Abstract: The invention concerns a Thickness Shear Mode (TSM) biosensor (1) which comprises an ex vivo living skin explant (2), the skin explant (2) comprising at least one of the skin layers among: hypodermis, dermis (2A), epidermis (2B) and the stratum corneum (2C), a TSM transducer (3) which comprises: an AT cut quartz resonator 3C which has two opposite exterior surfaces (3A,3B), and two conducting electrodes (4A, 4B), each conducting electrode being deposited on one of the two exterior surfaces (3A,3B), the TSM transducer (3) allowing to determine micro rheological characteristics of the living skin explant (2) by piezoelectric transducing using shear waves, the TSM transducer (3) presenting: measuring means (30), monitoring and calculating means (31) which monitor an evolution in time of an electrical response of the living skin explant (2), and which calculate in time, from the electrical response, micro rheological characteristics of the living skin explant (2), a bottom surface of the skin explant (2) being in

Abstract: A novel miniaturized and highly automated method for the controlled printing of large arrays of nano- to femtoliter droplets is presented by actively transporting mother droplets over hydrophilic-in-hydrophobic micropatches. The proposed technology consists of single plate or double-plate devices where mother droplets can be actuated and hydrophilic-in-hydrophobic micropatches on one or both plates of the device where nano- to femtoliter droplets are printed. Due to the selective wettability of the more wettable hydrophilic micropatches in a hydrophobic matrix, large nano- to femtoliter droplet arrays are created when mother droplets are transported over these arrays. The parent droplets can be moved by different droplet actuation principles, for example, by using the principle of electrowetting-on-dielectric droplet actuation. We propose another method that uses two plates that are placed on top of each other while being separated by a spacer.

Abstract: A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

Abstract: A method and a system are for three-dimensional (3D) synthetic aperture (SA) imaging. The method and system use spatial modulation on SA return signals as a function of their return angle distribution to account for local topography and provide 3D imaging capabilities. In some implementations, the method can involve a step of generating two spatially modulated two-dimensional (2D) SA images of a target region, each of which having a different spatial modulation profile, and a step of combining the two spatially modulated 2D SA images to obtain a 3D SA image. The 3D SA image can be used to determine an elevation map of the target region.

Abstract: The present invention relates to an in vitro method for determine the prognosis of the survival time of a patient suffering from a cancer comprising the steps consisting of i) determining the expression level of the couple DNMT3A/ISGF3? in a sample from said patient, ii) comparing said expression level with a predetermined reference value and iii) providing a good prognosis when the expression level is lower than the predetermined reference value and a poor prognosis when the expression level is higher than the predetermined reference value. The invention also relates a compound which is a DNMT3A/ISGF3? antagonist or a compound which is a DNMT3A/ISGF3? gene expression inhibitor for use in the treatment and prevention of cancer.

Abstract: There is provided a wound dressing prepared with a hydrocolloid gel, a polyurethane film, a PVA hydrogel, an alginate gel or the like, which has excellent stretchability and exudation absorbency of the wound surface for protection and prevention of infection on the wound surface in which continuity of a body tissue is destroyed by a physical impact or the like, can maintain a wet environment suitable for promoting healing of the wound surface, and has no pain or no worry to damage regenerated skin when the wound dressing is exchanged.

Abstract: The purpose of the present invention is to provide a method for predicting the effectiveness of an angiogenesis inhibitor in a subject suffering from a tumor. Provided is a method comprising a step of testing for the presence or absence of an a mutation or loss of expression of B-Raf and PTEN in a sample of tumor tissue from the subject. By using the presence or absence of or a mutation or loss of expression of B-Raf and PTEN as an indicator, this method enables the antitumor effectiveness of the angiogenesis inhibitor to be predicted without administering the angiogenesis inhibitor to the subject.

Abstract: Paving compositions comprising asphalt cement, wherein the asphalt cement may have a with a pen value greater than 50 dmm at 25° C., and the composition may further include a an aminated wax, a rejuvenator and/or a polymeric component. Paving structures include a substrate pavement layer with a tack coat applied thereto, and methods of making a paving structure include applying a tack coat to a substrate pavement layer, wherein the tack coat comprises asphalt cement, wherein the asphalt cement may have a with a pen value greater than 50 dmm at 25° C., and the tack coat may further include a an aminated wax, a rejuvenator and/or a polymeric component.

