Abstract: The present application discloses a method for preparing a hierarchical porous TS-1 molecular sieve, which uses a silicon-titanium ester polymer as both titanium source and silicon source. In the method, silicon and titanium are uniformly connected to a same polymer, and the hydrolysis rates thereof are equivalent during hydrolysis, which can prevent TiO2 precipitation and reduce the generation of non-framework titanium. Further, the silicon-titanium ester polymer is not only used as both silicon source and titanium source, but also can be used as mesoporous template in the synthesis process. The obtained TS-1 molecular sieve has mesoporous structure with narrow pore size distribution, which plays an important role in promoting the application of TS-1 molecular sieve in the field of catalysis.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases or tumors, containing, as an active ingredient, a tricyclic compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof, and a health food composition for preventing or alleviating autoimmune diseases or tumors, containing the tricyclic compound as an active ingredient, wherein the tricyclic compound represented by Chemical Formula 1 has an excellent inhibitory activity against IRAK4, and thus can be usefully used for the prevention, treatment, or alleviation of autoimmune diseases or tumors.

Abstract: The present disclosure provides a composition for preventing or treating a benign tumor. Provided is a composition for preventing or treating a benign tumor that comprises a WT1 peptide or an analog thereof, or a nucleic acid molecule encoding a WT1 peptide or an analog thereof. In a specific embodiment, the present disclosure provides a composition for preventing or treating a benign tumor that comprises a WT1 peptide or an analog thereof, or a nucleic acid molecule encoding a WT1 peptide or an analog thereof. In a preferred embodiment, the composition for preventing or treating a benign tumor (e.g. familial adenomatous polyposis) according to the present disclosure comprises a killer type WT1 peptide and/or a helper type WT1 peptide. In a further preferred embodiment, the WT1 peptide is WT1126 killer peptide and/or WT135 helper peptide.

Abstract: A method includes receiving sensor data associated with one or more inputs associated with a road portion, determining a level of risk associated with each of the one or more inputs, determining an estimated amount of computing resources that each of a plurality of candidate computing methods will consume, and selecting one or more computing methods from the plurality of candidate computing methods to associate with the one or more inputs based on the levels of risk associated with the one or more inputs and the estimated amount of computing resources that the candidate computing methods will consume.

Abstract: A real-time calibration-based tool condition monitoring system, device and method for repetitive machining operations to monitor tool conditions by a combination of a calibration procedure using a reference tool and similarity analysis comparing the reference tool with a working tool is disclosed.

Abstract: A data learning device in a deep learning network characterized by a high image resolution and a thin channel at an input stage and an output stage and a low image resolution and a thick channel in an intermediate deep layer includes a feature information extraction unit configured to extract global feature information considering an association between all elements of data when generating an initial estimate in the deep layer; a direct channel-to-image conversion unit configured to generate expanded data having the same resolution as a final output from the generated initial estimate of the global feature information or intermediate outputs sequentially generated in subsequent layers; and a comparison and learning unit configured to calculate a difference between the expanded data generated by the direct channel-to-image conversion unit and a prepared ground truth value and update network parameters such that the difference is decreased.

Abstract: Disclosed is an integrated circuit, which includes a DTC block including DTCs, receiving a first reference signal and a first division signal, and outputting a second reference signal and a second division signal based on the first reference signal, the first division signal, and control codes, a TDC comparing phases of the second reference signal and the second division signal and outputting a comparison signal, a digital loop filter filtering the comparison signal, an oscillator generating an output signal based on the filtered comparison signal, a delta-sigma modulator outputting a first signal and a quantized noise signal based on first and second division ratio signals, a divider dividing a frequency of the output signal based on the first signal and outputting the first division signal, and a probability modulator generating the control codes based on the quantized noise signal. Probability density functions of the control codes are time-invariant.

Abstract: A method for etching a surface including obtaining a structure comprising a plurality of nanowires on or above a substrate and a dielectric layer on or above the nanowires, wherein the dielectric layer comprises protrusions formed by the underlying nanowires; reacting a surface of the dielectric layer with a reactant, comprising a gas or a plasma, to form a reactive layer on the dielectric layer, wherein the reactive layer comprises a chemical compound including the reactant and elements of the dielectric layer and the reactive layer comprises sidewalls defined by the protrusions; and selectively etching the reactive layer, wherein the etching etches the protrusions laterally through the sidewalls so as to planarize the surface and remove or shrink the protrusions.

Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.

Abstract: In this invention, we propose a convolutional neural network (CNN) based architecture designed for the ITM to HDR consumer displays, called ITM-CNN, and its training strategy for enhancing the performance based on image decomposition using the guided filter. We demonstrate the benefits of decomposing the image by experimenting with various architectures and also compare the performance for different training strategies. To the best of our knowledge, this invention first presents the ITM problem using CNNs for HDR consumer displays, where the network is trained to restore lost details and local contrast. Our ITM-CNN can readily up-convert LDR images for direct viewing on an HDR consumer medium, and is a very powerful means to solve the lack of HDR video contents with legacy LDR videos.

