Abstract: The present invention is related to a digital circuit for use in a mixed-signal circuit.

Abstract: Improved apparatuses and methods are provided for ionizing samples and analyzing the samples with mass spectrometry.

Abstract: A system for improving dynamic response in a power supply includes a mainframe module having a memory and a mainframe microprocessor, the mainframe processor configured to calculate a plurality of tables in which each table represents a current/voltage (I/V) characteristic curve for the power supply, at least two power supply modules coupled to the mainframe module, each power supply module having a random access memory element, the random access memory element configured to receive and store a first table and a second table, wherein the mainframe microprocessor transfers the first table to each power supply module, and wherein each power supply module executes a respective first table while the mainframe processor calculates the second table for each power supply module and while the mainframe processor transfers the second table to each power supply module.

Abstract: Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or comparative genome hybridization microarray, comprising selecting a plurality of potential target sequences, generating a plurality of candidate probes from the target sequences, filtering the plurality of candidate probes by analyzing candidate probes for selected probe properties in silico. Microarrays comprising probes selected by the methods of the invention are particularly useful for comparative genome hybridization and location analysis.

Abstract: An oligonucleotide composition is provided. The subject composition comprises: a mixture of at least 10 of sets of oligonucleotides, wherein each of the sets of oligonucleotides comprises at least 100 different oligonucleotides of the following formula: X1—V—X2, wherein: X1 and X2 provide binding sites for a pair of PCR primers and V is a variable region that has a variable nucleotide sequence that is complementary to one or more discrete regions of a mammalian genome; the nucleotide sequences of X1 and X2 are the same for each oligonucleotide of a set and different for oligonucleotides of different sets; and the variable regions of each set are complementary to different discrete regions of said mammalian genome. Methods of using the composition and kits containing the composition are also provided.

Abstract: A device for providing a constant mass flow rate to a downstream column system of a gas chromatograph includes a small full scale mass flow controller that controls carrier gas to flow at a first mass flow rate and a flow resistance element, including an inlet port connected to a sample inlet, an outlet port connected to the downstream column system, and a pressure sensing port in fluid communication with the outlet port and the mass flow controller. A sample inlet pressure controller controls the sample inlet at a first pressure, and a pressure sensor measures a second pressure of the carrier gas at the pressure sensing port. A set point of the first pressure is determined as a function of the second pressure, flow resistance of the flow resistance element, and a second mass flow rate from the inlet port to the outlet port of the flow resistance element.

Abstract: A thermal modulation device for a gas chromatography (GC) system a cold zone, a first hot zone and a second hot zone, which are located outside of a GC oven of the GC system, and a flexible capillary column. The cold zone includes a thermoelectric cooler assembly. The first hot zone is adjacent a first side of the cold zone, and has a corresponding first heat source. The second hot zone is adjacent a second side of the cold zone, and has a corresponding second heat source. The flexible capillary column includes a first segment, configured to move between the first hot zone and the cold zone in accordance with a modulation frequency, and a second segment, configured to move between the cold zone and the second hot zone in accordance with the modulation frequency.

Abstract: A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosomal map of the genomic array data comprising a first positional indicator that indicates a position on the chromosomal map; and ii) a cytogenetic map of the cytogenetic data comprising a second positional indicator that indicates a position on the cytogenetic map.

Abstract: An apparatus for measuring spectral components of a signal is described. The apparatus comprises a measurement acquisition unit configured to receive an input signal and to provide a measurement trace. The apparatus also comprises a model module configured to model one or more of a phase noise from the apparatus, a broadband noise from the apparatus, and a third order intermodulation (TOI) product from the apparatus. The apparatus also comprises a display configured to show one or more of the phase noise from the apparatus, the broadband noise from the apparatus, and the TOI product from the apparatus.

Abstract: The present invention provides methods, compositions, and kits for the storage and stabilization of biological molecules. The methods comprise applying Tris(2-carboxyethyl)phosphine (TCEP) to at least one biological molecule bound to a solid substrate and storing in an organic solvent. Preferably, the biological molecules are nucleic acids. Compositions and kits for performing the process according to the invention are also provided.

Abstract: Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a labeled substrate to provide labeled RNA. Methods of performing an array analysis of a labeled RNA sample are also described.

Abstract: A fluidic device configured for separating components of a fluid includes a flow path within an interior of the fluidic device, and at least one heatable frit positioned in the flow path and arranged to selectively adjust a temperature of the fluid in the flow path within the interior of the fluidic device.

Abstract: A method for partitioning a genome is provided. In certain embodiments, the method comprises: a) nicking a region of the genome using a sequence-specific nicking endonuclease to produce a nicked double-stranded genomic region; b) hybridizing the nicked double-stranded genomic region with an oligonucleotide comprising: i. an affinity tag; and ii. a nucleotide sequence that is complementary to the nucleotide sequence that is immediately adjacent to the nick site, to produce a duplex in which a terminal nucleotide of the oligonucleotide lies immediately adjacent to said a nucleotide of the nick site; c) ligating the terminal nucleotide of the oligonucleotide to the nucleotide of the nick site to produce a ligation product; and d) separating the ligation product from unligated products using the affinity tag. Compositions and kits for practicing the method are provided.

Abstract: A system for adjusting a serial communications link includes a system under test including at least one transmitter and at least one receiver coupled together via a serial data communications link, wherein at least one of the transmitter and the receiver has at least one tunable parameter, at least one controller coupled to at least one of a transmitter and a receiver via a joint test action group JTAG interface, and logic configured to adjust the at least one tunable parameter to optimize a performance of the serial data communications link.

Abstract: A degassing apparatus (27) for degassing a liquid (240) comprises a vacuum chamber (200), a liquid conveyance member (210) disposed in the vacuum chamber (200) and adapted for transporting the liquid (240), and a pump (220) adapted to evacuate the vacuum chamber (200). The vacuum chamber (200) comprises a vent (270) adapted for venting the vacuum chamber (200).

Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.

Abstract: An apparatus (200) for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode (300) representing a desired behavior of the first fluidic device and has a first real operation mode (304) representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode (312) representing a desired behavior of the second fluidic device and has a second real operation mode (314) representing the actual behavior of the second fluidic device, the apparatus (200) comprising a first determining unit (202) adapted for determining the first real operation mode (304) based on the first target operation mode (300) and based on a preknown parameterization (302) of the first fluidic device, and a second determining unit (204) adapted for determining the second target operation mode (312) based on the determined first real operation mode (304) and based on a preknown parameterizatio

Abstract: A phase-locked loop includes: a voltage-controlled oscillator (VCO) system receiving one or more control signals and in response thereto generating a PLL output signal; a plurality of phase detectors for comparing a reference signal having a reference frequency to a PLL feedback signal having a PLL feedback frequency derived from the PLL output signal, and in response thereto to output a comparison signal; and a plurality of signal processing paths each connected to an output of a corresponding one of the phase detectors for outputting a phase detection output signal. The signal processing paths have different frequency responses from each other. In operation only one of the phase detectors is activated, and a switching arrangement selectively switches between outputs of the signal processing paths to select the phase detection output signal from the activated phase detector to generate the control signal(s) for the VCO system.

Abstract: A charged particle beam column package includes an assembly (e.g., comprising a plurality of layers, which can have a component coupled to one of the layers), and at least one deflector between an extractor and aperture of the assembly. Further, at least one of the layers has interconnects thereon.