Abstract: A method to detect beta-lactoglobulin (BLG) is described. The method includes the steps of adding a known concentration of hydrogen peroxide to a sample known to, or suspected of containing BLG; and electrolyzing the sample using a working electrode at a fixed potential sufficient to electrolyze BLG, and measuring a current signal within the sample. A diminution of the current signal in the sample as compared to a corresponding current signal from a standard solution containing a known concentration of hydrogen peroxide and no BLG indicates that the sample contains BLG.
Abstract: The present invention relates to novel compounds for modulating US28 receptor activity and methods for their use in preventing or treating US28 receptor-mediated disorders or conditions.
Type:
Application
Filed:
September 23, 2013
Publication date:
July 30, 2015
Applicants:
University of Central Florida Research Foundation,, Friedrich Alexander University
Abstract: Provided are graphene transistors having a tunable barrier. The graphene transistor includes a semiconductor substrate, an insulating thin film disposed on the semiconductor substrate, a graphene layer on the insulating thin film, a first electrode connected to an end of the graphene layer, a second electrode that is separate from an other end of the graphene layer and contacts the semiconductor substrate, a gate insulating layer covering the graphene layer, and a gate electrode on the gate insulating layer, wherein an energy barrier is formed between the semiconductor substrate and the graphene layer.
Type:
Application
Filed:
July 10, 2014
Publication date:
July 30, 2015
Applicant:
Sungkyunkwan University Research & Business Foundation
Inventors:
Jin-hong PARK, Jae-woo SHIM, Hyung-youl PARK, Jae-ho LEE
Abstract: According to example embodiments, a method of forming a multilayer graphene structure includes forming a sacrificial layer on the growth substrate, growing a first graphene layer on the sacrificial layer using a chemical vapor deposition (CVD) method, and growing at least one more graphene layer on the growth substrate. The growing at least one more graphene layer includes removing at least a part of the sacrificial layer.
Type:
Application
Filed:
June 19, 2014
Publication date:
July 30, 2015
Applicant:
Research & Business Foundation Sungkyunkwan University
Abstract: Example embodiments relate to methods of doping a 2-dimensional semiconductor. The method includes forming a semiconductor layer on a substrate, implanting ions into the semiconductor layer, forming a doped layer formed of a 2-dimensional semiconductor layer or an organic semiconductor layer on the semiconductor layer, and doping the doped layer by diffusing the ions of the semiconductor layer into the doped layer through annealing the substrate.
Type:
Application
Filed:
July 24, 2014
Publication date:
July 30, 2015
Applicant:
Sungkyunkwan University Research & Business Foundation
Inventors:
Jin-hong PARK, Hyung-youl PARK, Jae-woo SHIM, Jae-ho LEE
Abstract: A spectrometer employs multiple filters having complex filter spectra that can be generated robustly from received light over short optical path lengths. The complex filter spectra provide data that can be converted to a spectrum of the received light using compressed sensing techniques. The result is a more compact, easily manufactured spectrometer.
Abstract: The invention relates to a method of treating tumor cells within a patient wherein immature dendritic cells developed from the patient's monocyte cells and a lymphocyte cultured medium (LCM) adjuvant are introduced into the patient directly into the patient's tumor cells. The immature dendritic cells and LCM adjuvant combine with the antigens in the tumor cells to form a cancer vaccine, thereby immediately treating the tumor cells of the patient. The invention also provides a precursor treatment step of treating the patient with radiation therapy or a chemotherapy regimen.
Type:
Grant
Filed:
November 23, 2011
Date of Patent:
July 28, 2015
Assignee:
Hasumi International Research Foundation
Abstract: A high voltage analog switch operable by a binary signal is implemented in a low voltage semiconductor process. The switch has three parallel circuit paths, with each path comprising at least three series connected transistors. Control signals are selectively applied to the control terminals of the transistors to control the switch and selectively turn on or turn off each of the three circuit paths depending on the input voltage range, so that the breakdown voltage of all of the transistors is never exceeded in any mode of operation.
