Abstract: Disclosed is a multi-channel atomic magnetic detector (100), including at least one detection assembly, with each detection assembly including a plurality of detection air chambers (130) in the same plane and a light-splitting member (110) for allocating polarized beams from a light source (180) to each detection air chamber (130) in the detection assembly, wherein the plurality of detection air chambers (130) of each detection assembly are arranged in a centrally symmetric manner or an axially symmetric manner relative to the light-splitting member (110). The multi-channel atomic magnetic detector (100) has a high detection density and is beneficial for noise reduction.
Type:
Grant
Filed:
December 9, 2019
Date of Patent:
September 20, 2022
Assignees:
COGNITIVE MEDICAL IMAGING LTD., INSTITUTE OF BIOPHYSICS, CHINESE ACADEMY OF SCIENCES
Abstract: The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 18F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.
Type:
Grant
Filed:
August 19, 2020
Date of Patent:
September 20, 2022
Assignees:
California Institute of Technology, The Regents of the University of California
Inventors:
Christopher Martin Waldmann, Anton A. Toutov, Jennifer Marie Murphy, Robert H. Grubbs
Abstract: Systems and methods for the annotation of source data in accordance with embodiments of the invention are disclosed. In one embodiment, a data annotation server system obtains a set of source data, provides at least one subset of source data to at least one annotator device, obtains a set of annotation data from the at least one annotator device for each subset of source data, classifies the source data based on the annotation data using a machine classifier for each subset of source data, generates annotator model data describing the characteristics of the at least one annotator device, and generates source data model data describing at least one piece of source data in the set of source data, where the source data model data includes label data identifying the estimated ground truth for each piece of source data in the set of source data.
Type:
Grant
Filed:
March 19, 2018
Date of Patent:
September 20, 2022
Assignee:
California Institute of Technology
Inventors:
Pietro Perona, Grant Van Horn, Steven J. Branson
Abstract: Provided is a structure for operating a watertight door by use of buoyancy. The structure includes: a detention tank for storing rainwater flowing from a street inlet; a buoyant member which is installed in the detention tank; and a sensor installed in the detention tank, in which if the buoyant member raised by the buoyant of the rainwater collected in the detention tank comes into contact with the sensor, the watertight door is automatically operated. The watertight door structure manually operated at localized heavy rain is improved, and the watertight door is automatically operated if the water level reaches the predetermined level.
Type:
Grant
Filed:
October 16, 2020
Date of Patent:
September 20, 2022
Assignee:
KOREA INSTITUTE OF CIVIL ENGINEERING AND BUILDING TECHNOLOGY
Inventors:
In Hwan Park, Dong Sop Rhee, Ho Je Seong
Abstract: A lithium metal secondary battery including: an electrode assembly including a positive electrode, a lithium metal negative electrode, a separator interposed between the positive electrode and the lithium metal negative electrode, a protective layer interposed between the lithium metal negative electrode and the separator; and a non-aqueous electrolyte injected to the electrode assembly, wherein the protective layer includes a polymer having a sulfur chain group. A battery module including the lithium metal secondary battery is also disclosed.
Type:
Grant
Filed:
May 10, 2019
Date of Patent:
September 20, 2022
Assignees:
LG ENERGY SOLUTION, LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Jong-Keon Yoon, Kyung-Hwa Woo, Hyun-Jun Choi, Hye-Jin Lee, Hoe-Jin Hah, Hee-Tak Kim, Young-Il Roh, Hyun-Soo Jin
Abstract: The present invention comprises methods of treating an infection using a pharmaceutical composition comprising an active ingredient selected from Table 1. In some aspects, the infection can be caused by one or more pathogens, including fungal pathogens. For example, the infection may be Valley Fever.
