Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.

Abstract: A carrier assembly for injection molding a parison with internal threads. The carrier assembly may be used with an injection stretch blow molding machine that includes a core rod. The carrier assembly comprises a carrier insert surrounding a portion of the core rod. The carrier insert includes a thread-forming portion presenting an interior radial surface and an exterior radial surface. The interior radial surface is configured to be positioned adjacent to the core rod, and the exterior radial surface includes a threaded protrusion configured to extend away from the core rod. The carrier assembly also includes a pinion insert surrounding at least a portion of the threaded protrusion of the thread-forming portion of the carrier insert. The pinion insert is spaced apart from the thread-forming portion of the carrier insert so as to present a thread-forming cavity between the pinion insert and the carrier insert.

Abstract: A carrying case for a portable electronic device includes an adjustable viewing stand for supporting the electronic device at an angle selected by the user, the adjustable viewing stand comprising at least two panels hingably connected to one another and foldable so as to be able to reside inside the carrying case when the carrying case is closed.

Abstract: The invention relates to a method of isolating an immunoglobulin, comprising the steps of: a) providing a separation matrix comprising multimers of immunoglobulin-binding alkali-stabilized Protein A domains covalently coupled to a porous support, b) contacting a liquid sample comprising an immunoglobulin with the separation matrix, c) washing said separation matrix with a washing liquid, d) eluting the immunoglobulin from the separation matrix with an elution liquid, and e) cleaning the separation matrix with a cleaning liquid, wherein the alkali-stabilized Protein A domains comprise mutants of a parental Fc-binding domain of Staphylococcus Protein A (SpA), as defined by, or having at least 80% such as at least 90%, 95% or 98% identity to, SEQ ID NO 51 or SEQ ID NO 52, wherein the amino acid residues at positions 13 and 44 of SEQ ID NO 51 or 52 are asparagines and wherein at least the asparagine residue at position 3 of SEQ ID NO 51 or 52 has been mutated to an amino acid selected from the group consisting of

Abstract: A cleaning device, intended to spray at least one fluid towards a surface to be cleaned of a motor vehicle, such as an optical sensor of an optical detection system, comprises at least one fluid intake and distribution device (D) into which are selectively admitted a cleaning fluid and a drying fluid through two distinct sets of runs from an intake end-fitting (110, 111) specific to each fluid. According to the invention, a blocking element (5) is provided in the intake and distribution device (D). This blocking element is movable between a first position of blocking of the set of runs for a cleaning fluid and a second position of clearing of this set of runs for a cleaning fluid.

Abstract: A separator for a flowing electrolyte battery, and a method of forming such a separator, enable improved efficiency in a flowing electrolyte battery. The separator includes a sheet having a first surface and a second surface opposing the first surface. A first spacer element is disposed on the first surface, and a second spacer element is disposed on the second surface. The first spacer element is wider than the second spacer element in a direction that is both parallel to the first and second surfaces and perpendicular to longitudinal axes of the first and second spacer elements.

Abstract: The present disclosure provides a support for household appliance and a household appliance. The support for household appliance comprises a hydraulic plate; a sheath, which is fixedly connected with the hydraulic plate; a regulating element, which is arranged in the sheath and is axially movable relative to the sheath; an accommodation chamber, which is formed by the hydraulic plate, the sheath and the regulating element; a hydraulic medium, which is arranged in the accommodation chamber and is compressed/expands depending on pressure changes to drive the regulating element to axially move in the sheath for leveling; a communicating device, which enables at least two supports for household appliance to communicate with each other to allow the hydraulic medium to flow between the supports for household appliance; a one-way valve structure is arranged in the communicating device for conducting the hydraulic medium to flow in one direction.

Abstract: A streamlined flat windscreen wiper for a vehicle is disclosed. The flat wiper includes a longitudinal wiper blade, at least one longitudinal stiffening member, a longitudinal member for retaining the wiper blade and the stiffening member, a longitudinal streamlined portion including two terminal caps and a central mounting extending between the terminal caps and being connected thereto. The mounting includes means for fixing to the stiffening member or to the member for retaining the stiffening member, and each cap includes means for guiding in translation terminal parts of the member.

Abstract: An instrumented interface for quantifying at least one physiological parameter of the upper limbs of a person, capable of being secured to a gripping device, and including at least one gripping system which the person can hang from, the instrumented interface including at least one force sensor which measures a deformation of the interface when a person exerts a force on the interface via the one gripping device, and is capable of producing a value that translates a force value.