Type:
Grant
Filed:
August 26, 2010
Date of Patent:
July 28, 2015
Assignee:
Alfred E. Mann Foundation For Scientific Research
Abstract: One aspect of the present disclosure relates to an embolic filter device configured for placement in a blood vessel to capture emboli during a medical procedure. The embolic filter device can include an expandable frame member and a membrane. The expandable frame member can include a radial support member operably connected to first and second longitudinal struts, and an engaging portion extending between the first and second longitudinal struts. The engaging portion can be shaped and configured to temporarily receive, and sealingly mate with, a portion of an endovascular catheter during the medical procedure. The membrane can be securely connected to the frame member and define a collection chamber for captured emboli. The membrane can be configured to cover substantially all of the cross-sectional area of the blood vessel when the embolic filter device is deployed in the blood vessel.
Type:
Grant
Filed:
February 1, 2013
Date of Patent:
July 28, 2015
Assignee:
The Cleveland Clinic Foundation
Inventors:
Shubhayu Basu, Stephen Ellis, Dave Dudzinski, Ryan S. Klatte
Abstract: Semiconductor lasers comprise a substrate; an active layer configured to generate transverse magnetic (TM) polarized light under an electrical bias; an upper cladding layer; a lower cladding layer; and a distributed feedback (DFB) grating defined by the interface of a layer of metal and a layer of semiconductor under the layer of metal, the interface periodically corrugated in the longitudinal direction of the laser with a periodicity of ?DFB=m?/(2neff), wherein m>1. The DFB grating is configured such that loss of one or more antisymmetric longitudinal modes of the laser structure via absorption to the DFB grating is sufficiently maximized so as to produce lasing of a symmetric longitudinal mode of the laser with laser emission characterized by a single-lobe beam along each direction defined by the grating diffraction orders corresponding to emission away from the plane of the grating.
Type:
Grant
Filed:
December 11, 2013
Date of Patent:
July 28, 2015
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Luke J. Mawst, Dan Botez, Thomas L. Earles, Jeremy D. Kirch, Christopher A. Sigler
Abstract: Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. The invention provides S-acylated dithioamines which can be selectively activated reducing agents by removal of the S-acyl groups enzymatically or chemically. The invention further provides dithiane precursors of thioamino reducing agents. The invention provides dithioamine reducing agents, S-acylated dithioamines and dithianes which are immobilized on surfaces, including among others, glass, quartz, microparticles, nanoparticles and resins.
Abstract: The presently disclosed subject matter provides recombinant dopaminergic neurons and/or recombinant progenitors thereof that include one or more transgenes encoding a nurr-1 polypeptide, a pitx3 polypeptide, an Imxi a polypeptide, a biologically active fragment thereof, a biologically active derivative thereof, and/or any combination thereof. Also provided are methods for producing a recombinant dopaminergic neuron or recombinant progenitor thereof, methods for producing lineage primed cells, methods for ameliorating at least one symptom associated with a neurological disorder, methods for transplantation, methods for inducing growth, repair, ancllor regeneration of a neuron, for delivering a cytokine or a growth factor to the central nervous system, methods for providing a dopaminergic neuron function, and cell cultures that include recombinant olfactory epithelial-derived stem cells and/or a differentiated derivatives thereof.
Type:
Grant
Filed:
November 2, 2009
Date of Patent:
July 28, 2015
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Fred J. Roisen, Chengliang Lu, Meng Wang, Mengsheng Qiu
Abstract: The present invention relates to a composition consisting of Vitamin C, L-glutamine, L-cystine or L-cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10, and niacin. The present invention relates further to the use of the composition for minimizing the cell-damaging effect of radicals and harmful forms of oxygen, in particular of oxygen radicals or reactive oxygen species. The present invention relates to a composition comprising Vitamin C, L-glutamine, L-cystine or L-cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10, and niacin, wherein the composition is administered in a concentration ranging from 10 to 20 mg/kg body weight. The present invention relates further to the composition for use in the treatment and/or prevention of radical and harmful forms of oxygen derived diseases, in particular of oxygen radical or reactive oxygen species derived diseases. The present invention relates further to the composition as a food supplement or dietary supplement.
