Patents Assigned to Institute of Technology
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Patent number: 12040836Abstract: Methods and devices implementing a combination of multi-dimensional pulse position modulation (PPM) with wavelength division multiplexing (WDM) or wavelength division multiplexing multiple access (WDMA) for long range space communications are disclosed. The described multi-dimensional PPM scheme can use the laser wavelength and/or polarization as the additional dimension(s) to the time dimension. Through examples it is shown that the disclosed teachings result in a higher photon information efficiency. Various exemplary embodiments are also presented to highlight the applications benefiting from the disclosed methods and devices.Type: GrantFiled: May 26, 2023Date of Patent: July 16, 2024Assignee: California Institute of TechnologyInventors: Dariush Divsalar, William H Farr, Makan Mohageg, Samuel J Dolinar, Matthew D Thill
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Patent number: 12036240Abstract: This invention relates generally to compositions and methods for modulating complement component 3 (C3) activity or expression to treat, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells.Type: GrantFiled: June 14, 2019Date of Patent: July 16, 2024Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Aviv Regev, Ana Carrizosa Anderson, Ayshwarya Subramanian, Orit Rozenblatt-Rosen
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Patent number: 12036324Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).Type: GrantFiled: May 27, 2022Date of Patent: July 16, 2024Assignees: Massachusetts Institute of Technology, Novo Nordisk A/S, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer, Jorrit Jeroen Water, Morten Revsgaard Frederiksen, Bo Uldall Kristiansen, Mikkel Oliver Jespersen, Mette Poulsen, Peter Herskind, Brian Jensen
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Patent number: 12037639Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.Type: GrantFiled: February 25, 2019Date of Patent: July 16, 2024Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard CollegeInventors: Omar Abudayyeh, James Joseph Collins, Jonathan Gootenberg, Feng Zhang, Eric S. Lander
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Patent number: 12038746Abstract: A flying surface may comprise a plurality of interconnectable flying vehicles configured for mid-flight reconfiguration of the flying surface. Each flying vehicle may be entirely self-sufficient, including an onboard thrust unit, an onboard controller, an onboard power unit, and connectors configured to engage corresponding connectors of other flying vehicles to form a flying surface. The flying vehicles may additionally be configured for self-control, thereby enabling a distributed control model for a flying surface that does not require significant, centralized processing power and corresponding power storage. The flying surfaces may dynamically reconfigure mid-flight by attaching or detaching flying vehicles so as to enable a wide variety of in-flight maneuvers.Type: GrantFiled: September 27, 2019Date of Patent: July 16, 2024Assignee: California Institute of TechnologyInventor: Seyed Ali Hajimiri
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Patent number: 12038600Abstract: Disclosed herein is a pulse repetition rate multiplier including a photonic integrated circuit (PIC) including cascading Mach-Zehnder interferometers (MZIs). An input may be connected to one end of the PIC and an output may be connected to the other end of the PIC such that a signal from the input runs through the cascading MZIs and out the output. The input may be configured to receive an input pulsed signal and the output may be configured to output a repetition rate multiplied signal. Advantageously, using a PIC as opposed to an optical fiber-based pulse rate multiplier allows for accurate fabrication of a pulse repetition rate multiplier configured to accept higher frequency pulsed signals.Type: GrantFiled: December 13, 2021Date of Patent: July 16, 2024Assignee: California Institute of TechnologyInventors: Stephanie D. Leifer, Wei Zhang, Andrey B. Matsko
