Abstract: An in-vivo imaging device, typically an autonomous capsule, having a housing, the housing comprising a window; an illumination source located within the housing to illuminate a body lumen through the window; an imager to receive light reflected from the body lumen through the window; and a transmitter to transmit image data to a receiving system. The window is coated with liposomes containing a marker such that the imager may acquire images which include the marking.

Abstract: A device, system and method for capturing in-vivo images allows for size or distance estimations for objects within the images. According to one embodiment of the present invention there may be provided, in an in-vivo device at least an imager, an illumination source to provide illumination for the imager, an energy source to emit for example a light beam or a laser beam in a body lumen and a processor to, based on the light beam or laser beam image, estimate, for example the size of objects in a body lumen.

Abstract: An assembly for aligning an optical system over an image sensor is described. The assembly may include a lens structure positioned over an image sensor and a lens holder positioned over the lens structure and secured onto a substrate. The lens structure may incorporate an optical section and a structural section extending from the optical section and may rest directly on an image sensor with one or more stoppers that may serve to elevate the optical system with respect to the image sensor at a distance corresponding to a near optimal focal length distance. A lip also included in the structural section of the lens structure may abut two or more opposing sides to secure the lens structure over the image sensor in a centered position with respect to the image sensor.

Abstract: A system and method for detection of calorimetric abnormalities within a body lumen includes an image receiver for receiving images from within the body lumen. Also included are a transmitter for transmitting the images to a receiver, and a processor for generating a probability indication of presence of colorimetric abnormalities on comparison of color content of the images and at least one reference value.

Abstract: An in-vivo device, system and a method for imaging a body lumen, typically liquid filled body lumen. The in-vivo device may have a specific gravity of about 1 or a volume to weight ratio that enables it to float. The in-vivo device may include an optical system for viewing through a body lumen liquid and another optical system for viewing through a non liquid medium. The in-vivo device may be moved through the body lumen by the liquid movement in that lumen.

Abstract: Devices, systems and methods for displaying in-vivo images at variable rate. For example, a system includes a processor to gradually increase a frame display rate of an in-vivo image stream based on a similarity among two or more in-vivo frames of the in-vivo image stream.

Abstract: A device and method for example operating an in vivo imaging device wherein the illumination is operated at a certain rate or range of rates, and images are transmitted from the device.

Abstract: A wearable antenna assembly includes a posterior antenna assembly and an anterior antenna assembly. The posterior antenna assembly may include a posterior base that includes a lateral portion having a lateral line, and one or two protrusions that continue from the lateral portion and extend away from it, and one or more antenna elements that are formed in the respective protrusion. The protrusions may be configured such that each antenna element lies on the buttocks and is situated adjacent to, or in front of, a greater sciatic notch of the pelvis. The anterior antenna assembly may include an anterior lateral base having a lateral line, and n antenna elements that are formed in the anterior lateral base along the lateral line. The anterior lateral base may be configured such that, when the belt is worn, the n antenna elements are situated adjacent to, or in front of, the abdomen.

Abstract: A system and method for detection of colorimetric abnormalities within a body lumen includes an image receiver for receiving images from within the body lumen. Also included are a transmitter for transmitting the images to a receiver, and a processor for generating a probability indication of presence of colorimetric abnormalities on comparison of color content of the images and at least one reference value.

Abstract: A system and method for comparing captured sequences of in-vivo images with (e.g., template or model) sequences, for example, for computer-automated recognition of contractions. The size of the opening of an in-vivo lumen passageway represented in each frame in a subset of frames of an image stream captured in vivo may be measured. Frames in the subset of frames of the image stream having a local minimum size of the lumen passageway may be identified. The subset of frames may be divided into segments of sequential frames at frames having local maximum lumen sizes before and after the identified frame having a local minimum size of the lumen passageway to generate contraction sequences. A plurality of the contraction sequences may be compared to template sequences. A plurality of the contraction sequences may be displayed.

Abstract: An in-vivo device includes a magnetic steering unit (MSU) to maneuver it by an external electromagnetic field. The MSU may include a permanent magnets assembly to produce a magnetic force for navigating the device. The MSU may include a magnets carrying assembly (MCA) to accommodate the permanent magnet(s). The MCA may be designed to generate eddy currents, in response to AC magnetic field, to apply a repelling force. The in-vivo device may also include a multilayered imaging and sensing printed circuit board (MISP) to capture and transmit images. The MISP may include a sensing coil assembly (SCA) to sense electromagnetic fields to determine a location/orientation/angular position of the in-vivo device. Data representing location/orientation/angular position of the device may be used by a maneuvering system to generate a steering magnetic field to steer the in-vivo device from one location or state to another location or state.

