Patents Assigned to Foundation
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Patent number: 10293153Abstract: An implantable medical device can include an electrode substrate electrically connected to at least one electrode. The device can have a pseudoporous surface across the electrode substrate and electrode. This surface can result in a real surface area (RSA) greater than the geometric surface area (GSA) of the device. The pseudoporous surface can be a macroporous surface enabling a charge injection capacity greater than 1 mC/cm2 while minimizing rejection of the device by surrounding tissue in chronic implant applications. The electrode can be a thin layer of conductive material, such as platinum or another metal, conformally deposited on the pseudoporous surface of the electrode substrate. A method of making the implantable device can include forming the device having an electrode substrate and at least one electrode electrically coupled to the electrode substrate, and forming a pseudoporous surface on the electrode substrate and electrode.Type: GrantFiled: June 1, 2015Date of Patent: May 21, 2019Assignee: University of Utah Research FoundationInventors: Sandeep Negi, Rajmohan Bhandari
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Patent number: 10296779Abstract: Disclosed is a method of measuring red blood cell membrane fluctuations based on dynamic cell parameters using a digital holographic microscope; the method including a step of modeling the three-dimensional images of red blood cells to be measured, and a step of measuring red blood cell membrane fluctuations based on the three-dimensional images. According to this method, since the three-dimensional images of red blood cells to be measured are modeled and red blood cell membrane fluctuations are measured based on the three-dimensional images, red blood cell membrane fluctuations can be measured more easily.Type: GrantFiled: June 14, 2017Date of Patent: May 21, 2019Assignee: Industry-Academic Cooperation Foundation, Chosun UniversityInventors: Inkyu Moon, Keyvan Jaferzadeh
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Patent number: 10297221Abstract: A data driver includes a digital to analog converter configured to receive a reference gray voltage and image data, and configured to generate gray voltages corresponding to the image data, and an output buffer including a plurality of buffer circuits connected to an output terminal of the digital to analog converter, and configured to selectively receive one of the gray voltages.Type: GrantFiled: June 6, 2016Date of Patent: May 21, 2019Assignees: Samsung Display Co., Ltd., Sogang University Research FoundationInventors: Moon Sang Hwang, Weon Jun Choe, Jun Sang Park, Tai Ji An, Seung Hoon Lee
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Patent number: 10292854Abstract: Devices and methods can be used for the endoscopic treatment of conditions such as obesity and metabolic diseases. For example, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake. The devices provided herein can be endoscopically implanted such that direct visualization of the entire implant location within the gastrointestinal tract is attained. In some embodiments, the device is distally deployed utilizing a technique that is like that of single or double-balloon enteroscopy.Type: GrantFiled: April 10, 2015Date of Patent: May 21, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventor: Barham K. Abu Dayyeh
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Patent number: 10292891Abstract: A robotic walker and associated method are provided. The robotic walker includes a housing containing a control unit operatively connected to a drive unit. The drive unit is operatively connected to a pair of motorized drive wheels. The robotic walker includes first and second winches, each winch having a strap that can be retracted by its respective winch, each winch is operatively connected to the drive unit, each strap having an end adapted to be removably connected to a pair of leg braces worn by a user. The first and second winches may retract a portion of each respective strap to move the legs of the user forward. A first control button is operatively connected to the control unit. The control unit is configured to operate the robotic walker in at least one control mode and the first control button being operable to start the at least one control mode.Type: GrantFiled: March 27, 2018Date of Patent: May 21, 2019Assignee: Ohio State Innovation FoundationInventors: Yuan Fang Zheng, Hongfei Wang
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Patent number: 10294281Abstract: The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions.Type: GrantFiled: February 27, 2017Date of Patent: May 21, 2019Assignee: University of Florida Research Foundation, IncorporatedInventors: Arun Srivastava, George Vladimirovich Aslanidi, Kim M. Van Vliet, Mavis Agbandje-McKenna
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Patent number: 10294470Abstract: Systems and methods are provided for improving action potential morphology in iPSC-derived cardiac myocytes and utilizing such myocytes. Improved morphology may include, for example, physiological resting membrane potentials. Membrane voltages of the myocyte are measured and a synthetic inward rectifying current is applied to the myocyte based on the membrane voltage.Type: GrantFiled: May 19, 2014Date of Patent: May 21, 2019Assignee: The Research Foundation for The State University of New YorkInventors: Randall Lee Rasmusson, Glenna C. L. Bett
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Patent number: 10294478Abstract: The present invention relates to a nucleic acid aptamer molecule that includes a domain that binds to an estrogen receptor, molecular complexes that include the nucleic acid aptamer molecule and an estrogen receptor, and constructed DMA molecules and expression systems, as well as host cells, that the contain an RNA aptamer molecule of the invention. Use of these aptamers and encoding constructs to inhibiting estrogen receptor activity in a cell and to treat estrogen receptor-positive cancers is also described.Type: GrantFiled: August 16, 2012Date of Patent: May 21, 2019Assignee: The Research Foundation for The State University of New YorkInventors: Hua Shi, Daiying Xu, Vamsee Krishna Chatakonda
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Patent number: 10295362Abstract: A system and method of estimating an available driving distance of an electric vehicle are provided. The method includes dividing a road into sections and receiving driving information from a vehicle traveling through each of the sections. Fuel efficiency data of the corresponding section is generated and vehicle condition information, and departure point and destination information is received from the target vehicle. Additionally, the method includes receiving real time meteorological information and road traffic situation information for each of the sections and reflecting the vehicle condition information of the target vehicle, the meteorological information and the road traffic situation information in the fuel efficiency data generated for each of the sections of the road from the departure point toward the destination. Estimated fuel efficiency and an estimated available driving distance of the target vehicle are then determined to be provided to vehicle driver.Type: GrantFiled: November 23, 2016Date of Patent: May 21, 2019Assignees: Hyundai Motor Company, IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)Inventors: Kwon Hyoung Choi, Jin Hyung Lee, Jong Chan Jun, Jahng Hyon Park
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Patent number: 10294567Abstract: Aqueous dispersions of artificially synthesized, mussel-inspired polyopamine nanoparticles were inkjet printed on flexible polyethylene terephthalate (PET) substrates. Narrow line patterns (4 ?m in width) of polydopamine resulted due to evaporatively driven transport (coffee ring effect). The printed patterns were metallized via a site-selective Cu electroless plating process at a controlled temperature (30° C.) for varied bath times. The lowest electrical resistivity value of the plated Cu lines was about 6 times greater than the bulk resistivity of Cu. This process presents an industrially viable way to fabricate Cu conductive fine patterns for flexible electronics at low temperature, and low cost.Type: GrantFiled: December 10, 2015Date of Patent: May 21, 2019Assignee: The Research Foundation for the State University of New YorkInventors: Siyuan Ma, Liang Liu, Vadim Bromberg, Timothy Singler
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Patent number: 10292933Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.Type: GrantFiled: April 27, 2017Date of Patent: May 21, 2019Assignee: Technion Research & Development Foundation LimitedInventors: Marcelle Machluf, Tomer Bronshtein
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Patent number: 10293234Abstract: A portable, impact-absorbing apparatus having a striking portion, an energy-absorbing portion, and a mounting portion. The striking portion may be a padded plate and the mounting portion may be a collar that may mount to the vertical frame member of a squat rack. The energy-absorbing portion may be an insert that slides into the barrel of a hollow sleeve in which a spring is disposed. The sleeve may have slots in the top and bottom for bolts or pins, which are inserted therethrough for attachment to the insert, to define the longitudinal limits of the insert's extension.Type: GrantFiled: July 18, 2016Date of Patent: May 21, 2019Assignee: Ohio State Innovation FoundationInventor: Anthony Schlegel
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Patent number: 10294528Abstract: Collections of polynucleotides useful estimating breeding value or detecting likelihood of an increased susceptibility to contracting paratuberculosis are disclosed. The polynucleotides are used to detect genomic sequences quantitatively associated with an increased susceptibility to contracting paratuberculosis trait. Methods for using the collections to estimate breeding value or predict likelihood of an increased susceptibility to contracting paratuberculosis are also provided. Kits comprising the collection of polynucleotides are also provided.Type: GrantFiled: August 23, 2010Date of Patent: May 21, 2019Assignee: Wisconsin Alumni Research FoundationInventors: Brian W. Kirkpatrick, George W. Shook, Michael T. Collins
