Patents Assigned to Indena S.p.A.
  • Antitumoral agents with a benzophenanthridine structure and formulations containing them
    Patent number: 8337903
    Abstract: The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed.
    Type: Grant
    Filed: February 16, 2009
    Date of Patent: December 25, 2012
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Paolo Morazzoni, Antonella Riva
  • COMPOSITIONS COMPRISING ANDROGRAPHIS PANICULATA EXTRACTS COMBINED WITH GINKGO BILOBA EXTRACTS COMPLEXED WITH PHOSPHOLIPIDS, AND THEIR USE
    Publication number: 20120301560
    Abstract: The present invention relates to compositions comprising Andrographis paniculata extracts combined with Ginkgo biloba extracts complexed with phospholipids. Moreover, the compositions administered in oils rich in ?-3 polyunsaturated fatty acids demonstrate a further synergic effect between the ingredients. Said compositions are useful in the treatment of neurodegenerative disorders, in particular Alzheimer's disease and multiple sclerosis.
    Type: Application
    Filed: January 3, 2011
    Publication date: November 29, 2012
    Applicant: INDENA S.P.A
    Inventors: Ezio Bombardelli, Andrea Giori
  • Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel
    Patent number: 8318957
    Abstract: A process for the preparation of 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) said process comprising: reacting 10-deacetylbaccatin III with a trichloroacetic acid activated derivative to obtain a reaction mixture, and performing an isolation step on said reaction mixture obtain purified 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) having a content, of corresponding 7- or 10 mono-trichloroacetyl derivatives lower than 0.1% as determined by HPLC.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: November 27, 2012
    Assignee: Indena S.p.A.
    Inventors: Bruno Gabetta, Andrea Gambini, Ezio Bombardelli, Gabriele Fontana
  • p185-encoding DNA and therapeutical uses thereof
    Patent number: 8298821
    Abstract: Plasmids containing sequences encoding different fragments of p185neu oncoprotein, able to induce an immune response against tumours expressing oncogenes of the ErbB family, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: October 30, 2012
    Assignee: Indena S.p.A.
    Inventors: Augusto Amici, Federica Cavallo, Guido Forni, Cristina Marchini
  • FORMULATIONS WITH SANGUINARINE, CHELERYTHRINE OR CHELIDONINE FOR THE TREATMENT OF WARTS, VERRUCAS AND PSORIATIC PLAQUES
    Publication number: 20120263810
    Abstract: The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.
    Type: Application
    Filed: June 22, 2012
    Publication date: October 18, 2012
    Applicant: INDENA S.P.A
    Inventors: Ezio Bombardelli, Gabriele Fontana, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • Combinations of vasoactive agents and their use in the treatment of sexual dysfunctions
    Patent number: 8287926
    Abstract: Combinations of vasoactive substances which are useful in the treatment of sexual dysfunctions associated with poor local blood supply and/or insufficient lubrication are provided. The vasoactive compounds are esculoside, visnadine, forskolin or extracts thereof, purified lipophilic extracts from plants of the genus Ipomea, esters of ximenynic acid, icarin or icarin derivatives, amentoflavone, and Gingko biloba dimeric flavones. The combination of these vasoactive substances is incorporated in gels and lotions designed to be applied to the genital organs. These formulations are useful in inducing erection of the male and female sex organs and enhancing orgasm and sexual performance. The formulations are particularly useful in the treatment of female sexual dysfunctions.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: October 16, 2012
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • Process for the extraction, purification and enzymatic modification of soy 7S globulin alpha' subunit for use as hypocholesterolemizing agent
    Patent number: 8257758
    Abstract: A purified amino-terminal polypeptide fragment of the soy ?-conglycinin ?? subunit is prepared by selective extraction of defatted soy with an aqueous solution of sodium bisulfite, precipitation with ethanol, and Metal Affinity Chromatography (MAC) under denaturing conditions to obtain the ?? subunit. The ?? subunit is then enzymatically treated with chymotrypsin and subjected to further MAC to recover the amino-terminal fragment of the polypeptide (MW 28,000 Da).
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: September 4, 2012
    Assignee: Indena S.p.A.
    Inventors: Marcello Duranti, Paolo Morazzoni
  • Process for cosmetic treatment using ferutinine from genus plants
    Patent number: 8247005
    Abstract: The invention relates to a process for cosmetic treatment, including the reduction of superficial and deep wrinkles, using ferutinine from Ferula spp extracts.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: August 21, 2012
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombarrdelli, Gabriele Fontana, Aldo Cristoni, Enrico Mercalli
  • Formulations with sanguinarine, chelerythrine or chelidonine for the treatment of warts, verrucas and psoriatic plaques
    Patent number: 8226994
    Abstract: The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: July 24, 2012
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • Stable and bioavailable compositions of isomers of carotenoids for skin and hair
    Patent number: 8216619
    Abstract: The present invention relates to a method of manufacturing a stable composition enriched in cis-lycopene (z-isomers) by prolonged heating in solvents of tomatoes, parts of tomatoes, derivative thereof or tomato extracts in solvents.
    Type: Grant
    Filed: August 8, 2006
    Date of Patent: July 10, 2012
    Assignee: Indena S.p.A.
    Inventors: Andrea Giori, Federico Franceschi
  • Camptothecin derivatives with antitumor activity
    Patent number: 8217053
    Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: July 10, 2012
    Assignee: Indena S.p.A.
