Patent number: 4427592
Abstract: Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, and 6,7-dehydro derivatives thereof, wherein one of R.sub.1 and R.sub.2 is alkyl, aryl, arylalkyl, or cycloalkyl, and the other is alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, mono-, di- or trifluoroalkyl, cyanoalkyl, alkanoylalkyl or ##STR2## wherein n is 1, 2, 3 or 4 and Y.sub.1 and Y.sub.2 are the same or different and each is hydrogen or alkyl;R.sub.3 is hydrogen, hydroxy, alkoxy, aryloxy, oxo, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or fluorine;R.sub.4 is carbonyl, .beta.-hydroxymethylene or .beta.-acetyloxymethylene;R.sub.5 is hydrogen or halogen; andR.sub.6 is hydrogen, methyl, hydroxy, alkanoyl, alkanoyloxy or halogen.
Type:
Grant
Filed:
April 7, 1983
Date of Patent:
January 24, 1984
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Ravi K. Varma, Donald S. Karanewsky