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Patent number: 10295547Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.Type: GrantFiled: March 10, 2014Date of Patent: May 21, 2019Assignee: University of Florida Research Foundation, IncorporatedInventors: Laura Ranum, Tao Zu
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Patent number: 10292390Abstract: Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.Type: GrantFiled: November 5, 2012Date of Patent: May 21, 2019Assignee: Wisconsin Alumni Research FoundationInventors: Helen Blackwell, Reto Frei, Anthony Breitbach, David M. Lynn, Adam H. Broderick
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Patent number: 10294213Abstract: A series of multicoordinating and multifunctional ligands optimized for the surface-functionalization of luminescent quantum dots (QDs) and gold nanoparticles (AuNPs) alike is disclosed. An L-aspartic acid precursor is modified with functionality, through simple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG) moieties in the same ligand. These ligands were combined with a new photoligation strategy to yield hydrophilic and reactive QDs that are colloidally stable over a broad range of conditions, including storage at nanomolar concentration and under ambient conditions.Type: GrantFiled: December 1, 2016Date of Patent: May 21, 2019Assignee: The Florida State University Research Foundation, Inc.Inventors: Hedi Mattoussi, Naiqian Zhan, Goutam Palui
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Patent number: 10294220Abstract: The present disclosure relates to nucleosides, such as compositions, and methods useful for treating retinal damage and/or retinal degradation/retinal degeneration, for inhibiting inflammasome activation by Alu RNA associated with a cell, for reducing ATP-induced permeability of a cell, for reducing an amount of mitochondrial reactive oxygen species in a cell, and for reducing an amount of mitochondrial reactive oxygen species in a cell. The present disclosure further relates to nucleosides, such as compositions, and methods for use in protecting an RPE cell and/or for treating, including prophylactic and therapeutic treatment, of conditions associated with retinal damage and/or degradation including, but not limited to, dry age related macular degeneration (AMD) and wet AMD, Alzheimer disease, various forms of arthritis, atherosclerosis, diabetes mellitus, chronic obstructive pulmonary disease, inflammatory bowel disease, and Duchenne muscular dystrophy.Type: GrantFiled: February 26, 2016Date of Patent: May 21, 2019Assignee: University of Kentucky Research FoundationInventors: Jayakrishna Ambati, Benjamin Fowler, Kameshwari Ambati
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Patent number: 10293336Abstract: A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.Type: GrantFiled: June 8, 2016Date of Patent: May 21, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr.
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Patent number: 10292832Abstract: A spinal fixation device includes an outer housing and an end plate assembly coupled with the outer housing. The outer housing defines an aperture and a longitudinal axis. At least a portion of the end plate assembly is slidably received within the outer housing. The end plate assembly includes a first end plate configured to engage a vertebral body, wherein the end plate assembly is selectively movable between a first position in which the first end plate is spaced apart from the outer housing and a second position in which the first end plate is adjacent the outer housing. Further, the first end plate is selectively adjustable to an angular orientation of a plurality of angular orientations with respect to the longitudinal axis of the outer housing.Type: GrantFiled: November 10, 2015Date of Patent: May 21, 2019Assignees: Ohio State Innovation Foundation, K2M, Inc.Inventors: Chester Evan Sutterlin, III, Ehud Mendel, Michael Finn, Clint Boyd, Scott Jones, Todd Wallenstein, Jacob M. Buchowski
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Patent number: 10294826Abstract: A turbo-compression cooling system includes a power cycle and a cooling cycle coupled one to the other. The power cycle implements a waste heat waste heat exchanger configured to evaporate a first working fluid and a turbine configured to receive the evaporated working fluid. The turbine is configured to rotate as the first working fluid expands to a lower pressure. A condenser condenses the first working fluid to a saturated liquid and a pump pumps the saturated liquid to the waste heat waste heat exchanger. The cooling cycle implements a compressor increasing the pressure of a second working fluid, a condenser condensing the second working fluid to a saturated liquid upon exiting the compressor, an expansion valve expanding the second working fluid to a lower pressure, and an evaporator rejecting heat from a circulating fluid to the second working fluid, thereby cooling the circulating fluid.Type: GrantFiled: August 11, 2016Date of Patent: May 21, 2019Assignee: Colorado State University Research FoundationInventors: Todd M. Bandhauer, Torben P. Grumstrup