Patents Assigned to Arkray
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Publication number: 20190128796Abstract: An analysis device includes a guide-in section, a placement section, an illumination member, a pressing member, and a measurement member. The guide-in section is configured to guide a rectangular block shaped analysis kit containing a sample. The analysis kit is placed on the placement section in the guide-in section. The illumination member is inserted into an insertion hole formed in the analysis kit, contacts a bottom of the insertion hole, and illuminates light onto the sample. The pressing member is configured by a separate body to the illumination member and presses the analysis kit such that the analysis kit placed on the placement section is sandwiched between the pressing member and the placement section and retained at a predetermined position. The measurement section measures a component present in the sample using light illuminated from the illumination member onto the sample in the analysis kit placed on the placement section.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Applicant: ARKRAY, Inc.Inventors: Akihiro YAMAMOTO, Naoto SHICHI
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Publication number: 20190128912Abstract: An analysis device includes a guide-in section, a piercing member, an airtight member, a gas introduction member, and a measurement member. The guide-in section is configured to guide a rectangular block shaped analysis kit containing a sample. The piercing member pierces a sealing film at an upper face of a liquid reservoir formed in the analysis kit. The airtight member forms an airtight space against the analysis kit at the periphery of a location pierced by the piercing member. The gas introduction member introduces gas into the airtight space. The measurement member measures a component present in the sample in the analysis kit guided into the guide-in section.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Applicant: ARKRAY, Inc.Inventors: Akihiro Yamamoto, Daisuke Matsumoto, Masao Kawano
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Publication number: 20190128254Abstract: A method of driving a pump is used in a pressure-applying apparatus, the apparatus including a flow passage, a pump configured to impart pressure into the flow passage, an opening and closing valve configured to open and close the flow passage, a pressure detector configured to detect pressure in the flow passage, and an atmospheric air open valve configured to open an interior of the flow passage to atmospheric air. The method includes driving the pump after closing the opening and closing valve and opening the atmospheric air open valve, and evaluating a state of the pump, based on one of: the pressure detected by the pressure detector at a time at which a predetermined time period has elapsed after closing the atmospheric air open valve, and a time from closing of the atmospheric air open valve until detection of a predetermined pressure by the pressure detector.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Applicant: ARKRAY, Inc.Inventors: Naoto SHICHI, Daisuke MATSUMOTO, Takanari SHIGEMITSU
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Publication number: 20190128914Abstract: An analysis device employs an analysis kit including a chip provided with a capillary through which a sample flows and a cartridge superimposed on the chip and provided with a liquid reservoir. The analysis device includes a guide-in section into which the analysis kit is guided, a placement section on which the analysis kit placed so as to be supported, a pusher member that pushes the analysis kit from one side face of the analysis kit, contact members that oppose another side face on an opposite side in the horizontal direction to the one side face of the analysis kit placed on the placement section, and contact the other side face of the analysis kit being pushed in by the pusher member so as to position the analysis kit in the horizontal direction, and a measurement member that measures a component present in the sample in the analysis kit.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Applicant: ARKRAY, Inc.Inventors: Akihiro YAMAMOTO, Shigeru KITAMURA, Naoto SHICHI
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Publication number: 20190117154Abstract: A measuring apparatus includes: a measurement unit configured to measure a concentration value of a specified substance contained in a sample; an acquiring unit configured to acquire information about a user's activity status; a calculation unit configured to calculate a concentration value of the specified substance within a second period ranging from present time to second predetermined time after the present time, based on a concentration value of the specified substance within a first period ranging from first predetermined time before the present time to the present time and the information about the user's activity status within the first period; and an informing unit configured to inform a user of the information about the concentration value of the specified substance when the concentration value of the specified substance within the second period does not fall within a range of a predetermined concentration value.Type: ApplicationFiled: October 19, 2018Publication date: April 25, 2019Applicant: ARKRAY, Inc.Inventors: Takeshi Shimizu, Yasuhide Kusaka