Type:
Grant
Filed:
July 6, 2020
Date of Patent:
September 20, 2022
Assignees:
The Translational Genomics Research Institute, Arizona Board of Regents on behalf of Northern Arizona University
Inventors:
David Engelthaler, Elizabeth Driebe, Hongwei “Holly” Yin, Michael Valentine, Donald Chow, Jolene Bowers, Paul Keim, Bridget Barker
Abstract: The present invention provides methods for treating cancer using combinations of bromodomain and extra-terminal (BET) protein inhibitors and certain chemotherapeutic drugs.
Type:
Grant
Filed:
November 7, 2014
Date of Patent:
September 20, 2022
Assignee:
Dana-Farber Cancer Institute, Inc.
Inventors:
James E. Bradner, Michael R. McKeown, Margaret A. Shipp, Bjoern Chapuy, Kwok-kin Wong, Zhao Chen
Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
Type:
Grant
Filed:
March 29, 2020
Date of Patent:
September 20, 2022
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Avinoam D. Bar-Zion, Atousa Nourmahnad, David Maresca, Mikhail Shapiro
Abstract: Apparatus and methods are disclosed for restoring operation of a power grid comprising a plurality of reclosers and distributed energy resources (DERs) responsive to abnormal conditions by determining and implementing a reconfiguration for the power grid. The reconfiguration can specify respective new statuses for one or more of the reclosers and/or respective quantities of reactive power to be supplied by one or more of the DERs. The reconfiguration can be determined based on a plurality of constraints using an objective function, the constraints being determined based at least in part on recloser status data and/or DER power generation capability data. Respective cleared quantities of reactive power for the DERs to supply to the reconfigured power grid can be determined via a transactive control scheme, and the reconfiguration can be updated prior to implementation based on the results of the transactive control scheme.
Type:
Grant
Filed:
November 4, 2019
Date of Patent:
September 20, 2022
Assignee:
Battelle Memorial Institute
Inventors:
Nikitha Radhakrishnan, Jacob Hansen, Saptarshi Bhattacharya, Kevin P. Schneider, Bishnu P. Bhattarai, Wei Du, Md Jan E Alam, Abhishek Somani
Abstract: Disclosed is a battery pre-processing apparatus and method. The battery pre-processing apparatus includes a control mechanism, as well as an automatic feeding mechanism, a transmission mechanism, an electricity monitoring actuator, a non-destructive testing mechanism, a flexible grabber mechanism, a multi-station operating table, an automatic cutting mechanism, an automatic separation mechanism, and a recovery and dust collection system that are each electrically connected to the control mechanism.
Type:
Grant
Filed:
December 10, 2018
Date of Patent:
September 20, 2022
Assignee:
INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES
Inventors:
Hongbin Cao, Fei Kang, Zhi Sun, Xionghui Lu
Abstract: The present disclosure provides a neural network training device for recognizing a class of an object included in an image based on an artificial intelligence (AI) system and an application thereof, the neural network training method including: acquiring, by using a first learning network model trained based on source training images respectively included in at least one class, feature information of a query image included in a class different from the at least one class; obtaining a generated image from the feature information of the query image by using a second learning network model acquiring feature information of the obtained generated image by using the first learning network model; and updating weights of layers respectively included in the first and second learning network models, based on a difference between the feature information of the query image and the feature information of the generated image and on a difference between the query image and the generated image.
Type:
Grant
Filed:
September 4, 2018
Date of Patent:
September 20, 2022
Assignees:
SAMSUNG ELECTRONICS CO., LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Jun-mo Kim, Byung-ju Kim, Joo-chang Kim, Ye-gang Lee, Min-seok Park, Ju-seung Yun, Jae-young Lee, Dong-gyu Joo
Abstract: Provided are an apparatus and method for experiencing an augmented reality (AR)-based screen sports match which enable even a child, an elderly person, and a person with a disability to easily and safely experience a ball sports match, such as tennis, badminton, or squash, as a screen sports match without using a wearable marker or sensor, a wearable display, an actual ball, and an actual tool.
Type:
Grant
Filed:
June 29, 2021
Date of Patent:
September 20, 2022
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Jong Sung Kim, Youn Hee Gil, Seong Min Baek, Hee Sook Shin, Seong Il Yang, Cho Rong Yu, Sung Jin Hong
Abstract: The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.
Type:
Grant
Filed:
April 9, 2019
Date of Patent:
September 20, 2022
Assignee:
Institute of Pharmacology and Toxicology Academy of Millitary
Medical Sciences P.L.A. China
Inventors:
Wu Zhong, Song Li, Yanqun Zeng, Junhai Xiao, Xinbo Zhou, Zhibing Zheng, Xingzhou Li, Xiaokui Wang
Abstract: A support mechanism includes a fixed body, a rotating unit, a moving unit and a driving unit. The rotating unit is rotationally mounted to the fixed body. The moving unit, disposed at the fixed body, includes a ball screw spline shaft, a ball screw nut and a ball spline nut. The ball screw nut and the ball spline nut are both rotatably disposed at the ball screw spline shaft moved together with the rotating unit. The driving unit, disposed at the fixed body, includes a first driving member and a second driving member to rotate the ball screw nut and the ball spline nut, respectively. With different rotation pairs of the ball screw nut and the ball spline nut to the ball screw spline shaft, the ball screw spline shaft is driven to move, and the ball screw spline shaft is further to move the rotating unit.
Type:
Grant
Filed:
September 24, 2019
Date of Patent:
September 20, 2022
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.
Type:
Grant
Filed:
June 16, 2017
Date of Patent:
September 20, 2022
Assignee:
SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH
Inventors:
David Gin, Michelle Adams, Kai Deng, Philip Livingston, Govindaswami Ragupathi, Eric Chea, Alberto Fernandez-Tejada, Lars Ulrik Nordstroem, William Walkowicz, Jeffrey Gardner, Derek Tan
Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
Type:
Grant
Filed:
March 12, 2020
Date of Patent:
September 20, 2022
Assignee:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Inventors:
Nicholas David Peter Cosford, Dhanya Raveendra-Panickar, Douglas J. Sheffler, John Howard Hutchinson, Reto Andreas Gadient
Abstract: The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.
Type:
Grant
Filed:
January 11, 2019
Date of Patent:
September 20, 2022
Assignee:
Korea Research Institute Of Bioscience And Biotechnology
Inventors:
Bo Yeon Kim, Joonsung Hwang, Nak Kyun Soung, Jong Seog Ahn, Kyung Ho Lee, Jiyun Mun, Srinivasrao Ganipisetti, Hyunjoo Cha, Mija Ahn, Hee Gu Lee, Jae-Hyuk Jang, In Ja Ryoo, Sung-Kyun Ko
Abstract: A resource management method, a resource management system, and a workload scheduling apparatus for network slicing are provided. In the method resource management, a service request related to an application type of a terminal device is received. A monitoring report of the terminal device is obtained according to the service request. The monitoring result relates to a condition of the radio resource used by the terminal device. A usage situation of a slicing resource is analyzed based on the slicing resource requested by the service request and the monitoring report to predict a predicted arrangement result of the slicing resource. The slicing resource requested by the service result is arranged according to the predicted arrangement result to transmit a corresponding setting configuration to the radio access network. The setting configuration serves to adjust the slicing resource. Accordingly, the request of the service and the current condition are fulfilled.
Type:
Grant
Filed:
December 25, 2020
Date of Patent:
September 20, 2022
Assignee:
Industrial Technology Research Institute
Abstract: In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of pro teases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions (e.g., metastatic cancer, infection with certain pathogenic agents).
Type:
Grant
Filed:
April 7, 2017
Date of Patent:
September 20, 2022
Assignee:
Massachusetts Institute of Technology
Inventors:
Sangeeta N. Bhatia, Darrell J. Irvine, Karl Dane Wittrup, Andrew David Warren, Jaideep S. Dudani, Naveen K. Mehta