Abstract: Filarial parasites Brugia, Wuchereria, Loa Loa and Onchocerca cause over 20 million infections worldwide and pose a significant social and economic burden in endemic areas. The invention provides compositions and methods to treat parasitic infections in animals and plants, and to kill and inhibit the replication of parasites in infected hosts. The methods can include administering to a host in need of treatment an effective antiparasitic amount of a composition comprising biodegradable polyanhydride microparticles or nanoparticles that encapsulate antiparasitic agents, optionally in combination with antibacterial agents. Through co-encapsulation of antiparasitic and antibacterial agents into the particles, the invention provides the ability to effectively kill parasitic helminthes, worms, and flukes, with up to a 40-fold reduction in the amount of drug used.

Abstract: Embodiments of the present invention relate to the detection and diagnosis of cancer. More particularly, the present invention relates to a method for the early detection and diagnosis of cancer by measuring the amount of LINE-1 ORF-1 protein in a liquid biological sample obtained from a human.

Abstract: A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM).

Abstract: The present application discloses roles for miR-93 in treating hypoxia and ischemia. Endothelial cells (HUVEC) and myocytes (C2C12) expressed miR-93 and up-regulated miR-93 in response to hypoxia and serum starvation. Over-expression of miR-93 in HUVECs promoted cell proliferation, prevented hypoxia-induced apoptosis, and enhanced endothelial cell tube formation. miR-93 knockdown in HUVECs resulted in increased hypoxia-induced apoptosis and decreased tube formation. Over-expression or knockdown of miR-93 in myocytes resulted in reduced or increased hypoxia-induced apoptosis, respectively. Down-regulation of miR-93 in C57BL/6 mice with antagomiR resulted in attenuated perfusion recovery (% non-ischemic leg at day-21: Scramble 85.22.9 vs. AntagomiR-93 67.96). Over-expression of miR-93 in BALB/C mice improved perfusion recovery (% non-ischemic leg at day 21: PremiR-93 757.5 vs. Scramble 59.62.5).

Abstract: The present invention comprises methods, systems and compositions comprising cell culture analog systems, comprising components which optionally comprise biologically functional cells, and the components and systems function similarly to in vivo conditions.

Abstract: Embodiments of the present disclosure, in one aspect, relate to compositions including a vacancy-engineered (VE)-ZnO nanocomposite, methods of making a composition, methods of using a composition, and the like.

Abstract: The present invention relates to optical wave guide having multiple independent optical path and optical gas sensor using that, having an effect of improving optical efficiency by elongating optical path and condensing incident light without a separate artificial structure, by using first focus points of multiple 3 dimensional elliptical mirrors as a common focus point and equipping a light source at a first focus point and optical sensor parts at each second focus points in an optical structure using multiple 3 dimensional elliptical mirrors, and by placing so that virtual lines of first elliptical mirror and second elliptical mirror form a constant angle for improving optical efficiency in a structure equipping a light source at a second focus point of any one of elliptical mirror of multiple 3 dimensional elliptical mirrors and optical sensor parts at each second focus points of another 3 dimensional elliptical mirror.

Abstract: An apparatus and method for passing fluid flow through at least a portion of a blade of turbomachinery such as a gas turbine or the like. The fluid flow is directed through a plurality of flow channels which are interwoven with each other. Each flow channel is non-intersecting with any other flow channel and thus does not contact fluid flowing within any other flow channel. The method and apparatus of this invention can be used to reduce heat transfer and thus reduce thermal stresses, particularly in the blade.

Abstract: A method of generating the correlation function of a TMBOC(6,1,4/33) signal according to the present invention includes generating a signal delayed based on a phase delay 2 with respect to a signal pulse train of a TMBOC(6,1,4/33)-modulated received signal, generating 12 partial correlation functions by performing the autocorrelation operation of the received signal and the delayed signal with respect to a total time T(OT) , generating a sub-correlation function by performing an elimination operation of sixth and seventh partial correlation functions, and generating a main correlation function by summing results obtained by performing elimination operations between the remaining 10 partial correlation functions, excluding the sixth and seventh early partial correlation functions from the 12 partial correlation functions, and the sub-correlation function.

Abstract: A dual slot microwave probe for tissue ablation provides axially spaced slots producing an improved heating pattern with reduced axial extent. Degradation in this heating pattern caused by the addition of ceramic support elements and/or fluid cooling is realized through a feeding structure delivering separate sources of microwave energy to the different slots of the probe aligned with the slots of the probe.

Abstract: A system and method are provided for retaining brake pads in disc brakes, such as air-operated disc brakes utilized on commercial vehicles, and for installing and removing brake pads, without the need to employ brake pad retaining devices which radially over-top the brake pads. A preferred embodiment includes a retaining element, preferably a spring steel clip, having protrusions which face in opposite directions to engage corresponding slots in a brake pad lateral edge and in a brake pad carrier brake pad-facing surface. When installed in a radially-inward direction, the brake pad carrier side protrusion engages the brake pad carrier slot, and cooperates with the brake pad lateral side protrusion to resist brake pad movement in the radially-outward direction. The brake pad carrier side protrusion may be manually pressed toward the brake pad to disengage the protrusion from the carrier slot to permit withdrawal of the brake paid from the carrier.

Abstract: A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.

Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.

Abstract: A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5 ?m within which distinct organisms are encapsulated in viable form.

Abstract: Processor(s) for detecting malicious software. A hardware virtual machine monitor (HVMM) operates under a host OS. Container(s) initialized with network application template(s) operate under a guest OS VM. A detection module operates under the guest OS VM includes a trigger detection module, a logging module and a container command module. The trigger detection module monitors activity on container(s) for a trigger event. The logging module writes activity report(s) in response to trigger event(s). The container command module issues command(s) in response to trigger event(s). The command(s) include a container start, stop and revert commands. A virtual machine control console operates under the host OS and starts/stops the HVMM. A container control module operates under the guest OSVM and controls container(s) in response to the command(s). The server communication module sends activity report(s) to a central collection network appliance that maintains a repository of activities for infected devices.

Abstract: An actuator configured to rapidly vary the throat geometry of a microjet nozzle. Varying the throat geometry rapidly changes the characteristics of the microjet produced by the microjet nozzle. The inventive device is capable of producing pulsed flow. In some embodiments it is also capable of producing rapidly variable flow in order to provide active control.

Abstract: A method of applying a nondestructive mechanical force on one or more cells in aqueous environment by inducing heat generated acoustic pressure pulses. The method comprises providing an energy transmission pattern to induce the applying of a desired nondestructive mechanical force on a at least one cell by forming a plurality of heat generated acoustic pressure pulses in an aqueous environment and instructing the radiation of a target area in proximity to the at least one cell in the aqueous environment with light energy according to the energy transmission pattern.

Abstract: Block copolymer-based mask structures for the growth of patterned polymer brushes via surface-initiated atom transfer radical polymerization (SI-ATRP) are provided. Also provided are methods of making the mask structures and methods of using the mask structures to grow patterned polymer brushes. The mask structures comprise a substrate having a surface, a neutral layer comprising a crosslinked copolymer film disposed on the surface of the substrate and a domain-forming block copolymer film disposed on the crosslinked copolymer film. The crosslinked copolymer film comprises crosslinked random copolymer chains having pendant alkyl halide functional groups that are capable of acting as ATRP initiating sites.

Abstract: Proteases such as memapsin-1 are import enzymes, playing roles in a variety of diseases including diabetes. The inventors have developed inhibitors of memapsin 1 and methods of use therefore in the treatment of disease.

Abstract: Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an ocular active agent delivery device (40) having an active agent reservoir (44) disposed in an annular body (42), the annular body (42) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule.