Abstract: A nuclear magnetic resonance (NMR) probe circuit assembly includes one or more probe circuits in signal communication with one or more respective sample coils configured for transmitting and/or receiving radio-frequency (RF) energy to and/or from a sample of interest. One or more of the probe circuits have a suspended substrate configuration in which variable capacitors share a common dielectric substrate that is separated from a ground plane by an air gap. Each variable capacitor includes an electrode that is movable by a user-actuated adjusting device. One or more of the probe circuits may have a multiply resonant or broadband configuration, and may have one or more individual channels. One or more of the variable capacitors enable tuning to resonant frequencies of selected nuclei. One or more other variable capacitors may enable impedance matching.

Abstract: A gas sampling device has a high-vacuum tight chamber formed within its casing, which communicates with an ambient outside through an inlet hole for the gas flow to be ionized and the ambient downstream the ionization chamber with an outlet hole for the ionized gas. A high-vacuum tight membrane separates the inlet hole from the ambient outside the chamber. The membrane has at least one nanohole formed therethrough with a diameter in the order of nanometers.

Abstract: A fitting element is configured for coupling tubing to a fluidic device having a receiving cavity configured for receiving the fitting element, where the tubing has an inner contact surface of a biocompatible material, the inner contact surface being configured to contact a fluid to be conducted by the tubing, and the receiving cavity having a receiving contact surface of a bio-compatible material. The fitting element includes a first sealing element of a bio-compatible material configured for sealing to the bio-compatible material of the inner contact surface of the tubing, and a second sealing element configured for sealing against a pressure ambient to a pressure of the fluid in the tubing. Upon coupling of the tubing to the fluidic device, at least a portion of the receiving contact surface, the first sealing element, and the second sealing element enclose an interspace, each surface of the interspace being a bio-compatible material.

Abstract: A method for operating a computer system to generate a layout of a device and a computer-readable medium containing instructions that cause a computer system to carry out that method are disclosed. The computer system has a display that includes a display area. The computer system provides a list of objects and creates user selected objects from the list for inclusion in the display area. The computer assigns one of a plurality of operating modes for each connectivity object in the layout. The computer generates a Net assignment for each connectivity object that is not forced to have a specific Net assignment and for which automatic assignment of a Net is allowed. The computer generated assignment depends on the operating mode associated with that connectivity object. The operating mode of at least one of the connectivity objects can be altered by input from a user of said computer system.

Abstract: A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.

Abstract: A method is provided for determining a measure of error of a device under test (DUT). The method includes storing baseband data received from the DUT in a storage device, segmenting the baseband data into multiple data segments, determining processing parameters for one data segment of the plurality of data segments, and storing the determined processing parameters for the one data segment. The method further includes retrieving additional data segments of the multiple data segments from the storage device, and processing the additional data segments using the stored processing parameters for the one data segment. The measure of error of the DUT is determined based at least in part on data from the processed additional data segments.

Abstract: An optical emission spectrometer system includes a light source and a dichroic beam combiner. The light source emits first light in a first direction and second light in a second direction different from the first direction. The dichroic beam combiner receives the first light via a first light path and the second light via a second light path, reflects a portion the first light into an entrance aperture of a light detection and measurement apparatus, and transmits a portion of the second light into the entrance aperture, enabling analysis and measurement of both first and second light characteristics simultaneously. The portion of the first light reflected into the entrance aperture predominately has wavelengths in a first range of wavelengths and the portion of the second light transmitted into the entrance aperture predominately has wavelengths in a second range of wavelengths, different from the first range of wavelengths.

Abstract: An output signal is generated from a received input data stream representing a sequence of digital data values. For each group of successive data values in the sequence of data values, a respective waveform pattern is assigned in dependence of the data content of the respective group of successive data values. The output signal is generated by generating the assigned respective waveform patterns corresponding to the input data stream.

Abstract: A computer readable medium stores a program, executable by a computer, for enabling translation of machine-centric commands in an instrument protocol to a programming language for controlling an instrument configured to use the machine-centric commands. The computer readable medium includes an identifying code segment for identifying instrument protocol commands executable by the instrument, and a generating code segment generates methods corresponding to the instrument protocol commands, each method including programming language source code or compiled machine code for executing the corresponding instrument protocol command. A storing code segment stores the methods in a program library associated with the instrument, the program library enabling selection of at least one method by a programming language program that controls the instrument, in order to execute the instrument protocol command corresponding to the selected method.

Abstract: An automated liquid handling system is disclosed. A system includes a first pipetting group, which includes at least one pipettor, movably arranged on a first arm; and a second pipetting group, which includes at least one pipettor, movably arranged on a second arm, wherein the first arm and the second arm are movably arranged on at least one track such that the first arm and the second arm can independently move along the at least one track while keeping the first arm parallel with the second arm, wherein the at least one pipettor of the first pipetting group is arranged on a side of the first arm facing the second pipetting group, wherein the at least one pipettor of the second pipetting group is arranged on a side of the second arm facing the first pipetting group.