    Inventors: Gabriele Fontana, Ezio Bombardelli, Carla Manzotti, Arturo Battaglia, Maria Grazia Allegri, legal representative, Cristian Samori′
  • CLONING, YEAST EXPRESSION, PURIFICATION AND BIOLOGICAL ACTIVITY OF THE EXTENSION REGION OF THE SOYBEAN 7S GLOBULIN ALFA' SUBUNIT INVOLVED IN HEP G2 CELL CHOLESTEROL HOMEOSTASIS
    Publication number: 20120172316
    Abstract: A truncated form of ?? chain (e??), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha? subunit. The e?? polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.
    Type: Application
    Filed: June 16, 2010
    Publication date: July 5, 2012
    Applicant: INDENA S.P.A.
    Inventors: Paolo Morazzoni, Antonella Riva, Cesare Ponzone, Davide Berlanda, Marcello Duranti, Alessandro Consonni
  • Combinations of vasoactive substances with estrogens and their use in the treatment of female sexual dysfunctions
    Patent number: 8211479
    Abstract: Compositions comprising: vasokinetic natural coumarins or extracts containing them; anti-phosphodiesterase agents selected from 3,7-O-di-(2-hydroxyethyl)icaritin or 7-O-hydroxyethyl-icariside II and/or forskolin or extracts containing them; phytoestrogens selected from ferutinine or ferutinine-containing extracts of Ferula sp. or p-pivaloylferutinine.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: July 3, 2012
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • Method of reducing blood cholesterol and triglyceride levels using combinations of vasoprotective agent
    Patent number: 8206759
    Abstract: Combinations of vasoprotective agents useful for the treatment of reducing blood cholesterol and triglyceride levels induced by an excess of plasma lipids. The agents include polycosanols, tocotriends and/or lycopene, procyanidole oligomers and vegetable oil rich in insaturated fatty acids.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: June 26, 2012
    Assignee: Indena S.p. A.
    Inventor: Ezio Bombardelli
  • Camptothecin derivatives with antitumor activity
    Patent number: 8193210
    Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: June 5, 2012
    Assignee: Indena S.p.A.
    Inventors: Gabriele Fontana, Ezio Bombardelli, Carla Manzotti, Arturo Battaglia, Maria Grazia Allegri, legal representative, Cristian Samori
  • PLANT EXTRACTS FOR USE AS PHYTOCHEMICALS
    Publication number: 20120121742
    Abstract: The invention concerns the use of grape (Vitis vinifera) seeds extracts as agents for the treatment and prevention of plant diseases caused by pathogens, particularly by fungi and oomycetes, as well as fungicidal compositions comprising Vitis vinifera extracts for application to plants affected or liable to be affected by a pathogen, especially a fungus or oomycete.
    Type: Application
    Filed: November 3, 2009
    Publication date: May 17, 2012
    Applicant: INDENA S.P.A.
    Inventor: Francois Mairel
  • PROCESS FOR REMOVING PESTICIDES FROM GINKGO BILOBA EXTRACTS, AND EXTRACTS OBTAINABLE BY SAID PROCESS
    Publication number: 20120100232
    Abstract: Process for removing pesticides from Ginkgo biloba extracts, which involves submitting an extract obtained by conventional methods to the following steps: a. Liquid-liquid extraction of the extract to obtain a medium polarity fraction containing ginkgo terpenes and pesticides not removable with hexane, and a high polarity fraction containing ginkgo flavone glycosides; b. crystallisation from the medium polarity fraction obtained at step a) to give an intermediate with a ginkgolide content of not less than 50%; c. crystallisation from the residual solution obtained at step b) to give an intermediate with a bilobalide content of not less than 50%; d. mixing of the high polarity fraction obtained at step a) with the ginkgo terpene intermediate and the bilobalide intermediate obtained at steps b) and c).
    Type: Application
    Filed: March 31, 2010
    Publication date: April 26, 2012
    Applicant: INDENA S.P.A.
    Inventors: Andrea Giori, Giacomo Mombelli, Sabrina Arpini, Mario Acerbi
  • PROCESS FOR COSMETIC TREATMENT USING FERUTININE FROM FERULA GENUS PLANTS
    Publication number: 20120095094
    Abstract: The invention relates to a process for cosmetic treatment, including the reduction of superficial and deep wrinkles, using ferutinine from Ferula spp extracts.
    Type: Application
    Filed: December 13, 2011
    Publication date: April 19, 2012
    Applicant: INDENA S.P.A.
    Inventors: Ezio BOMBARDELLI, Gabriele Fontana, Aldo Cristoni, Enrico Mercalli
  • COMPOSITIONS COMPRISING LIPOPHILIC EXTRACTS OF ZINGIBER OFFICINALE AND ECHINACEA ANGUSTIFOLIA FOR THE PREVENTION AND TREATMENT OF GASTRO-OESOPHAGEAL REFLUX AND CHEMOTHERAPY-INDUCED EMESIS
    Publication number: 20120040031
    Abstract: The present invention relates to compositions consisting of a combination of lipophilic extracts of Zingiber officinale and Echinacea angustifolia, obtained by extraction with carbon dioxide under supercritical conditions, which are useful for the prevention and treatment of oesophageal reflux and chemotherapy-induced emesis.
    Type: Application
    Filed: January 15, 2010
    Publication date: February 16, 2012
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • Hyperforin derivatives, the use thereof and formulations containing them
    Patent number: RE43280
    Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: March 27, 2012
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati