Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.

Abstract: Various embodiments are described that relate to a battery. A battery, such as a battery with a common input/output terminal, can be tested. Part of this testing can include charging the battery and discharging the battery. It can be dangerous to switch out an interface between charging and discharging. Therefore, a single interface can be employed that enables the battery to be charged and discarded. With this, the battery can be charged and discharged without the danger of switching the interface.

Abstract: An embodiment of the invention provides a method to measure fluid within a body cavity where data is received with an interface 210, the data being received from an ultrasound transducer. A three-dimensional sonographic image is generated with an image generator 220 connected to the interface 210, the three-dimensional sonographic image being generated from the data received from the ultrasound transducer. The body cavity is identified in the three-dimensional sonographic image with an image processor 230 connected to the image generator 220; and, an area of fluid in the body cavity in the three-dimensional sonographic image is identified with the image processor 230. The volume of the area of fluid is calculated using the three-dimensional sonographic image and a stacked crescents process, a spherical fill process, a convex hull process, and/or a triangulation process.

Abstract: One example is test system for testing the propulsion system(s) of vehicles. The test system includes a retention fixture, a linking device, a test logic, a measurement device and a result logic. The retention fixture is for rigidly mounting first and second vehicles to the retention fixture. The linking device links propulsion systems of the first and second vehicles so that the propulsion systems operate a different rates. The test logic subjects the second vehicle's propulsion system to a propulsion test. The measurement device measures at least one parameter associated with the propulsion system of the first vehicle while the first vehicle is subjected to the propulsion test. The result logic determines if the first vehicle under test passed the propulsion test based, in part, on the at least one parameter and generates an indication if the first vehicle passed or failed the propulsion test.

Abstract: Various embodiments that pertain to signal based arrangement of pin tumbler pins are described. A receiver can receive and process a signal. The signal can indicate an arrangement for the pins of the pin tumblers. With a proper signal, the pins can be placed so that the pin tumbler unlocks. Security measures can be put into place to make sure the signal is a valid signal, such as through employment of a hash function set (e.g., two hash functions).

Abstract: An embodiment of the invention provides an aerosol concentrating apparatus for use with an aerosol aging drum, where the aerosol concentrating apparatus includes an outer housing, an aerosol inlet tube connected to the outer housing, and an extraction tube connected to the outer housing. An axle connected to the outer housing is axially centered within the outer housing, where the axle is formed from porous material. An inner housing is connected to the axle, such that the axle is axially centered within the inner housing, and such that the inner housing is adapted to spin about the axle within the outer housing to separate aerosol particles by size. Aerosol particles below a first threshold size are forced out of the aerosol concentrating apparatus through the axle; and, aerosol particles between the first threshold size and a second threshold size are suspended within the inner housing.

Abstract: The invention described herein provides antibodies to Zika virus. The novel polypeptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Zika virus.

Abstract: An explosive reactive armor (ERA) enclosure for an ERA tile includes a bottom and a plurality of sidewalls extending from the bottom, where the plurality of sidewalls are continuous with each other and with the bottom so as to define an internal volume. The plurality of sidewalls are formed from a fiber-reinforced composite material having a plurality of plies of fiber sheet material. Additionally, a sidewall seam defined by abutting edges of the first ply is offset from a sidewall seam defined by abutting edges of the second ply. Methods of manufacturing ERA enclosures, including applying wrap layers and forming attachment structures for securing the fiber-reinforced composite ERA enclosure to an armor element, are also described. The composite enclosure is inexpensive and lightweight and improves the dynamic capabilities of armored vehicles using such ERA tiles.

Abstract: In this application is described a mutant Acinobacter baumannii strain having a deletion or mutation in its genome. The deletion or mutation interrupts the proper translation of the Hcp protein.

Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.

Abstract: Improved systems and methods for diagnosing an injury of a patient. The system and methods provide for more accurate scans of the injury thereby enabling a combat medic, a medical technician, or even untrained individuals to quickly diagnose the injury. By providing more accurate information, the systems and methods provide the technician with additional information regarding treatment options, such as whether to transport the patient or treat the patient in place, potential for aspiration, and other information about dangerous fluid build-up such as size, depth, and types of surrounding tissues, thereby increasing survivability of the patient. The systems and methods can also provide a diagnosis of the injury as well as suggestions on actions to take to treat the patient.

Abstract: The invention generally relates to a purified inactivated Zika virus (ZIKV), methods for producing the purified inactivated ZIKV, immunogenic compositions and vaccines comprising the purified inactivated ZIKV and methods for the prevention and/or treatment of infection by ZIKV.

