Patents Assigned to Bayer
  • Polynucleotide molecules encoding proteins having proteinase inhibitor activity
    Patent number: 6689582
    Abstract: BTL.010 is a novel human serine proteinase inhibitor of the Kunitz family that exhibits greater potency towards neutral serine proteinases, particularly leukocyte elastase and proteinase 3 than towards trypsin-like proteinases. BTL.010, or variants thereof, may be employed as therapeutics in diseases such as emphysema, idiopathic pulmonary fibrosis, adult respiratory distress syndrome, cystic fibrosis, rheumatoid arthritis, organ failure, and glomerulonephritis in which uncontrolled proteolysis due to neutral serine proteinase activity results in tissue damage.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: February 10, 2004
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Christopher Davies, Dadong Chen, Steve Roczniak
  • Substituted pyridines and pyridazines with angiogenesis inhibiting activity
    Patent number: 6689883
    Abstract: Substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: February 10, 2004
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Jacques P. Dumas, Stephen James Boyer, Julie A. Dixon, Teddy Kite Joe, Harold C. E. Kluender, Wendy Lee, Dhanapalan Nagarathnam, Robert N. Sibley, Ning Su
  • Chromatographic separation of enantiomers of lactones
    Patent number: 6689889
    Abstract: The present invention relates to the use of optically active polymers of N-acryloyl-phenylalanine neomenthylamide as such, in crosslinked form and/or in carrier-bonded form as stationary phases for the chromatographic separation of enantiomers of lactones.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: February 10, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Lange, Rolf Grosser, Burkhard Köhler, Stefan Michel, Bruno Bömer, Uwe Zweering
  • Process for producing yellow iron oxide pigments
    Patent number: 6689206
    Abstract: The present invention relates to a process for producing a yellow iron oxide pigments comprising the steps of I) mixing preprecipitated FeCl2 and an &agr;-FeOOH nucleus produced by the “alkali” process, II) oxidizing the suspension in a first oxidation step at 20 to 45° C. III) oxidizing the suspension in a first oxidation step at 55 to 85° C.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: February 10, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventor: Ulrich Meisen
  • Liquid sulfur-containing oligosiloxanes and their use in rubber mixtures
    Patent number: 6689834
    Abstract: The invention relates to sulfur-containing oligosiloxanes which are liquid at −25-100° C., processes for their preparation and their use in silica-containing rubber mixtures which can be crosslinked with sulfur.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: February 10, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jürgen Ackermann, Hermann-Josef Weidenhaupt, Stefan Grabowski
  • Stabilized interleukin 2
    Patent number: 6689353
    Abstract: A stable pharmaceutical preparation comprising Human interleukin-2 or a variant thereof and a stabilizing amount of histidine. A preferred formulation includes glycine and sucrose and a variant of IL-2 having a single mutation, N88R. The preferred formulation is in lyophilized form which, on reconstitution with an aqueous diluent, results in a solution having a pH ranging from about 5.0 to 6.5.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: February 10, 2004
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Wei Wang, Rajiv Nayar, Michael A. Shearer
  • Molded cross vehicle beam
    Patent number: 6688680
    Abstract: A molded cross vehicle beam which includes a hollow blow molded thermoplastic rigid member that is integrally attached to a rigid support, e.g., a U-shaped metal plate, and at least one attachment element, is described. The rigid support (12) has a first surface, a second surface and a plurality of perforations having edges. The attachment element(s) (81, 84) have a first surface, a second surface and a plurality of perforations having edges. The attachment element provides a manner of attaching the molded cross vehicle beam to a separate structure (e.g., the A-pillars of an automobile). A thermoplastic parison precursor of the hollow rigid thermoplastic member (15) is blow molded against the first surfaces of the rigid support (12) and the attachment element (81, 84).