Abstract: A composition comprising a plurality of particles, wherein said particles comprise: 40 to 95 w.t. % polyethylene glycol, wherein the polyethylene glycol has a weight average molecular weight from 4000 to 12000; 0.1 to 50 w.t. % anhydrous saccharide comprising one to ten monosaccharide units; and 0.1 to 20 w.t. % perfume materials.

Abstract: A system includes a processor and a non-transitory computer readable medium storing instructions executable in the processor. The instructions cause the processor to perform operations which include receiving from a computing device of a first party a request including a first list of parameters associated with a product or a service to be acquired; receiving from a computing device of a second party a response including a second list of parameters associated with a product or a service to be supplied. The operations additionally include determining a correspondence between the first list of parameters and the second list of parameters based on weighted scores; and displaying on third party computing devices information associated with the request, the response, and the correspondence, wherein the identity of the first party and the second party remain anonymous.

Abstract: Fastening device for a windshield wiper actuation linkage system, this device including a plate (32) intended to be fastened to a vehicle body (36) and at least one fastening member (34) intended to be inserted into a first orifice in said plate and an aligned second orifice in said body, said at least one fastening member being configured to be rotatable in said first and second orifices from a first, unlocking position to a second, locking position, and vice versa, characterized in that said plate comprises positioning means intended to cooperate in a form-fitting manner with complementary means of said body.

Abstract: An articulated handle for a container is described. The articulated handle comprises a collar, a grip, and a securing means. The collar is configured for surrounding a container and comprises an articulated joint for positioning the collar between an open state for receiving the container and a close state for surrounding the container. The articulated joint divides the collar in a first portion and a second portion. The grip projects outwardly from the collar and comprises a first grip portion integrally formed to the first portion of the collar and a second grip portion integrally formed to the second portion of the collar. The first and second grip portions are each configured for comprising a complementary portion. The complementary portions comprise a securing means which connects together the first and second grip portions when the collar is in the close state, thereby securing the articulated handle to the container.

Abstract: Sail construction comprising foldable sail supports (2), a crossbeam (3), a holder (1.1), a sail (1), a bottom holder (4), ropes (4.3) and a bolt and tackle system. The sail can be a self-inflatable sail (1 SN) designed similarly to paragliders, partially or fully inflatable.

Abstract: A method for exposing a pattern in an area on a surface using a charged particle beam lithography is disclosed and includes inputting an original set of exposure information for the area. A backscatter is calculated for the area of the pattern based on the exposure information. An artificial background dose is determined for the area. The artificial background dose comprises additional exposure information and is combined with the original set of exposure information creating a modified set of exposure information. A system for exposing a pattern in an area on a surface using a charged particle beam lithography is also disclosed.

Abstract: A system for transmitting medically-necessary video or images over a collaborative set of wireless and/or satellite networks is provided. The system utilizes a number of interfaces to one or more wireless networks and bonds these connections together to provide a reliable data stream, such as for streaming an ultrasound image from an ambulance or other remote location for viewing by a waiting surgeon or other medical professional.

Abstract: The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.

Abstract: A multi-relay including a first relay switch operable over a first current range; a second relay switch operable over a second current range; and a current sensor configured to: detect an input current; in response to the input current being within the first current range, activate the first relay switch; and in response to the input current being within the second current range, activate the second relay switch.

Abstract: According to some embodiments, a method of inserting a lateral implant within an intervertebral space defined between an upper vertebral member and a lower vertebral member includes creating a lateral passage through a subject in order to provide minimally invasive access to the intervertebral space, at least partially clearing out native tissue of the subject within and/or near the intervertebral space, positioning a base plate within the intervertebral space, wherein the base plate comprise an upper base plate and a lower base plate and advancing an implant between the upper base plate and the lower base plate so that the implant is urged into the intervertebral space and the upper vertebral member is distracted relative to the lower vertebral member.