Abstract: Various embodiments that pertain to a bridge between networks. There can be a desire for a first communication network to share messages with a second communication network. However, these networks can individually have their own security measures that make direct network-to-network communication difficult if not impossible. Therefore, a bridge can be created that allows for communication between the networks.

Abstract: In at least one embodiment, a system includes an inhalation source; a plenum in fluid communication with the inhalation source; at least one challenge plethysmography mask in fluid communication with the plenum, for each challenge plethysmography mask including a mask having a cavity to receive at least a nose of a test animal, a delivery conduit in fluid communication with the plenum and the cavity of the mask, at least one exhaust conduit in fluid communication with the cavity of the mask and the plenum, and a pressure sensor attached to the mask to measure pressure within the cavity of the mask; at least one processor in electrical communication with the at least one pressure sensor, the processor configured to process an output signal of the pressure sensor into respiratory data for each test animal during an exposure study; and an exhaust system in fluid communication with the plenum.

Abstract: Various embodiments associated with a segmented magnetic core are described. The segmented magnetic core can be made up of multiple singular structures so as to allow an individual singular structure to be removed with ease and without disturbing another magnetic core. This modular core design allows for a significant reduction in motor housing weight due to compatibility of the design with lightweight materials and the potential absence of extensive housing when so designed. This modular core design can be incorporated into a motor or a generator and this modular core design can be accomplished, in one example, by way of stacking and/or interlocking employing low cost assembly. In one example, a motor or a generator uses sensors to detect an operational failure in a magnetic core, notifying a user early of the failure.

Abstract: The disclosure generally provides a WRrNYVAC comprising multiple antigens from different stages of a malaria parasite (Plasmodium) life cycle, methods for producing them, immunogenic vaccine formulations comprising WRrNYVAC, such as P. vivax containing formulations (WRPvrNYVAC) and P. falciparum containing formulations (WRPfrNYVAC) and methods for the prevention and/or treatment of malaria infections and poxvirus infections.

Abstract: A cross-layer security scheme can be used for a Multi-Input Multi-Output (MIMO) antenna-based large-scale multihop mobile ad hoc network (MANET) with a set of frequency-nonselective, slow/Rayleigh fading, and uncoded channels along with interference combining both physical, link, and higher layer encryption techniques for the payload in addition to signaling. Furthermore, MIMO-aware cross-layer secure MANET physical and key-based logical hierarchical routing proving scalability can be used. Security can be provided in Multi-Hop MIMO MANETs in Physical, medium access control (MAC), and internet protocol (IP) Routing layer. The MIMO-aware MANET IP Routing can include two kinds of routing: Physical Routing such as secure ad-hoc on-demand distance vector (SAODV) in the access MANET and Secure Key-based distributed hash table (DHT) “logical” routing in the backbone MANET. Both security and performance metrics can be employed to improve (e.g., optimize) both network secrecy and throughput/bandwidth capacity.

Abstract: One example is an antenna structure with a metamaterial having a flexible metamaterial layer, a two-dimensional antenna layer and a spacer layer. The flexible metamaterial layer has a metamaterial thickness allowing the metamaterial layer to be attached to a curved conducting surface of a vehicle. The metamaterial layer is formed with a two-dimensional array of elements having a passive magnetic property with the array of elements formed with elongated individual elements each having a top end and a bottom end. The elongated individual elements have curved outer surfaces between the top end and the bottom end. The two-dimensional antenna layer receives electromagnetic signals. The spacer layer is located between the metamaterial layer and the antenna layer separating the metamaterial layer and the antenna layer.

Abstract: Disclosed herein are multi-layer structures comprising a first composite layer disposed over a second composite layer, wherein the first composite layer contains a first active material dispersed in a first polymer containing an elastomeric polymer and the second composite layer contains a second polymer which may have a second active material dispersed therein, wherein the first active material chemically or physically interacts with at least one toxic chemical and is selected from the group consisting of metal-organic frameworks (MOFs), metal oxides, metal hydroxides, zeolites, and combinations thereof, and wherein the active material and the second active material (if present) are the same as or different from each other, and the first polymer and second polymer are the same as or different from each other, subject to the proviso that the first composite layer and the second composite layer compositionally differ from each other in at least one respect.

Abstract: A method of estimating a body temperature of an individual based on physiological data including a heart rate received from at least one sensor 510 and received environmental data. The physiological data and the environmental data are inputted into a model present on a processor 520. The model generates an estimated body temperature and an estimated physiological condition based on the inputs. The processor 520 compares the estimated physiological condition to a measured physiological condition in the physiological data. A controller 530 modifies at least one parameter in the model when the difference between the estimated physiological condition and the measured physiological condition is above a threshold.