Abstract: A local backwashing apparatus 110 for a filtering system comprises an enclosure 119 having an open lower end, positionable above a surface of filter media 92 supported by a drainage layer 96. The enclosure is connected to a mechanical member (300, FIG. 6A) configured to force the enclosure into the filter media and release the force prior to the lower end of the enclosure contacting the drainage layer. The lower end of the enclosure being brought into contact with the drainage layer through a pressure differential between the interior and exterior of the enclosure. A pneumatic system such as an air pump, is in fluid communication with the upper part 127 of the enclosure and is configured to determine an air pressure therein. A pipe system connects the upper part of the enclosure with the pneumatic system and with a discharge structure 132. A control unit is connected to the pneumatic system. Also disclosed is a method of backwashing a filtering system. The backwashing apparatus may be used to pre-treat water.

Abstract: A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

Abstract: [Problem] To protect a leading end part of a drill having a coolant hole which is adapted for drilling a thin diameter or very thin diameter hole in a workpiece. [Solution] A coolant hole 33 is formed in a shank 3 and a shaft body 7 so as to extend through from a rear end surface 31 of the shank 3 to a leading end surface 15 of the shaft body 7 along an axis thereof. A leading end part of the coolant hole 33 is branched into a pair of discharge holes 35, at a position slightly toward a base end relative to the leading end surface 15 of the shaft body 13. The discharge holes 35 extend in the opposite directions, perpendicular to the coolant hole 33, respectively, and open at opposite side surfaces 37, 37 to define discharge ports 39, 39. A leading end opening 41 of the coolant hole 33 is closed by a bottom face 17 of the drill part 9.

Abstract: The present invention relates to a connector (1) for a wiper blade, designed to be interposed between an adapter and a structural element of the wiper blade. The connector (1) extends longitudinally between a first longitudinal end (14) and a second longitudinal end (14). The connector (1) comprises at least one fixing block (22) configured such as mechanically to connect the connector (1) to the structural element of the wiper blade and a linking block (13) configured such as mechanically to connect the connector (1) to the adapter. The connector (1) comprises at least one skirt (23) that extends longitudinally from the fixing block (22). The skirt (23) comprises at least one rib (24) that extends between the fixing block (22) and one of the longitudinal ends (14).

Abstract: A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

Abstract: A single automated accounting and business analysis system is employed to acquire, organize, record, analyze and plan all the relevant financial and non-financial metrics utilized by an individual or group. This includes all the internally generated metrics and external metrics such as data related to the economy, a particular industry, weather conditions, etc. The system employs heuristics to learn from previous associations and links data based on previous associations.

Abstract: A system may be configured to identify that a user device is connected to a first radio access network (“RAN”), via a first technology; and to identify that the user device is capable of accessing a second RAN, via a second technology. The system may further be configured to instruct the user device to concurrently connect to the second RAN and the first RAN, send or receive a first type of traffic via the first RAN, and send or receive a second type of traffic via the second RAN.

Abstract: Connecting device (2) for connecting a wiper arm (1) to a drive arm of a wiper system for a vehicle, comprising at least one connector (5) mounted pivotably relative to a drive arm and including means (20) forming a pivoting interface defining an axis of rotation (18), said connector (5) comprising a plurality of tabs (30) for mechanically connecting the connector to the wiper arm, characterized in that said pivoting interface is longitudinally offset relative to a transverse mid-plane (TMP) of the connecting device, and in that at least one tab is situated on either side of a transverse vertical interface plane (TP) comprising the axis of rotation (18) and parallel to the transverse mid-plane (TMP).

Abstract: The invention relates to a personal care composition, more particularly to a composition for use to reduce or prevent inflammation on a topical surface of a human or animal body. The composition could be delivered in the form of a skin, scalp, hair or oral care product, more particularly a skin care product. The benefit is delivered via a combination of a polyunsaturated fatty acid (PUFA) or an ester thereof and a vitamin B3 compound wherein the mole ratio of the PUFA or ester thereof to the vitamin B3 compound is 1:15 to 1:500.

Abstract: Various techniques are described herein for providing ticketing reservation and purchasing functionality for enabling and/or facilitating users in performing activities/operations relating to group ticket reservations and/or automated conditional ticket purchases for various types of events which are scheduled to occur at one or more different venues.

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.