Abstract: Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement a combination of drift-type ion mobility (IM) separation and time-of-flight mass spectrometry (TOF MS). Both separation techniques are carried out in tandem while applying mass filtering with a wide window of ion isolation. One mode of operation entails utilizing a mass filter to limit ion packets to ions in a selected m/z range that remains constant over the entire course of data acquisition. Another mode entails utilizing the mass filter to limit ion packets to an m/z range that varies over the course of data acquisition.

Abstract: A sample probe includes a tip including a distal end for penetrating a cellular membrane, an opening located at or proximal to the distal end, and tip microchannels extending through the tip and communicating with the opening; and a body adjoining the tip and including body microchannels, wherein at least one of the body microchannels communicates with at least one of the tip microchannels. A method for sampling intracellular material includes inserting a probe tip through a cellular membrane; aspirating intracellular material from the cell, through an opening of the tip, and into a first microchannel of the tip; flowing isolator fluid from a second microchannel of the tip into the first microchannel to form a plug of intracellular material; and aspirating the plug and the isolator fluid through the first microchannel.

Abstract: Scroll pumping apparatus includes a first scroll element and a second scroll element; a drive mechanism operatively coupled to the second scroll element for producing orbiting motion of the second scroll element relative to the first scroll element, the drive mechanism having an axis of rotation; and an isolation element to isolate a first volume and a second volume in the scroll pumping apparatus. The isolation element includes a first resilient annular member coupled, directly or indirectly, to the first scroll element, a second resilient annular member coupled, directly or indirectly, to the second scroll element, and a tubular member coupled between the first and second annular members.

Abstract: A time-of-flight mass spectrometer (TOF MS) includes an ion gate, an ion guide downstream of the ion gate, and a TOF analyzer downstream of the ion guide. The TOF MS is operated with an adjustable duty cycle to limit the amount of ions entering a TOF analyzer and avoid saturating a detector system of the TOF MS. The duty cycle is adjusted by controlling the ion gate. The ion guide emits ions as a continuous beam, without trapping the ions. The ion guide may be operated as a collision cell. The TOF MS may also include a mass filter upstream of the ion guide.

Abstract: A device under test (DUT) is tested by: receiving a signal transmitted by the DUT, wherein the signal includes first portions that include scrambled bits produced from a selected bit pattern and a selected scrambling algorithm, and further includes second portions that include unscrambled bits, the first portions and second portions being interspersed within the signal; detecting received scrambled bits within the received signal; generating a test bit sequence using the selected scrambling algorithm and the selected bit pattern, including generating a bit of the test bit sequence for each of the received scrambled bits within the received signal, and not generating a bit of the test bit sequence for each of the received unscrambled bits within the received signal; and comparing the received scrambled bits to the test bit sequence to determine a bit error rate of the received signal.

Abstract: A method and apparatus are described for generally passive intermodulation measurement to specify a location and strength of an intermodulation source of a passive component in a transmission line. Beneficially, the apparatus and method are comparatively simple and inexpensive.

Abstract: A sealed fluidic component (280) for use in a fluidic flow path is made by providing a composite material (300) comprising a first material (305) and a second material (310), wherein the first material (305) and the second material (310) are different PAEK materials with the first material (305) having a lower melting point than the second material (310). The composite material (300) is heated in order to provide a sealing by the first material (305).

Abstract: A method for analyzing a random telegraph signal according to the present invention includes the steps of: performing band-pass filter processing with respect to signal data; subsequently calculating a histogram; subsequently performing threshold determination processing; further performing, based on a result of the threshold determination, binarization processing with respect to the filtered signal data; and further obtaining, based on a result of the binarization, coefficients ?.

Abstract: A method for proteomic analysis of a biological sample is disclosed, which includes obtaining peptide sequences of proteins in a target list; and identifying proteins in the biological sample by mapping the obtained peptide sequences on proteins in a proteomic database, wherein the target list is determined using information of RNA transcripts in the biological sample and/or the target list is determined using information of RNA transcripts in the biological sample. The peptide sequences are determined using a mass spectrometer. The mapping is performed on a subset of proteins based on the information of RNA transcripts.

Abstract: An apparatus for providing time adjustment of an input signal includes a coarse timing digital-to-analog converter (DAC), a replica delay element and an interpolator. The coarse timing DAC has multiple delay settings for providing a coarse timing adjustment of the input signal, and outputs a first delayed signal by delaying the input signal by a first delay time corresponding to a selected setting of the multiple delay settings. The replica delay element receives the first delayed signal from the coarse timing DAC and outputs a second delayed signal by delaying the first delayed signal by a predetermined second delay time. The interpolator blends either the input signal and the first delayed signal or the first delayed signal and the second delayed signal for providing a fine timing adjustment of the input signal, and outputs a timing adjusted output signal including the coarse timing adjustment and the fine timing adjustment.

Abstract: An inductively coupled plasma MS/MS mass analyzer (ICP-MS/MS) may include a first vacuum chamber which draws plasma containing an ionized sample into vacuum, a second vacuum chamber which includes a device or means which extracts and guides ions as an ion beam from the ions output from the first vacuum chamber, a third vacuum chamber which has a first ion optical separation device or means, a fourth vacuum chamber which has a cell into which reaction gas is introduced, and a fifth vacuum chamber which has a second optical separation device or means and a detector, wherein the second vacuum chamber and third vacuum chamber are individually evacuated.

Abstract: A method for determining a loop response for an apparatus for an atomic force microscope is disclosed. The method comprises: determining a loop response for an on-surface movement of a cantilever over a frequency range; determining a loop response for an off-surface movement of the cantilever over the frequency range; and adjusting an output of the controller at a frequency based on the loop response for the off-surface movement. An atomic force microscopy system is disclosed.

Abstract: A method and system of providing a phase reference signal includes generating a reference signal having a reference frequency, modulating the reference signal at a modulation frequency lower than the reference frequency to obtain a modulated drive signal, receiving the modulated drive signal at a phase reference, and generating the phase reference signal based on the modulated drive signal. The phase reference signal including multiple reference tones having corresponding tone frequencies clustered around multiples of the reference frequency. A spacing between adjacent tones of the multiple reference tones is the same as the modulation frequency or an integer multiple of the modulation frequency.

Abstract: A phase noise extraction apparatus and technique that extracts phase noise induced by a component of a transmitter from a radio frequency (RF) signal and attenuates noise induced from other sources. The RF signal is digitized, modulation is removed, and the carrier is suppressed to provide a noise signal including the phase noise and the noise induced from the other sources. A complementary autocorrelation operation is applied to the noise signal to attenuate the noise from the other sources. The correlated signal is transformed into the frequency domain to generate a power spectrum of the phase noise that may be measured or displayed.

Abstract: A device analyzer for analyzing power devices. An example device analyzer comprises a collector supply to generate supply signal pulses with selected voltage or current levels and a supply signal pulse width at a high current. The supply signal pulses are applied at a collector supply source terminal when DUT is connected to conduct current between the collector supply source terminal and a collector supply common terminal. A supply switch closes or opens the DUT current path in narrow pulses having a narrow pulse width narrower than the supply signal pulses to conduct the supply signal pulses as narrowed sweep signal pulses having the high current capacity of the collector supply current. The supply switch alternatively regulates the current in the current path at constant current levels. Other modules capable of high power test capabilities may also be added.

Abstract: This disclosure provides a method comprising: a) clamping the top and bottom strands of a double stranded DNA molecule to produce a duplex in which the top and bottom strands are linked; b) denaturing the duplex to produce a denatured product; and c) renaturing the denatured product in the presence of a labeled oligonucleotide that is complementary to a sequence of nucleotides in the double stranded DNA molecule, thereby producing a D-loop-containing product. Kits for performing the method and products made by the method are also provided.

Abstract: An apparatus and technique that reduces induced cross-talk current between transformer windings. The apparatus includes a transformer having a first secondary winding that provides a first voltage relative to earth ground, a second secondary winding that provides a second voltage relative to floating ground, and a shield disposed between the first and second secondary windings. A correction circuit connected to the first secondary winding is configured to generate a correction voltage. The correction voltage drives a shield to induce a correction current into the second secondary winding to reduce cross-talk current induced between the first and second secondary windings.

Abstract: An injection device (100) comprising: a housing (102) defining a space (104); a seat (110) located in said space (104), the seat (110) being configured for receiving a flow path element (116) capable of injecting a pressurized fluid into the injection device (100) through the seat (110); a pressure source (132) for pressurizing a medium in said space (104), thereby reducing the pressure difference between the pressurized fluid in said flow path element (116) and said medium.

Abstract: A method for optically controlling an atomic force microscope (AFM) includes acquiring an optical image of a sample using an optical imaging device, identifying a feature of interest on the sample using the optical image, acquiring a high resolution AFM image of the sample using an AFM imaging device, the AFM imaging device comprising a cantilever having a tip, overlaying the AFM image with the optical image at the feature of interest, and positioning the probe tip over the feature of interest using the optical image.

Abstract: A pre-packaged electrophoresis cassette (1), the cassette (1) comprising a gel layer (2) and a buffer solution layer (3), the gel layer comprising a first polymer made from a monomer and a cross-linker, and being in contact with the buffer solution layer to form a gel-buffer interface (4) for receiving a sample which is to undergo electrophoresis. The gel and/or the buffer solution are such that absorption of water by the gel layer from the buffer solution layer is inhibited, thereby maintaining the performance capabilities of the electrophoresis cassette during storage.