Patents Assigned to Advanced Cardiovascular Systems
  • Patent number: 7824729
    Abstract: A process for coating an implantable device is disclosed. In this process, at least one implantable device is tumbled. As the implantable device is being tumbled, a coating substance is introduced to coat the implantable device with the coating substance.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: November 2, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Wouter E. Roorda, Stephen D. Pacetti
  • Publication number: 20100269751
    Abstract: A sleeve is positioned over a radially-expandable rod assembly and a stent is positioned over the sleeve. A mandrel is inserted into the rod assembly to thereby press the sleeve against the inner surface of the stent and expand the stent. A coating (such as a solvent, a polymer and/or a therapeutic substance) is then applied to the outer (abluminal) surfaces of the stent, by spraying, for example. The sleeve advantageously prevents the coating material from being applied to inner (luminal) surfaces of the stent and also allows the coating material to be efficiently applied to the abluminal surfaces.
    Type: Application
    Filed: July 8, 2010
    Publication date: October 28, 2010
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventors: Yung Ming Chen, Jeff H. Smith, Celenia Gutierrez
  • Publication number: 20100269752
    Abstract: A sleeve is positioned over a radially-expandable rod assembly and a stent is positioned over the sleeve. A mandrel is inserted into the rod assembly to thereby press the sleeve against the inner surface of the stent and expand the stent. A coating (such as a solvent, a polymer and/or a therapeutic substance) is then applied to the outer (abluminal) surfaces of the stent, by spraying, for example. The sleeve advantageously prevents the coating material from being applied to inner (luminal) surfaces of the stent and also allows the coating material to be efficiently applied to the abluminal surfaces.
    Type: Application
    Filed: July 8, 2010
    Publication date: October 28, 2010
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventors: Yung Ming Chen, Jeff H. Smith, Celenia Gutierrez
  • Patent number: 7819833
    Abstract: In one embodiment, there is disclosed a device adapted to be used for percutaneous minimally invasive heart surgery including a catheter having a proximal end and a distal end adapted to be fed through a blood vessel, a pump associated with the distal end of the catheter, and a tool associated with the distal end of the catheter. The tool is adapted to be used for percutaneous minimally invasive heart surgery. Examples of the tools include a tool for excising natural tissue, a tool for excising a natural valve, and anthretomy device, a prosthetic valve delivery system, a balloon catheter, a knife, a stapler, and a screwdriver. The pump is used for maintaining blood flow around the site of the heart surgery while the surgery is taking place without the use of cardiopulmonary bypass.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: October 26, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Robert D. Ainsworth, Hongzhi Bai, Greg Hyde
  • Patent number: 7820229
    Abstract: Coatings for stents that include a polymer and a drug are provided. A method of forming the coatings is also provided.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: October 26, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Veronica J. Santos, Santosh Prabhu
  • Patent number: 7820732
    Abstract: Methods for modulating and enhancing thermal and mechanical properties and biocompatibilities of coatings on implantable devices are disclosed. Implantable devices containing the enhanced thermal and mechanical properties and biocompatibilities are also described. The implantable devices can be used to treat a medical condition such as vulnerable plaque or restenosis.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: October 26, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Yiwen Tang, Harshad Borgaonkor, Jessica Reneé DesNoyer, Stephen D. Pacetti
  • Patent number: 7820190
    Abstract: Coatings, particularly primer coatings, for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients. The primer coatings include diacrylates and polyacrylates.
    Type: Grant
    Filed: January 2, 2004
    Date of Patent: October 26, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Publication number: 20100266659
    Abstract: Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
    Type: Application
    Filed: April 19, 2010
    Publication date: October 21, 2010
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Patent number: 7807211
    Abstract: A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: October 5, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Yiwen Tang, Manish Gada
  • Patent number: 7807210
    Abstract: The present invention relates to providing a porous, hydrophobic polymer with a hemocompatible substance and to the materials produced thereby. One embodiment of the present invention relates to the providing of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible substance is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible substance material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrochlorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation.
    Type: Grant
    Filed: April 5, 2004
    Date of Patent: October 5, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Wouter E. Roorda, Niraj Shah, André-Jean Lundkvist
  • Patent number: 7807722
    Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, and a method of coating the device with the composition, and an implantable device coated with the composition are provided.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: October 5, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Patent number: 7803394
    Abstract: Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coating includes a hydrogel including polycationic peptides, for example the R7.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: September 28, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Syed F. A. Hossainy
  • Patent number: 7803406
    Abstract: Methods of forming coatings comprising a polycationic peptide for medical devices are disclosed. Also disclosed is a coating comprising a polycationic peptide.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: September 28, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen D. Pacetti, Eugene T. Michal, Syed F. A. Hossainy, Ni Ding, Wouter E. Roorda
  • Patent number: 7799346
    Abstract: A method of treatment, including separately delivering a treatment agent and a barrier having a binding member to a tissue, the binding member having a property adapted to couple to a surface of the tissue, wherein the barrier is present in an amount sufficient to permit transport of the treatment agent from the tissue at a lower rate than transport in the absence of the barrier component, wherein the barrier is biodegradable and hinders transport of the treatment agent away from the tissue but allows the treatment agent to migrate toward the tissue.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: September 21, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Vinayak D. Bhat
  • Patent number: 7794743
    Abstract: Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: September 14, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Murthy V. Simhambhatla, Ni Ding, Stephen D. Pacetti
  • Patent number: 7794402
    Abstract: An echogenic catheter, such as a needle catheter, formed at least in part of an intrinsically conductive organic polymer for providing a highly conductive surface in combination with an improved ability to ultrasonically image the catheter, and a method of performing a medical procedure using a catheter of the invention.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: September 14, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Edwin Y. Wang
  • Patent number: 7795467
    Abstract: Bioabsorbable, polyurethane-based stent coatings that comprise non-fouling coatings with polyethylene glycol and hyaluronic acid are disclosed. In addition to these coatings, medical devices comprising these coatings and methods of applying the coatings are disclosed.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: September 14, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen Dirk Pacetti, Charles Claude, Irina Astafieva
  • Patent number: 7794777
    Abstract: A stent mandrel fixture and method for supporting a stent during the application of a coating substance is provided.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: September 14, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Arkady Kokish, Charles Snyder
  • Patent number: 7794495
    Abstract: Stents fabricated from hydrolytically degradable polymers with accelerated degradation rates and methods of fabricating stents with accelerated degradation rates are disclosed.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: September 14, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: David C. Gale, Bin Huang, Vincent J. Gueriguian, Syed Faiyaz Ahmed Hossainy
  • Publication number: 20100222872
    Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
    Type: Application
    Filed: May 18, 2010
    Publication date: September 2, 2010
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Syed Hossainy, Irina Astafieva, Stephen Pacetti, Thierry Glauser, Jessica Desnoyer, Florian N. Ludwig