Patents Assigned to Arkray
  • Electrolysis Device
    Publication number: 20180230608
    Abstract: An electrolysis device comprising a cell containing a solution, a pair of electrodes installed in the cell, and a voltage application device connected to the pair of electrodes. One electrode of the pair of electrodes is a small electrode, and another electrode of the pair of electroeds is a large electrode. An area of a liquid-contacting portion of the small electrode with the solution is smaller than an area of a liquid-contacting portion of the large electrode with the solution. In a state in which the solution is contained in the cell, only the solution is present between the liquid-contacting portion of the small electrode and a liquid surface of the solution vertically above the liquid-contacting portion of the small electrode.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 16, 2018
    Applicant: ARKRAY, Inc.
    Inventor: Tokuo Kasai
  • Electrolysis Device
    Publication number: 20180230613
    Abstract: An electrolysis device including a cell that contains a solution and a pair of electrodes installed in the cell. One electrode of the pair of electrodes is a carbon electrode, and a liquid-contacting portion of the carbon electrode that makes contact with the solution in the cell is configured by only a three-dimensional curved face.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 16, 2018
    Applicant: ARKRAY, Inc.
    Inventor: Tokuo Kasai
  • Mixing container used for reagents
    Patent number: 10035149
    Abstract: A mixing container includes a first container that stores two or more reagents and a second container for mixing two or more reagents. The first container includes reagent storage chambers that are respectively provided for the two or more reagents and have openings formed at portions thereof, and a sealing member that seals the respective openings of the reagent storage chambers. The second container includes an opening portion formed such that the first container can be connected thereto, and protruding portions disposed so as to pierce the sealing member when the first container is connected to the opening portion.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: July 31, 2018
    Assignees: ARKRAY, Inc., BODITECH MED INC.
    Inventors: Fumito Hiramura, Hironori Hasegawa, Park Ki Tae, Kim Cheol Min
  • Nuclear medicine diagnostic imaging agent
    Patent number: 10029022
    Abstract: Provided is a radioactive labeled compound capable of detecting a secondary mutation of an epidermal growth factor receptor, where the compound is represented by Formula (1) or a pharmaceutically acceptable salt thereof, where Y, L1, R1 and R2 are as defined.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: July 24, 2018
    Assignees: Kyoto University, ARKRAY, Inc.
    Inventors: Hideo Saji, Hiroyuki Kimura, Hirokazu Matsuda, Shuichi Nakanishi
  • FLOW CELL AND MEASURING DEVICE
    Publication number: 20180202915
    Abstract: A flow cell has: a flow path in which a specimen fluid and a sheath fluid flow; a specimen flow path that introduces the specimen fluid into the flow path; a first sheath flow path and a second sheath flow path that introduce the sheath fluid into the flow path; and a merging portion at which the specimen flow path, the first sheath flow path and the second sheath flow path merge together. The specimen flow path is provided on a central flow line of the flow path. At the merging portion, the first sheath flow path and the second sheath flow path face directions intersecting the central flow line of the flow path, and are disposed at positions that are offset in a depth direction of the flow path.
    Type: Application
    Filed: December 28, 2017
    Publication date: July 19, 2018
    Applicant: ARKRAY, Inc.
    Inventor: Shigeki MASUDA
  • Analysis method and analysis system
    Patent number: 10018589
    Abstract: A method for analyzing a sample using capillary electrophoresis is provided. By the method, following steps are performed. First, an original sample and an anionic group-containing compound are fixed to form a mixed sample, where the original sample contains an analysis component to be analyzed and a sub component other than the analysis component. Then, an aggregate of the sub component and the anionic group-containing compound is removed from the mixed sample. Then, electrophoresis is performed in a capillary tube with respect to a complex in which the analysis component and the anionic group-containing compound are bound to each other, while the mixed sample is continuously supplied.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: July 10, 2018
    Assignee: ARKRAY, Inc.
    Inventor: Naotsugu Onuma
  • Analytical Tool and Analytical System
    Publication number: 20180164247
    Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 14, 2018
    Applicant: ARKRAY, Inc.