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: February 10, 2004
    Assignee: Bayer Polymers LLC
    Inventors: Christopher Cooper, Olaf J. Zoellner
  • Method and device for producing bisphenol a prills and bisphenol a prills produced according to this method
    Patent number: 6689464
    Abstract: A method for producing bisphenol A in prill form is disclosed. Molten bisphenol is top-fed into a prilling tower via a plate containing a plurality of nozzles. A gas coolant guided through a circuit is led into said tower in a counter flow direction. The prills are cooled to about room temperature, collected at the bottom of the tower and removed. Also disclosed is the device for carrying out the inventive method and the prills thus produced.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: February 10, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Lanze, Alfred Eitel, Rainer Neumann, Steffen Kühling, Frieder Heydenreich, Tony van Osselaer, Rainer Bellinghausen, Heiko Herold
  • Aryl ureas with raf kinase and angiogenisis inhibiting activity
    Publication number: 20040023961
    Abstract: This invention relates to methods of using aryl ureas to treat diseases mediated by raf kinase and diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes.
    Type: Application
    Filed: February 11, 2003
    Publication date: February 5, 2004
    Applicant: BAYER CORPORATION
    Inventors: Jacques Dumas, William J. Scott, James Elting, Holia Hatoum-Makdad
  • Methods of treating viral infections
    Patent number: 6685950
    Abstract: The present invention relates to the use of strains of Parapoxvirus ovis as immunotherapeutic agents for immunodeficiencies of an infectious or non-infectious nature, and to the use of strains of Parapoxvirus ovis for treating tumor diseases and viral infections, and diseases which accompany them, and the use of strains of Parapoxvirus ovis for producing medicaments for use in humans and animals.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Olaf Weber, Tobias Schlapp, Angela Siegling, Andreas Knorr, Claudia Hirth-Dietrich, Gudrun Theiss
  • Thienylsulphonylamino(thio)carbonyl compounds
    Patent number: 6686478
    Abstract: The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), in which Q represents oxygen or sulphur, R1 represents cyano, halogen or in each case optionally cyano-, halogen- or C1-C4-alkoxy-substituted alkyl, alkenyl, alkinyl, alkoxy, alkenyloxy or alkinyloxy having in each case up to 6 carbon atoms, R2 represents cyano, halogen or in each case optionally cyano-, halogen- or C1-C4-alkoxy-substituted alkyl, alkenyl, alkinyl, alkoxy, alkenyloxy or alkinyloxy having in each case up to 6 carbon atoms, and R3 represents in each case optionally substituted heterocyclyl having 5 ring members, at least one of which represents oxygen, sulphur or nitrogen and one to three others may represent nitrogen, and salts of compounds of the formula (I), to processes and novel intermediates for preparing the novel compounds and to their use as herbicides.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus-Helmut Müller, Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Johannes Rudolf Jansen, Rolf Kirsten, Joachim Kluth, Klaus König
  • Flame-resistant polycarbonate ABS moulding compounds
    Patent number: 6686404
    Abstract: Flame-retardant thermoplastic moulding compositions containing an aromatic polycarbonate or polyestercarbonate, a graft polymer, a thermoplastic vinyl copolymer, a fluorinated polyolefin, 0.5 to 20 parts by weight of at least one phosphorus compound of general formula (I) wherein the average degree of polycondensation N of component D is always >5, a very finely divided inorganic powder with an average diameter of 0.1 to 200 nm and/or a monophosphorus compound, wherein the sum of the parts by weight of all the components is 100.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Eckel, Michael Zobel, Dieter Wittmann, Nikolaus Janke
  • Method and computer system for establishing a relationship between a stress and a strain
    Patent number: 6687624
    Abstract: The relationship between the stress &sgr; and the strain &egr; is firstly established in step 100 with short-term tests as a function of the temperature T. In steps 101 to 104, a Findley model is extended in such a way as to obtain a relationship between the strain &egr; and the stress &sgr; as a function of the time t and the temperature T. The two models are combined in steps 105 and 106, so as to obtain overall a relationship between the stress &sgr; and the strain &egr; as a function of the time t and the temperature T.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bahman Sarabi, Martin Wanders, Dietmar Wächtler, Andreas Wende
  • Preparation of functionalized alkoxyamine initiator and its use
    Patent number: 6686424
    Abstract: A one-pot process for the preparation of functional alkoxyamines of the general formula (I), is disclosed. The process entails (1) reacting an oxidizing agent with a sterically hindered secondary amine to produce an aqueous phase and a nitroxyl radical (2) removing the aqueous phase and adding to the nitroxyl radical one or more vinyl monomer(s) conforming to a formula and a system which produces free radicals. Also disclosed is a process of polymerizing monomers using the functional alkoxyamine.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Christophe Detrembleur, Thomas Gross, Rolf-Volker Meyer
  • Heterocyclically substituted aromatic amino compounds with a herbicidal effect
    Patent number: 6686318
    Abstract: The invention relates to new substituted aromatic amino compounds of the general formula (I) in which R1, R2, R3, R4 and Z have the meanings given in the description, to a process for their preparation, and to their use as herbicides.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Roland Andree, Mark Wilhelm Drewes, Kurt Findeisen, Joachim Kluth, Karl-Heinz Linker, Klaus-Helmut Müller, Otto Schallner, Markus Dollinger
  • Preparation of virally inactivated intravenously injectable immune serum globulin
    Patent number: 6686191
    Abstract: Method of reducing the anticomplement activity (ACA) resulting from viral inactivation treatment of a solution of antibodies, the method comprising contacting the solution with a trialkylphosphate, such as tri-n-butyl phosphate, and a detergent, such as sodium cholate, under conditions sufficient to reduce substantially the virus activity, and then incubating the solution under controlled conditions of time, pH, temperature, and ionic strength such that the anticomplement activity is reduced to an acceptable level. In a preferred embodiment, the ACA is reduced to less than 60 CH50 units/mL, the incubation is for at least about ten days at a pH from 3.5 to 5.0, the temperature is maintained within a range of 2 to 50° C., and the ionic strength of the solution is less than about 0.001 M.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: February 3, 2004
    Assignee: Bayer HealthCare LLC
    Inventor: William R. Alonso
  • Lyopohilization method
    Patent number: 6684524
    Abstract: The invention relates to a lyophilization method which comprises the following steps: reducing the pressure in the drying chamber until the onset of a visible crystallization of the solvent at a temperature in the drying chamber which is above the solidification point of the preparation; reducing the temperature in the drying chamber to a temperature which is below the solidification point of the preparation or is identical to it, until completion of the crystallization of the solvent, resulting in a frozen solvent; and sublimation of the frozen solvent by means of reduced pressure.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd Sennhenn, Martin Kramer
  • Processes for preparing 3.3-dimethylbutyric acid
    Patent number: 6686501
    Abstract: A process for preparing 3,3-dimethylbutyric acid includes the steps of reacting trimethylpyruvic acid with a first portion of hydrazine to obtain a ketazine, and treating the ketazine with base and a second portion of hydrazine.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: February 3, 2004
    Assignee: Bayer Corporation
    Inventor: Dennis E. Jackman
  • Synergistic insecticidal mixtures
    Patent number: 6686387
    Abstract: The invention relates to insecticidal mixtures of spinosyns and agonists or antagonists of nicotinic acetylcholine receptors for protecting plants against attack by pests.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfram Andersch, Hans-Jürgen Schnorbach, Detlef Wollweber
  • Use of N-(aminoalkyl) pyrrolidines as catalysts for the polyisocyanate polyaddition process
    Patent number: RE38415
    Abstract: The present invention relates to a process for preparing polyisocyanate polyaddition products by reacting (a) polyisocyanates with (b) relatively high molecular weight compounds containing at least two isocyanate-reactive hydrogen atoms and (c) chain-extending agents, in the presence of (d) N-(aminoalkyl)pyrrolidine catalysts corresponding to formula (I) in which R is a C2-12 alkylene group (optionally containing O or N atoms but not isocyanate-reactive groups) and R′ is hydrogen or a C1-4 alkyl group, (e) optionally, other known catalysts, and (f) other known additives.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: February 3, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Richard Weider, Uwe Scholz