's lumen.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: February 9, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Lyudmila Kokish
  • Patent number: 7654979
    Abstract: The end cap is preferably formed of a relatively high durometer material with an inner surface on an outer surface of the shaft and on an outer surface of the balloon skirt section, and contacts a compression member on the balloon outer surface. The configuration prevents or inhibits failure at the balloon seals which otherwise results from the compression member moving or the balloon pulling off the shaft and out from under the compression member during inflation of the balloon. As a result, the balloon catheter of the invention has an improved consistent burst pressure and/or failure mode.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: February 2, 2010
    Assignee: Advanced Cardiovascular System, Inc.
    Inventor: John Arthur Simpson
  • Patent number: 7651695
    Abstract: The invention provides bioactive compositions and methods of delivery for ameliorating a vascular diseased state, particularly for the management of stenosis or restenosis following a vascular trauma or disease.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: January 26, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Wouter E. Roorda, Vinayak D. Bhat, Steven L. Mouw, Syed F. A. Hossainy, Steven Z. Wu, Deborra Sanders Millare
  • Patent number: 7648727
    Abstract: Methods of coating a stent subsequent to mounting or crimping of the stent on a balloon of a catheter assembly are disclosed. One method includes forming a sacrificial layer on a balloon of a catheter assembly; followed by mounting a stent on the balloon, the stent including struts separated by gaps; followed by forming a stent coating on the stent; and followed by removal of the sacrificial layer. Another method includes mounting a stent on a balloon, the stent including struts separated by gaps; followed by forming a sacrificial layer on the balloon in the areas of the gaps between struts of the stent; followed by forming a coating on the stent; and followed by removing the sacrificial layer, wherein the coating remains on an outer surface of the stent.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: January 19, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Srinivasan Sridharan, James Jacobs
  • Patent number: 7648725
    Abstract: A mounting assembly for supporting a stent and a method of using the same to coat a stent is disclosed.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: January 19, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jason Van Sciver, Manish Gada, Jessie Madriaga
  • Patent number: 7645242
    Abstract: The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the device. The guidewire of the present invention is formed, at least in part, of a composite elongate core formed, at least in part, of precipitation hardened material. The elongate core members of the present invention will have an ultimate tensile strength and modulus of elasticity greater than the same for an identically dimensioned elongate member formed from superelastic NITINOL alone.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: January 12, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Marc Mehrzad Jalisi, David M. Anderson, Wayne E. Cornish, Nancy A. Nicotra, Mark T. Richardson
  • Patent number: 7645504
    Abstract: Coatings for implantable medical devices and methods for fabricating thereof are disclosed. The coatings include a layer comprising a hydrophobic polymer and a layer comprising a hydrophilic or amphiphilic polymer.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: January 12, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Patent number: 7645474
    Abstract: A method and system for purifying polymers to use with medical devices, particularly for a drug eluting stent, is described.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: January 12, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jaya Pathak, Fuh-Wei Tang
  • Patent number: 7645409
    Abstract: The present invention is directed to an expandable polymer link hybrid stent for implantation in a body lumen, such as a coronary artery along with a method of making the stent. The stent generally includes a series of metallic cylindrical rings longitudinally aligned on a common axis of the stent and interconnected by a series of polymeric links. The polymer links are formed by applying polymer layers between the rings and laser ablating the excess material. The polymeric material forming the polymeric links, provides longitudinal and flexural flexibility to the stent while maintaining sufficient column strength to space the cylindrical rings along the longitudinal axis. The metallic material forming the rings provides the necessary radial stiffness.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: January 12, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Richard J. Saunders, Joseph R. Callol, James Hong
  • Patent number: 7641838
    Abstract: An intraluminal catheter having at least a section of the catheter shaft being relatively transparent, and the method of manufacture thereof. In a presently preferred embodiment, the intraluminal catheter is a balloon catheter having a transparent shaft section formed of a polyetheretherketone polymeric material. The substantially transparent shaft section, of the catheter, is amorphous, and is substantially free of water marks and gels that would limit the transparency.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: January 5, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen G. Schaible, Timoteo J. Tomas
  • Patent number: 7637941
    Abstract: Bioerodable devices such as stents containing one or more endothelial cell binding agents are provided.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: December 29, 2009
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Yatheendhar Manicka, Syed Faiyaz Ahmed Hossainy, Charles Claude, Anne Moberg Abreu
  • Patent number: 7638156
    Abstract: Masking apparatus and methods of masking a medical article, such as stent, for selective application of a coating composition on the article are disclosed.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: December 29, 2009
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Gordon Stewart, Srinivasan Sridharan, Arkady Kokish, Klaus Kleine, Benjamyn Serna, Bjorn G. Svensson
  • Patent number: 7632914
    Abstract: Provided herein is a coating comprising a polymer.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: December 15, 2009
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Patent number: 7632307
    Abstract: Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: December 15, 2009
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen Dirk Pacetti, Jessica DesNoyer, Yung-Ming Chen, Lothar Kleiner, Syed F. A. Hossainy
  • Patent number: 7632303
    Abstract: A medical device has a structure differentiated in terms of its stiffness or elasticity. Such stiffness differentiation is achieved through the use of superelastic or shape-memory materials which transition between a relatively malleable phase to a stiffer phase at a transition temperature which is adjustable by heat treatment. A differentiation of the stiffness of the structure forming the medical device is achieved by differentially adjusting the transition temperature of select portions of the medical device before the medical device is placed in its operational mode, usually implanted in a body at body temperature.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: December 15, 2009
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Kent C. B. Stalker, Masoud Molaei, John F. Boylan, Matthew J. Gillick