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Patent number: 12037650Abstract: A method and system are disclosed for detecting microbial pathogens in a sample suspected of containing the pathogens. The method includes combining loop-mediated isothermal amplification (LAMP) reagents and a polymer gel, such as a hydrogel, together with the sample to form a mixture. The gel polymerizes over a short time to immobilize the viral particles within the mixture. If target DNA/RNA are present in the sample, amplicons are produced. The target microorganisms are detected by visually detecting the presence or absence of the amplicons. The target microorganism concentrations may be determined based on the number of fluorescent amplicon dots after the reaction using a smartphone or a fluorescent microscope. The method may be employed for rapidly and inexpensively quantifying microbial pathogens in environmental water samples with high sensitivity.Type: GrantFiled: March 30, 2022Date of Patent: July 16, 2024Assignee: California Institute of TechnologyInventors: Xiao Huang, Michael R. Hoffmann
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Publication number: 20240230881Abstract: A handheld system radio frequency identification (RFID) system for fine-grained RFID localization of an RFID target. Also disclosed is a mechanism for localizing RFID targets at all orientations through software-controlled polarization of two LP antennas. The system may detect an RFID target using a generated circularly polarized (CP) RF signal and accurately localize the RFID target using a generated linearly polarized (LP) signal. The disclosed systems and techniques discover and localize RFID concurrently and regardless of RFID target orientation.Type: ApplicationFiled: November 9, 2023Publication date: July 11, 2024Applicant: Massachusetts Institute of TechnologyInventors: Fadel ADIB, Laura Noelle DODDS, Aline EID, Isaac S. PERPER
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Publication number: 20240226302Abstract: Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I) and (II).Type: ApplicationFiled: December 26, 2023Publication date: July 11, 2024Applicants: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Daniel Griffith Anderson, Amab Rudra, Akash Gupta, Kaelan Reed
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Publication number: 20240229014Abstract: The invention, in part, includes systems and methods for conducting and optimizing continuous evolution of molecules capable of forming multi-body complexes, such as but not limited to evolution of molecules capable of forming three- and four-molecule multi-body complexes.Type: ApplicationFiled: January 9, 2024Publication date: July 11, 2024Applicant: Massachusetts Institute of TechnologyInventors: Emma J. Chory, Kevin Esvelt, Vainavi Mukkamala
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Publication number: 20240228700Abstract: An object is to provide a crosslinked polyester resin that does not lose bond exchange activity even when immersed in water, an organic solvent, or the like and in which bond exchange is fast. Another object is to provide a polyester resin in which bond exchange is fast. A crosslinked polyester resin in which a polyester resin having a plurality of side chains each having a carboxy group and a plurality of side chains each having a tertiary amino group is crosslinked by an epoxy-based crosslinking agent having a plurality of epoxy groups.Type: ApplicationFiled: March 10, 2022Publication date: July 11, 2024Applicants: Nagoya Institute of Technology, TOYOBO CO., LTD.Inventors: Mikihiro HAYASHI, Takaya INABA, Shoko UCHIYAMA
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Publication number: 20240230627Abstract: Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.Type: ApplicationFiled: August 30, 2023Publication date: July 11, 2024Applicant: Massachusetts Institute of TechnologyInventors: Michael Birnbaum, Connor Dobson
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Publication number: 20240226854Abstract: Provided is a method for manufacturing a catalyst with which it is possible to obtain a supported metal ammonia synthesis catalyst, in which there are restrictions in terms of producing method and producing facility, and particularly large restrictions for industrial-scale producing, in a more simple manner and so that the obtained catalyst has a high activity. This method for manufacturing an ammonia synthesis catalyst includes: a first step for preparing 12CaO·7Al2O3 having a specific surface area of 5 m2/g or above; a second step for supporting a ruthenium compound on the 12CaO·7Al2O3; and a third step for performing a reduction process on the 12CaO·7Al2O3 supporting the ruthenium compound, obtained in the second step. This invention is characterized in that the reduction process is performed until the average particle diameter of the ruthenium after the reduction process has increased by at least 15% in relation to the average particle diameter of the ruthenium before the reduction process.Type: ApplicationFiled: March 21, 2024Publication date: July 11, 2024Applicants: Tokyo Institute of Technology, Tsubame BHB Co., Ltd.Inventors: Hideo Hosono, Masaaki Kitano, Toshiharu Yokoyama, Jiang Li, Shigeki Kawamura, Kazuhisa Kishida
