Patents Assigned to IDEXX Laboratories
  • Phospholipid gel compositions for drug delivery and methods of treating conditions using same
    Patent number: 7858115
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: December 28, 2010
    Assignee: IDEXX Laboratories
    Inventor: Yerramilli V. S. N. Murthy
  • Phospholipid gel compositions for drug delivery and methods of treating conditions using same
    Patent number: 7854943
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: December 21, 2010
    Assignee: IDEXX Laboratories
    Inventor: Yerramilli V. S. N. Murthy
  • Phospholipid gel compositions for drug delivery and methods of treating conditions using same
    Patent number: 7846472
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: December 7, 2010
    Assignee: IDEXX Laboratories
    Inventor: Yerramilli V. S. N. Murthy
  • DIVA (differentiate infected from vaccinated animals)
    Patent number: 7842473
    Abstract: Ehrlichia canis antigens that can be used to differentiate E. canis infected animals from animals that have been challenged with E. canis, e.g., vaccinated against E. canis, are disclosed. The invention also provides compositions and methods for determining the presence of E. canis antigens and antibodies.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: November 30, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Eugene Regis Krah, III, Melissa Beall
  • DIVA (differentiate infected from vaccinated animals)
    Patent number: 7842474
    Abstract: Ehrlichia canis antigens that can be used to differentiate E. canis infected animals from animals that have been challenged with E. canis, e.g., vaccinated against E. canis, are disclosed. The invention also provides compositions and methods for determining the presence of E. canis antigens and antibodies.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 30, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Eugene Regis Krah, III, Thomas Patrick O'Connor, Jr., Melissa Beall
  • Feline Pancreatic Lipase
    Publication number: 20100267131
    Abstract: Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of monoclonal antibodies that specifically binds to the feline pancreatic lipase polypeptides, and cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of feline pancreatic lipase in a biological sample. The methods include using standards or calibrators of recombinant feline pancreatic lipase to quantify the lipase in a sample. Devices and kits for performing methods for detecting feline pancreatic lipase in biological samples.
    Type: Application
    Filed: June 10, 2010
    Publication date: October 21, 2010
    Applicant: IDEXX LABORATORIES, INC.
    Inventors: Philip Andersen, Melissa Jane Beall, Jesse Buch, Ku-chuan Hsiao, Stacey Pazar Huth, Eugene Regis Krash, III, Barbara O'Brien, Marilyn Strong-Townsend
  • Method for calibrating clinical chemistry instruments
    Publication number: 20100268504
    Abstract: A method of deriving correction for instrument-to-instrument variations in the illumination band centroid wavelengths and wavelength band shapes of the optical systems of clinical chemistry instruments includes the steps of determining the centroid wavelength and wavelength band shape of a light source used in the optical system of a clinical chemistry instrument to provide a determined wavelength band shape and centroid wavelength, comparing the determined wavelength band shape and centroid wavelength with a known reflection density or absorbance wavelength spectrum of a specific type of chemical reagent test to provide a correction value, and calculating the correction value, which is to be used to modify a reflection density or absorbance measurement taken by the instrument of a reagent test of the a specific type of chemical reagent test.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 21, 2010
    Applicant: IDEXX Laboratories, Inc.
    Inventor: Garland Christian Misener
  • Lateral flow device with onboard reagents
    Patent number: 7816122
    Abstract: Devices, methods and kits for conducting an assay to determine the presence or amount of an analyte in a fluid sample. The device includes a sample application element and a flow path matrix that facilitates fluidic flow by capillary action. The sample application element includes a non-absorbent or absorbent carrier that has a conjugate reagent that is readily solubilized by the liquid sample. In various aspects of the invention, the sample application element and the matrix are associated with a housing that allows for releasable contact between the element and the matrix. In other aspects, the invention includes methods using the device and kits including the device.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: October 19, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Scott Marshall Clark, Keith Alan Nassif
  • CHEMICAL ANALYZER
    Publication number: 20100254854
    Abstract: A chemical analyzer includes a slide transport mechanism having a slide track adapted to hold a plurality of reagent test slides, a sample metering device, an incubator formed as a part of the slide transport mechanism to precisely maintain the temperature of the reagent test slides, a slide ejector mechanism to remove the slides from the slide transport mechanism, a sample preparation station, which includes a centrifuge, and associated electronics and software. The slide transport mechanism holds a plurality of trapezoidally-shaped reagent test slides about its circumference, which slides are loaded onto the transport mechanism by the slide inserter mechanism. The slide transport mechanism positions the reagent test slides under the sample metering device, which device deposits a predetermined volume of sample onto each slide. The slide transport mechanism also carries the slides above a reflectometer.
    Type: Application
    Filed: May 7, 2008
    Publication date: October 7, 2010
    Applicant: IDEXX Laboratories, Inc.
    Inventors: Carl Russell Rich, Garland Christian Misener, Mark R. Dumont, Justin Jay Griffin, Jonathan William Lawrence, Mark Christopher Garrepy, Stephan Hersey, Stanislaw Barski, Mark Weston Pierson, Alyssa J. Dassa, Michael Thomas Bush, Mark Wayne Lemieux, Mary Kathleen Fent
  • ROUNDWORM COPROANTIGEN DETECTION
    Publication number: 20100248217
    Abstract: A composition, device, kit and method for detecting the presence or absence of roundworm in a fecal sample. The composition, device, kit and method of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm.
    Type: Application
    Filed: June 11, 2010
    Publication date: September 30, 2010
    Applicant: IDEXX LABORATORIES, INC.
    Inventors: David Allen Elsemore, Laurie A. Flynn
  • PHARMACEUTICAL COMPOSITIONS FOR THE ADMINISTRATION OF APTAMERS
    Publication number: 20100240741
    Abstract: Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a sphingomyelin. Methods of treating or preventing a condition in an animal comprising administering to the animal the pharmaceutical compositions.
    Type: Application
    Filed: May 28, 2010
    Publication date: September 23, 2010
    Applicant: IDEXX Laboratories, Inc.
    Inventor: Yerramilli V.S.N. Murthy
  • Tissue sampling device and method
    Patent number: 7794410
    Abstract: A device for obtaining a sample from inside a body includes a tubular body portion defining a chamber for receiving a sample of material therein; a plunger assembly operatively associated with the tubular body portion, the plunger assembly having a stopper slidably disposed within the chamber of the body portion; feedback elements provided on the tubular body and/or the plunger assembly for providing a user with audible and/or tactile indications regarding an amount of displacement of the plunger assembly relative to the body portion; and a cutting element is provided to facilitate sample removal.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: September 14, 2010
    Assignee: Idexx Laboratories, Inc.
    Inventors: Thomas Luke Mikulka, Nevena Novkovic Djuranovic, Stanislaw Barski, Jr., Tracy Lynn Hessel Libby
  • Pipette tip
    Patent number: 7794664
    Abstract: A pipette tip includes a main body having an upper end, a lower end and a sidewall extending between the two ends. A bore extends axially through the main body between the upper and lower ends. The lower end has a bottom surface in which is formed a central opening that communicates with the axial bore to allow the passage of fluid therethrough. The bottom surface is formed with at least one groove that may be concentrically disposed or spirally disposed about the central opening. The at least one groove acts to inhibit fluid passing through the central opening from at least partially flowing along the outer surface of the sidewall from the central opening toward the upper end of the main body of the pipette tip.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: September 14, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Dominic Pelletier, Jeffrey Phelps, Jason Aguiar, Jeremy Hammond, William J. Traigle, Chandler G. Sinnett
  • Compositions containing prodrugs of florfenicol and methods of use
    Patent number: 7786167
    Abstract: The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: August 31, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V. S. N. Murthy, Robert H. Suva
  • Apparatus and method for testing liquid samples
    Patent number: 7781185
    Abstract: An article for holding a liquefied sample for the quantification of biological material in the sample includes a device having a reaction chamber enclosing a volume therein, the reaction chamber having an upper opening through which a liquefied sample can be poured and a plurality of discrete non-permeable compartments, each of the compartments having an upper rim and being configured and dimensioned to hold separate aliquots of a liquefied sample therein; and a gasket lid removably secured to the top of the device, the gasket lid being configured and dimensioned for sealing the upper rim of each compartment to prevent liquid communication between the compartments.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: August 24, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Ross Bryan Goldman, David Edward Townsend, Kenneth E. Smith, Kathleen R. McCarthy
  • Detection of analytes in fecal samples
    Patent number: 7781170
    Abstract: A method for detecting a parasitic worm infection of the digestive tract of a mammal. The method includes detecting the binding of a worm antibody to a worm antigen present in the soluble portion of a fecal sample of infected mammals.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: August 24, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Quentin Tonelli, Michael Monn, Randall Groat
  • Method and device for detecting feline immunodeficiency virus
    Patent number: 7776546
    Abstract: A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the polypeptides. The determination of whether an animal is infected with FIV or has been vaccinated against FIV can be determined by measuring the animal's immune response to an FIV env polypeptide. A device for detecting FIV antibodies is provided.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: August 17, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Randall G. Groat, Quentin J. Tonelli
  • Pharmaceutical Compositions for Administering Oligonucleotides
    Publication number: 20100204303
    Abstract: The invention relates to pharmaceutical compositions useful for administering an oligonucleotide to an animal in need thereof. The pharmaceutical compositions include nano-particles or micro-particles of (i) a protonated oligonucleotide and (ii) a pharmaceutically acceptable organic base or include nano-particles or micro-particles of (i) an oligonucleotide and (ii) a divalent metal ion.
    Type: Application
    Filed: September 24, 2008
    Publication date: August 12, 2010
    Applicant: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V.S.N. Murthy, Michael Atkinson
  • Methods to determine the presence or amount of canine pancreatic lipase with antibodies
    Patent number: 7771959
    Abstract: Isolated nucleic acid molecules having a nucleotide sequence encoding canine pancreatic lipase polypeptides, allelic variants and fragments thereof. Vectors and host cells containing the polynucleotide sequences and methods for expressing the polypeptides. Monoclonal antibodies that specifically binds to the canine pancreatic lipase polypeptides. Cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of canine pancreatic lipase in a biological sample. The methods include using the monoclonal antibodies to specifically bind to canine pancreatic lipase polypeptides. The method includes using standards of recombinant canine pancreatic lipase. Devices and kits for performing methods for detecting canine pancreatic lipase in biological samples.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: August 10, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Melissa Beall, Stacey Pazar Huth, Eugene Regis Krah
  • Feline pancreatic lipase
    Patent number: 7771960
    Abstract: Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of monoclonal antibodies that specifically binds to the feline pancreatic lipase polypeptides, and cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of feline pancreatic lipase in a biological sample. The methods include using standards or calibrators of recombinant feline pancreatic lipase to quantify the lipase in a sample. Devices and kits for performing methods for detecting feline pancreatic lipase in biological samples.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: August 10, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Philip Andersen, Melissa Jane Beall, Jesse Buch, Ku-chuan Hsiao, Stacey Pazar Huth, Eugene Regis, Barbara O'Brien, Marilyn Strong-Townsend