    Inventor: Naotsugu Onuma
  • Substrate modification method
    Patent number: 9995709
    Abstract: Provided is a substrate modification method that enables improvement of reproducibility in measurement with use of capillary electrophoresis. The substrate modification method includes immobilizing, to a substrate surface, at least two types of modification groups selected from three types of modification groups that are a type of a modification group having one functional group, a type of a modification group having two to nine functional groups, and a type of a modification group having ten or more functional groups.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: June 12, 2018
    Assignee: ARKRAY, Inc.
    Inventor: Yusuke Nakayama
  • Method for manufacturing chip comprising microchannel and chip
    Patent number: 9989494
    Abstract: A method for manufacturing a chip that includes a microchannel is described, wherein the method includes the steps of: fixing a cationic polymer having a quaternary onium group to at least one surface of each of a pair of resin substrates; and joining the resin substrates together on the surfaces on which the cationic polymer has been fixed.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: June 5, 2018
    Assignee: ARKRAY, Inc.
    Inventor: Naotsugu Onuma
  • Analysis method, analysis chip, and analysis system
    Patent number: 9983170
    Abstract: A method is provided for analyzing a sample using capillary electrophoresis. According to the method, an electrophoretic liquid filling step is performed for filling a capillary tube with an electrophoretic liquid. In an introducing step, a predetermined amount of sample is introduced to an introducing tank linked to the capillary tube. In a flow step, performed after the introducing step, the sample is caused to flow in the introducing tank, thereby generating a shear flow at a link portion between the capillary tube and the introducing tank. In an electrophoresis step, electrophoresis is performed in the capillary tube while the sample is continuously supplied.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: May 29, 2018
    Assignee: ARKRAY, Inc.
    Inventor: Naotsugu Onuma
  • Substance measurement method and measurement device employing electrochemical biosensor
    Patent number: 9976168
    Abstract: A method is provided for measuring a substance using a biosensor, the method comprising: introducing a sample containing the substance into an electrochemical measurement cell which comprises an insulating base plate; at least two electrodes formed on the insulating base plate; and a reagent layer that is disposed on at least one of the electrodes and comprises an oxidoreductase; applying a voltage to the electrodes; detecting a charge transfer limiting current which is generated due to the transfer of electrons from the substance in the sample to the electrode; and determining the concentration of the substance contained in the sample based on the charge transfer limiting current.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: May 22, 2018
    Assignees: ARKRAY, Inc., BioEngineering Laboratories, LLC
    Inventor: Koji Katsuki
  • Analytical Method and Analytical System
    Publication number: 20180120256
    Abstract: An analytical method and an analytical system capable of more accurate analysis, in which a sample is analyzed by a capillary electrophoresis technique in which a voltage is applied to a sample solution introduced to a micro flow path, a separation analysis is performed for a component contained in the sample solution, and an optically measured value corresponding to an elapsed time after starting a measurement is measured. The analytical method comprises: a process of determining an interface arrival time point, based on the optically measured value when an interface between the sample solution and a migration liquid reaches a predetermined measurement position in the micro flow path; and a process of identifying the component contained in the sample solution using the optically measured value at the elapsed time after the interface arrival time point.
    Type: Application
    Filed: October 25, 2017
    Publication date: May 3, 2018
    Applicant: ARKRAY, Inc.
    Inventor: Masao Kawano
  • Microchip, Analysis System, and Method of Producing Microchip
    Publication number: 20180113094
    Abstract: One embodiment of the invention provides: a microchip including a sample collection section and an analysis section, in which the sample collection section and the analysis section are imparted with both hydrophilicity and a positively-charged layer; an analysis system including the microchip; and a method of producing the microchip. The microchip includes: a sample collection section for collecting a sample; and an analysis section for analyzing the sample. In the microchip, a cationic polymer bonded with a hydrophilization substance is immobilized on inner walls of the sample collection section and the analysis section.
    Type: Application
    Filed: October 19, 2017
    Publication date: April 26, 2018
    Applicant: ARKRAY, Inc.
    Inventors: Takanari Shigemitsu, Naotsugu Onuma
  • Quantification Method for Ammonia, Quantification Reagent Kit, Test Piece, and Ammonia Quantification Device
    Publication number: 20180112250
    Abstract: A method of quantifying ammonia, which method includes: performing a first reaction in which a test liquid containing ammonia is reacted with ATP and L-glutamic acid in the presence of glutamine synthetase to produce ADP; performing a second reaction in which the produced ADP is reacted with glucose in the presence of ADP-dependent hexokinase to produce glucose-6-phosphate; performing a third reaction in which the produced glucose-6-phosphate is reacted with an oxidized NAD compound in the presence of glucose-6-phosphate dehydrogenase to produce a reduced NAD compound; and quantifying the reduced NAD compound to quantify ammonia.
    Type: Application
    Filed: October 19, 2017
    Publication date: April 26, 2018
    Applicant: ARKRAY, Inc.
    Inventors: Takehiro Funamoto, Masaki Murakami
  • Biosensor comprising electrode for measuring hematocrit value
    Patent number: 9952197
    Abstract: Provided is a method for measuring the concentration of a substance in a blood sample, comprising: supplying the blood sample to a biosensor comprising a hematocrit electrode for measuring a hematocrit value on the surface of which electrode an electrically conductive polymer is covalently immobilized; and calculating the concentration of the substance from the measured value of a first current resulting from application of a first voltage; and correcting the concentration of the substance with the value of a second current resulting from application of a second voltage or the hematocrit value calculated from the value of the second current.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: April 24, 2018
    Assignee: ARKRAY, Inc.
    Inventors: Megumi Saeda, Hisashi Kaneda
  • Polypeptide and imaging method
    Patent number: 9950083
    Abstract: A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3); (Sequence ID No. 3) Xaa1-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg- Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser- Ser-Gly-Ala-Pro-Pro-Pro-Ser (3) where Xaa1 represents an aspartic acid in which a —Y—X? group binds to an ?-amino group, X? includes a chelating site and a radioactive metal nuclide chelated by the chelating site, the chelating site being diethylenetriaminepentaacetic dianhydride (DTPA) or 1,4,7-triazacyclononnane-N,N?,N?-triacetic acid (NOTA), and Y represents a linker including a group selected from the group consisting of —CH2—(C6H4)—, —NH—C(?S)—, —NH—(CH2)5—C(?O)—, and a combination thereof.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: April 24, 2018
    Assignees: Kyoto University, ARKRAY, Inc.
    Inventors: Hideo Saji, Nobuya Inagaki, Hiroyuki Kimura, Kentaro Toyoda, Hirokazu Matsuda, Mikako Ioroi, Asami Kon
  • Method for Collecting Rare Cells
    Publication number: 20180100850
    Abstract: The present disclosure relates to a method for collecting or detecting cells, and a cell collection system. The present disclosure also relates to a method for collecting or detecting rare cells in a specimen, and a rare cell collection system used therefor.
    Type: Application
    Filed: October 4, 2017
    Publication date: April 12, 2018
    Applicant: ARKRAY, Inc.
    Inventors: Hidenori Takagi, Masahiro Kozuka, Hiroshi Ito
  • Plasma Spectroscopic Analysis Method and Inhibitor of Plasma Emission Derived from Non-Target
    Publication number: 20180100803
    Abstract: A plasma spectroscopic analysis method includes a concentration process of concentrating a target in a sample, in the vicinity of one of a pair of electrodes in the presence of the sample; a plasma generation process of generating plasma in the sample by applying a voltage to the pair of electrodes; and a detection process of detecting emission of the target generated by the plasma, wherein the plasma generation process is performed in the presence of a defoaming agent.
    Type: Application
    Filed: October 4, 2017
    Publication date: April 12, 2018
    Applicant: ARKRAY, Inc.
    Inventor: Tokuo Kasai
  • Microdevice for Capturing Particles, and Method for Capturing, Concentrating, or Separating Particles Using the Same
    Publication number: 20180093271
    Abstract: The present disclosure relates to a microdevice for capturing particles from a sample, a method for capturing particles from a sample, and a method for concentrating or separating particles using the same.
    Type: Application
    Filed: September 29, 2017
    Publication date: April 5, 2018
    Applicants: The University of Tokyo, ARKRAY, Inc.
    Inventors: Teruo Fujii, Soo Hyeon Kim, Hiroshi Ito
  • Oral cavity testing device
    Patent number: D828574
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: September 11, 2018
    Assignee: ARKRAY, INC.
    Inventors: Takaaki Fujiwara, Kazuyoshi Kamekawa