Abstract: Coatings for stents that include a polymer and a drug are provided. The stent's struts are generally linear segments interrupted by a curved or bent segment that contain a drug/polymer coating wherein the concentration of the drug in the coating is greater in at least a portion of the curved or bent segment as compared to the linear segments.
Abstract: One aspect of the invention is directed to a balloon catheter with a multilayered polymeric sleeve at the rapid exchange intermediate section, having an outer layer formed of a polymer with a relatively low processing temperature (i.e., melting temperature for semi-crystalline polymers or glass transition temperature for amorphous polymers), and having an inner layer.
Abstract: Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.
Type:
Grant
Filed:
April 27, 2007
Date of Patent:
February 16, 2010
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
David C. Gale, Klaus Kleine, Anthony J. Abbate, Svava Maria Atladottir, Stephen D. Pacetti
Abstract: A method and apparatus for simultaneously polishing the inner and outer surfaces of an unpolished polymeric stent using a heat process. The unpolished stent can be mounted, for example, on a “spiral-mandrel,” a tubular helical structure with gaps in between a series of coils of the structure. Heat from a heat source can then applied to the spiral-mandrel at a range between the glass transition temperature and melting temperature of the polymer of the stent.
Abstract: A drug delivery device for delivering therapeutic agents and a method of making such a device is disclosed. The device includes an inflatable balloon having a plurality of holes formed in the wall of the balloon. A microporous coating covers a portion of the outer surface of the wall of the balloon. The thickness of the coating and the size of the micropores can permit controlled delivery of a substance from the micropores of the coating and into the tissue of a patient's lumen.
Abstract: The end cap is preferably formed of a relatively high durometer material with an inner surface on an outer surface of the shaft and on an outer surface of the balloon skirt section, and contacts a compression member on the balloon outer surface. The configuration prevents or inhibits failure at the balloon seals which otherwise results from the compression member moving or the balloon pulling off the shaft and out from under the compression member during inflation of the balloon. As a result, the balloon catheter of the invention has an improved consistent burst pressure and/or failure mode.
Abstract: The invention provides bioactive compositions and methods of delivery for ameliorating a vascular diseased state, particularly for the management of stenosis or restenosis following a vascular trauma or disease.
Type:
Grant
Filed:
May 18, 2001
Date of Patent:
January 26, 2010
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Wouter E. Roorda, Vinayak D. Bhat, Steven L. Mouw, Syed F. A. Hossainy, Steven Z. Wu, Deborra Sanders Millare
Abstract: Methods of coating a stent subsequent to mounting or crimping of the stent on a balloon of a catheter assembly are disclosed. One method includes forming a sacrificial layer on a balloon of a catheter assembly; followed by mounting a stent on the balloon, the stent including struts separated by gaps; followed by forming a stent coating on the stent; and followed by removal of the sacrificial layer. Another method includes mounting a stent on a balloon, the stent including struts separated by gaps; followed by forming a sacrificial layer on the balloon in the areas of the gaps between struts of the stent; followed by forming a coating on the stent; and followed by removing the sacrificial layer, wherein the coating remains on an outer surface of the stent.
Type:
Grant
Filed:
August 26, 2004
Date of Patent:
January 19, 2010
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed F. A. Hossainy, Srinivasan Sridharan, James Jacobs
Abstract: The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the device. The guidewire of the present invention is formed, at least in part, of a composite elongate core formed, at least in part, of precipitation hardened material. The elongate core members of the present invention will have an ultimate tensile strength and modulus of elasticity greater than the same for an identically dimensioned elongate member formed from superelastic NITINOL alone.
Type:
Grant
Filed:
December 22, 1999
Date of Patent:
January 12, 2010
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Marc Mehrzad Jalisi, David M. Anderson, Wayne E. Cornish, Nancy A. Nicotra, Mark T. Richardson
Abstract: Coatings for implantable medical devices and methods for fabricating thereof are disclosed. The coatings include a layer comprising a hydrophobic polymer and a layer comprising a hydrophilic or amphiphilic polymer.
Abstract: The present invention is directed to an expandable polymer link hybrid stent for implantation in a body lumen, such as a coronary artery along with a method of making the stent. The stent generally includes a series of metallic cylindrical rings longitudinally aligned on a common axis of the stent and interconnected by a series of polymeric links. The polymer links are formed by applying polymer layers between the rings and laser ablating the excess material. The polymeric material forming the polymeric links, provides longitudinal and flexural flexibility to the stent while maintaining sufficient column strength to space the cylindrical rings along the longitudinal axis. The metallic material forming the rings provides the necessary radial stiffness.
Type:
Grant
Filed:
October 3, 2008
Date of Patent:
January 12, 2010
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Richard J. Saunders, Joseph R. Callol, James Hong
Abstract: An intraluminal catheter having at least a section of the catheter shaft being relatively transparent, and the method of manufacture thereof. In a presently preferred embodiment, the intraluminal catheter is a balloon catheter having a transparent shaft section formed of a polyetheretherketone polymeric material. The substantially transparent shaft section, of the catheter, is amorphous, and is substantially free of water marks and gels that would limit the transparency.
Abstract: Masking apparatus and methods of masking a medical article, such as stent, for selective application of a coating composition on the article are disclosed.
Type:
Grant
Filed:
December 19, 2005
Date of Patent:
December 29, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed F. A. Hossainy, Gordon Stewart, Srinivasan Sridharan, Arkady Kokish, Klaus Kleine, Benjamyn Serna, Bjorn G. Svensson
Abstract: Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.
Type:
Grant
Filed:
December 16, 2004
Date of Patent:
December 15, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Stephen Dirk Pacetti, Jessica DesNoyer, Yung-Ming Chen, Lothar Kleiner, Syed F. A. Hossainy
Abstract: A medical device has a structure differentiated in terms of its stiffness or elasticity. Such stiffness differentiation is achieved through the use of superelastic or shape-memory materials which transition between a relatively malleable phase to a stiffer phase at a transition temperature which is adjustable by heat treatment. A differentiation of the stiffness of the structure forming the medical device is achieved by differentially adjusting the transition temperature of select portions of the medical device before the medical device is placed in its operational mode, usually implanted in a body at body temperature.
Type:
Grant
Filed:
May 21, 2002
Date of Patent:
December 15, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Kent C. B. Stalker, Masoud Molaei, John F. Boylan, Matthew J. Gillick