Abstract: Improved apparatuses and methods are provided for ionizing samples and analyzing the samples with mass spectrometry.

Abstract: A method of determining a coefficient for converting an analog current value into a pulse count value in an inductively coupled plasma mass spectroscopy apparatus (ICP-MS) is described. The ICP-MS is configured to generate the pulse count value and the analog current value as a signal intensity indicating a density of an element in a sample to be measured.

Abstract: A method and system are provided for generating a nonlinear simulation model of a device under test (DUT). The method and system include receiving large-signal nonlinear waveform data based on responses of the DUT to input signals, determining a set of first dynamical variables and a set of second dynamical variables from the nonlinear waveform data, calculating values of second dynamical variables, providing nonlinear constitutive relations as functions of the first dynamical variables and the calculated values of the second dynamical variables, and compiling the nonlinear simulation model of the DUT using the identified nonlinear constitutive relations.

Abstract: A variable capacitor device includes a stator and a rotor. The stator includes first and second stator plates separated by electrically insulating material. The rotor includes first and second rotor plates connected by a rod, the rotor being configured to move axially for adjusting alignment of the first rotor plate relative to the first stator plate and the second rotor plate relative to the second stator plate, respectively. The first stator plate and the first rotor plate form a first variable capacitor, and the second stator plate and the second rotor plate form a second variable capacitor connected in series with the first variable capacitor. A first capacitance of the first variable capacitor and a second capacitance of the second variable capacitor are simultaneously adjustable upon the axial movement of the rotor to provide an adjustable total capacitance of the variable capacitor device.

Abstract: A method provides modeling of surface roughness effect of an electrical conductor. The method includes identifying first protrusions of a first level using an original flat surface of the conductor as a first base surface and determining a first correction factor of the first level using parameters of the first protrusions. The method further includes identifying second protrusions of a second level using the first protrusions and the first base surface as a second base surface, and determining a second correction factor of the second level using parameters of the second protrusions and regarding the second base surface as being a smooth surface, the smooth surface being a surface of the conductor without surface roughness effect. A final correction factor of the conductor is determined by combining the first correction factor and the second correction factor.

Abstract: A method for positioning a tip of an atomic force microscope relative to a intracellular target site in a cell is provided. In general terms, the method comprises: a) positioning a fluorescent tip of an atomic force microscope over a cell comprising a fluorescent intracellular target site so that said tip is above target site; b) moving the tip toward said target site while obtaining images of the distal end of said tip and/or the target site using a fluorescence microscope; and c) arresting the movement of the tip when the target site and the distal end of the tip are both in focus in the fluorescence microscope. A microscope system for performing the method is also provided.

Abstract: A downconverter mixes a first comb spectrum with a local oscillator signal to generate a second comb spectrum in a lower frequency range. The first comb spectrum comprises frequency components separated from each other according to a frequency spacing interval, and the LO signal has a frequency offset relative to the first comb spectrum, where the frequency offset is a rational fraction of the frequency spacing interval. The second comb spectrum comprises lower and upper sideband responses corresponding to respective lower and upper sideband signals of the first comb spectrum. The lower and upper sideband responses in the second comb spectrum can be distinguished from each other based on the frequency offset.

Abstract: A method for measuring a property of a binding interaction between a capture agent and a binding partner for the capture agent is provided. In certain embodiments, this method comprises: a) contacting a population of particles that are linked to a capture agent with a substrate comprising a binding partner to produce capture agent/binding partner complexes, wherein the population of particles comprises first particles that are bound to a single molecule of the capture agent and second particles that are bound to two molecules of the capture agent; b) applying a force to the bound support, wherein the force is in a direction that separates the particles from the support; and c) separately measuring the forces required to disassociate the first particles and the second particles from their respective complexes.

Abstract: In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream.

Abstract: A mixer for mixing a fluid having a property varying along a flow direction of the fluid includes an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet. The mixer also includes a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and a flow combiner for combining the partial flows from the plurality of flow channels to the outlet flow. Each flow channel has a first flow section having a hydraulic resistance substantially representing a hydraulic resistance of the flow channel. One or more of the flow channels each have a second flow section coupled in series with the first flow section of the respective flow channel.

Abstract: An apparatus for determining an operation mode of a device, wherein the device is capable of adjusting a physical condition at a source position to correspondingly influence a physical condition at a destination position, the apparatus comprising a determining unit adapted for determining the operation mode by defining a time dependency of the physical condition at the source position so that a target time-dependency of the physical condition is obtained for the destination position, the target time-dependency representing a resultant variation of the physical condition over time.