Abstract: Disclosed herein are a gateway-signaling method for frequency/timing offsets and an apparatus for the same. An apparatus for transmitting a broadcast signal according to an embodiment of the present invention includes a frequency/timing decision unit for determining a center frequency to which a frequency offset is applied using a carrier offset, which is identified using a timing and a management packet transmitted through a Studio-to-Transmitter Link (STL); and an RF signal generation unit for generating an RF signal to be transmitted, which corresponds to the center frequency.

Abstract: Disclosed are camera pose determination methods and apparatuses. The method includes determining first pixels in a current image and second pixels in a previous image, determining second pixel points with the preconfigured semantics in a previous image frame before the current image frame, the first pixel points corresponding to at least a portion of the second pixel points, determining an error between the first pixel points and the second pixel points, and a camera pose change value of the current image frame relative to the previous image frame based on the error, and determining a camera pose of the current image based on a camera pose of the previous image and the camera pose change. Related devices and storage media are also disclosed.

Abstract: The present disclosure relates to a device for playing an acoustic sound and a touch sensation, and more particularly, to a device for emitting a sound to a front surface of a speaker and playing a touch sensation feedback to a rear surface of the speaker through a driving modulation using two or more speakers while simultaneously concentrating an acoustic pressure generated according to a vibration of a membrane of the speaker to a surface of a module through a movement pipe when an audio signal is applied.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of cancers, particularly cancers that exhibit arm-level loss of chromosome 16q, focal copy loss of 16q13 and/or low expression of metallothionein proteins, such as certain uterine, ovarian, gastroesophageal and lung cancers. Three known drugs, disulfiram, elesclomol and thiram, as well as certain disulfiram metabolites, are specifically provided for killing cancer cells characterized by arm-level loss of chromosome 16q, focal copy loss of 16q13 and/or low expression of metallothioneins. The instant disclosure therefore provides for selecting and/or administering disulfiram, elesclomol and thiram and/or active metabolites or derivatives of disulfiram, elesclomol and thiram as a therapeutic agent(s) to target a cancer cell and/or subject having or at risk of developing a cancer. Methods and compositions for therapies that include such compounds are also provided.

Abstract: A method and a system for simultaneously tracking several 6 DoF poses of a movable object and a movable camera are provided. The method the following steps: A series of images are captured by a movable camera, several environmental feature points are extracted from the images and are matched to compute several camera matrixes of the movable camera, and the 6 DoF poses of the movable camera are computed using the camera matrixes. At the same time, several feature points of the movable object are inferred from the images captured by the movable camera, the coordinates of the feature points of the movable object are corrected using the camera matrixes corresponding to the images as well as the predefined geometric and temporal constraints. Then, the 6 DoF poses of the movable object are computed using the coordinates of the corrected feature points and their corresponding camera matrixes.

Abstract: A divider for dividing a radio signal includes an input port, a plurality of output ports and a cavity having one surface coupled to the input port and other surface coupled to the plurality of output ports. The other surface is formed as a curved surface, and the plurality of output ports is disposed on the other surface at certain intervals. The side of the cavity is slantly formed from the one surface to the other surface at a certain angle. The distances between the input port and the plurality of output ports is the same.

Abstract: A role of molecular mechanisms determine the longevity of an organism, particularly, method of mimicking benefits of dietary restriction by transiently upregulating endoplasmic stress response.

Abstract: A method including: manufacturing a standard transmission object; simulating a transmission measurement process using simulation calculation method, to establish a database with respect to a transmission thickness, an equivalent water density, an original reconstruction density of the standard transmission object, a space angle cosine of the transmission source and an energy of a ? ray, fitting a corresponding relationship of the space angle cosine of the transmission source with respect to parameters of the standard transmission object and the energy of the ? ray based on the database; selecting a corresponding standard transmission object for transmission measurement for a transmission source to be characterized, to obtain an original reconstruction density of the standard transmission object; reading the space angle cosine of the transmission source to be characterized from the database according to fitted corresponding relationship of known parameters of the standard transmission object and the energy of

Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems, wherein the guide sequence is modified by secondary structure to increase the specificity of the CRISPR-Cas system and whereby the secondary structure can protect against exonuclease activity and allow for 5? additions to the guide sequence.

Abstract: 3D cell cultures and devices for 3D cell culture, and methods of use thereof are provided. In some embodiments, the 3D cell culture comprise pancreatic ? cells and can be generated in multi-well plates, allowing for high throughput assays on the cell culture.