Abstract: The invention provides compounds of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom ? with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom ? with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R1 is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims.

Abstract: Porous cross-linked polyimide-urea networks are provided. The networks comprise a subunit comprising two anhydride end-capped polyamic acid oligomers in direct connection via a urea linkage. The oligomers (a) each comprise a repeating unit of a dianhydride and a diamine and a terminal anhydride group and (b) are formulated with 2 to 15 of the repeating units. The subunit was formed by reaction of the diamine and a diisocyanate to form a diamine-urea linkage-diamine group, followed by reaction of the diamine-urea linkage-diamine group with the dianhydride and the diamine to form the subunit. The subunit has been cross-linked via a cross-linking agent, comprising three or more amine groups, at a balanced stoichiometry of the amine groups to the terminal anhydride groups. The subunit has been chemically imidized to yield the porous cross-linked polyimide-urea network. Also provided are wet gels, aerogels, and thin films comprising the networks, and methods of making the networks.

Abstract: Disclosed is a digital phase-locked-loop including: a time-to-digital converter (TDC) configured to output a digital bit based on an input clock and a reference clock, in which the TDC includes: a first arbiter group configured to compensate for a phase difference between the input clock and the reference clock with a first average offset and output a first logic value; a second arbiter group configured to compensate for a phase difference between the input clock and the reference clock with a second average offset and output a second logic value; and a signal processor configured to output the digital bit based on the first and second logic values.

Abstract: A reactor containing a heat exchanger is disclosed, which can be operated with co-current or counter-current flow. Also disclosed is a system that includes a reactor having a reformer and a vaporizer, a fuel supply, and a water supply. The reactor includes a source of combustion gas, a reformer operative to receive reformate, and a vaporizer operative to receive water. The reformer and vaporizer each include a stack assembly formed by a combination of separator shims and channel shims. The separator shims and channel shims are stacked in a regular pattern to form two sets of channels within the stack assembly. One set of channels will have vertical passageways at either end and a horizontal flowpath between them, while the other set of channels has only a horizontal flowpath.

Abstract: Embodiments of the invention include a method inserting a new face in a polygonal mesh comprising receiving an input corresponding to: a polygonal mesh having a plurality of faces, a selection of a face (fm) of the plurality of faces, a direction vector (d), a modified target plane (pm), and a threshold angle ?. For each edge (e) of the selected face fm, the method further includes determining each adjacent face (fadj) to selected face fm, and inserting a new face at edge e if no adjacent face exists or if fadj is substantially parallel to pm and within threshold ?. In some embodiments, the new face has a normal orthogonal to e and d.

Abstract: Exemplary embodiments of the present invention relate to a low-power current mode logic (CML)-less transmitter architecture. A transmitter comprises a main multiplexer configured to generate a main data signal by multiplexing parallel main data signals retimed from a retimer for time margin between parallel input data signals and a multiphase clock signals from a clock distributor, a secondary multiplexer configured to generate a post data signal by multiplexing parallel post data signals retimed from the retimer, and a plurality of output drivers configured to generate a serial data signal by summing the main data signal and the post data signal.

Abstract: A chip-scale, air-clad semiconductor pedestal waveguide can be used as a mid-infrared (mid-IR) sensor capable of in situ monitoring of organic solvents and other analytes. The sensor uses evanescent coupling from a silicon or germanium waveguide, which is highly transparent in the mid-IR portion of the electromagnetic spectrum (e.g., between ?=1.3 ?m and ?=6.5 ?m for silicon and ?=1.3 ?m and ?=12.0 ?m for germanium), to probe the absorption spectrum of the fluid surrounding the waveguide. Launching a mid-IR beam into the waveguide exposed to a particular analyte causes attenuation of the evanescent wave's spectral components due to absorption by carbon, oxygen, hydrogen, and/or nitrogen bonds in the surrounding fluid. Detecting these changes at the waveguide's output provides an indication of the type and concentration of one or more compounds in the surrounding fluid.

Abstract: An electrode for solar conversion including a porous structure configured to contain therein at least one of an electrolyte, a catalyst, a chromophore, a redox couple, a hole-conducting polymer, an electron-conducting polymer, a semiconducting organic conjugated polymer, an electron acceptor, and a hole acceptor. The porous structure has a set of electrically conductive nanoparticles adjoining each other. The set of electrically conductive nanoparticles forms a meandering electrical path connecting the nanoparticles together. The porous structure has a semiconductive coating disposed conformally on the electrically conductive nanoparticles to form an exterior surface for reception of charge carriers.

Abstract: A thermoelectric conversion module according to one aspect of embodiments of the present invention as disclosed herein includes a plurality of layered planar bodies. Each of the plurality of layered planar bodies includes a base material having a planar shape, a plurality of p-type granular bodies made of a p-type thermoelectric material, and a plurality of n-type granular bodies made of an n-type thermoelectric material. The plurality of p-type granular bodies and the plurality of n-type granular bodies are held by the base material in such a manner as to be spaced apart from each other in a direction along a face of the base material crossing a layered direction of the plurality of layered planar bodies.

Abstract: Network-coding-enabled reliability architectures and techniques are provided that are capable of enhancing data transfer reliability and efficiency in next generation wireless networks. In some embodiments, the techniques and architectures utilize a flexible thread-based coding approach to implement network coding. The techniques and architectures may also, or alternatively, utilize systematic intra-session random linear network coding as a packet erasure code to support reliable data transfer.

Abstract: Disclosed herein is a gait rehabilitation apparatus including a first frame having a bottom surface which is movable at predetermined speed; a second frame extending upwards from a tip of the first frame; a load support unit which is mounted to an upper end of the second frame and is rotatable about a rotation axis thereof; a connection string, one end of which is connected to the load support unit, and the other end of which is connected to an upper body of a rehabilitant; a safety bar which is connected to the second frame and is rotatable so as to be tilted upwards; and a gait assistance link member which has a structure able to be tilted upwards, and is connected to each leg of the rehabilitant entering onto the first frame to assist rehabilitation training of the rehabilitant through mechanical movement of the gait assistance link member.

Abstract: Some embodiments relate to a device for generating stimulation signals, comprising: a stimulation delivery circuit; a first component to monitor charge delivered in at least one charge pulse via the stimulation delivery circuit; and a second component to ensure delivered charge substantially corresponds to charge of a charge pulse intended to be delivered by the stimulation delivery circuit. In some embodiments, the device may further comprise a charge setting circuit responsive to a charge pulse setting signal, such as a constant current of fixed pulse width, to set the charge of the charge pulse intended to be delivered.

Abstract: The present invention relates compounds for stabilizing cells and methods of their use.

Abstract: The present invention relates to a method of providing proximity service communication between terminals. In accordance with an embodiment, a first terminal makes connection to a second terminal with network assistance. The first terminal requests information required to search for the second terminal from a network management server. The network management server determines a communication mode for proximity service communication. The network management server transmits a request message requesting communication between the first terminal and the second terminal in the communication mode to the first and second terminals. In accordance with another embodiment, a first terminal may switch its proximity service communication technology for better QoS without network assistance. The first terminal monitors link status. If the link status is deteriorated, the first terminal requests a second terminal to change proximity service communication technology.

Abstract: A dosing regime for providing therapy for a neurological trauma such as spinal cord injury in a human subject. The dosing regime comprises intravenous administration of a plurality of minocycline doses for a 7-day period at 12-h intervals such that a steady state level of minocycline is reached and maintained in a subject's serum and/or cerebrospinal fluid after administration of three minocycline doses. An initial minocycline dose of at least 800 mg is preferably administered within 12 h after an occurrence of the neurological trauma. The minocycline dosage is sequentially tapered to 400 mg and then maintained at 400 mg for the remainder of the 7-day treatment period.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Abstract: Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ECM) deposition, interstitial fibroblasts, interstitial volume, expression of Collagen I mRNA and protein, expression of profibrotic cytokines and macrophage infiltration by Cysteamine treatment.

Abstract: The use of a medical care algorithm in clinical care reduces the number of mistakes made in treating a patient. The use of a medical care algorithm in clinical care also increases the confidence of a health care provider in providing care for a patient. The invention provides a system and a method for effectively, thoroughly, and easily granting a health care provider with real-time access to critical, semi-critical, and non-critical medical care algorithms. The invention also provides a system and a method for a health care provider to consult proactive guidelines commonly used in health care. The invention also allows the health care provider a method to utilize the algorithms as a refresher tool for review and continuing education. Furthermore, the invention provides a method for the documentation of algorithm based treatments as an electronic medical record.

Abstract: Piezoelectric oriented ceramics containing a Pb(Ti, Zr)O3-based compound having a high degree of orientation not lower than 0.64, which was calculated with the Lotgering method based on an X-ray diffraction pattern in a prescribed cross-section thereof, and having a sintered density not lower than 85% of a theoretical density.