Abstract: The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): Wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual.
Type:
Grant
Filed:
December 1, 2016
Date of Patent:
September 29, 2020
Assignees:
The Procter & Gamble Company, The Cleveland Clinic Foundation
Inventors:
Stanley Leon Hazen, Jose Carlos Garcia-Garcia, George Franklin Gerberick, John August Wos, David Thomas Stanton, Thomas Alfred Inglin, Michael Reilly, Angela Jane Deutsch, Jodie Michele Reed, David Blair Cody
Abstract: The subject invention relates in part to a combination of a cadherin peptide derived from Alphitobius diaperinus and a Cry protein capable of inhibiting an insect. In certain embodiments, the combination is capable of overcoming Cry protein resistance in insects that are resistant to the Cry protein alone.
Type:
Grant
Filed:
February 6, 2017
Date of Patent:
September 29, 2020
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: An engagement guarantee system uses a gamification method and includes a sensor configured to sense vehicle data from a vehicle tag attached to a vehicle, to sense tool data from a tool tag attached to a tool, and to transmit the sensed data to a server A controller is configured to receive the vehicle data and the tool data from the server, to transmit an engagement torque corresponding to the vehicle to the tool, and to receive an engagement result from the tool An analyzer is configured to receive the engagement result from the controller, to analyze the engagement result, and to transmit an analyzed result to a display unit. The display unit is configured to display the analyzed result transmitted from the analyzer.
Type:
Grant
Filed:
September 11, 2017
Date of Patent:
September 29, 2020
Assignees:
HYUNDAI MOTOR COMPANY, KIA MOTORS CORPORATION, IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)
Inventors:
Jongho Shin, Chang Ho Jung, Hyunwoo Lee, Yoon Jang, Seunghwan Roh, Jiyoung Lee, Kyoungwon Seo, Jihyo Kim, Hokyoung Ryu
Abstract: Embodiments of the invention are directed to a method for production of a nuclear fuel pellet by spark plasma sintering (SPS), wherein a fuel pellet with more than 80% TD or more than 90% TD is formed. The SPS can be performed with the imposition of a controlled uniaxial pressure applied at the maximum temperature of the processing to achieve a very high density, in excess of 95% TD, at temperatures of 850 to 1600° C. The formation of a fuel pellet can be carried out in one hour or less. In an embodiment of the invention, a nuclear fuel pellet comprises UO2 and a highly thermally conductive material, such as SiC or diamond.
Type:
Grant
Filed:
August 15, 2013
Date of Patent:
September 29, 2020
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Ghatu Subhash, Ronald Howard Baney, James S. Tulenko, Edward McKenna, III, Lihao Ge, Sunghwan Yeo
Abstract: A quantum computer architecture employs logical qubits that are constructed from a concatenation of doubly periodic Josephson junction circuits. The series concatenation of the doubly periodic Josephson junction circuits provides exponential robustness against local noise. It is possible to perform discrete Clifford group rotations and entangling operations on the logical qubits without leaving the protected state.
Type:
Grant
Filed:
April 18, 2019
Date of Patent:
September 29, 2020
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Lev Ioffe, Lara Faoro, Robert Francis McDermott
Abstract: A method for preventing, improving, or treating fatty liver includes administering an effective amount of an azelaic acid or a pharmaceutically acceptable salt thereof to a subject. Azelaic acid which is a compound primarily contained in a natural product, has no or fewer side effects and reduces accumulation of triglycerides in liver tissue, and thus may prevent, improve, or treat a non-alcoholic fatty liver. In addition, due to an anti-inflammatory effect, azelaic acid may be used in the treatment of steatohepatitis. Therefore, the azelaic acid according to the present disclosure is expected to be effectively used in a food composition, a pharmaceutical composition and a health functional food composition to treat fatty liver or steatohepatitis.
Type:
Grant
Filed:
February 19, 2019
Date of Patent:
September 29, 2020
Assignee:
Korea University Research and Business Foundation
Abstract: A solid-state lubricant composition is disclosed. The solid-lubricant contains graphene, an oxide of a metal, and one or more polymeric binders. A method of making a solid-state lubricant coating on various substrates is disclosed. The method includes the steps of making a homogeneous slurry comprising powder of an oxide of a metal, graphene, and a polymeric binder with organic volatile solvent; coating a substrate with the homogeneous slurry with desired thicknesses; and drying the slurry on the substrate naturally or applying additional heat, resulting in a solid lubricant coating on the substrate. Substrates with coated solid composite lubricant show wear reduction and lower coefficient of friction compared with uncoated substrates.
