Abstract: An embodiment of the present disclosure provides an etching method, having the following steps: forming a modified layer having a thickness of one or several atom layers on a selected region of a surface of a semiconductor material layer by using a modifier; and removing the modified layer. When a semiconductor is processed, this method achieves precise control over the etching thickness and improves the etching rate at the same time.

Abstract: Disclosed are an intelligent separation and drying system for maggots and a method of operating the same. The intelligent separation and drying system includes an intelligent light control unit, an intelligent scraping unit, a separation unit, a drying unit, a travelling unit and a central control unit. The central control unit is connected to other units through signals. Multidisciplinary techniques, including spectrum analysis, machine learning algorithm and artificial neural network, are combined to automatically, systematically, intelligently and continuously separate maggots and maggot feed as well as dry the maggots with high efficiency in a clean manner.

Abstract: The application relates to a compound of Formula (I) which modulate the amount of STK4, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease or disorder associated with the modulation of STK4.

Abstract: Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Abstract: Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein.

Abstract: A method for detecting an anchor-free object based on deep learning may include receiving a target image for object detection, inputting the image to a backbond network and performing learning to generate a heatmap, post-processing the heatmap, and outputting the post-processed result on a screen.

Abstract: A flying capacitor multilevel (FCML) converter including a gate driver circuit comprising a DC-DC flyback converter having a plurality of isolated outputs. In various examples, the FCML circuit further includes a first control circuit connected to the FCML circuit determining the load current associated with a desired power output from the load; and determining a desired output voltage associated with the load current; a second control circuit that drives an inductor current (IL) through the inductor so that the output applies an output voltage comprising the desired output voltage; and a third control circuit obtaining a comparison of an average of the inductor current (IL) through the inductor with a predetermined reference current (ILREF) and setting the duty cycle so that the average does not exceed the predetermined reference current. Also described is the converter driving a load comprising a plasma and a propulsion system comprising the converter.

Abstract: Provided are a system and method for managing a neuromorphic memory. The system includes a memory having a multi-dimensional lattice structure, a prescience estimator (PSE) configured to separately estimate memory use of two or more data sets and determine a sequence of inputting the two or more data sets to the memory, and a prescience manager (PSM) configured to allocate memory regions in which the two or more data sets will be stored according to estimation results of the PSE, store the data sets, and perform learning and inference.

Abstract: Devices and methods described herein decode a sequence of coded symbols by guessing noise. In various embodiments, noise sequences are ordered, either during system initialization or on a periodic basis. Then, determining a codeword includes iteratively guessing a new noise sequence, removing its effect from received data symbols (e.g. by subtracting or using some other method of operational inversion), and checking whether the resulting data are a codeword using a codebook membership function. This process is deterministic, has bounded complexity, asymptotically achieves channel capacity as in convolutional codes, but has the decoding speed of a block code. In some embodiments, the decoder tests a bounded number of noise sequences, abandoning the search and declaring an erasure after these sequences are exhausted. Abandonment decoding nevertheless approximates maximum likelihood decoding within a tolerable bound and achieves channel capacity when the abandonment threshold is chosen appropriately.

Abstract: The present disclosure provides multispecific (e.g., bispecific) antibodies that specifically bind to human GITR and/or human OX40 as well as compositions comprising such antibodies. In a specific aspect, the multispecific antibodies specifically bind to human GITR and OX40 and modulate GITR and/or OX40 activity, e.g., enhance, activate, or induce GITR and/or OX40 activity, or reduce, deactivate, or inhibit GITR and/or OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., enhances, activates, or induces GITR and/or OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., reduces, deactivates, or inhibits GITR and/or OX40 activity.

Abstract: An anonymous credential authentication system receives an anonymous credential signature value indicating that setting proposition information using a credential is satisfied from a user device that has been issued the credential combined with multiple pieces of attribute information constituting personal information, generates signer authentication information that confirms a signer of the anonymous credential signature value using an opening key, and outputs the signer authentication information.

