Abstract: The present invention provides compounds of Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, pro-drugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I), (II) or (III) for treating diseases associated with the over-expression of phosphoglycerate dehydrogenase (PHGDH) in a subject, such as proliferative diseases (e.g., cancers (e.g., breast cancer, ER negative breast cancer, melanoma, cervical cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases). Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the activity of PHGDH or inhibit the serine biosynthetic pathway, or both.

Abstract: The present disclosure is directed generally to a lens that provides a stop signal to a myopic eye, over a substantial portion of the spectacle lens that the viewer is using. The present disclosure is directed to devices, methods and/or systems of imposing a stop signal to eye growth, using a spectacle lens in conjunction with a micro lenslet array. The present disclosure is also directed to devices, methods and/or systems of modifying incoming light through spectacle lenses that utilizes chromatic cues to decelerate the rate of myopia progression. The present disclosure is directed to devices, methods and/or systems of imposing a stop signal to eye growth, using a spectacle lens in conjunction with a refractive optical element and/or diffractive optical element that offer conflicting or contradictory optical signals at a wavelength between 510 nm and 610 nm.

Abstract: Provided is a method of manufacturing a mechanoluminescent fiber. The method includes the steps of: preparing an elastic fiber having a longitudinal groove on the surface thereof; forming a primer layer including a coupling agent on the elastic fiber; filling the groove of the elastic fiber with a mixture of a stress transfer substance and a stress luminescent substance; and forming a silicon adhesive layer on the elastic fiber of which the groove is filled with the mixture of a stress transfer substance and a stress luminescent substance. The silicon adhesive layer is 3-dimensionally bonded to the elastic fiber and the mixture of a stress transfer substance and a stress luminescent substance.

Abstract: An apparatus and system for a combination space and water heater including a controller device and a method for control. The controller device is a self-contained system that can be added to, or in combination with, existing water heaters and hydronic air heating systems using standard plumbing connections, and provides a potable water system without any need of an intermediary heat exchanger. The controller device automatically monitors a heating capacity of the water heater and the hydronic heating coil over time, and correlates measured heating loads with one or more environmental temperatures, thermostats, user settings, and/or a supplemental heating system.

Abstract: A method for dynamically adjusting a broadcast area is provided. The method includes the following steps. Information of at least one target base station which subscribes a broadcast service is obtained. A broadcast service base station list corresponding to a broadcast area identification code is set to contain the at least one target base station. The broadcast area identification code corresponds to the broadcast service. A command for adding a new broadcast area identification code is selectively transmitted to the at least one target base station in the broadcast service base station list so that the at least one target base station records the broadcast area identification code to receive the broadcast service corresponding to the broadcast area identification code.

Abstract: A method for directly preparing p-xylene from synthetic gas and aromatic hydrocarbon. The method includes contacting the feedstock containing synthetic gas and aromatic hydrocarbon excluding p-xylene with the catalyst in the reaction zone under reaction conditions sufficient to convert at least part of the feedstock to obtain a reaction effluent containing p-xylene; and separating p-xylene from the reaction effluent, where the catalyst includes a highly dispersed metal oxide material confined by an inert carrier, an acidic molecular sieve, and optionally at least one of graphite powder and dispersant, where in the highly dispersed metal oxide material confined by the inert carrier, the inert carrier is at least one of silicon oxide and alumina, and the content of the metal oxide in terms of metal is less than or equal to 10% by mass calculated based on the weight of the highly dispersed metal oxide material confined by the inert carrier.

Abstract: This disclosure concerns a method for making a hybrid organic/inorganic material having an architecture. The method includes combining a peptoid comprising a sequence of N-substituted glycine residues and an inorganic material or inorganic material precursor to form a hybrid organic/inorganic material comprising the peptoid and the inorganic material, the hybrid organic/inorganic material having an architecture based at least in part on the peptoid sequence. The hybrid organic/inorganic materials include a cluster of nanoparticles of an inorganic material and peptoids, the cluster formed by random attachment of nanoparticles to one another by peptoid-peptoid and peptoid-nanoparticle surface interactions, wherein the hybrid material has an architecture based at least in part on the peptoid sequence.

Abstract: Provided is a method for simulating a semiconductor device. The method includes extracting a Hamiltonian and an overlap matrix of a semiconductor device using a density functional theory or a tight-binding method, calculating each of Bloch states for each corresponding energy, obtaining a first reduced Hamiltonian and a first reduced overlap matrix with a reduced matrix size, and calculating a final transformation matrix and a final energy band structure in which all of unphysical branches, wherein the semiconductor device includes a source region, a drain region, and a channel region between the source region and the drain region, wherein the channel region includes unit cells, each of which includes different material or has different structure.

