Abstract: A pharmaceutical composition is provided which has excellent stability, when dispersed in water has a pH of at least about 9, and includes a medicament which is sensitive to a low pH environment such as pravastatin, one or more fillers such as lactose and/or microcrystalline cellulose, one or more binders, such as microcrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder), one or more disintegrating agents such as croscarmellose sodium, one or more lubricants such as magnesium stearate and one or more basifying agents such as magnesium oxide.
Type:
Grant
Filed:
May 20, 1991
Date of Patent:
January 19, 1993
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Yatindra M. Joshi, Pierina Chiesa, Nemichand B. Jain
Abstract: An antimicrobial composition comprising an inorganic particle with a first coating providing antimicrobial properties and a second coating providing a protective function, method for preparing the same and uses; further processes for producing polymeric articles and a method for controlling microorganisms.
Type:
Grant
Filed:
August 9, 1991
Date of Patent:
January 19, 1993
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
Howard W. Jacobson, Michael H. Scholla, Sam L. Samuels
Abstract: A process for the dehydrohalogenation of saturated hydrogen-containing polyhalocarbons using liquid alkali metal acid fluoride and/or alkali metal fluoride compositions to form haloolefins.
Abstract: An improved security seal includes a plastic housing with a chamber open at one end and a plastic rotor which is insertable in the chamber. The housing wall contains bores aligned across the chamber and two annular grooves adjacent the chamber entrance. Tabs are formed adjacent the chamber entrance. The rotor has a bore and two annular ridges near its top. The ridges are relieved complementarily to the tabs. The rotor may be partially inserted in the housing by snapping the lower ridge into the upper groove and locating the tabs in the relieved areas to align all of the bores so that a seal wire may thereafter be inserted through the seal. The ridge-groove and tab-relief cooperation prevent inadvertent relative rotation of the rotor and housing and full insertion of the rotor. With a seal wire inserted, the rotor and housing are relatively rotated to wrap the wire about the rotor. The rotor is then fully inserted into the housing so each ridge snaps into one groove.
Abstract: In a process for treating a radiation sensitive member which includes image-wise exposure to radiation, development and burning-in of the member, after the development and prior to the burning-in, an aqueous solution including ethyl hexyl sulphate is applied to the member.
Abstract: An ink for ink jet printers which comprises an aqueous carrier medium, pigment dispersion or dye and a polyol/alkylene oxide condensate cosolvent which eliminates film formation on thermal ink jet resistor surfaces thereby eliminating non-uniformity in optical density. The cosolvent present at least 5% has a solubility in water of at least 4.5 parts in 100 parts of water at 25.degree. C. and a general formula: ##STR1## wherein X=--H or --CH.sub.3 ;R=--H, --CH.sub.3, --C.sub.2 H.sub.5, --C.sub.3 H.sub.7, --C.sub.4 H.sub.9, or --CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.e H;b=0 or 1,a+d+f(c+e)=2-100; andf=1-6, the cosolvent being present in the amount of at least 4.5% based on the total weight of the ink jet ink composition. These inks exhibit freedom from thermal resistor film formation, have excellent decap performance, are storage stable and give images having excellent print quality.
Type:
Grant
Filed:
November 5, 1991
Date of Patent:
January 19, 1993
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
Howard Matrick, Michele E. Shepard, Young S. You
Abstract: A winding device for simultaneously winding several widths of material onto reel cores has a driven reel axle on which at least one reel core is rotatably arranged, and has a torque-transmission device to transmit a torque from the reel axle to the reel core. The torque-transmission device has a sliding hub element disposed on the reel axle, and a core-receiving element which slides in the reel core and which is affixed in the reel core in the rotating and axial directions. The torque-transmission device is arranged in the radial direction between the reel axle and the reel core, and the hub element is attached to the reel axle in the axial direction. The torque-transmsision device generates a magnetic coupling field between the hub element and the core-receiving element which is sufficient to transmit a torque therebetween.
Abstract: A multi-purpose apparatus to prepare a road surface is disclosed. The apparatus includes a scoop which cuts, profiles and collects material. A conveyor connected to the scoop transports the material from the scoop to a rock crusher. The rock crusher reduces the size of the rock and deposits the crushed rock back on the road bed. An articulated bucket assembly is mounted on the apparatus to excavate overburden and to deposit the overburden into the scoop.
Abstract: Imidazole compounds such as 5-[4-(3-(N-isopropylamino)hydroxypropoxy)indole-2-carboxamidomethyl]-2-n-b utyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloroimidazole and their pharmaceutically suitable salts are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin-II.
Type:
Grant
Filed:
November 25, 1991
Date of Patent:
January 12, 1993
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
Andrew T. Chiu, Victor J. De Noble, John J. V. Duncia, Pancras C. B. Wong
Abstract: Polymeric composite materials having a decreasing concentration gradient of polymer matrix from the material's surface to the material's interior. The composite is produced by a process whereby polymer matrix is extracted from the interior of the material in such a manner that the matrix concentration at the material's surface increases.