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Publication number: 20190120749Abstract: A determination method includes: using a microchip, including a capillary flow path and a sample reservoir connected to the capillary flow path at an upstream side, to fill the capillary flow path with a first solution for electrophoresis, and supply the sample reservoir with a second solution containing an analyte; applying a voltage between the sample reservoir supplied with the second solution and the inside of the capillary flow path filled with the first solution, to move a component contained in the second solution in the capillary flow path and separate the component in the capillary flow path; optically detecting a value related to a component difference between the first solution and the second solution, other than a value related to the analyte, for the separated component; and determining whether the optical detection is favorable or poor by comparing the optically detected value with a predetermined threshold value.Type: ApplicationFiled: October 17, 2018Publication date: April 25, 2019Applicant: ARKRAY, Inc.Inventor: Takanari Shigemitsu
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Publication number: 20190120861Abstract: An ascorbic acid responsive electrode comprising an electrode, and a detection layer comprising a non-catalytic electron acceptor that receives an electron from ascorbic acid, an amino acid, and a saccharide and/or a soluble protein; wherein in the detection layer the electron acceptor is reduced by the ascorbic acid, and the reduced electron acceptor is oxidized at the electrode.Type: ApplicationFiled: October 23, 2018Publication date: April 25, 2019Applicant: ARKRAY, Inc.Inventor: Kazuo Fukuda
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Publication number: 20190120790Abstract: The present analysis method for analyzing a sample uses capillary electrophoresis by applying a voltage to a sample solution introduced to a micro flow path, performing separation analysis for a component contained in the sample solution, and measuring an optical measurement value at a measurement section of the micro flow path corresponding to an elapsed time after a start of measurement.Type: ApplicationFiled: October 17, 2018Publication date: April 25, 2019Applicant: ARKRAY, Inc.Inventors: Masao Kawano, Naotsugu Onuma
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Publication number: 20190101742Abstract: A plurality of images of a sample are simultaneously captured at different focal lengths by a plurality of cameras. An analysis apparatus includes: a branch section configured to cause light passing through the sample containing a material component to branch off into a plurality of optical paths; a plurality of imaging devices for simultaneously capturing images of the sample in a flow path at different focal points by using the light caused to branch off into the plurality of optical paths; and a controller configured to process the captured images.Type: ApplicationFiled: September 27, 2018Publication date: April 4, 2019Applicant: ARKRAY, Inc.Inventors: Shinya NAKAJIMA, Shigeki MASUDA, Kenji NAKANISHI, Yukio WATANABE
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Patent number: 10238714Abstract: A method for forming an immune-tolerant site, and a method for attracting immunosuppressive cells, comprising contacting an agent comprising SEK-1005 (Ser, 3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) and/or fibroblast growth factor (FGF) with a site in the body tissue.Type: GrantFiled: April 13, 2016Date of Patent: March 26, 2019Assignees: KYOTO UNIVERSITY, ARKRAY, Inc., KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATIONInventors: Hiroo Iwata, Rei Kuwabara, Masahide Hamaguchi, Kunio Hirano, Shimon Sakaguchi
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Patent number: 10234414Abstract: A measurement apparatus to measure a physical quantity related to a measurement target by use of a sensor, comprising: an apparatus enclosure; a control unit to be electrically connected to the sensor; and a moving member including a sensor holding unit to hold the sensor, the moving member being movable to protrude the sensor holding unit outwardly of the apparatus enclosure and further including a conductive member to electrically connect the sensor to the control unit.Type: GrantFiled: May 12, 2015Date of Patent: March 19, 2019Assignee: ARKRAY, Inc.Inventors: Yuji Kurata, Kazuo Fukuda, Yoshiharu Sato, Gai Go
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Patent number: 10228341Abstract: A biosensor includes a plurality of electrodes including a working electrode, and a detection layer which is immobilized on the working electrode and contains a crosslinking agent, an electrically conductive macromolecule and an enzyme transferring and receiving electrons to and from the working electrode. The working electrode is in an open system.Type: GrantFiled: October 14, 2016Date of Patent: March 12, 2019Assignees: ARKRAY, Inc., Ultizyme International Ltd.Inventors: Koji Katsuki, Megumi Saeda, Junko Shimazaki
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Publication number: 20190064100Abstract: A method for quantifying a substance, which method includes the steps of: introducing a sample containing a measurement target substance to a biosensor comprising an enzyme electrode comprising an electrode and an oxidoreductase placed on the electrode in a state where direct electron transfer with the electrode occurs, and a counter electrode; applying an AC voltage to the enzyme electrode to carry out impedance measurement; and calculating the substance concentration based on an index obtained by the impedance measurement; is provided.Type: ApplicationFiled: August 24, 2018Publication date: February 28, 2019Applicants: ARKRAY, Inc., Ultizyme International Ltd.Inventors: Koji Sode, Junko Shimazaki
