Patents Assigned to Institute of Technology
  • Patent number: 12040836
    Abstract: Methods and devices implementing a combination of multi-dimensional pulse position modulation (PPM) with wavelength division multiplexing (WDM) or wavelength division multiplexing multiple access (WDMA) for long range space communications are disclosed. The described multi-dimensional PPM scheme can use the laser wavelength and/or polarization as the additional dimension(s) to the time dimension. Through examples it is shown that the disclosed teachings result in a higher photon information efficiency. Various exemplary embodiments are also presented to highlight the applications benefiting from the disclosed methods and devices.
    Type: Grant
    Filed: May 26, 2023
    Date of Patent: July 16, 2024
    Assignee: California Institute of Technology
    Inventors: Dariush Divsalar, William H Farr, Makan Mohageg, Samuel J Dolinar, Matthew D Thill
  • Patent number: 12036240
    Abstract: This invention relates generally to compositions and methods for modulating complement component 3 (C3) activity or expression to treat, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: July 16, 2024
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Aviv Regev, Ana Carrizosa Anderson, Ayshwarya Subramanian, Orit Rozenblatt-Rosen
  • Patent number: 12036324
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: July 16, 2024
    Assignees: Massachusetts Institute of Technology, Novo Nordisk A/S, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer, Jorrit Jeroen Water, Morten Revsgaard Frederiksen, Bo Uldall Kristiansen, Mikkel Oliver Jespersen, Mette Poulsen, Peter Herskind, Brian Jensen
  • Patent number: 12037639
    Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: July 16, 2024
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Omar Abudayyeh, James Joseph Collins, Jonathan Gootenberg, Feng Zhang, Eric S. Lander
  • Patent number: 12038746
    Abstract: A flying surface may comprise a plurality of interconnectable flying vehicles configured for mid-flight reconfiguration of the flying surface. Each flying vehicle may be entirely self-sufficient, including an onboard thrust unit, an onboard controller, an onboard power unit, and connectors configured to engage corresponding connectors of other flying vehicles to form a flying surface. The flying vehicles may additionally be configured for self-control, thereby enabling a distributed control model for a flying surface that does not require significant, centralized processing power and corresponding power storage. The flying surfaces may dynamically reconfigure mid-flight by attaching or detaching flying vehicles so as to enable a wide variety of in-flight maneuvers.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: July 16, 2024
    Assignee: California Institute of Technology
    Inventor: Seyed Ali Hajimiri
  • Patent number: 12038600
    Abstract: Disclosed herein is a pulse repetition rate multiplier including a photonic integrated circuit (PIC) including cascading Mach-Zehnder interferometers (MZIs). An input may be connected to one end of the PIC and an output may be connected to the other end of the PIC such that a signal from the input runs through the cascading MZIs and out the output. The input may be configured to receive an input pulsed signal and the output may be configured to output a repetition rate multiplied signal. Advantageously, using a PIC as opposed to an optical fiber-based pulse rate multiplier allows for accurate fabrication of a pulse repetition rate multiplier configured to accept higher frequency pulsed signals.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: July 16, 2024
    Assignee: California Institute of Technology
    Inventors: Stephanie D. Leifer, Wei Zhang, Andrey B. Matsko
  • Patent number: 12037650
    Abstract: A method and system are disclosed for detecting microbial pathogens in a sample suspected of containing the pathogens. The method includes combining loop-mediated isothermal amplification (LAMP) reagents and a polymer gel, such as a hydrogel, together with the sample to form a mixture. The gel polymerizes over a short time to immobilize the viral particles within the mixture. If target DNA/RNA are present in the sample, amplicons are produced. The target microorganisms are detected by visually detecting the presence or absence of the amplicons. The target microorganism concentrations may be determined based on the number of fluorescent amplicon dots after the reaction using a smartphone or a fluorescent microscope. The method may be employed for rapidly and inexpensively quantifying microbial pathogens in environmental water samples with high sensitivity.
    Type: Grant
    Filed: March 30, 2022
    Date of Patent: July 16, 2024
    Assignee: California Institute of Technology
    Inventors: Xiao Huang, Michael R. Hoffmann
  • Publication number: 20240230881
    Abstract: A handheld system radio frequency identification (RFID) system for fine-grained RFID localization of an RFID target. Also disclosed is a mechanism for localizing RFID targets at all orientations through software-controlled polarization of two LP antennas. The system may detect an RFID target using a generated circularly polarized (CP) RF signal and accurately localize the RFID target using a generated linearly polarized (LP) signal. The disclosed systems and techniques discover and localize RFID concurrently and regardless of RFID target orientation.
    Type: Application
    Filed: November 9, 2023
    Publication date: July 11, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Fadel ADIB, Laura Noelle DODDS, Aline EID, Isaac S. PERPER
  • Publication number: 20240226302
    Abstract: Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I) and (II).
    Type: Application
    Filed: December 26, 2023
    Publication date: July 11, 2024
    Applicants: Massachusetts Institute of Technology, Children's Medical Center Corporation
    Inventors: Daniel Griffith Anderson, Amab Rudra, Akash Gupta, Kaelan Reed
  • Publication number: 20240229014
    Abstract: The invention, in part, includes systems and methods for conducting and optimizing continuous evolution of molecules capable of forming multi-body complexes, such as but not limited to evolution of molecules capable of forming three- and four-molecule multi-body complexes.
    Type: Application
    Filed: January 9, 2024
    Publication date: July 11, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Emma J. Chory, Kevin Esvelt, Vainavi Mukkamala
  • Publication number: 20240228700
    Abstract: An object is to provide a crosslinked polyester resin that does not lose bond exchange activity even when immersed in water, an organic solvent, or the like and in which bond exchange is fast. Another object is to provide a polyester resin in which bond exchange is fast. A crosslinked polyester resin in which a polyester resin having a plurality of side chains each having a carboxy group and a plurality of side chains each having a tertiary amino group is crosslinked by an epoxy-based crosslinking agent having a plurality of epoxy groups.
    Type: Application
    Filed: March 10, 2022
    Publication date: July 11, 2024
    Applicants: Nagoya Institute of Technology, TOYOBO CO., LTD.
    Inventors: Mikihiro HAYASHI, Takaya INABA, Shoko UCHIYAMA
  • Publication number: 20240230627
    Abstract: Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.
    Type: Application
    Filed: August 30, 2023
    Publication date: July 11, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Michael Birnbaum, Connor Dobson
  • Publication number: 20240226854
    Abstract: Provided is a method for manufacturing a catalyst with which it is possible to obtain a supported metal ammonia synthesis catalyst, in which there are restrictions in terms of producing method and producing facility, and particularly large restrictions for industrial-scale producing, in a more simple manner and so that the obtained catalyst has a high activity. This method for manufacturing an ammonia synthesis catalyst includes: a first step for preparing 12CaO·7Al2O3 having a specific surface area of 5 m2/g or above; a second step for supporting a ruthenium compound on the 12CaO·7Al2O3; and a third step for performing a reduction process on the 12CaO·7Al2O3 supporting the ruthenium compound, obtained in the second step. This invention is characterized in that the reduction process is performed until the average particle diameter of the ruthenium after the reduction process has increased by at least 15% in relation to the average particle diameter of the ruthenium before the reduction process.
    Type: Application
    Filed: March 21, 2024
    Publication date: July 11, 2024
    Applicants: Tokyo Institute of Technology, Tsubame BHB Co., Ltd.
    Inventors: Hideo Hosono, Masaaki Kitano, Toshiharu Yokoyama, Jiang Li, Shigeki Kawamura, Kazuhisa Kishida
  • Publication number: 20240234042
    Abstract: Systems and methods involving nanomaterial-based electrodes, such as supercapacitor and battery electrodes that can be flexible, are described.
    Type: Application
    Filed: October 25, 2023
    Publication date: July 11, 2024
    Applicants: Massachusetts Institute of Technology, Analog Devices, Inc.
    Inventors: Karen K. Gleason, Brian L. Wardle, Estelle Cohen, Yue Zhou, Xiaoxue Wang, Yosef Stein
  • Publication number: 20240236451
    Abstract: According to some embodiments, a pressure tolerant camera system includes: an enclosure filled with an incompressible fluid and having a viewport through which light can pass; a digital image sensor provided within the enclosure; and a plurality of mirror lenses provided within the enclosure and arranged to reflect light from the viewport onto the digital image sensor.
    Type: Application
    Filed: January 5, 2024
    Publication date: July 11, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Gregory Cappiello, George Turner, Brian Edwards, Emma Landsiedel, Ryan Little
  • Patent number: 12029566
    Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.
    Type: Grant
    Filed: August 8, 2023
    Date of Patent: July 9, 2024
    Assignee: California Institute of Technology
    Inventors: Yu-Chong Tai, Shane S. Shahrestani
  • Patent number: 12033763
    Abstract: A “liquid sandwich” vacuum vessel for magnetic confinement fusion of plasma includes two rigid structural “bread” members that form a double-walled vessel and a non-structural “cheese” material disposed between the walls. The inner member is semi-conductive and encloses a volume of fusing plasma, while the outer member may contact a neutron shield (e.g. a molten salt blanket) and is corrosion-resistant. The non-structural material is solid at room temperature, but is molten during fusion, and is preferably lead. The structural members may be steel or silicon carbide, or similar structural material. During a disruption of fusion, excess electrical energy that escapes from the plasma into the vessel will primarily shear the liquid material rather than the structural members, allowing the “bread” to be thin.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: July 9, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Jeffrey Freidberg, Sara Ferry, Dennis G. Whyte, Caroline Sorensen, Ethan Peterson
  • Patent number: 12030839
    Abstract: Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: July 9, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Mircea Dinca, Constanze Nicole Neumann
  • Patent number: 12032116
    Abstract: Various embodiments described herein provide for a balloon-borne aeroseismometer that can detect infrasonic signals and concurrent vibrations caused by the infrasonic signals. Through a set of motion sensors that can detect acceleration in three planes, the aeroseismometer can determine the direction of vibration and thus determine a travel path of the infrasonic signal relative to the aeroseismometer. The aeroseismometer can also translate the direction of the source from a reference frame of the aeroseismometer to an external reference frame, such as a planetary coordinate system, in order to identify potential locations of a source of the infrasonic signals.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: July 9, 2024
    Assignees: National Technology & Engineering Solutions of Sandia, LLC, California Institute of Technology
    Inventors: Daniel Bowman, Jerry Rouse, Siddharth Krishnamoorthy, Attila Komjathy, James Cutts
  • Patent number: 12034481
    Abstract: A system includes, in part, a first optical modulator adapted to modulate a first optical signal with a first data to generate a first modulated optical signal, a second optical modulator adapted to modulate a second optical signal with a first clock signal to generate a second modulated optical signal, an optical multiplexer adapted to multiplex the first and second optical signals to generate a multiplexed optical signal, and an optical fiber adapted to carry the multiplexed optical signal. The second optical signal has a second wavelength that is different from the first wavelength.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: July 9, 2024
    Assignee: California Institute of Technology
    Inventor: Seyed Ali Hajimiri