Type:
Grant
Filed:
June 20, 2018
Date of Patent:
September 29, 2020
Assignee:
Purdue Research Foundation
Inventors:
Vilas Ganpat Pol, Farshid Sadeghi, Abdullah Alazemi, Arthur D. Dysart
Abstract: A home robot device includes a memory, a movement module, and a processor. The processor is configured to execute a motion based on specified motion execution information stored in the memory, obtain feedback information of a user, generate modified motion execution information by modifying at least a portion of the specified motion execution information based on the feedback information of the user, where the modified motion execution information includes a movement value of at least one joint unit of the home robot device or at least one support linked to the at least one joint unit selected from a probability model of the specified motion execution information, and execute a motion of the home robot device based on the modified motion execution information.
Type:
Grant
Filed:
December 5, 2017
Date of Patent:
September 29, 2020
Assignees:
Samsung Electronics Co., Ltd., SNU R&DB Foundation
Inventors:
So Hee Lee, Dong Hyun Kwak, Eun Sol Kim, Ji Seob Kim, Kyoung Woon On, Byoung Tak Zhang, Kyung Shik Roh, Suk June Yoon
Abstract: The present disclosure discloses a novel omniphobic, paper-based, smart bandage (OPSB) devices, and the methods to make and use the omniphobic, paper-based, smart bandage devices. The OPSB device of the present disclosure provides a simple, low-cost, and non-invasive strategy to monitor open wound status wirelessly. This disclosure also provides the demonstration of in-vivo early detection and monitoring of pressure ulcers using wireless smart bandages.
Abstract: This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Type:
Application
Filed:
February 5, 2020
Publication date:
September 24, 2020
Applicant:
University of Tennessee Research Foundation
Inventors:
Ramesh NARAYANAN, Duane D. MILLER, Thamarai PONNUSAMY, Dong-Jin HWANG, Yali HE
Abstract: A method for processing a three-dimensional holographic image includes obtaining depth images from depth data of a three-dimensional object, dividing each of the depth images into a predetermined number of sub-images, obtaining interference patterns of computer-generated hologram (CGH) patches corresponding to each of the sub-images by performing a Fourier transform to calculate an interference pattern in a CGH plane for object data included in each of the sub-images, and generating a CGH for the three-dimensional object using the obtained interference patterns of the CGH patches.
Type:
Application
Filed:
February 3, 2020
Publication date:
September 24, 2020
Applicants:
SAMSUNG ELECTRONICS CO., LTD., Korea University Research and Business Foundation, Sejong Campus
Inventors:
Hoon Song, Hwi Kim, Jongha Park, Hojung Kim, Yongkyu Kim
Abstract: A composition of matter includes one or more functionalized vinylbenzyl components of the formula covalently connected to one or more R functional components; the one or more R functional groups selected from a group including one or more hydroxyl methyl (—CHOH—) moieties and/or derivatives thereof, one or more ethoxy (—CH2—CH2—O—) moieties and/or derivatives thereof, end one or more benzene (C6H6) and/or derivatives thereof; and ether links that connect the functionalized vinylbenzyl components and the R functional components.
Abstract: The present disclosure described herein generally relates to a dye-sensitized solar cell including an organic-inorganic composite dye having a perovskite structure, and a producing method of the same
Type:
Application
Filed:
June 8, 2020
Publication date:
September 24, 2020
Applicant:
Research & Business Foundation Sungkyunkwan University
Inventors:
Nam-Gyu PARK, Huiseon KIM, Changryul LEE, Jeong-Hyeok IM
Abstract: A non-transitory computer-readable medium encoded with a computer-readable program which, when executed by a processor, will cause a computer to execute a method of authenticating a 3-D object with a 2-D camera, the method including building a pre-determined database. The method additionally includes registering the 3-D object to a storage unit of a device comprising the 2-D camera, thereby creating a registered 3-D model of the 3-D object. Additionally, the method includes authenticating a test 3-D object by comparing the test 3-D object to the registered 3-D model.
