Abstract: A system includes, in part, a first optical modulator adapted to modulate a first optical signal with a first data to generate a first modulated optical signal, a second optical modulator adapted to modulate a second optical signal with a first clock signal to generate a second modulated optical signal, an optical multiplexer adapted to multiplex the first and second optical signals to generate a multiplexed optical signal, and an optical fiber adapted to carry the multiplexed optical signal. The second optical signal has a second wavelength that is different from the first wavelength.

Abstract: The present disclosure provides compositions comprising: a) a copolymer prepared by a method comprising polymerizing in the presence of a metathesis catalyst: i) a first monomer, wherein each instance of the first monomer is independently of the formula: or salt thereof; ii) a second monomer, wherein each instance of the second monomer is independently of the formula: or a salt thereof; iii) optionally a third monomer, wherein the third monomer is different from the first monomer and the second monomer; and iv) optionally a reprocessing catalyst; and b) optionally the reprocessing catalyst; wherein the reprocessing catalyst is a Brønsted acid, Lewis acid, Brønsted base, Lewis base, or a salt thereof; provided that the composition comprises at least one of the reprocessing catalyst of iv) and the reprocessing catalyst of b). The compositions may be reprocessed (e.g., remolded) under elevated temperature and/or elevated pressure.

Abstract: The present disclosure provides compounds of Formula I, methods of preparing the compounds, compositions, kits, and methods of using the compounds for treating or preventing microbial infections.

Abstract: Methods and compositions for determining multiplex interactions between drugs and drug transporters using an intestinal tissue explant are provided.

Abstract: This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide a broad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

Abstract: This crane control device controls the operation of a boom and a winch and transports a load from a start point to an end point, the control device comprising: an acquisition unit that acquires position information of the start point and position information of the end point; a horizontal trajectory generation unit that, by using an optimal control theory, generates a horizontal trajectory for a distal-end part of the boom as represented by a horizontal-direction component of a straight line linking the start point and the end point; a movement trajectory generation unit that generates a trajectory of movement of the boom for transporting the load so as to follow the horizontal trajectory, and a trajectory of rotational movement of the winch; and a movement control unit that controls the boom and the winch based on the trajectory of movement of the boom and the winch.

Abstract: Systems and methods for generating high-pressure hydrogen are described. The hydrogen generation systems include hybrid electrolyzer systems and catalytic compression systems. The systems can directly generate gaseous hydrogen at a pressure of at least 700 bar.

Abstract: A dynamic decoupling control method for a multi-degree-of-freedom precision comprises defining a dynamic decoupling controller and parameterizing elements in the form of a finite impulse response (FIR) filter, applying a nominal decoupling control method to measure an actual position signal of an actual system and an output of a nominal decoupling controller, calculating a virtual control quantity, and optimizing an indicator function to obtain an estimated value of a coefficient to be optimized of the dynamic decoupling controller. Decoupling at medium and high frequency bands can be effectively realized with improved accuracy of decoupling, and an algorithm flow is simplified. The method is prone to engineering implementation.

Abstract: A collaborative scheduling method for high-rise elevators based on Internet of Things is provided. The method includes: obtaining the number of people carried at the current moment of each elevator in the elevator group, the target distance corresponding to the current moment of each elevator, and the number of people waiting at the current moment of each floor; predicting the number of people waiting for the going up and the number of people waiting for the going down at the current moment of each floor based on the monitoring video data of the elevator door every day in the preset historical days, and constructing the corresponding feature vectors of each elevator at the current moment and the corresponding feature vectors of the skyscraper at the current moment, and then obtaining the corresponding state vectors at the current moment, controlling each elevator based on state vector and ES-Reinforcement learning network.

Abstract: An asymmetric system containing a first conductive polymer modified with a redox active moiety and a second conductive polymer modified with a surfactant is used for the separation of organic compounds from aqueous solutions. The asymmetric system has complementary hydrophobicity tunability in response to electrochemical modulations. For example, both materials are hydrophobic in their respective neutral states, therefore exhibiting affinity toward organic compounds. Application of a mild potential drives the desorption of the organic compounds and regeneration of the materials. The asymmetric system can be used in a cyclic fashion, through repeated electrical discharge or shorting of the two electrodes to program the capture of organics from a feed solution, and application of a potential to stimulate the release of the adsorbed organics.

Abstract: A power generator includes a plurality of amplifier blocks and a combiner. Each of the amplifier blocks include one or more amplifiers, and the combiner combines modulated power signals output from the amplifier blocks to generate an RF power signal of a load. The amplifier blocks are controlled to outphase the modulated power signals based on a phase angle. Ones of the amplifier blocks may perform discrete modulation to generate a respective one of the modulated power signals. The discrete modulation includes selecting different combinations of the amplifiers in one or more of the amplifier blocks to change the RF power signal in discrete steps. In embodiments, the amplifiers may be radio frequency power amplifiers.

Abstract: A method of generating an output trajectory of an ego vehicle is described. The method includes extracting high-level features from a bird-view image of a traffic environment of the ego vehicle. The method also includes generating, using an automaton generative network, an automaton including an automaton state distribution describing a behavior of the ego vehicle in the traffic environment according to the high-level features. The method further includes generating the output trajectory of the ego vehicle according to extracted bird-view features of the bird-view image and the automaton state distribution describing the behavior of the ego vehicle in the traffic environment.

Abstract: The present disclosure provides methods for preparing ?-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a ?-substituted serine, and iii) a tryptophan synthase ?-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the ?-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new ?-substituted tryptophan analogs are also described.

Abstract: Disclosed are devices and methods of detecting and mitigating oscillatory instabilities in systems with turbulent flow, such as thermoacoustic, aeroacoustic or aeroelastic equipment. The system includes a sensor array for measuring one or more parameters of an operating equipment S, and an analysis and prediction unit. The analysis and prediction unit is configured to estimate a state tensor to identify a state of the equipment indicating stable operation or impending oscillatory instability. The system further includes an actuator array configured to implement a control action to promote stable operation of the equipment. Methods for robust prediction of the state of stability are also disclosed. A neural ordinary differential equation (ODE) method of predicting stability or instability is disclosed, involving forming a neural network that incorporates an equation characteristic of the operational state.

Abstract: Disclosed are locational or positional methods concerning CRISPR-Cas systems, and apparatus therefor.

Abstract: This invention relates to a Nanostructured Lipid Carrier (NLC) particle comprising a therapeutic agent encapsulated therein for ocular delivery of the therapeutic agent, wherein the Nanostructured Lipid Carrier comprises: (i) a solid outer shell comprising a solid lipid, and (ii) a liquid core comprising a liquid lipid; and wherein the core comprises the therapeutic agent. Compositions of the NLC particles, use of the NLC particles, methods of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.

Abstract: A device useful as a receiver including a waveguide interface to an antenna guiding a radio frequency (RF) signal to an RF waveguide cavity coupling the RF signal to a crystal resonator. The crystal resonator comprises a nonlinear material generating an optical output in response to a nonlinear interaction between the RF signal and an optical pump in the resonator. An optical port coupled to the crystal resonator for outputting the optical output from which the RF signal received on the antenna can be determined.

Abstract: According to one aspect of the disclosure, a converter having a first port and a second port, the converter comprises: a piezoelectric transformer (PT) having a first port and a second port; one or more first switches configured to operate in accordance with a first switching sub-sequence to transfer energy from the first port of the converter to the first port of the PT, the first switching sub-sequence having at least six (6) stages; and one or more second switches configured to operate in accordance with a second switching sub-sequence to transfer energy from the second port of the PT to the second port of the converter.

Abstract: A method for calibrating eye information includes receiving eye state data measured during a calibration period, receiving head state data measured during the calibration period, calibrating the eye state data based on the head state data, and generating an eye angle measurement based on the calibrated eye state data. Calibrating the eye state data may include correlating the eye state data with the head state data during a period when a vestibulo-ocular reflex occurs. In some implementations, the eye state data may include eye movement data and the head state data may include head movement data. The calibrated eye state data is considered to have improved accuracy and therefore may be used as a more reliable basis for determining a variety of health conditions.