Abstract: A vessel includes a cylindrical section, a bottom section, a lower ring, and an upper ring. The cylindrical section includes an inside and, an outside vessel surfaces, an upper end region terminating at a rim circumscribing a vessel opening, a vessel groove formed at the outside vessel surface in the upper end region, and a lower end region axially spaced from the upper end region. The bottom section is disposed at the lower end region. The lower ring includes annular lateral and an annular flange portions. The lateral portion is disposed in the vessel groove and includes an outer lateral surface concentric with the inside vessel surface. The flange portion includes an upper and a lower flange surfaces perpendicular to the inside vessel surface. The upper ring includes an inner section extending over at least a portion of the rim, and an outer section securely engaging the upper flange surface.

Abstract: A digital oscilloscope comprises a sampling unit configured to sample an input signal received from an oscilloscope probe to produce a first stream of digital samples, a first acquisition system configured to store and process the stream of digital samples to produce a first data set, a second acquisition system configured to store and process the first stream of digital samples independent of the first acquisition system to produce a second data set, and a display system configured to concurrently display the first data set in a first format and the second data set in a second format different from the first format.

Abstract: A method of identifying a biopolymer in a sample that includes one or more biopolymers. The biopolymers may be polypeptides, polynucleotides, or polysaccharides. The method makes use of mass spectral datasets. A first dataset includes measured masses of the one or more biopolymers that are in the sample. A second dataset includes measured masses of a collection of fragments of the one or more biopolymers. The method selects a mass from the first dataset and then matches masses from the second dataset with the selected mass. The matched masses represent fragments of the biopolymer with the selected mass. Once the masses in the second dataset have been matched they are compared to determine a monomer sequence for the biopolymer with the selected mass. The method may be repeated with additional masses in the first dataset.

Abstract: A calibration kit (100) for calibrating a connectable network analyzer (102), including a converter (104, 106) adapted for performing a conversion between an electrical signal and an optical signal, a calibration standard (108, 110) for calibrating the network analyzer (102), and a switch array (112) adapted for switching the converter (104, 106) and the calibration standard (108, 110) in a manner to enable an electrical calibration of the network analyzer (102) and a calibration of the converter (104, 106) coupled to the network analyzer (102).

Abstract: A fitting for coupling a capillary to another component of a fluidic device is disclosed. The fitting includes a ferrule configured for enclosing a front part of the capillary and for contributing to a fluidic sealing between the fitting and the other component; a ferrule chuck configured for enclosing a back part of the capillary; and a housing configured for accommodating at least a part of the ferrule chuck and for pushing the ferrule chuck against the ferrule.

Abstract: A method for generating interference signals and a device to carry out said method, in which an interference signal (1) is added in a signal combination and separation network (3) with a desired signal (4) that carries a test message, the sum signal being sent to a device being tested (5). The interference signal (1) is generated with a single source connected to a signal divider and conditioner block (7) that attenuates additional interference produced by the source of generation of interference signals (1), while providing as many interference signals (1) as the device (5) under test has antennas (Rx, Rx/Tx), and in which each interference signal (1) is sent to a respective amplification and isolation block (8), which adjusts the power level of the interference signal (1) and attenuates the reverse intermodulation products produced by the transmission of signals by the device (5) under test.

Abstract: A system comprises a voltage source, a piezoelectric material arranged in a first current path between the voltage source and a first reference voltage, a capacitor arranged in a second current path between the voltage source and a second reference voltage, and a correction circuit configured to adjust the first reference voltage to increase or decrease the current in the first current path according to the current in the second current path.

Abstract: A system and a method for displaying an emitter location are disclosed. The system includes a plurality of receivers at different locations in a field. Each receiver generates a receiver signal that depends on the magnitude of a signal from the emitter. The system also includes a processor that receives the receiver signal and generates a likelihood map indicative of an approximation of a probability as a function of position in the field of the emitter location. The likelihood map includes a plurality of receiver maps. Each receiver map includes a probability as a function of position in the field of the emitter location based on the signal magnitude for at least one of the receiver signals. Each receiver map may depend on a ratio of the signal magnitudes from a corresponding pair of the receivers, or on one of the signal magnitudes from a corresponding one of the receivers.

Abstract: In an atmospheric inductively coupled plasma generating apparatus, impedance matching between a coil for plasma generation and an RF power source is effected at a high speed. A control method and/or condition for the output frequency of an oscillator which supplies a power to the coil for plasma generation or a control method and a control condition for the output power of the oscillator are changed appropriately in accordance with a generation state of a plasma. When a plasma is not generated, the output frequency is controlled according to a first condition and, when a plasma is generated, the output frequency is controlled according to a second condition different from the first condition. When a plasma is not generated, the output power is controlled according to a third condition and, when a plasma is generated, the output power is controlled according to a fourth condition different from the third condition.