Abstract: Devices, systems and methods for in-vivo cauterization. An autonomous in-vivo device may include a heating mechanism to cauterize in-vivo tissue. A system may include an autonomous in-vivo heating device having a heating mechanism to cauterize in-vivo tissue, and an in-vivo imaging device to acquire in-vivo images.

Abstract: A device, system and method for automatic detection of contractile activity of a body lumen in an image frame is provided, wherein image frames during contractile activity are captured and/or image frames including contractile activity are automatically detected, such as through pattern recognition and/or feature extraction to trace image frames including contractions, e.g., with wrinkle patterns. A manual procedure of annotation of contractions, e.g. tonic contractions in capsule endoscopy, may consist of the visualization of the whole video by a specialist, and the labeling of the contraction frames. Embodiments of the present invention may be suitable for implementation in an in vivo imaging system.

Abstract: An intra-luminal medical device includes a fixation mechanism to attach the medical device to tissue within a body lumen, and a detachment mechanism to permit selective detachment of the medical device from the tissue attachment site without the need for endoscopic or surgical intervention. An electromagnetic device may be provided to mechanically actuate the detachment mechanism. Alternatively, a fuse link may be electrically blown to detach the medical device. As a further alternative, a rapidly degradable bonding agent may be exposed to a degradation agent to detach the medical device from a bonding surface within the body lumen. The medical device may eliminate problems associated with uncertain and inconsistent detachment of intra-luminal medical devices.

Abstract: A system, apparatus and method may indicate in-vivo device location within a body utilizing for example illumination irregularities for calculation of location. There may be provided with an in-vivo imaging device a set of dedicated illumination source and a set of detectors located on an in-vivo device, such as a swallowable capsule.

Abstract: A method and system cascade analysis for intestinal contraction detection is provided by extracting from image frames captured in-vivo. The method and system also relate to the detection of turbid liquids in intestinal tracts, to automatic detection of video image frames taken in the gastrointestinal tract including a field of view obstructed by turbid media, and more particularly to extraction of image data obstructed by turbid media.

Abstract: An in-vivo examining device, system and method for identifying the presence of strictures in the small bowel are provided. The in-vivo examining device includes a monitoring mechanism that becomes deactivated when exposed to in-vivo substances native to the small bowel or the colon, and a degradable device body that includes at least a first body portion which degrades at a slow rate when exposed to in-vivo substances native to the small bowel and at a fast rate when exposed to in-vivo substances native to the colon. The degradation of the degradable device body exposes the monitoring mechanism to substances native to the small bowel or the colon and thus indicates whether the examining device has safely passed through the small bowel or whether it is retained in the small bowel due to strictures in the small bowel.

Abstract: A method of assembling an in-vivo imaging device with a flexible circuit board. The flexible circuit board may include a plurality of flexible installation units connected to one another through flexible connection units. The flexible installation units may be capable of having electrical components disposed thereon at a size suitable for being included in an in-vivo imaging device which may be inserted into a body lumen, e.g., a capsule endoscope.

Abstract: A device for cryotherapy treatment of gastrointestinal lesions includes a cooling member that may be attached to a first tube for pressurizing cryogenic fluid through the tube and into the cooling member through nozzles located at the distal end of the first tube. A second tube may be attached to the cooling member for evacuating the cryogenic fluid from within the cooling member, following the fluid's expansion once it exits the first tube. The cryotherapy device may be attached to an endoscope such that the first tube may be passed through the endoscope's working channel, while the second tube may be passed along the endoscope's circumference. The cryotherapy device may further comprise securing means attached to the first tube, for securing the first tube to the endoscope's working channel, thus preventing free rotation of the cryotherapy device within the endoscope, relative to the rotation of the endoscope.

Abstract: Devices, systems and methods for detecting in vivo pathology are provided. An in vivo sensing device comprises a reacting layer with at least one type of binding agent attached thereon, a sensor configured for sensing an optical change occurring on the reacting substrate, and at least one illumination source. In-vivo fluids are in constant contact with the reacting substrate so that in vivo marker indicating pathology may bind to the binding agent attached onto the reacting layer and may be viewed by the sensor.