Abstract: Systems and methods for imaging within depth layers of a tissue include illuminating light rays at different changing wavelengths (frequencies), collimating illuminated light rays using a collimator, and splitting light rays using a beam splitter, such that some of the light rays are directed towards a reference mirror and some of the rays are directed towards the tissue. The systems and methods further include reflecting light rays from the reference mirror towards the imager, filtering out non-collimated light rays reflected off the tissue by using a telecentric optical system, and reflecting collimated light rays reflected off the tissue towards the imager, thus creating an image of an interference pattern based on collimated light rays reflected off the tissue and off the reference mirror. The method may further include creating full 2D images from the interference pattern for each depth layer of the tissue using Fast Fourier transform.

Abstract: In-vivo medical devices, systems and methods of operating such devices include a permanent magnetic assembly interacting with external magnetic fields for magnetically maneuvering said device to a desired location along a patient's GI tract, and anchoring said devices to the desired location for a period of time. The in-vivo medical device includes illumination sources, an optical system, and an image sensor for imaging the GI tract and thus assisting in locating the desired location. Some in-vivo medical devices include a concave window, which enables better imaging of small areas along the tissue. Furthermore, in-vivo devices with a concave window enable carrying operating tools without damaging the tissue of the GI tract, since prior to operation, the tools protrude from the concave window but remain behind the ends of the edges of the concave window.

Abstract: This invention relates to methods for enhancing an image by expanding the color contrast of the image presented to a wider range of colors that is optimized for the item sought to be viewed. The method also increases contrast of an image or a portion of an image for example an in vivo image captured by an autonomous in vivo device. A user interface with a display provides the user with the option of viewing selected images captured by the in-vivo imaging device in either regular view or in a color enhanced view to enable more distinct viewing of the selected images.

Abstract: An in-vivo sensing system incorporating a sensing device movably disposed within a housing such that the orientation of the sensing device may be moved or changed in response to substantially small forces. The in-vivo sensing device may be ingested and may naturally traverse a lumen such as the GI tract or may be anchored at a surgical site. In a preferred embodiment, the in vivo sensing system is an imaging system (100) incorporating a sensing device such as an imaging device (112) suspended in a liquid (114) encapsulated in an covering or housing (110).

Abstract: The invention relates to an in vivo sensing device having a specific gravity of about 1 or a volume to weight ratio that enables it essentially to float. In one embodiment the in vivo sensing device consists of an image sensor system and a buoyant body. The buoyant body, which is attached to the sensor system or which can optionally house one or more elements of the sensor system, keeps the sensor system essentially floating in a body lumen liquid.

Abstract: A system and method may allow automatic display of un-viewed images of an image stream, which may be produced by an ingestible capsule. A set of images acquired by an in-vivo device disposed within a body lumen is received by a receiver or workstation, and a portion of the set of images is selected for display as an image stream. The selected portion of images is displayed as a first image stream, and a complementary portion of the set of images is displayed as a second image stream. The complementary portion includes unselected images from the set of images, and/or images which are indicated as unviewed images. A graphical user interface is provided for selecting a viewing mode which is determined based on previously viewed images and users' review history.

Abstract: A method and system for determining intestinal dysfunction condition are provided by classifying and analyzing image frames captured in-vivo. The method and system also relate to the detection of contractile activity in intestinal tracts, to automatic detection of video image frames taken in the gastrointestinal tract including contractile activity, and more particularly to measurement and analysis of contractile activity of the GI tract based on image intensity of in vivo image data.

Abstract: A method and system for detection of intestinal contraction may include detecting an obstructed portion of an image frame captured in-vivo. The obstructed portion of the image frame may include an area within an image frame that is obstructed by turbid intestinal content. The method and system may set a threshold for the area of the obstructed portion in the image frame, to determine an invalid frame and may remove the invalid frame from an image stream.

Abstract: A method for controlling movement of an imaging device in vivo, the method comprising the steps of providing an imaging device having a longitudinal axis and a magnetic component, said device to be inserted into a patient's body; providing a rotating magnetic field outside the patient's body; and advancing the rotating magnetic filed along the patient's body in a desired direction.

