Abstract: Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.

Abstract: Priority assignment embodiments are discussed. In one embodiment, a system comprises a comparison component configured to make a first comparison of a first message of a message set against a mission with regard to a similarity of the first message to the mission to produce a first message similarity result and make a second comparison of a second message of the message set against the mission with regard to a similarity of the second message to the mission to produce a second message similarity result. The system also comprises a priority component configured to assign a transfer priority order among the first message and the second message through use of the first message similarity result and the second message similarity result, where the transfer priority order is based, at least in part, on the more similar a message is to the mission the higher priority given to the message.

Abstract: A process for preparing a stable LixMn2-yMeyO4-zClz material with a MOb or MMnaOb charge transfer catalyst coating is provided, where Me is Fe, Co, or Ni and M is Bi, As, or Sb. In addition, a LixMn2-yMeyO4-zClz material with a MOb or MMnaOb charge transfer catalyst coating is provided. Furthermore, a lithium or lithium ion rechargeable electrochemical cell is provided, which includes a cathode material (in a positive electrode) containing a LixMn2-yMeyO4-zClz material with a MOb or MMnaOb charge transfer catalyst coating.

Abstract: Linear movement of a heel strike sequence for a shoe insole can be converted into rotational movement. This rotational movement can cause rotation of an interior of a generator. Rotation of this interior of the generator can cause an electricity to be generated and outputted. The generator can be considered a source of damping, so at the start of the heel strike sequence the generator can be non-engaged. After some time, the generator can be engaged and in turn rotate. This can allow for standing inertia to be more quickly overcome.

Abstract: A process for preparing a stable Group VIII Period 4 element (iron, cobalt, or nickel) “B” site and chlorine “O” site modified lithium manganese-based AB2O4 spinel cathode material is provided. The general formula of the “B” and “O” site modified lithium manganese-based AB2O4 spinel is LixMn2-yMyO4-z(Clz) where M is Fe, Co or Ni. In addition, a Group VIII Period 4 element (iron, cobalt, or nickel) “B” site and chlorine “O” site modified lithium manganese-based AB2O4 spinel cathode material is provided. Furthermore, a lithium or lithium ion rechargeable electrochemical cell is provided, incorporating the Group VIII Period 4 element (iron, cobalt, or nickel) “B” site and chlorine “O” site modified lithium manganese-based AB2O4 spinel cathode material in a positive electrode.

Abstract: An apparatus for isolating corneal endothelial cells (CECs) includes a housing with an interior wall that defines a hollow interior of the housing. At least four fluid channels are formed in the housing with two of the channels terminating in respective openings in an upper portion of the interior wall and two of the channels terminating in respective jets in the upper portion of the interior wall. A convex projection is centrally located on the circular base of the hollow interior and is configured to receive an inverted cornea. A circular insert for the housing has an opening therein in which the convex projection projects when the insert is mated with the lower portion of the interior wall. CECs are harvested from the inverted cornea.

Abstract: Various embodiments are described that relate to random number generation. When a desire arises for a random number a circuit can be completed with a reverse biased semiconductor-junction element. When the circuit is completed an analog voltage spike can be produced that is random due to properties of the reverse biased semiconductor-junction element. This analog voltage spike can be converted into a digital value that serves as the random number. The digital value can be outputted and used as the random number.

Abstract: The invention relates to compounds, compositions and methods for activating, reactivating, reversing or preventing the deactivation of cholinesterases, such as acetylcholinesterase and butyrylcholinesterase.

Abstract: Various embodiments associated with an interface that displays a visualization are described. In a combat or other environment, a great deal of information can be made available. In addition, this information can be compared against a metric of performance. This metric of performance could be qualitative or quantitative. In a complex environment, a relatively large amount of information can be gathered and it can be beneficial to produce an interface that enables a user to quickly understand the information with specific emphasis on how an entity related to the information is performing against the metric. The interface can include various features, such as time controls that allows for playback of previous information, measures of performance, and a structured tree view that illustrates hierarchical relationships of elements.

Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.

Abstract: The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

Abstract: The invention contemplates a new synthetic, codon-optimized Sin Nombre virus (SNV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The SNV ORF was cloned into a plasmid to form the first stable recombinant SNV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a vaccine system, and is useful to protect mammals against infection with Sin Nombre virus.

Abstract: An apparatus (8) for isolating corneal endothelial cells (34) (CECs) includes a base portion (10) having an interior recessed opening (14) with a bottom surface (16). A convex projection (18) is centrally located on the bottom surface (16) and is configured to receive an inverted cornea (32). A top portion (12) is configured to mate with the base portion (10). The top portion (12) includes a fluid chamber (24) with a lower surface (20). The lower surface (20) has an opening (22) therein in which the convex projection (18) projects when the top portion (12) is mated with the base portion (10).

Abstract: The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.

Abstract: Priority assignment embodiments are discussed. In one embodiment, a system comprises a comparison component configured to make a first comparison of a first message of a message set against a mission with regard to a similarity of the first message to the mission to produce a first message similarity result and make a second comparison of a second message of the message set against the mission with regard to a similarity of the second message to the mission to produce a second message similarity result. The system also comprises a priority component configured to assign a transfer priority order among the first message and the second message through use of the first message similarity result and the second message similarity result, where the transfer priority order is based, at least in part, on the more similar a message is to the mission the higher priority given to the message.

Abstract: Provided herein is an adjuvant formulation comprising a monophosphoryl lipid A (MPLA)-containing liposome composition to saponin (e.g., QS-21), wherein the liposome composition comprises i) a lipid bilayer comprising phospholipids in which the hydrocarbon chains have a melting temperature in water of ?23° C. and ii) cholesterol at a mole percent concentration of greater than about 50% (mol/mol), preferably about 55% to about 71% (mol/mol), or more preferably about 55% (mol/mol). The adjuvant formulation displays minimal toxicity of either lipid A or saponin.

Abstract: Various embodiments are described that relate to a generalized Bloom filter design methodology. The Bloom filter design methodology can be used for preventing Bloom filter-specific cyber-attacks instead of designing special-purpose Bloom filters that can be applied preventing a specific kind of attack for a given kind of communications networking environment. The resultant security functionalities that can be considered as a package for the generalized secure Bloom filter can include Identifier Modifications, Secure Indexes, Dynamic Salting, Independent Multiple Hash Functions, Random Bit Insertions, Fake Bit Injections, Secure Record Linkage, Single Bloom Filter with all Identifiers, and Encryption. The overall secure generalized Bloom filter algorithms can be devised along with numerous sub-algorithms for these functionalities for making the Bloom-filter-based communications over a network providing robust security, reliability, and availability, preventing known cyber-attacks.

Abstract: Various embodiments associated with an interface that displays a visualization are described. In a combat or other environment, a great deal of information can be made available. In addition, this information can be compared against a metric of performance. This metric of performance could be qualitative or quantitative. In a complex environment, a relatively large amount of information can be gathered and it can be beneficial to produce an interface that enables a user to quickly understand the information with specific emphasis on how an entity related to the information is performing against the metric. The interface can include various features, such as time controls that allows for playback of previous information, measures of performance, and a structured tree view that illustrates hierarchical relationships of elements.

Abstract: The present invention addresses a need for antibodies useful for filovirus infections.

Abstract: Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.