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Publication number: 20240234042Abstract: Systems and methods involving nanomaterial-based electrodes, such as supercapacitor and battery electrodes that can be flexible, are described.Type: ApplicationFiled: October 25, 2023Publication date: July 11, 2024Applicants: Massachusetts Institute of Technology, Analog Devices, Inc.Inventors: Karen K. Gleason, Brian L. Wardle, Estelle Cohen, Yue Zhou, Xiaoxue Wang, Yosef Stein
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Publication number: 20240236451Abstract: According to some embodiments, a pressure tolerant camera system includes: an enclosure filled with an incompressible fluid and having a viewport through which light can pass; a digital image sensor provided within the enclosure; and a plurality of mirror lenses provided within the enclosure and arranged to reflect light from the viewport onto the digital image sensor.Type: ApplicationFiled: January 5, 2024Publication date: July 11, 2024Applicant: Massachusetts Institute of TechnologyInventors: Gregory Cappiello, George Turner, Brian Edwards, Emma Landsiedel, Ryan Little
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Patent number: 12029566Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.Type: GrantFiled: August 8, 2023Date of Patent: July 9, 2024Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Shane S. Shahrestani
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Patent number: 12033763Abstract: A “liquid sandwich” vacuum vessel for magnetic confinement fusion of plasma includes two rigid structural “bread” members that form a double-walled vessel and a non-structural “cheese” material disposed between the walls. The inner member is semi-conductive and encloses a volume of fusing plasma, while the outer member may contact a neutron shield (e.g. a molten salt blanket) and is corrosion-resistant. The non-structural material is solid at room temperature, but is molten during fusion, and is preferably lead. The structural members may be steel or silicon carbide, or similar structural material. During a disruption of fusion, excess electrical energy that escapes from the plasma into the vessel will primarily shear the liquid material rather than the structural members, allowing the “bread” to be thin.Type: GrantFiled: March 3, 2021Date of Patent: July 9, 2024Assignee: Massachusetts Institute of TechnologyInventors: Jeffrey Freidberg, Sara Ferry, Dennis G. Whyte, Caroline Sorensen, Ethan Peterson
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Patent number: 12030839Abstract: Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols.Type: GrantFiled: November 30, 2020Date of Patent: July 9, 2024Assignee: Massachusetts Institute of TechnologyInventors: Mircea Dinca, Constanze Nicole Neumann
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Patent number: 12032116Abstract: Various embodiments described herein provide for a balloon-borne aeroseismometer that can detect infrasonic signals and concurrent vibrations caused by the infrasonic signals. Through a set of motion sensors that can detect acceleration in three planes, the aeroseismometer can determine the direction of vibration and thus determine a travel path of the infrasonic signal relative to the aeroseismometer. The aeroseismometer can also translate the direction of the source from a reference frame of the aeroseismometer to an external reference frame, such as a planetary coordinate system, in order to identify potential locations of a source of the infrasonic signals.Type: GrantFiled: March 14, 2022Date of Patent: July 9, 2024Assignees: National Technology & Engineering Solutions of Sandia, LLC, California Institute of TechnologyInventors: Daniel Bowman, Jerry Rouse, Siddharth Krishnamoorthy, Attila Komjathy, James Cutts
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Patent number: 12034481Abstract: A system includes, in part, a first optical modulator adapted to modulate a first optical signal with a first data to generate a first modulated optical signal, a second optical modulator adapted to modulate a second optical signal with a first clock signal to generate a second modulated optical signal, an optical multiplexer adapted to multiplex the first and second optical signals to generate a multiplexed optical signal, and an optical fiber adapted to carry the multiplexed optical signal. The second optical signal has a second wavelength that is different from the first wavelength.Type: GrantFiled: September 15, 2021Date of Patent: July 9, 2024Assignee: California Institute of TechnologyInventor: Seyed Ali Hajimiri