Abstract: A system and method for comparing captured sequences of in-vivo images with (e.g., template) sequences, for example, for computer-automated diagnosis. Captured in vivo images may be divided into a plurality of captured image sequences. For each of the plurality of captured sequences, the processor may assign a first and second set of scores to each frame in the captured sequence and align each frame in the captured sequence with one or more frames in the template sequence for which the comparisons therebetween generate the minimum scores in the first and second sets of scores. The processor may define a match between the template sequence and captured sequences having a combination of scores in the first and second sets of scores for the frames in the captured sets compared with the one or more aligned frames in the template sequence, which are below or above a threshold value.

Abstract: An in-vivo imaging system and method to screen for colorectal polyps in the GI tract may include an in-vivo imaging device for capturing a stream of image frames in a GI tract, a polyp detector for detecting and/or identifying one or more image frames from the stream of image streams that may show colorectal polyps, and a graphical user interface (GUI) to display image frames detected.

Abstract: This invention relates to methods and apparatus for localizing an in vivo imaging device by means of a single magnetic source coil assembly and a single magnetic detector coil assembly. This invention also relates to methods and apparatus to enable the use of a single magnetic source coil assembly to also transmit and receive information, images, and controls signals, as well as for the coil assembly to be used in DC-DC voltage conversion. A user interface with a display provides the user with the option of viewing selected images captured by the in vivo imaging device.

Abstract: An electromagnetic localization signal may be sensed by an electromagnetic field sensor in an in-vivo device with an electromagnetic field interference that is superimposed on the electromagnetic localization signal. The electromagnetic field interference may be filtered by outputting, by the electromagnetic field sensor, an alternating signal that represents, or in response to, the electromagnetic localization signal; sampling a first (e.g., positive) portion of the alternating signal during a first sampling window or period to obtain a first set of samples, sampling a second (e.g., negative) portion of the alternating signal during a second sampling window or period to obtain a second set of samples; and calculating a number, NR, from the first and second sets of samples, that approximately represents a substantially interference free electromagnetic localization signal.

Abstract: This invention relates to a system and methods for determining the initiation and/or the termination of an autonomous in vivo imaging procedure, such as by a capsule imaging the gastro intestinal tract.

Abstract: A system and method for classification of images of an image stream includes receiving an image stream of unclassified images, for example produced by an in-vivo imaging device, and adapting an initial classification algorithm to classify images to groups based on at least a subset of the received image stream of unclassified images.

Abstract: A device, system and method for motility measurement and analysis. For example, a system includes a processor to determine contractile activity within a body lumen based on an analysis of data received from an autonomous in-vivo device.

Abstract: A device, system and method for automatic detection of contractile activity of a body lumen in an image frame is provided, wherein image frames during contractile activity are captured and/or image frames including contractile activity are automatically detected, such as through pattern recognition and/or feature extraction to trace image frames including contractions, e.g., with wrinkle patterns. A manual procedure of annotation of contractions, e.g. tonic contractions in capsule endoscopy, may consist of the visualization of the whole video by a specialist, and the labeling of the contraction frames. Embodiments of the present invention may be suitable for implementation in an in vivo imaging system.

Abstract: A device, system and method for in-vivo sampling. An in-vivo device and method for use thereof may include a sampling chamber and a gating mechanism. The sampling chamber may store a sample of a body lumen substance, and the gate may close and open an opening of the sampling chamber.

Abstract: Embodiments of the present invention provide a system and method for a concurrent transferring of an image stream gathered by an in-vivo sensing device, including creating a plurality of segments from at least a portion of the image stream and concurrently transferring the created segments. Other embodiments of the present invention provide and system and method for a concurrent processing of an image stream gathered by an in-vivo sensing device, including creating a plurality of segments from at least a portion of the image stream and concurrently processing the created segments.

Abstract: An in-vivo imaging device including a camera may include a frame storage device. Systems and methods which vary the frame capture rate of the camera and/or frame display rate of the display unit of in-vivo camera systems are discussed. The capture rate is varied based on physical measurements related to the motion of the camera. Alternatively, the frame capture rate is varied based on comparative image processing of a plurality of frames. The frame display rate of the system is varied based on comparative image processing of a multiplicity of frames. Both the frame capture and the frame display rates of such systems can be varied concurrently.