Patents Assigned to Agilent Technologies
  • Patent number: 7998437
    Abstract: A microfluidic assembly (1;57) has at least one microfluidic flow path (17,27,29,35,38;82,85,95) and at least one inlet port (11,13,15;81,97,101) coupled to the flow path (17,27,29,35,38;82,85,95). The microfluidic assembly (1;57) has a first microfluidic device (7;63) that executes a microfluidic process and has a second microfluidic device (9;61). The microfluidic assembly (1;57) has an interface (5;65). The interface (5;65) couples the first microfluidic device (7;63) and the second microfluidic device (9;61).
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: August 16, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: Manfred Berndt, Marcus Gassmann
  • Patent number: 7999087
    Abstract: Nucleoside monomers, nucleic acids, e.g., oligonucleotides and polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein. Aspects of the invention include 2? silyl containing thiocarbonate protecting groups. Corresponding compositions and methods are provided.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: August 16, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: Douglas J. Dellinger, Agnieska Sierzchala, Marvin H. Caruthers, Geraldine F. Dellinger
  • Patent number: 7999084
    Abstract: Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, and a sorbent associated with the support capable of binding matrix interfering agents present in the bioanalytical sample, wherein the device further comprises filtering means for removing precipitated protein particles. The filtering means is a size exclusion filter or a polymeric or inorganic monolith having a maximum pore size less than or equal to the diameter of the particles to be removed from the sample, and can be integral with the sorbent or associated with the sorbent. The sorbent is characterized by sufficient selectivity between the matrix interfering agents and analytes of interest to provide retention of the matrix interfering agents while providing elution of the analytes of interest (e.g., a reversed phase or a polar modified reversed phase).
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: August 16, 2011
    Assignee: Agilent Technologies, Inc.
    Inventor: David C. Jones
  • Publication number: 20110192217
    Abstract: A mixer for mixing a fluid having a property varying along a flow direction of the fluid includes an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet. The mixer also includes a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and a flow combiner for combining the partial flows from the plurality of flow channels to the outlet flow. Each flow channel has a first flow section having a hydraulic resistance substantially representing a hydraulic resistance of the flow channel. One or more of the flow channels each have a second flow section coupled in series with the first flow section of the respective flow channel.
    Type: Application
    Filed: February 8, 2010
    Publication date: August 11, 2011
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Konstantin Choikhet, Klaus Witt, Martin Baeuerle
  • Patent number: 7994771
    Abstract: A current measurement circuit includes: a constant-voltage loop circuit including an operational amplifier, and a first resistor for current detection connected to an output of the operational amplifier, the output of the operational amplifier being fed back to an inverting input terminal of the operational amplifier via the first resistor; a differential amplifier for current detection with an input of a voltage between both ends of the first resistor; and a saturation prevention and recovery circuit connected to the both ends of the first resistor for preventing saturation of the operational amplifier and/or accelerating recovery from the saturation thereof.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: August 9, 2011
    Assignee: Agilent Technologies, Inc.
    Inventor: Hiroshi Sakayori
  • Patent number: 7992429
    Abstract: A liquid chromatograph includes a mobile phase supplying apparatus including liquid-feeding pumps to feed mobile phases, liquid-feeding flow paths, a mixer to mix the mobile phases, at least one control device to control each liquid-feeding pump, flow rate measuring sections provided downstream in each liquid-feeding flow path configured to measure an actual flow rate and to detect a back-flow, and actual flow rate computing sections configured to compute an actual flow rate in the corresponding liquid feeding flow path. Also included are a sample injecting section downstream of the mobile phase supplying apparatus, a separating column for separating an injected sample into its constituents, and a detector for detecting each of the separated constituents. When one of the actual flow rate measuring sections detects a back-flow, the corresponding actual flow-rate computing section computes an actual back-flow rate and outputs a signal to the corresponding control device to cancel the back-flow.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: August 9, 2011
    Assignee: Agilent Technologies, Inc.
    Inventor: Hans-Georg Weissgerber
  • Publication number: 20110186497
    Abstract: A sealing configuration is configured for sealingly coupling a first fluid flow path of a first device to a second fluid flow path of a second device. The sealing configuration comprises a contact surface comprising a structure configured for increasing a surface pressure when coupling the first device to the second device. The contact surface comprises a metal coating configured for increasing sealing.
    Type: Application
    Filed: February 3, 2011
    Publication date: August 4, 2011
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Joachim Wagner, Hans-Georg Haertl
  • Patent number: 7989765
    Abstract: An ion trap comprising elongate rods, electrodes, a first circuit, and a second circuit. The rods are for defining the radial extent of a trapping volume. The first circuit is connected to the rods for applying thereto a first RF signal that generates adjacent the trapping volume a radial RF containment field that radially contains ions of different polarities within the trapping volume. The electrodes define the axial extent of the trapping volume. The second circuit is connected to the electrodes for applying thereto a second RF signal that generates adjacent the trapping volume an axial RF containment field that axially contains the ions of different polarities within the trapping volume. The axial RF containment field is independent of the radial RF containment field.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: August 2, 2011
    Assignee: Agilent Technologies, Inc.
    Inventor: Stuart Carl Hansen
  • Publication number: 20110180699
    Abstract: A device includes a first substrate having a principal surface having a plurality of sample sites having a corresponding sample; a second substrate having a principal surface facing and spaced apart from the principal surface of the first substrate, the second substrate having a plurality of ultraviolet emission sites corresponding to the sample sites of the first substrate, each of the ultraviolet emission sites being spaced apart from and facing a corresponding one of the sample sites of the first substrate, each of the ultraviolet emission sites being configured to emit ultraviolet light to a corresponding one of the sample sites on the first substrate, and to ionize at least a portion of a sample provided at each sample site; and an ion extraction device configured to extract ions from a gap between the first substrate and the structure.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 28, 2011
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: James Edward COOLEY, Viorica LOPEZ-AVILA, Randall URDAHL
  • Publication number: 20110180702
    Abstract: A mass analyzer comprises a pair of planar electrode structures. The electrode structures are disposed opposite to each other, parallel to each other, and axially offset from each other. The electrode structures are configured to generate, in response to an applied voltage, a cylindrically-symmetric, annular electric field comprising an annular radially focusing central lens region surrounding an axis of symmetry, and an annular mirror region surrounding the annular radially focusing central lens region.
    Type: Application
    Filed: January 31, 2011
    Publication date: July 28, 2011
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Curt A. FLORY, Trygve RISTROPH
  • Publication number: 20110181370
    Abstract: A signal bus includes multiple interconnects for transporting electronic signals. The interconnects have different physical path lengths and different structures to equalize the different the physical path lengths, so that the electronic signals traverse the corresponding interconnects in same period of time.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 28, 2011
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: Nathaniel GUILAR
  • Patent number: 7987006
    Abstract: Linear PID controllers have a transfer function that resembles the frequency response of a notch filter. The PID parameters, KP, KI, and KD (proportional, integral, and derivative gains, respectively) can be extracted from the parameters of a linear notch filter. The linearized modes of scanning probe microscope (SPM) actuators have frequency responses that resemble those of simple second order resonance. Reasonable feedback control can be achieved by an inverse dynamics model of the resonance. A properly parameterized notch filter can cancel the dynamics of a resonance to give good closed-loop response.
    Type: Grant
    Filed: August 29, 2007
    Date of Patent: July 26, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: Daniel Y Abramovitch, Storrs T. Hoen, Richard K. Workman
  • Publication number: 20110175531
    Abstract: A plasma generation device includes: a substrate having a first surface and a second surface; a stripline resonant ring disposed on the first surface of the substrate, and defining a discharge gap; a pair of electrode extensions connected to the stripline resonant ring at the discharge gap; a ground plane disposed on the second surface of the substrate; a gas flow element configured to flow gas between at least one of: (1) the discharge gap, and (2) the pair of electrode extensions; and a structure disposed adjacent the substrate to form an enclosure that substantially encloses at least a region including the discharge gap and the electrode extensions, the enclosure being adapted to contain a plasma.
    Type: Application
    Filed: January 15, 2010
    Publication date: July 21, 2011
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Randall URDAHL, James Edward COOLEY, Gregory S. LEE, August Jon HIDALGO, Martin L. GUTH
  • Publication number: 20110174969
    Abstract: A method of replacing an ion source in a mass spectrometer (MS) system is provided, where the ion source includes an ionization volume, at least one ionizing element and at least one focusing element, and where the mass MS system includes the ion source, a vacuum chamber that houses the ion source, and an interlock chamber. The method includes opening a valve between the interlock chamber and the vacuum chamber, moving the ion source into the interlock chamber through the opened valve and closing the valve, and removing the ion source from the interlock chamber. The ion source may further include means for plugging into a docking station in substantially one action, where the docking station provides sufficient electrical connection, upon plugging with the ion source, for operation of the ion source.