Abstract: A method of using data-driven predictive modeling to predict and classify battery cells by lifetime is provided that includes collecting a training dataset by cycling battery cells between a voltage V1 and a voltage V2, continuously measuring battery cell voltage, current, can temperature, and internal resistance during cycling, generating a discharge voltage curve for each cell that is dependent on a discharge capacity for a given cycle, calculating, using data from the discharge voltage curve, a cycle-to-cycle evolution of cell charge to output a cell voltage versus charge curve Q(V), generating transformations of ?Q(V), generating transformations of data streams that include capacity, temperature and internal resistance, applying a machine learning model to determine a combination of a subset of the transformations to predict cell operation characteristics, and applying the machine learning model to output the predicted battery operation characteristics.

Abstract: Described are devices, systems and techniques for implementing atomic memory objects in a multi-writer, multi-reader setting. In an embodiment, the devices, systems and techniques use maximum distance separable (MDS) codes, and may be specifically designed to optimize a total storage cost for a given fault-tolerance requirement. Also described is an embodiment to handle the case where some of the servers can return erroneous coded elements during a read operation.

Abstract: The present application provides, in some aspects, methods of treating cancers, such as homologous recombination (HR)-deficient cancers. In some embodiments, the disclosure provides a method for treating cancer by administering to a subject a compound of Formula (I):(I), or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides for methods of identifying cell types and cell subtypes from a biological sample or population of target cells. The methods further provide for determining cell type or cell subtype signatures. The method further provides for bipolar cell subtypes and markers and cell signatures thereof.

Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.

Abstract: A cathode of a lithium ion battery is provided. The cathode of a lithium ion battery includes a collector material. A first electrode layer including a lithium manganese iron phosphate (LMFP) material is disposed on a surface of the collector material. A second electrode layer including an active material is disposed on the first electrode layer. The active material includes lithium nickel manganese cobalt oxide (NMC), lithium nickel cobalt aluminum oxide (NCA), lithium cobalt oxide (LCO), Li-rich cathode material, or a combination thereof.

Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

Abstract: The image decoding method according to the present invention comprises the steps of: determining the availability of a block adjacent to a current block; configuring a merge candidate list for the current block on the basis of the result of the determined availability; and performing motion compensation for the current block on the basis of the merge candidate list, wherein the step of determining availability comprises the steps of inducing block availability information on the adjacent block and inducing the availability of motion information on the adjacent block, and the step of determining the availability of the adjacent block is such that when there is more than one adjacent block, the availability of adjacent blocks can be determined in accordance with a predetermined order restriction.

Abstract: A transfer support adapted to contact a plurality of elements is provided. The transfer support has a first surface, a second surface opposite to the first surface, a recess located on the second surface, a plurality of platforms protruded from the first surface, a plurality of supporting pillars distributed in the recess and a plurality of through holes. The platforms have carry surfaces adapted to contact the plurality of elements. The through holes extend from the carry surfaces of the platforms to the recess, and two of the adjacent supporting pillars are spaced apart from each other to form an air passage. In addition, a transfer module is also provided.

Abstract: Provided are a water and/or alcohol adsorbent including organic-inorganic hybrid nanoporous materials, and use thereof, and more particularly, a water and/or alcohol adsorbent having a high adsorption amount at a low relative humidity or partial pressure, of which desorption/regeneration is possible at a low temperature, the water and/or alcohol adsorbent including organic-inorganic hybrid nanoporous materials having 0.5 to 3 mol of a hydroxyl group (OH) or a hydroxide anion group (OH?) per 1 mol of a central metal ion, and use thereof.

Abstract: A high speed connector includes an insulated shelter for accommodating at least one main body. The main body includes at least one terminal group integrated with the main body by having two opposing sides thereof to extend out of the main body, in which the two opposing sides are defined as a contact portion and a welding portion, respectively. The terminal group further includes a plurality of terminals. The insulated plastic element has a slot for enclosing up terminal group, and a height of a section in the slot is larger than a thickness of the plurality of terminals, so that at least one gap can be formed in the slot. By having the gap, dielectric coefficients and electromagnetic properties around the terminals can be adjusted to reduce the crosstalk effects upon the signal terminals. In addition, an insulated plastic element is also provided.

Abstract: In a method for forming a holographic image, light is provided to a flat-panel holographic video display that includes waveguide elements that each have a light-guiding substrate and an array of transducers configured to produce a diffraction grating comprising surface acoustic waves. The grating causes the waveguide to outcouple light, focusing it to, or producing wavefront curvatures consistent with it having emanated from, one or more points, in order to form a holographic image. The transducer array may include a large number of densely packed, vertically-adjacent transducers for each hogel for full parallax or may include a small number of vertically-adjacent transducers and a cylindrical optical element for each hogel. The display may be edge-illuminated by a collinear multicolor source. The substrate exit face may have nanopatterned areas alternated with flat areas in order to create regions of optimal internal reflection next to regions of low reflection.