Type:
Application
Filed:
March 15, 2020
Publication date:
September 24, 2020
Applicant:
Purdue Research Foundation
Inventors:
He Wang, Siyuan Cao, Habiba Farrukh, Reham Mohamed Aburas
Abstract: Disclosed are a method of manufacturing an aluminum alloy clad section, and an aluminum alloy clad section manufactured by the method. The method includes preparing a composite powder by ball-milling aluminum powder and carbon nanotubes, preparing a billet from the composite powder, and subjecting the billet to direct extrusion using an extrusion die. The method is simple in procedure and uses simple equipment because it is based on direct extrusion which is suitable for mass production. Thus, the method is capable of producing a lightweight high-strength functional aluminum alloy clad section having a competitive advantage in terms of price over conventional aluminum alloy clad sections.
Type:
Application
Filed:
May 31, 2019
Publication date:
September 24, 2020
Applicant:
Pukyong National University Industry-University Cooperation Foundation
Abstract: This document describes methods and materials for improving the delivery of electroporation. For example, this document describes methods and devices for delivering electroporation while mitigating risks of ventricular fibrillation.
Type:
Application
Filed:
December 11, 2018
Publication date:
September 24, 2020
Applicant:
Mayo Foundation for Medical Education and Research
Abstract: Systems and methods for repairing a surface defect in a metallic substrate can have a transducer that generates acoustic energy and an acoustic energy coupling tool connected to the transducer. The acoustic energy coupling tool receives the acoustic energy from the transducer and oscillates at a frequency corresponding to a frequency of the acoustic energy. A filler material is provided within the surface defect and the oscillation of the acoustic energy coupling tool causes a deforming impact of the acoustic energy coupling tool with the filler material within the surface defect, such that the filler material conforms to at least a portion of an internal surface of the surface defect. Additionally, the acoustic energy coupling tool is used to irradiate the filler material while it is being deformed with the acoustic energy.
Type:
Application
Filed:
March 18, 2020
Publication date:
September 24, 2020
Applicant:
University of Louisville Research Foundation, Inc.
Abstract: This invention provides slippery liquid-infused porous surfaces (SLIPS) using nanoporous or microporous and chemically reactive polymer multilayers. This approach permits fabrication of slippery anti-fouling coatings on complex surfaces and provides new means to manipulate the mobilities of contacting aqueous fluids. The results expand the range of tools that can be used to manipulate the behaviors of SLIPS and open the door to new applications of this emerging class of soft materials.
Type:
Application
Filed:
January 10, 2020
Publication date:
September 24, 2020
Applicant:
Wisconsin Alumni Research Foundation
Inventors:
David LYNN, Uttam MANNA, Matthew CARTER
Abstract: The present invention relates to a vitamin E-based amphipathic compound, a method for producing same, and a method for extracting, solubilizing, stabilizing, or crystallizing a membrane protein using same. By using a compound according to the present invention, not only is an excellent membrane protein extraction and solubilization effect achieved, but the membrane protein can be stably stored for a long period of time in an aqueous solution, and thus the compound can be utilized in analyzing the function and structure of the membrane protein. Moreover, the vitamin E-based amphipathic compounds exhibited superb properties in the visualization of protein compounds through an electron microscope.
Type:
Application
Filed:
February 28, 2018
Publication date:
September 24, 2020
Applicant:
Industry-University Cooporation Foundation Hanyang University Erica Campus
Abstract: Aspects of the disclosure relate to systems and methods for obtaining and interpreting magnetic resonance spectroscopy (MRS) data obtained from the pancreas of a subject. In some embodiments, systems and methods of the disclosure relate to analyzing MRS spectra of metabolites, for example y-Aminobutyric acid (GABA), to assess pancreatic islet density and function in a subject. In some embodiments, systems and methods described by the disclosure are useful for the diagnosis and/or treatment of diseases associated with impaired pancreatic function, for example diabetes.
Type:
Application
Filed:
October 17, 2018
Publication date:
September 24, 2020
Applicants:
University of Florida Research Foundation, Incorporated, Johns Hopkins University, The
Inventors:
Eric C. Porges, Damon Lamb, Martha Campbell Thompson, Richard Edden