Abstract: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain are provided. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds C1q, and optionally activating Fc receptors, but that is significantly reduced for binding to the inhibitory Fc?RIIb receptor. Furthermore, methods and compositions are provided for promoting complement dependent cytotoxicity (CDC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or a different non-Fc binding domain.

Abstract: A non-transitory machine readable storage medium having a machine readable program stored therein, wherein the machine readable program, when executed on a processing system, causes the processing system to perform a procedure of modeling many particle systems, wherein the procedure includes discretizing a many particle system into a first set of basis functions, thereby producing a discretized many particle system, wherein the first set of basis functions comprises a plurality of basis functions. The procedure further includes extracting a plurality of observables in the many particle system represented in the first set of basis functions by applying a respective operator on a corresponding Green's function of the plurality of Green's functions.

Abstract: The present invention relates to a self-humidifying ion-exchange composite membrane including an aromatic hydrocarbon polymer ion-exchange membrane formed on the surface of a porous polymer support and a thin hydrophobic coating layer having a nanocracked morphology pattern on the surface of the ion-exchange membrane. The self-humidifying ion-exchange composite membrane of the present invention has good thermal/chemical stability, high mechanical strength, high ion-exchange capacity, and good long-term operational stability. Particularly, the self-humidifying ion-exchange composite membrane of the present invention is able to self-hydrate even under high-temperature and low-humidity conditions. Due to these advantages, it is expected that the self-humidifying ion-exchange composite membrane of the present invention will be commercialized as an electrolyte membrane for a fuel cell or a membrane for water treatment.

Abstract: Provided is a neural processing device including a noise classifier configured to perform a preprocessing on input data to determine a noise characteristic of the input data, a network selector configured to select one of a plurality of neural networks based on the noise characteristic, and an operator configured to perform inference on the input data based on selected weights corresponding to the selected neural network.

Abstract: The present invention relates to a newly developed resorcinarene-based amphipathic compound, a method for producing the same, and a method for extracting, solubilizing, stabilizing, crystallizing, or analyzing a membrane protein by using the same. In addition, compared to a conventional compound, the compound can efficiently extract, from a cell membrane, membrane proteins having a greater variety of structures and characteristics, and can stably store such membrane proteins for a long time in an aqueous solution. Therefore, the compound can be used to analyze the functions and structures of such membrane proteins. Analysis of the structures and functions of membrane proteins, being closely related to the development of new drugs, is one of the fields of greatest interest in biology and chemistry today.

Abstract: Provided is a method and system for group-based energy harvesting. The group-based energy harvesting method performed by an access point in an energy harvesting system includes allocating an access period in each group including at least one station, receiving an energy state from the station in the group corresponding to the allocated access period, and scheduling stations in each group as a data transmission station or an energy reception station based on the received energy state.

Abstract: The present disclosure relates to a novel method for dispersion of nanocellulose in melt-processed polymers without the introduction of solvent during melt processing.

Abstract: The present disclosure relates to an adaptive mode switching method for simultaneous wireless power/information transmission operating in a dual mode and an apparatus for performing the same. The adaptive mode switching apparatus for simultaneous wireless power/information transmission operating in a dual mode includes: an energy harvesting unit; a single tone information receiving unit; a multi-tone information receiving unit; a time-division switch; and an adaptive mode switching control unit which determines a communication mode and a modulation index based on a battery status, the magnitude of the received signal, and a data transmission rate and controls the time-division switch in accordance with the selected communication mode and modulation index.

Abstract: The present invention relates to a method for preparing a mutant strain having high producibility of phytoene and a mutant strain prepared thereby. More particularly, a Deinococcus radiodurans mutant strain, prepared by the method of the present invention, having high producibility of phytoene, does not retain an artificial antibiotic-resistant gene, although constructed by introducing a metabolism engineering method, and has high producibility of phytoene. Thus, the mutant strain prepared according to the method can find useful applications in the mass production of phytoene.

Abstract: The present invention relates to a composition for preventing or treating chronic allograft dysfunction, comprising bisphosphonate which is used as a therapeutic agent for osteoporosis. The composition for preventing or treating chronic allograft dysfunction, comprising bisphosphonate, according to the present invention has an excellent prophylactic and/or therapeutic effect on chronic allograft dysfunction caused by a gradual decrease in the function of a transplanted tissue or organ which occurs after tissue or organ transplantation surgery, and thus is expected to be able to remarkably increase a long-term survival after transplantation surgery.

Abstract: The present invention relates to a microbial insecticide for control of thrips, comprising a Beauveria bassiana ERL836 strain (KCCM11506P) or a spore thereof. The insecticide of the present invention shows an insecticidal activity as potent as pre-existing chemical insecticides against thrips, is environmentally friendly, and easy to manage and produce, thus finding outstanding commercial applications.

Abstract: The present invention provides therapeutic formulations, including therapeutic nanoemulsions, and related methods for the in vivo delivery of hydrophobic compounds. Formulations and methods of the invention include semifluorinated block copolymers and an imaging compound to form a theranostic nanoemulsion, capable of forming a stable nanoemulsion. In certain embodiments, emulsion-based formulations are provided that are capable of formulating, delivering and releasing amounts of hydrophobic drugs effective for a range of clinical applications, including treating cancer and fungal infections in patients. In certain embodiments, emulsion-based formulations are provided that are capable of supporting controlled release, for example, over a range of rates useful for clinical applications including sustained release.

Abstract: Disclosed is a deep neural network-based method and apparatus for combining noise and echo removal. The deep neural network-based method for combining noise and echo removal according to one embodiment of the present invention may comprise the steps of extracting a feature vector from an audio signal that includes noise and echo; and acquiring a final audio signal from which both noise and echo have been removed, by using a combined nose and echo removal gain estimated by means of the feature vector and deep neural network DNN.

Abstract: The present disclosure relates to a method for providing information for determining lung tumor through inhalation of a fluorescent contrast agent, more particularly to a method of inhaling a small amount of Indocyanine green. The present disclosure does not have the problem of the existing intravenous injection that the administered fluorescent contrast agent is distributed throughout the body. In addition, when comparing the cancer detection efficiency of inhalation administration and intravenous injection, the inhaled fluorescent contrast agent exhibits remarkably higher cancer detection effect than the intravenously injected fluorescent contrast agent.

Abstract: Disclosed herein are methods to engineer single chain variable fragments (scFv's) that specifically bind a plurality of antigens in vivo, as well as novel scFv's produced therefrom. The disclosed novel scFV's can be used a variety of applications.

Abstract: A quantization device includes: a trellis-structured vector quantizer which quantizes a first error vector between an N-dimensional (here, “N” is two or more) subvector and a first predictive vector; and an inter-frame predictor which generates a first predictive vector from the quantized N-dimensional subvector, wherein the inter-frame predictor uses a predictive coefficient comprising an N×N matrix and performs an inter-frame prediction using the quantized N-dimensional subvector of a previous stage.

Abstract: A barrier according to an embodiment of the present invention is provided. The barrier includes a polymer configured of a plurality of first atoms; and an inorganic material configured of a plurality of second atoms and coexisting with the organic material, wherein an atomic planar density defined by the number of atoms per cm2 of the first atoms and the second atoms exceeds 1.9×1017 atoms/cm2.

Abstract: Disclosed are a collimator for reducing noise of a scanned image and an imaging catheter system comprising the same. The disclosed noise attenuation collimator comprises: a transparent tube having a diameter larger than a cladding diameter of double-clad fiber, wherein a coatingless region of the double-clad fiber is inserted into the transparent tube; and a first resin layer which is applied to an exterior of the transparent tube and has a refractive index lower than the refractive index of the transparent tube.

Abstract: Various examples of devices, methods and systems related to pulse based arithmetic units. In one example, a pulse domain device includes an augend area calculator to provide an augend area output for an augend pulse train; an addend area calculator to provide an addend area output for an addend pulse train; a resultant sum area (RSA) decoder to provide a RSA output using the augend and addend area outputs; and a pulse timing calculator to provide RSA output pulse timing. In another example, a pulse domain device includes a multiplicand area calculator to provide an multiplicand area output for a multiplicand pulse train; a multiplier area calculator to provide a multiplier area output for a multiplier pulse train; a resultant product area (RPA) decoder to provide a RPA output using the multiplicand and multiplier area outputs; and a pulse timing calculator to provide RPA output pulse timing.

Abstract: The present invention provides a method for forwarding an uplink packet performed by a node in a wireless communication system, the method being characterized in that the uplink packet including a first cost is received, the first cost is compared with a second cost corresponding to a cost of the node to determine whether to forward the uplink packet, and on the basis of the determination the uplink packet is forwarded, the node forwards the uplink packet when a value of the second cost is smaller than a value of the first cost, and the node does not forward the uplink packet when the second cost value is not smaller than the first cost value.