Abstract: A fluorescent member according to present invention is composed of a sintered body for wavelength conversion containing a matrix containing magnesium oxide and magnesium hydroxide as main components, and phosphor particles dispersed in the matrix. A thermal conductivity of the fluorescent member is preferably 5 W/(m·K) or higher. A fluorescent member having both a satisfactory thermal conductivity and a satisfactory fluorescent property is provided without requiring a high-temperature sintering process (a high-temperature process at a temperature higher than 250° C.). Further, a method for manufacturing such a fluorescent member and a light-emitting apparatus using such a fluorescent member are provided.

Abstract: It remains a challenge to generate coherent radiation in the spectral range of 0.1-10 THz (“the THz gap”), a band for applications ranging from spectroscopy to security and high-speed wireless communications. Here, we disclose how to produce coherent radiation spanning the THz gap using efficient second-harmonic generation (SHG) in low-loss dielectric structures, starting from an electronic oscillator (EO) that generates coherent radiation at frequencies of about 100 GHz. The EO is coupled to cascaded, hybrid THz-band dielectric cavities that combine (1) extreme field concentration in high-quality-factor resonators with (2) nonlinear materials enhanced by phonon resonances. These cavities convert the input radiation into higher-frequency coherent radiation at conversion efficiencies of >103%/W, making it possible to bridge the THz gap with 1 W of input power.

Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.

Abstract: A gallium nitride structure that includes: a substrate; a gallium nitride layer opposed to the substrate and containing gallium nitride as a main component thereof; and a first electrode between the gallium nitride layer and the substrate. The first electrode includes at least one hafnium layer containing a single metal of hafnium as a main component thereof, and the at least one hafnium layer is in contact with the gallium nitride layer.

Abstract: A system and related method for predicting movement of a plurality of pedestrians may include one or more processors and a memory. The memory includes an initial trajectory module, an exit point prediction module, a path planning module, and an adjustment module. The modules include instructions that when executed by the one or more processors cause the one or more processors to obtain trajectories of the plurality of pedestrians, predict future exit points for the plurality of pedestrians from a scene based on the trajectories of the plurality of pedestrians, determine trajectory paths of the plurality of pedestrians based on the future exit points and at least one scene element of a map, and adjust the trajectory paths based on at least one predicted interaction between at least two of the plurality of pedestrians.

Abstract: Disclosed is a pyrimidinone-containing compound represented by formula I, a preparation method thereof, a pharmaceutical composition, and an application thereof. The pyrimidinone-containing compound of the present disclosure can be used as HIV-1 inhibitor and can be also used in the treatment of human immunodeficiency virus infection.

Abstract: A rotating grooming brush comprising a brush hub having grooming elements and shroud elements, and method for grooming a surface having an unwanted material thereon. The elements extend from the brush hub and may be positioned near its outer periphery. The elements may be grooming elements forming an array and shroud elements forming a shroud array. A rigid or elastomeric shroud extending from the brush hub surface may optionally be included about the edge of the brush hub, to the outside of the grooming elements. Rotation of the grooming attachment brush causes a low pressure region to build in the central area of the brush. This low pressure region creates a resulting force that forcefully attracts the grooming attachment brush to the surface to be groomed. The resulting force is controlled by the diameter of the brush hub, arrangement, of the elements and the speed of rotation.

Abstract: The present invention provides a method for improving transformation efficiency of a plant. The method according to the present invention comprises the use of a nucleic acid encoding the amino acid sequence set forth in SEQ ID NO: 2 or 4, or a nucleic acid encoding a polypeptide comprising an amino acid sequence having at least 85% identity with the amino acid sequence set forth in SEQ ID NO: 2 or 4, and having a function of improving transformation efficiency of a plant.

Abstract: The present invention relates to the design, fabrication and applications of three-dimensional (3D) bioreactor for cell expansion and cell secreted substance production. The bioreactors have relatively low levels of potentially cytotoxic compounds, can be coated with substituted or unsubstituted poly(p-xylene) type coatings and can also be separately formed from liquid crystal photopolymerizable monomers.