Abstract: The invention includes a pharmaceutical composition comprising an expression or activity regulator of AKAP12 (A-kinase anchoring protein 12) as the active ingredient. The compositions of the invention are useful for treating central nervous system diseases. The invention further includes a method of treating central nervous system diseases using a pharmaceutical composition of the invention. The central nervous system diseases contemplated within the invention include post-traumatic stress syndrome, stroke, and spinal injury.
Abstract: The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
Type:
Grant
Filed:
April 18, 2012
Date of Patent:
July 28, 2015
Assignees:
Myongji University Industry and Academia Cooperation Foundation, The Board of Trustees of the University of Illinois
Inventors:
Jong Woo Kim, Sang Wook Lee, Sang Jin Park, Joo Won Suh, In Ae Lee, Tae Mi Yoon, Jong Keun Choi, Ji Ean Lee, Jin Yong Kim, Ying Yu Jin, Scott Franzblau, Sanghyun Cho, Wei Gao, Guido Pauli, James McAlpine, Jose Napolitano, Birgit Jaki, Brent Friesen, Maria Florencia Rodriguez Brasco, David Lankin
Abstract: A liquid crystal display device, includes a first substrate including a first insulating substrate, a first thin film positioned on the first insulating substrate, and a first alignment layer positioned on the first thin film and including a first exposing area that exposes the first thin film, a second substrate facing the first substrate and including a second insulating substrate, a spacer positioned between the first substrate and the second substrate and including at least a part that corresponds to the first exposing area, and a liquid crystal layer positioned between the first substrate and the second substrate.
Type:
Grant
Filed:
June 20, 2008
Date of Patent:
July 28, 2015
Assignees:
Samsung Display Co., Ltd., Industry-University Cooperation Foundation, Hanyang University
Abstract: The present invention provides an X-ray needle module for local radiation therapy containing: an X-ray generating part supplied with external electric power; and an X-ray needle forming part which collects the X-rays generated by the X-ray generating part and extracts the collected X-rays into high-intensity short-wavelength parallel X-rays so as to form an X-ray needle. The X-ray needle forming part includes a housing with an entrance hole at one surface through which the X-rays generated by the X-ray generating part enter and an exit hole at another surface through which the X-ray needle exits, the X-ray needle, provided in the housing, which collects the X-rays generated by the X-ray generating part and forms the X-ray needle of the high-intensity short-wavelength parallel X-rays and a position controller, provided at a leading end of the X-ray mirror.
Type:
Grant
Filed:
May 9, 2012
Date of Patent:
July 28, 2015
Assignee:
Industry Foundation of Chonnam National University
Abstract: An apparatus and method for recommending software process improvement are disclosed. The method includes generating improvement packages from correlated findings by analyzing correlations between findings identified from different processes, refining the improvement packages by performing an additional correlation analysis on the improvement packages, and providing an action plan for process improvement by building recommendations from the refined improvement packages.
Type:
Grant
Filed:
May 30, 2013
Date of Patent:
July 28, 2015
Assignee:
Sogang University Research Foundation
Inventors:
Soo Yong Park, Su Jin Choi, Dae-Kyoo Kim
Abstract: Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.
Type:
Grant
Filed:
September 6, 2012
Date of Patent:
July 28, 2015
Assignee:
University of Iowa Research Foundation
Inventors:
Mark E. Anderson, Peter J. Mohler, Douglas R. Spitz, Jr., Jeffrey Robert Erickson
Abstract: Methods for labeling a substrate using a hetero-Diels-Alder reaction are disclosed. The hetero-Diels-Alder reaction includes the reaction of an o-quinone methide (e.g., an o-naphthoquinone methide) with a polarized olefin to form a hetero-Diels-Alder adduct. The o-quinone methide or the polarized olefin can be attached to a surface of a substrate, and the other of the o-quinone methide or the polarized olefin can include a detectable label. The o-quinone methide can conveniently be generated by irradiation of a precursor compound, preferably in an aqueous solution, suspension, or dispersion.
Type:
Grant
Filed:
May 5, 2011
Date of Patent:
July 28, 2015
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Vladimir V. Popik, Selvanathan Arumugam