Abstract: A nuclear magnetic resonance (NMR) probe comprises a superconducting material formed in a spiral having a plurality of fingerlets separated by a plurality of slits, and a normal-metal overlayer formed on the spiral over the plurality of fingerlets and the plurality of slits.

Abstract: An ionization device comprises: a plasma source configured to generate a plasma. The plasma comprises light, plasma ions and plasma electrons. The plasma source comprises an aperture disposed such that at least part of the light passes through the aperture and is incident on a gas sample. The ionization device further comprises an ionization region; and a plasma deflection device comprising a plurality of electrodes configured to establish an electric field, wherein the electric field substantially prevents the plasma ions from entering the ionization region.

Abstract: The invention provides an apparatus and method for sequencing and identifying a biopolymer. The invention provides a first electrode, a second electrode, a first gate electrode, a second gate electrode, a gate voltage source and a potential means. The gate electrodes may be ramped by a voltage source to search and determine a resonance level between the first electrode, biopolymer and second electrode. The potential means that is in electrical connection with the first electrode and the second electrode is maintained at a fixed voltage. A method of biopolymer sequencing and identification is also disclosed.

Abstract: Tracer gas leak detection is provided by a calibration system with a gas leak detector having a test port for receiving a sample containing a tracer gas and coupled to a vacuum pump; a calibrated leak for a calibration sample containing the tracer gas; a mass filter coupled to the test port for receiving the test sample in an operating mode, coupled to the calibrated leak through a calibrated leak valve for receiving the calibration sample in a calibration mode, having controllable transmission of the tracer gas and providing a filtered sample; detector detecting the tracer gas in the filtered sample; a programmable gain element providing a measured value of leak rate in response to the detector signal; and a controller configured, in response to a mode control signal, to operate the leak detector in the calibration mode over two or more working ranges using the calibrated leak.

Abstract: Methods of deprotecting polynucleotides are disclosed. One aspect of the method of deprotecting polynucleotides, among others, includes: providing a polynucleotide, wherein the polynucleotide includes at least one nucleotide monomer that has at least one protecting group selected from the following: a base having a protecting group, a 2?-hydroxyl protecting group, and a combination thereof, and deprotecting at least one of the protecting groups of the polynucleotide by introducing the polynucleotide to a solution including an ?-effect nucleophile.

Abstract: An optical spectroscopy method and apparatus increases signal to noise ratio of detected signals. Sample light passed through a sample includes attenuated light pulses and characteristic light located between the attenuated light pulses, the characteristic light formed by interaction between light pulses incident the sample and sample molecules. The attenuated light pulses are substantially removed from the sample light emerging from the sample prior to detection, to increase signal to noise ratio of the detected signal.

Abstract: An amplifier device having an extended bandwidth includes a DC coupled amplifier and multiple low noise amplifiers connected in series with one another and connected in parallel with at least a portion of the DC coupled amplifier. The DC coupled amplifier has a broad bandwidth, and each of the low noise amplifiers has a narrow bandwidth and a center frequency higher than a high end frequency of the broad bandwidth of the DC coupled amplifier. The extended bandwidth of the amplifier device is a combination of the broad bandwidth and the first narrow bandwidth.

Abstract: An apparatus and method for measuring the mobility of molecules in a sample are disclosed. Molecules in a sample are tagged with a dye having active and inactive states that are generated by exposing dye to light of an activation wavelength and an inactivation wavelength, respectively, the activation wavelength being different from the inactivation wavelength. The sample is illuminated in a microscope with a light pattern that includes a first region in which the dye is activated and a second adjacent region in which the first dye is inactivated. After the sample is so illuminated, an image of the activated first molecules is recorded when the first molecules are illuminated with light of an excitation wavelength. Molecules having the first dye in the inactive state are distinguishable from molecules having the first dye in the active state in the microscope when illuminated with light of the excitation wavelength.

Abstract: A clock recovery circuit includes a phase detector, a loop filter, a phase rotator, a predictor and a delay line. The phase detector receives an input data signal and generates a phase error signal for estimating phase error in the input data signal when referred to a recovered clock. The loop filter receives the phase error signal and determines a phase control signal based on the phase error signal. The phase rotator receives the phase control signal, and provides a phase adjusted clock based on a reference clock and the phase control signal. The predictor receives the phase error signal, and determines a delay control signal based on the phase error signal. The delay line outputs the recovered clock by delaying the phase adjusted clock from the phase rotator using the delay control signal from the predictor, and provides the recovered clock to the phase detector.

Abstract: Certain embodiments described in this disclosure relate to a method of sample analysis. In certain cases, the method comprises: a) contacting a genomic sample comprising double-stranded genomic DNA with a first restriction endonuclease that recognizes a nucleotide sequence that comprises a SNP site in the double stranded genomic DNA, wherein: i. the restriction endonuclease cleaves the genomic DNA at the sequence regardless of the allele of the SNP present at the SNP site; and ii. cleavage of the sequence by the restriction enzyme creates a 5? overhang that comprises the SNP site; b) contacting the digested genomic sample with a extension enzyme and a first labeled nucleotide that is used by the extension enzyme to fill in the overhang only if the overhang comprises a first allele of the SNP.