Patents Assigned to Corixa
  • Compounds and methods for therapy and diagnosis of lung cancer
    Patent number: 6696247
    Abstract: Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: February 24, 2004
    Assignee: Corixa Corporation
    Inventor: Tongtong Wang
  • Methods of modulating dendritic cells using adjuvants
    Publication number: 20040033213
    Abstract: The present invention relates to a method for culturing large amounts of antigen presenting cells, in particular of proliferating dendritic cell precursors, and of inducing their maturation ex vivo to mature dendritic cells. In addition, the present invention is directed to antigen-activated dendritic cells and provides methods of using such activated dendritic to elicit an immune response in a patient.
    Type: Application
    Filed: February 28, 2003
    Publication date: February 19, 2004
    Applicant: Corixa Corporation
    Inventors: Edwin Walker, C. Gregory Sowell
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20040033230
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: June 2, 2003
    Publication date: February 19, 2004
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Jiangchun Xu, Davin C. Dillon, Marc W. Retter, Susan L. Harlocker
  • Compounds and methods for the diagnosis and treatment of B. microti infection
    Publication number: 20040023865
    Abstract: Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and immunogenic compositions comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.
    Type: Application
    Filed: November 13, 2002
    Publication date: February 5, 2004
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Michael J. Lodes, Raymond L. Houghton, Paul R. Sleath, Patricia D. McNeill, Mary J. Homer, Heather Secrist
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6686447
    Abstract: Compositions comprising polypeptides encoded by polynucleotides of the present invention, such as SEQ ID NO:790 or portions thereof, are disclosed. Such compositions may be used, for example, for the prevention, treatment, therapy, and diagnosis of diseases such as lung cancer.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: February 3, 2004
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Liqun Fan
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20040018204
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: April 30, 2003
    Publication date: January 29, 2004
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Patricia D. McNeill, Nomalie Jaya
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 6680197
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: January 20, 2004
    Assignee: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu, Susan L. Harlocker, William T. Hepler, Robert A. Henderson
  • Microspheres and adjuvants for DNA vaccine delivery
    Publication number: 20040009941
    Abstract: A nucleic acid delivery system that offers, in one system, a combination of high encapsulation efficiency, rapid release kinetics and preservation of DNA in supercoiled form is provided. The nucleic acid delivery system comprises nucleic acid molecules, such as deoxyribonucleic acid (DNA), encapsulated in biodegradable microspheres, and is particularly suited for delivery of DNA vaccines. The invention further provides a method for encapsulating nucleic acid molecules in microspheres. The invention additionally provides a composition comprising nucleic acid molecules encapsulated in microspheres produced by a method of the invention, and a method for delivering a nucleic acid molecule to a subject. The invention further provides an adjuvant for modulating the immunostimulatory efficacy of microspheres encapsulating nucleic acid molecules comprising an aminoalkyl glucosaminide 4-phosphate (AGP).
    Type: Application
    Filed: April 22, 2003
    Publication date: January 15, 2004
    Applicant: Corixa Corporation
    Inventors: Mark E. Johnson, Sally Mossman, Tricia Cecil, Lawrence Evans
  • Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
    Publication number: 20040005561
    Abstract: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
    Type: Application
    Filed: May 23, 2002
    Publication date: January 8, 2004
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Paul A. Algate, Jane Mannion, Marc W. Retter
  • Compounds and methods for the diagnosis and treatment of ehrlichia infection
    Patent number: 6673356
    Abstract: Compounds and methods for the diagnosis and treatment of Ehrlichia infection, inparticular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containingsuch polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: January 6, 2004
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Michael J. Lodes, Raymond L. Houghton, Patricia D. McNeill
  • Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
    Publication number: 20040002068
    Abstract: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
    Type: Application
    Filed: January 22, 2002
    Publication date: January 1, 2004
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Paul A. Algate, Jane Mannion, Jonathan David Clapper, Aijun Wang, Nadia Ordonez, Lauren Carter, Patricia Dianne McNeill
  • Compositions and methods for therapy of ovarian cancer
    Patent number: 6670463
    Abstract: Compositions and methods for the therapy of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: December 30, 2003
    Assignee: Corixa Corporation
    Inventors: Jennifer L. Mitcham, Tony N. Frudakis, Gordon E. King
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030236209
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: December 4, 2002
    Publication date: December 25, 2003
    Applicant: Corixa Corporation
    Inventors: Teresa M. Foy, Andria McNabb, Yoshihiro Watanabe, Steven G. Reed, Tongtong Wang
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20030235557
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: September 16, 2002
    Publication date: December 25, 2003
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Martin A. Cheever
  • Fusion proteins of Mycobacterium tuberculosis
    Publication number: 20030235593
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: February 18, 2003
    Publication date: December 25, 2003
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Jeff Guderian, Steven Reed
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6667154
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: December 23, 2003
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Chaitanya S. Bangur, Michael J. Lodes, Gary R. Fanger, Thomas S. Vedvick, Darrick Carter, Marc W. Retter, Jane Mannion, Liqun Fan
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20030232056
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Application
    Filed: February 14, 2003
    Publication date: December 18, 2003
    Applicant: Corixa Corporation
    Inventors: Gary R. Fanger, Steven P. Fling
  • Compounds for immunotherapy of prostate cancer and methods for their use
    Patent number: 6664377
    Abstract: Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: December 16, 2003
    Assignee: Corixa Corporation
    Inventor: Jiangchun Xu
  • Compositions and methods for viral delivery
    Publication number: 20030228279
    Abstract: Compositions and methods comprising a recombinant virus and an immunostimulant are provided for enhancing the immune response to a polypeptide expressed from the recombinant virus. Preferably this is done without also enhancing the neutralizing antibody response to the recombinant virus. Illustrative compositions comprise an adenovirus and an adjuvant such as, for example, monophosphoryl lipid A, an alkyl glucosaminide phosphate, a saponin, or a combination thereof. The disclosed compositions and methods are useful, for example, in the treatment of diseases such as cancer or infectious disease.
    Type: Application
    Filed: October 29, 2002
    Publication date: December 11, 2003
    Applicant: Corixa Corporation
    Inventors: Sally Mossman, Lawrence Evans, Ryan M. Swanson
  • Compositions for the treatment and diagnosis of breast cancer and methods for their use
    Publication number: 20030229020
    Abstract: Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.
    Type: Application
    Filed: May 16, 2003
    Publication date: December 11, 2003
    Applicant: Corixa Corporation
    Inventors: Jiang Yuqiu, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu