Patents Assigned to INSTITUTE
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Patent number: 9746470Abstract: In some aspects, the invention provides methods of identifying, detecting, and/or measuring protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein activity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some aspects, the invention provides methods for identifying and/or characterizing compounds and/or for assessing compound specificity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some embodiments, a client protein is a kinase. In some embodiments, a compound is a kinase inhibitor. In some aspects, the invention provides methods of profiling kinase inhibitor specificity.Type: GrantFiled: May 9, 2012Date of Patent: August 29, 2017Assignee: Whitehead Institute for Biomedical ResearchInventors: Mikko Taipale, Susan Lindquist
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Patent number: 9744224Abstract: A immunogenic composition is provided for use in methods for treating or preventing the development of a cancer, comprising a nucleic acid sequence encoding a cancer antigen and a nucleic acid sequence encoding fibroblast activation protein (FAP). In one embodiment, the composition comprises a vector comprising a first expression cassette comprising a nucleic acid sequence encoding an antigen of a, operatively linked to an expression control sequence that directs the expression of the antigen in a mammalian host cell. The composition further contains a vector comprising a second expression cassette comprising a nucleic acid sequence encoding fibroblast activation protein (FAP) operatively linked to an expression control sequence directing the expression of FAP in a mammalian host cell. In one embodiment, the cancer is one in which tumor progression depends on the fibroblasts expressing fibroblast activation protein (FAP).Type: GrantFiled: June 23, 2016Date of Patent: August 29, 2017Assignee: The Wistar Institute of Anatomy and BiologyInventors: Hildegund C. J. Ertl, Ying Zhang
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Patent number: 9749081Abstract: Provided herein is a wavelength/bandwidth tunable optical filter capable of flexibly tuning a wavelength and bandwidth, the wavelength/bandwidth tunable optical filter including an optical circulator configured to receive a WDM (Wavelength-Division-Multiplexing) optical signal from an optical cable; and a plurality of wavelength-tunable optical filters configured to receive the WDM optical signal via the optical circulator, wherein the plurality of wavelength-tunable optical filters reflect wavelengths of different bandwidths from one another.Type: GrantFiled: February 1, 2016Date of Patent: August 29, 2017Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventor: Jong Sool Jeong
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Patent number: 9748141Abstract: Provided are a semiconductor device and a method for manufacturing the same. An example method may include: forming a first semiconductor layer and a second semiconductor layer sequentially on a substrate, wherein the first semiconductor layer is doped; patterning the second and first semiconductor layers to form an initial fin; forming a dielectric layer on the substrate to substantially cover the initial fin, wherein a portion of the dielectric layer on top of the initial fin has a thickness sufficiently less than that of a portion of the dielectric layer on the substrate; etching the dielectric layer back to form an isolation layer, wherein the isolation layer partially exposes the first semiconductor layer, thereby defining a fin above the isolation layer; and forming a gate stack intersecting the fin on the isolation layer.Type: GrantFiled: November 19, 2012Date of Patent: August 29, 2017Assignee: Institute of Microelectronics, Chinese Academy of SciencesInventor: Huilong Zhu
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Patent number: 9748555Abstract: A Ni—Mn composite oxalate powder is provided. The Ni—Mn composite oxalate powder includes a plurality of biwedge octahedron particles represented by the general formula: NiqMnxCoyMzC2O4.nH2O, wherein q+x+y+z=1, 0<q, x<1, 0?y<1, 0?z<0.15, 0?n?5, and M is at least one of Mg, Sr, Ba, Cd, Zn, Al, Ga, B, Zr, Ti, Ca, Ce, Y, Nb, Cr, Fe and V. The above powder may be further calcined with a lithium salt to form a lithium transition metal oxide powder for use as a positive electrode material in lithium ion-batteries.Type: GrantFiled: December 9, 2016Date of Patent: August 29, 2017Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, NATIONAL TAIWAN UNIVERSITYInventors: Hung-Chun Wu, Yu-Ting Chen, Nae-Lih Wu, Wen-Chin Chen, Shih-Chieh Liao, Yih-Chyng Wu
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Patent number: 9745366Abstract: This disclosure provides methods and compositions to inhibit or prevent infection of a cell by a bacteria that exports DNABII proteins by administering to a tissue infected with the bacteria an effective amount of an antibody that specifically recognizes and binds the DNABII proteins, thereby inhibiting or preventing infection of the bacteria. Treatment methods, screens and kits are further provided.Type: GrantFiled: September 22, 2014Date of Patent: August 29, 2017Assignees: University of Southern California, Research Institute at Nationwide Children's HospitalInventors: Steven D. Goodman, Sheryl S. Justice
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Method for determining color difference component quantization parameter and device using the method
Patent number: 9749632Abstract: Disclosed are a method for determining a color difference component quantization parameter and a device using the method. Method for decoding an image can comprise the steps of: decoding a color difference component quantization parameter offset on the basis of size information of a transform unit; and calculating a color difference component quantization parameter index on the basis of the decoded color difference component quantization parameter offset. Therefore, the present invention enables effective quantization by applying different color difference component quantization parameters according to the size of the transform unit when executing the quantization.Type: GrantFiled: October 31, 2016Date of Patent: August 29, 2017Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Sung Chang Lim, Hui Yong Kim, Se Yoon Jeong, Jong Ho Kim, Ha Hyun Lee, Jin Ho Lee, Jin Soo Choi, Jin Woong Kim -
Patent number: 9746356Abstract: According to embodiments of the present invention, a sensor for determining a flow parameter of a fluid is provided. The sensor includes a polymer membrane, an elongate microstructure extending from the polymer membrane, and a hydrogel coupled to at least a portion of the elongate microstructure, wherein the hydrogel and the elongate microstructure are arranged to cooperate to cause a displacement of the polymer membrane in response to a fluid flowing and interacting with the sensor, and wherein the sensor is configured to provide a measurement indicative of a flow parameter of the fluid based on the displacement of the polymer membrane. According to further embodiments of the present invention, a method for forming a sensor and a method of controlling a sensor are also provided.Type: GrantFiled: December 31, 2013Date of Patent: August 29, 2017Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ajay Giri Prakash Kottapalli, Jianmin Miao, Mohsen Asadniaye Fard Jahromi, Michael Triantafyllou
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Patent number: 9748422Abstract: A semiconductor nanocrystal include a first I-III-VI semiconductor material and have a luminescence quantum yield of at least 10%, at least 20%, or at least 30%. The nanocrystal can be substantially free of toxic elements. Populations of the nanocrystals can have an emission FWHM of no greater than 0.35 eV.Type: GrantFiled: January 22, 2009Date of Patent: August 29, 2017Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Peter Matthew Allen, Moungi G. Bawendi
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Patent number: 9747144Abstract: There are provided a function processing apparatus and function processing method dynamically process network function using commands. A function processing apparatus includes a communication unit for performing communication with at least one user interface and at least one software component, and a controller for, if first command related information is received from the at least one software component, forming a command tree on the basis of the first command related information and transmitting the first command related information to the at least one user interface, and, if second command related information is received from at least one user interface, transmitting the second command related information to a software component corresponding to the second command related information.Type: GrantFiled: June 23, 2016Date of Patent: August 29, 2017Assignee: Electronics and Telecommunications Research InstituteInventors: Pyung Koo Park, Hyub Woo Jeon, Ho Yong Ryu
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Patent number: 9744526Abstract: A SAPO-34 molecular sieve and method for preparing the same, whose chemical composition in the anhydrous state is expressed as: mSDA.(SixAlyPz)O2, wherein m is 0.08-0.3, x is 0.01-0.60, y is 0.2-0.60, z is 0.2-0.60, and x+y+z=1. The template agent SDA is in micropores of the molecular sieve. SDA is an organic amine with the structural formula (CH3)2NRN(CH3)2, wherein R is a saturated straight-chain or branched-chain alkylene group with having from 2-5 carbon atoms. There is a slight Si enrichment phenomenon on the crystal surface of the molecular sieve crystal, and the ratio of the surface Si content to the bulk Si content of the crystal ranges from 1.50-1.01. Said SAPO-34 molecular sieve, after being calcined at a temperature range from 400-700° C. in air, can be used as a gas adsorbent and catalyst for an acid-catalyzed reaction or oxygenate to olefin reaction.Type: GrantFiled: September 26, 2012Date of Patent: August 29, 2017Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Peng Tian, Zhongmin Liu, Dong Fan, Xiong Su, Ying Zhang, Yue Yang
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Patent number: 9749170Abstract: A method and apparatus for generating a sampling frequency are provided. A signal is generated, of which frequency is a predetermined multiple of a reference clock, and a frequency offset in a channel is extracted from the entire frequency offset. The amount of shift is calculated by dividing the extracted frequency offset by a predetermined value, and a final sampling frequency is obtained by shifting the frequency of the generated signal by the amount of shift.Type: GrantFiled: May 27, 2015Date of Patent: August 29, 2017Assignee: Electronics and Telecommunications Research InstituteInventor: Dukhyun You
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Patent number: 9749526Abstract: Security guards at big facilities, such as airports, monitor multiple screens that display images from individual surveillance cameras dispersed throughout the facility. If a guard zooms with a particular camera, he will lose image resolution, along with perspective on the surrounding area. Embodiments of the inventive Imaging System for Immersive Surveillance (ISIS) solve these problems by combining multiple cameras in one device. When properly mounted, example ISIS systems offer 360-degree, 100-megapixel views on a single screen. (Other resolutions may also be employed.) Image-stitching software merges multiple video feeds into one scene. The system also allows operators to tag and follow targets, and can monitor restricted areas and sound an alert when intruders breach them.Type: GrantFiled: April 21, 2015Date of Patent: August 29, 2017Assignee: Massachusetts Institute of TechnologyInventors: Daniel B. Chuang, Lawrence M. Candell, William D. Ross, Mark E. Beattie, Cindy Y. Fang, Bobby Ren, Jonathan P. Blanchard
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Patent number: 9749098Abstract: A method and apparatus of receiving system information of an SeNB, including configuring connection to an MeNB and receiving a RRC Connection Reconfiguration message including the system information of a cell included in a SCG controlled by the SeNB, and a method of sharing frame offset between a MCG controlled by an MeNB and an SCG controlled by an SeNB connected to the MeNB through non-ideal backhaul, including measuring system frame number (SFN) and subframe number (SN) of a cell included in the SCG and sharing the frame offset, which is determined based on the SFN and the SN, with the MeNB or the SeNB are provided.Type: GrantFiled: May 8, 2015Date of Patent: August 29, 2017Assignee: Electronics and Telecommunications Research InstituteInventors: Seung-Kwon Baek, Eunkyung Kim, Kwang Jae Lim, Jae Sun Cha, Sung Cheol Chang
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Patent number: 9746587Abstract: Disclosed herein is a shape-variable optical element including: a shape-variable lens; a first electrode unit configured to be connected to the shape-variable lens; a second electrode unit configured to face the first electrode unit; and a deformation part configured to be disposed between the first electrode unit and the second electrode unit.Type: GrantFiled: June 26, 2014Date of Patent: August 29, 2017Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Ki-Uk Kyung, Sung-Ryul Yun, Sun-Tak Park, Bong-Je Park, Sae-Kwang Nam
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Patent number: 9747414Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.Type: GrantFiled: May 23, 2014Date of Patent: August 29, 2017Assignee: Industrial Technology Research InstituteInventors: Chao-Chi Pan, Jenn-Yeh Fann, Chung-Fan Chiou, Hung-Chi Chien, Hui-Ling Chen
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Patent number: 9746745Abstract: A zoom lens is provided, which includes an electrode pattern on a substrate, and a liquid-crystal material on the electrode pattern. The electrode pattern includes a plurality of concentric ring electrodes surrounding an innermost electrode. Each of the concentric ring electrodes has an opening. A first trace extends from a first electrode out of an outermost concentric ring electrode to the innermost electrode. The first trace has greater resistance than the concentric ring electrodes and the innermost electrode. A second trace connecting the innermost electrode and a second electrode out of the outermost concentric ring electrode through the openings. The liquid-crystal material includes a liquid-crystal compound with a chemical structure of wherein R is C4-10 alkyl group, n=1 or 2, and each of X is independently H or F.Type: GrantFiled: December 22, 2016Date of Patent: August 29, 2017Assignee: Industrial Technology Research InstituteInventors: Chien-Wen Lin, Yi-Lang Tsai, Shih-Hsien Liu, Kung-Lung Cheng, Huang-Ming Philip Chen
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Patent number: 9749164Abstract: Systems, apparatus, and methods of asynchronous digital communication include at least one transmitter and/or at least one receiver communicatively coupleable to at least one communication interface for encoding and transmitting digital information as and/or receiving and decoding digital information from a transition between a first symbol and a second symbol, based on a predetermined relationship between the first symbol and the second symbol in such a way that the timing of the symbols is no longer relevant.Type: GrantFiled: July 23, 2015Date of Patent: August 29, 2017Assignee: Massachusetts Institute of TechnologyInventors: Grant Seaman Anderson, Charles Giona Sodini
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Patent number: 9746575Abstract: Borehole electromagnetic exploration or tomography (EM tomography). An induction type broadband 3-component borehole magnetic measuring sensor can accurately and precisely measure a broadband magnetic field about x, y and z axes using a three-dimensional (3D) model within a borehole by monitoring natural variations in the earth's magnetic field or based on EM tomography using the borehole. The measuring sensor is applicable to energy resource fields such as petroleum and coal, mineral resources fields and civil engineering and environmental fields.Type: GrantFiled: October 31, 2014Date of Patent: August 29, 2017Assignee: Korea Institute of Geoscience and Mineral ResourcesInventors: Tae Jong Lee, Yoonho Song, Myeong Jong Yi
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Patent number: 9748600Abstract: The present invention relates to a novel phosphate based composite anode material, preparation method and uses thereof. Specifically disclosed is a phosphate based composite cell anode material, the material having monoclinic and orthorhombic crystal lattice structures with the chemical formula of A3?xV2?yMY(PO4)3, wherein A is Li+, Na+ or the mixture thereof, M is Mg, Al, Sc, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn or Nb, 0?x?3.0, 0?y?2.0, and C is the carbon layer. Also disclosed are a preparation method and uses of the composite material. Unlike simple physical mixing, the composite material of the present invention has the advantages of an adjustable electric potential plateau, high reversible capacity, good cycle stability, power consumption early warning and the like.Type: GrantFiled: September 12, 2012Date of Patent: August 29, 2017Assignee: Ningbo Institute of Materials Technology & Engineering, Chinese Academy of SciencesInventors: Yuanhao Tang, Chenyun Wang, Deyu Wang, Jun Li