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Publication number: 20190056347Abstract: A measuring method includes applying a first signal having a first value to a sample disposed in the flow passage by using a working electrode and a counter electrode, measuring a first electric response value of the sample to the first signal, applying contiguously for a given time a second signal having a second value higher than the first value to the sample disposed in the flow passage by using the working electrode and the counter electrode, measuring a second electric response value of the sample within the given time to the second signal, the second electric response value indicating amount of electric charge generated by electrolysis of water in the sample, and correcting a value obtained from the first electric response value based on the second electric response value.Type: ApplicationFiled: August 17, 2018Publication date: February 21, 2019Applicant: ARKRAY, Inc.Inventors: Hisashi Kaneda, Ayano Nakatani
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Publication number: 20190056346Abstract: A measuring method includes applying a first signal, which is a direct current signal, having a first value to a sample in a flow passage using a first electrode and a fourth electrode which is different from the first, second, and third electrodes, measuring a first electric response value, applying a second signal having a second value higher than the first value to the sample using the second and third electrodes, measuring a second electric response value, and correcting a value obtained from the first electric response value based on the second electric response value.Type: ApplicationFiled: August 17, 2018Publication date: February 21, 2019Applicant: ARKRAY, Inc.Inventors: Hisashi Kaneda, Ayano Nakatani
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Publication number: 20190051011Abstract: Detection and analysis of a tangible component in a sample are implemented at lower cost. Provided is an analysis apparatus including a flow cell which includes a flow path for a sample, a branch section configured to cause light having passed through the flow path to branch at least to a first optical path and a second optical path, a first imaging section and a second imaging section configured to capture images of the sample in the flow path by using the light in the first optical path and the light in the second optical path, and a controller configured to process the captured images. The first imaging section and the second imaging section capture images that have the same angle of view but have different characteristics.Type: ApplicationFiled: August 8, 2018Publication date: February 14, 2019Applicant: ARKRAY, Inc.Inventors: Shigeki MASUDA, Yukio WATANABE
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Publication number: 20190048373Abstract: A reagent for glutamine synthetase reaction comprising a chelating agent and glutamine synthetase, and a reagent for quantification of ammonia comprising a chelating agent, ATP, glutamic acid, glutamine synthetase, glucose, an oxidized NAD compound, ADP-dependent hexokinase, and glucose-6-phosphate dehydrogenase, are provided.Type: ApplicationFiled: August 8, 2018Publication date: February 14, 2019Applicant: ARKRAY, Inc.Inventors: Masaki Murakami, Takehiro Funamoto
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Publication number: 20190041358Abstract: The disclosure provides an analysis chip that includes a microchip employing capillary electrophoresis and a cartridge.Type: ApplicationFiled: July 30, 2018Publication date: February 7, 2019Applicant: ARKRAY, Inc.Inventor: Naotsugu Onuma
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Publication number: 20190015054Abstract: A presentation method for presenting a time period to measure a blood glucose level, the presentation method includes: acquiring first information, the first information including a measurement result in which a glucose level of a user is measured with a time interval using a first measurement device and a measurement time at which the measurement result was acquired; determining, based on a comparison result obtained by comparing the first information with a predetermined threshold of the glucose level and a preset period, the time period for the user to measure the blood glucose level by using a second measurement device; and presenting the time period at a display.Type: ApplicationFiled: July 13, 2018Publication date: January 17, 2019Applicant: ARKRAY, Inc.Inventors: Keiko KOIDE, Atsushi WADA, Hideaki TAKEDA
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Publication number: 20190017102Abstract: A target analysis method and target analyzing chip are provided to directly detect a target, such as microRNA, without performing PCR. The target analysis method of the present embodiment includes: a process in which a target in a sample, a labeled probe that binds to the target, and a carrier-binding probe that binds to the target and to a carrier, contact each other, and the target, the labeled probe, and the carrier-binding probe react to bind to each other to form a first bound body; a process in which the first bound body and the carrier contact each other, and the first bound body and the carrier react to bind to each other to form a second bound body; a process to concentrate the carrier; and a process in which the target in the sample is analyzed by detecting a label of the labeled probe bound to the concentrated carrier.Type: ApplicationFiled: January 16, 2017Publication date: January 17, 2019Applicants: ARKRAY, Inc., National University Corporation Kyoto Institute of TechnologyInventors: Akira Murakami, Akio Kobori, Asako Yamayoshi, Yuichiro Noda