Patent number: 4680409
Abstract: Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen or alkyl of 1 to 4 carbon atoms, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cycloalkyl ring;R.sub.3 is hydrogen or alkyl;R.sub.4 is hydrogen or alkyl, and R.sub.5 is hydrogen, alkyl, phenyl, substituted phenyl, a 4,5,6 or 7-membered heterocycle, phenylalkyl, (substituted phenyl)alkyl, (4,5,6 or 7-membered heterocycle)alkyl, ##STR2## or together R.sub.4 and R.sub.5 are .dbd.CH--Y.sub.7 ; wherein Y.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, methylcarbonyl, trifluoromethylcarbonyl, phenylcarbonyl, (substituted phenyl)carbonyl, carboxymethyl, methylsulfonyl, phenylsulfonyl, (substituted phenyl)sulfonyl, aminocarbonyl, aminocarbonylamino, aminoethyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, phenylcarbonylamino, (substituted phenyl)carbonylamino, 1-pyrrolidinyl or 1-piperidinyl; Y.sub.
Type:
Grant
Filed:
December 23, 1985
Date of Patent:
July 14, 1987
Assignee:
E. R. Squibb & Sons, Inc.
Inventor:
Uwe D. Treuner