Abstract: A magnetically coupled ball drive system for actuation of spherical surfaces and wheels is disclosed. An internal support structure interacts with exterior drive wheels magnetically to produce rotational motion. A related improvement involving reduction of slip due to insufficient traction is also presented to establish a design for a more robust and versatile device that can be used in robotics or for producing vehicle locomotion.

Abstract: Systems and methods relate to arranging atoms into 1D and/or 2D arrays; exciting the atoms into Rydberg states and evolving the array of atoms, for example, using laser manipulation techniques and high-fidelity laser systems described herein; and observing the resulting final state. In addition, refinements can be made, such as providing high fidelity and coherent control of the assembled array of atoms. Exemplary problems can be solved using the systems and methods for arrangement and control of atoms.

Abstract: The present system and method allow for the detection and diagnosis of abrupt changes of a device operating condition using a sensor array disposed in the coolant where the device is located. The purpose of the sensor array is to identify, in real time, abrupt changes quickly and detect the location of the incident. It may be used, for example, for quench detection of superconducting cables and magnets. This system and method are not only limited to use with superconducting conductors such as magnets, power transmission cables, SMES, MRI, motors and generators, but could also be used for any electric devices disposed in liquid or gas. It can also be used for a liquid level meter. Further, this system and method are not limited to low temperature devices, but may also be used in room temperature or elevated higher temperature devices disposed in gas and/or liquid.

Abstract: Catalytic compositions and sequential catalytic methods are generally described. In some embodiments, a composition comprises a first catalyst comprising a Cu-modified zeolite, and a second catalyst capable of a coupling reaction between (a) an intermediate resulting from a reaction of a reactant at the first catalyst, and (b) a co-reagent, wherein a rate of diffusion of the co-reagent within one or more cages and/or pores of the first catalyst is lower than a rate of diffusion of the intermediate within the one or more cages and/or pores of the first catalyst.

Abstract: Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell types such as the brain and lung. The rAAV compositions described herein also have tropisms showing decreased specificity and decreased efficiency of viral transduction in an off-target cell type such as the liver. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Upon systemic delivery to a subject, the rAAV is capable of increased specificity and increased transduction of the transgene in a target cell-type, as compared to a parental or reference AAV.

Abstract: A probe for use with an imaging system, including a scanning device configured to receive a first light beam from a light source, a beam-divider configured to split the first light beam into a plurality of second light beams, and a focusing device configured to focus each of the second light beams on respective locations in an object of interest is disclosed.

Abstract: Amorphous metal thermal management devices are described. The amorphous metal thermal management devices are advanced heat transfer systems that utilize the unique properties of amorphous metal to transfer heat away from components that generate heat in numerous applications. These devices feature either rigid or flexible vapor chambers, for dissipating heat and can be used to cool a wide range of devices. The resulting cooling solution is both effective and reliable.

Abstract: A front-leg assistive exoskeleton provides the ability to augment a human gait. A shin mount comprising a material secures to a shin of a person such that the shin mount is enabled to push and pull on the shin in a normal direction. A foot mount attaches to a top of a shoe. A connector connects the shin mount to the foot mount. The connector houses an actuator that applies forces that generates torque about an ankle that modifies a gait of the person.

Abstract: A system and method for oxidizing methane can include an environmentally friendly catalyst material that converts methane to an oxidized product at low temperatures and concentrations, for example, under 350° C. at concentrations less than 40% methane, including less than 5% methane.

Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.

Abstract: Near infrared and shortwave infrared dyes can have polymethine structures.

Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.

Abstract: Described are methods for making three dimensional objects. A nozzle is positioned within a gel inside a container of gel. The position of the nozzle within the gel is changed while depositing solidifying material through the nozzle. The gel supports the solidifying material at the position at which the solidifying material is deposited. The solidifying material is solidified to form a solid material, which is a three-dimensional object.

Abstract: The subject matter disclosed herein is generally directed to detecting and modulating novel gene signatures for the treatment and prognosis of cancer. The novel gene signatures predict overall survival in cancer and can be targeted therapeutically. Specifically, disclosed is a resistance program identified by a comprehensive single-cell profiling study in melanoma patients, which was validated in two large validation cohorts. Using a large-scale in silico prediction, CDK4/6 inhibitors were identified as a class of drugs that may reverse this resistance program. These predictions were validated in melanoma cell lines, patient-derived co-culture models, and melanoma in vivo models, which show that the combination of abemaciclib and immune checkpoint blockade (ICB) overcome intrinsic drug resistance. The present invention provides for detecting an immunotherapy resistance signature and modulating the signature with CDK4/6 inhibition.

Abstract: Disclosed multifunctional compounds, conjugates, macromolecules, and polymers that target dysregulated proteins for degradation. Also disclosed are methods of preparation, compositions, kits, and methods of use relating to the degraders.

Abstract: Peptide-major histocompatibility (MHC) Class I nucleic acids and proteins are provided. Methods of their use, for example in methods of identifying antigen-specific T cells and adoptive cell therapy, are also provided.

Abstract: Enhancing condensation heat transfer performance in applications including power generation, thermal management of high-performance electronics, water purification, distillation, natural gas processing, and air conditioning can be achieved with heat transfer devices. Condensation heat transfer can be enhanced via a hierarchical structure attached on a condenser surface. This novel hierarchical structure is composed of a thin, highly permeable, thermally conductive porous wick and a highly porous, robust, intrinsically hydrophobic membrane bonded or attached on top of the wick.

Abstract: An object of the present invention is to realize an environment-friendly manufacturing process for textile products that solves the problem of wastewater by using a solvent instead of conventionally used water in a sizing process and/or desizing process of textile products. According to an aspect of the present invention, there is provided a method for applying a sizing agent to a textile product, the method including: a step of sizing the textile product by bringing the textile product into contact with a fluid containing the sizing agent and supercritical carbon dioxide.

Abstract: In-network Optical Inference (IOI) provides low-latency machine learning inference by leveraging programmable switches and optical matrix multiplication. IOI uses a transceiver module, called a Neuro Transceiver, with an optical processor to perform linear operations, such as matrix multiplication, in the optical domain. IOI's transceiver modules can be plugged into programmable packet switches, which are programmed to perform non-linear activations in the electronic domain and to respond to inference queries. Processing inference queries at the programmable packet switches inside the network, without sending them to cloud or edge inference servers, significantly reduces end-to-end inference latency experienced by users.

Abstract: The next-generation of optoelectronic systems will require efficient optical signal transfer between many discrete photonic components integrated onto a single substrate. While modern assembly processes can easily integrate thousands of electrical components onto a single board, photonic assembly is far more challenging due to the wavelength-scale alignment tolerances required. Here we address this problem by introducing a self-aligning photonic coupler insensitive to x, y, z displacement and angular misalignment. The self-aligning coupler provides a translationally invariant evanescent interaction between waveguides by intersecting them at an angle, which enables a lateral and angular alignment tolerance fundamentally larger than non-evanescent approaches such as edge coupling. This technology can function as a universal photonic connector interfacing photonic integrated circuits and microchiplets across different platforms.