Abstract: An apparatus for delivering substances into living cells and tissues includes an impeller of the type adapted to use an explosive charge for sending a macroprojectile through an accelerator passage into a vacuum chamber. The vacuum chamber is divided into an upper vacuum chamber having an impact receiving plate against which the macroprojectile will impact and a lower vacuum chamber in which the biological material to be impregnated by the substance is located. The substance may be carried by a plurality of microprojectiles adhered to the base of the macroprojectile so that upon impact of the macroprojectile against the impact plate in the upper vacuum chamber the microprojectiles carrying the substance will pass through an aperture in the impact plate and enter the biological material.
Type:
Grant
Filed:
February 11, 1992
Date of Patent:
January 12, 1993
Assignee:
E. I. Du Pont de Nemours & Co.
Inventors:
John C. Sanford, Edward D. Wolf, Nelson K. Allen
Abstract: Disclosed herein are cathodic electrocoat compositions which contain electroconductive pigments. These pigments are light in color, and can be added at higher pigment to binder ratios for improved edge coverage. More specifically, the electroconductive pigments are a two-dimensional network of antimony-containing tin oxide crystallites which exist in a unique association with amorphous silica or with a silica-containing material.
Abstract: Novel aromatic polyimide gas separation membranes and the process of using such membranes to separate one or more gases from a gaseous mixture is disclosed.
Type:
Grant
Filed:
January 13, 1992
Date of Patent:
January 12, 1993
Assignees:
E. I. Du Pont de Nemours and Company, L'Air Liquide, SA
Abstract: An ostomy bag coupling appliance has body side and bag side couplings each including a seal means. The bag side coupling includes one ring like member carrying the seal means associated with a locking ring which can be rotated relative to the member. The locking ring and the body side coupling have interengaging parts whereby upon relative rotational movement (about the axis of the coupling) these cooperating parts can be engaged and disengaged so locking together, or allowing to be released, as the case may be, the body side and bag side couplings.
Abstract: A rotary exercise apparatus includes a frame which supports a seat assembly and a rotary crank mechanism. The frame has two sets of legs, one which supports the apparatus in an upright position where the crank mechanism can be used by someone sitting on the seat assembly to perform upper body exercises, and another which supports the apparatus in a reclined position where the crank mechanism can be used by someone sitting on the seat assembly to perform lower body exercises. The crank mechanism permits variable amounts of resistance to be imparted against its rotation by urging a shoe having a high friction liner against a rotatably mounted shaft that carries the crank arms. The location of the crank mechanism along the frame and the length of the arms are adjustable to accommodate different size users. In addition, the arms are replaceable to permit different size and shape arms carrying appropriate engagement devices to be used for each type of exercise.
Type:
Grant
Filed:
February 14, 1992
Date of Patent:
January 12, 1993
Assignees:
Jerry L. Wilson, Marilyn E. Wilson, Connie D. Wilson, Stuart B. Wilson, Brian D. Wilson, Molly M. Wilson
Abstract: A process for solubilizing solid formaldehyde oligomers without contaminating the solution product with undesirable solvent products by treating the oligomer with heated hydroxyacetic acid.
Type:
Grant
Filed:
December 19, 1990
Date of Patent:
January 12, 1993
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
Edward J. Balthazar, Harold E. Bellis, Charles J. Denham
Abstract: The invention provides an improved method and apparatus for feeding solids to a fluidized bed reactor. A back pressure control valve regulates the pressure drop between the pressure above a solids column in a standpipe and the pressure in the reactor. Solids are fed from the standpipe via a conduit without valve means, the conduit contains a bend of an angle greater than the angle of repose of the solids.
Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof have been found to possess activity as cell-selective HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula, ##STR2## R.sup.1 is hydrogen, alkyl, cycloalkyl, aryl or arylalkyl; and R.sup.2 is hydrogen, alkyl, ammonium, or alkali metal.
Type:
Grant
Filed:
April 3, 1990
Date of Patent:
January 5, 1993
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Ravi K. Varma, Sam T. Chao, Eric M. Gordon
Abstract: An improved sand pan and flushing jet apparatus is provided along with a process to separate solids from a fluid stream. The sand pan has openings along the side which increase in flow area with increasing distance from a slurry blowdown. Flushing jets are provided within the sand pan to remove slurry drawn into the sand pan by blowdown flow.
Type:
Grant
Filed:
January 30, 1992
Date of Patent:
January 5, 1993
Assignee:
Shell Western E&P Inc.
Inventors:
Robert W. Chin, Eugene B. Greene, Timothy A. League, Christaan M. P. De Ridder