Patents Assigned to Institute of Technology
  • Publication number: 20240273308
    Abstract: Systems, methods, and other embodiments described herein relate to enhancing and complementing a creative process of a user that includes generating and iterating visual content with an emphasis on diverse design ideas. In one embodiment, a method includes generating a plurality of texts that are related and semantically diverse based on one or more prompts using a generative language model and generating a plurality of images based on at least a portion of the plurality of texts using a generative visual model.
    Type: Application
    Filed: October 31, 2023
    Publication date: August 15, 2024
    Applicants: Toyota Research Institute, Inc., Toyota Jidosha Kabushiki Kaisha, Massachusetts Institute of Technology
    Inventors: Alice X. Cai, Thomas W. Malone, Yanxia Zhang, Alexandre Filipowicz, Matthew K. Hong, Steven R. Rick, Heishiro Toyoda
  • Publication number: 20240270898
    Abstract: The present disclosure provides copolymers prepared by polymerizing a first monomer comprising at least one C?C and/or at least one C?C; and a second monomer of Formula (B): wherein at least one first monomer and/or at least one second monomer comprises a latent-fluoride moiety (e.g., pentafluorophenyl). Upon contacting the copolymers with a nucleophile (e.g., a thiol) and/or a base, the latent-fluoride moiety may release fluoride ions, which may in turn degrade the copolymers by cleaving the O—Si bonds. The copolymers may be useful for drug delivery, or as degradable (e.g., biodegradable) polymers, adhesives, coatings, or structural materials.
    Type: Application
    Filed: June 1, 2022
    Publication date: August 15, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Peyton Shieh, Christopher M. Brown
  • Patent number: 12063720
    Abstract: The present disclosure is directed to processes for forming or otherwise creating a transparent, conductive film from a heavy hydrocarbon material. It allows for what is often considered to be waste material to be transformed into a useful product, such as a heating element. Such heating elements can be incorporated into many contexts where it can be important to have transparency and/or a thin heating element, such as in windshields. The process involves dissolving a heavy hydrocarbon material in a solvent, casting the heavy hydrocarbon solution that results from the dissolving onto a substrate to form a film, and then annealing the film. The disclosure also provides for objects in which such resulting films can be used, such as Joule heaters.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: August 13, 2024
    Assignees: Massachusetts Institute of Technology, ExxonMobil Technology and Engineering Company
    Inventors: Jeffrey Grossman, Brent Keller, Owen Morris, Mark Disko, Heather Elsen, Xining Zang, Nicola Ferralis, Ximena Hasbach
  • Patent number: 12061199
    Abstract: A method for diagnosing cancer in an expanded biological tissue sample of a patient comprising providing at least one sample image of the expanded biological tissue sample; providing a computer configured to analyze the sample; analyzing, with the computer, the sample detect and segment nuclei; calculating, with the computer, molecular characteristics of those nuclei; and determining, with the computer, a diagnosis of cancer of the sample by comparing the sample with a benign normal tissue reference.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: August 13, 2024
    Assignees: Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center, Inc
    Inventors: Edward Stuart Boyden, Andrew Hanno Beck, Yongxin Zhao, Octavian Bucur, Humayun Irshad
  • Patent number: 12060412
    Abstract: Transcriptomes of individual neurons provide rich information about cell types and dynamic states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, because isolation from dense adult tissue is challenging, and markers for each phase are limited. Here, Applicants developed Nuc-seq, Div-Seq, and Dronc-Seq. Div-seq combines Nuc-Seq, a scalable single nucleus RNA-Seq method, with EdU-mediated labeling of proliferating cells. Nuc-Seq can sensitively identify closely related cell types within the adult hippocampus. Div-Seq can track transcriptional dynamics of newborn neurons in an adult neurogenic region in the hippocampus. Dronc-Seq uses a microfluidic device to co-encapsulate individual nuclei in reverse emulsion aqueous droplets in an oil medium together with one uniquely barcoded mRNA-capture bead. Finally, Applicants found rare adult newborn GABAergic neurons in the spinal cord, a non-canonical neurogenic region.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: August 13, 2024
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, MA
    Inventors: Aviv Regev, Feng Zhang, Naomi Habib, Yinqing Li, Matthias Heidenreich, Lukasz Swiech, Anindita Basu, David Weitz, Inbal Avraham Davidi
  • Patent number: 12059562
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one 5 or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In certain embodiments, the self-righting article a tissue 10 interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: August 13, 2024
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, David Dellal
  • Patent number: 12062879
    Abstract: Described is a partitioned cable joint comprising a plurality of physically distributed joint elements with the plurality of joint elements taken together defining a joint length. Joint elements may have a first mounting region having a shape selected to accept one petal of superconducting cable and a second mounting region having a shape selected to accept one petal of a second conductor.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: August 13, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Christopher Craighill, Alexey Radovinsky, Rui Vieira, Vincent Fry, Colin O'Shea, Sera Evcimen
  • Patent number: 12061188
    Abstract: Compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.
    Type: Grant
    Filed: August 30, 2023
    Date of Patent: August 13, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael Birnbaum, Connor Dobson
  • Patent number: 12061194
    Abstract: Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: August 13, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy Manning Swager, Hadley Sikes Johnson, Qifan Zhang, Eric Alexander Miller, Lukas Zeininger, Ki-Joo Sung, Kosuke Yoshinaga
  • Patent number: 12059728
    Abstract: A deformation-driven solid-phase extrusion device and a one-step alloy bar preparation method by using the same are provided. The device includes a stir tool, an extrusion container and an ejector rod. The stir tool has an integral structure composed of an upper mounting part and a lower working part and having a hollow channel. The lower working part is disposed in a groove of the extrusion container, and the ejector rod is disposed in the hollow channel of the stir tool. The method includes adding alloy powder to the extrusion container, enabling the stir tool to exert a pressure and revolve at a high speed to cause large plastic deformation of the powder and generate heat by friction and deform among powder and the friction working surface of the working part, sintering the alloy powder and extruding the same through the hollow channel of the stir tool.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: August 13, 2024
    Assignee: Harbin Institute of Technology
    Inventors: Yongxian Huang, Yuming Xie, Xiangchen Meng, Feifan Wang, Junchen Li, Long Wan
  • Patent number: 12059250
    Abstract: Systems and methods for a self-powered wireless wearable sensor system include a freestanding triboelectric nanogenerator (FTENG), used as a power source for a wearable sensor. The FTENG includes stator panels and corresponding slider panels with a grating pattern. Movement, such as cardiovascular exercise causes the slider panel(s) to slide across the stator panel(s) inducing a charge and powering a wearable device sufficiently to support data transmission and continuous monitoring. An integrated self-powered wireless wearable sensor system includes a microfluidic sweat sensor patch which may be connected to lower-power wireless sensor circuitry for regulating power efficiently and is powered by the FTENG.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: August 13, 2024
    Assignee: California Institute of Technology
    Inventors: Wei Gao, Yu Song
  • Patent number: 12061187
    Abstract: Compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: August 13, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael Birnbaum, Connor Dobson
  • Patent number: 12061186
    Abstract: Provided herein are compositions and methods of use relating to a novel class of dendritic cells, referred to herein as ISG+ DC, having anti-tumor activity.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: August 13, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Stefani Spranger, Ellen Duong
  • Patent number: 12059230
    Abstract: A system and method of enhancing fluorescence assays can include signal modulation using an an excitation beam directed at a sensor having a modulation frequency and a detector configured to monitor emission from the sensor at a multiple of the modulation frequency.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: August 13, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael Strano, Volodymyr Koman, Naveed Bakh
  • Publication number: 20240264163
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Application
    Filed: January 17, 2024
    Publication date: August 8, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward BOYDEN, Adam Henry MARBLESTONE, Samuel Gordon RODRIQUES
  • Publication number: 20240264321
    Abstract: A computer-implemented method and system provide the ability to detect an earthquake. Distributed acoustic sensing (DAS) data is obtained. A deep neural network model that picks seismic phase arrival times on the DAS data is acquired. A semi-supervised learning approach is utilized to train the deep neural network model. The semi-supervised learning approach utilizes existing labels from a defined seismic dataset to generate pseudo labels on the DAS data. An earthquake is detected by applying the trained deep neural network model to new DAS data.
    Type: Application
    Filed: February 7, 2024
    Publication date: August 8, 2024
    Applicant: California Institute of Technology
    Inventors: Weiqiang Zhu, Zhongwen Zhan, Zachary E. Ross
  • Publication number: 20240267091
    Abstract: A wireless communication device includes an antenna section configured to be provided with a plurality of antenna units that transmit and receive n communication signals having different directivities, a multiplexer configured to be connected to the antenna section, and n signal transmitting and receiving units configured to be connected to the multiplexer, to generate transmission signals, to demodulate reception signals, and to be provided corresponding to the n communication signals. The multiplexer switches connections between the antenna section and the n signal transmitting and receiving units in a time-division manner in a sampling period shorter than a period of a symbol of each of n reception signals to sequentially sample the n reception signals for each of the directivities at a time of reception. The antenna section sequentially receives divided reception signals obtained by dividing the reception signal corresponding to the directivity in the sampling period.
    Type: Application
    Filed: June 8, 2022
    Publication date: August 8, 2024
    Applicant: Tokyo Institute of Technology
    Inventor: Kenichi Okada
  • Publication number: 20240262538
    Abstract: Femto-satellites are very small satellites that can be deployed in constellations from a larger mothership satellite for distributed measurement. They are too small to accommodate the GNSS receivers that many satellites use for navigation, but they can be located with an electromagnetic beam from the mothership satellite. The mothership satellite scans this beam across a constellation of femto-satellites. When the beam scans across a particular femto-satellite, the femto-satellite transmits an acknowledgement to the mothership satellite, e.g., by retroreflecting the beam or via a separate radio link. The beam can be modulated with commands for the femto-satellite, such as to make a measurement or transmit previously acquired data, as well with commands for determining the femto-satellite's location, such as a time stamp or beam pointing information.
    Type: Application
    Filed: May 3, 2022
    Publication date: August 8, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Kerri Cahoy, Christian Haughwout, Paul Serra, Ruonan HAN, Anantha CHANDRAKASAN
  • Publication number: 20240264154
    Abstract: The invention provides ultrasensitive methods for detection and quantification of target analytes in samples. The methods can be multiplexed to allow simultaneous detection and quantification of multiple target analytes. The methods can achieve an attomolar limit of detection. The invention also provides related compositions and kits.
    Type: Application
    Filed: March 27, 2024
    Publication date: August 8, 2024
    Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
    Inventors: David R. Walt, Connie Wu, Richard Novak, Tyler Dougan, Rushdy Ahmad
  • Patent number: 12055493
    Abstract: A sensor can include a nanostructure in a housing configured to contact a sample.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: August 6, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael Strano, Daichi Kozawa, Xun Gong, Daniel Salem, Sooyeon Cho, Freddy T. Nguyen