    Type: Application
    Filed: January 19, 2010
    Publication date: July 21, 2011
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: Carolyn Broadbent SEYFARTH
  • Publication number: 20110168880
    Abstract: A mass spectrometer includes: an accelerator for receiving ions travelling in a drift direction and accelerating the ions in an acceleration direction orthogonal to the drift direction; a detector downstream of the accelerator with respect to the drift direction; and an ion mirror assembly intermediate the accelerator and the detector. The ion mirror assembly includes at least a first ion mirror and a second ion mirror spaced apart from each other in the acceleration direction. The accelerator, detector, and ion mirror assembly provide a folded ion path between the accelerator and the detector for separating the ions according to their mass-to-charge ratio so that a flight time of the ions is substantially independent of ion energy. The first and second ion mirrors each apply an electrostatic potential to the ions that is curved in both the drift direction and a lateral direction orthogonal to both the drift and acceleration directions.
    Type: Application
    Filed: January 13, 2010
    Publication date: July 14, 2011
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Trygve RISTROPH, Curt Alan FLORY
  • Patent number: 7979031
    Abstract: In a communication network architecture having multiple technology coverage areas that support different network technologies, a service provider monitors its customer's experience as the customer roams between technology coverage areas. An agent, such as software installed on-board the customer's mobile equipment, measures parameters that are related to the network technology, and communicates the measured parameters to the service provider, over the communication network.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: July 12, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: Lance A. Tatman, Jerry J. Liu, Glenn R. Engel, Glen L Purdy, Jr.
  • Patent number: 7979215
    Abstract: Methods of evaluating candidate CGH probe nucleic acid sequences are provided. Aspects of the methods include providing a candidate CGH probe nucleic acid sequence for a target sequence of a copy number variation (CNV) of a genome. A proximity score is then determined for the candidate CGH probe nucleic acid sequence and employed to evaluate the sequence. Aspects of the invention further include computer programming and systems that include the same which are configured to evaluate candidate CGH probe nucleic acid sequences using a proximity score.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: July 12, 2011
    Assignee: Agilent Technologies, Inc.
    Inventor: Nicholas M. Sampas
  • Patent number: 7977119
    Abstract: Methods and compositions for generating mixtures of product molecules from an initial chemical array are provided. In the subject methods, a chemical array of surface immobilized first moieties is subjected to cleavage conditions such that a composition of solution phase first moieties is produced. The resultant composition of solution phase first moieties is then contacted with one or more reactants to produce a mixture of product molecules that are different from the first moieties. Also provided are the arrays employed in the subject methods and kits for practicing the subject methods.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: July 12, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: Mel N. Kronick, Eric M. Leproust
  • Patent number: 7977649
    Abstract: Provided is a plasma ion source mass spectrometer with an ion deflector lens having an improved removal ratio of photons and neutral particles as compared with the conventional art while an ion transmittance is maintained. The ion deflector includes an input side plate-like electrode, an output side plate-like electrode, and a tubular electrode disposed between the input side plate-like electrode and the output side plate-like electrode. The tubular electrode is of a point asymmetrical configuration. The tubular electrode is arranged so that a center axis of the tubular electrode is closer to an axis of travel of ions upstream of the input side plate-like electrode than an axis of travel of ions downstream of the output side plate-like electrode.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: July 12, 2011
    Assignee: Agilent Technologies, Inc.
    Inventor: Kazushi Hirano
  • Patent number: 7977996
    Abstract: A digital pulse generator including a fractional delay filter is provided as having a plurality of step response functions that can be selected on a sample by sample basis by selection of filter coefficients. The step response functions are all identical but each have different group delay. Responsive to an input waveform having leading and trailing edges aligned with a system clock, the fractional delay filter can output the impulse responses as a pulse waveform having respective leading and trailing edges delayed by different respective fractions of a signal clock cycle from the respective leading and trailing edges of the input waveform. The pulse waveform as output can thus have desired pulse width and desired period of repetition with finer edge placement resolution of improved accuracy.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: July 12, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: David Paul Kjosness, Bryan D. Boswell