Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

Abstract: The present disclosure provides crystalline polymorphs of 5-aza-4?-thio-2?-deoxycytidine. The crystalline polymorphs may be formulated in a pharmaceutical composition, optionally in combination with an additional chemotherapeutic agent. The crystalline polymorphs are useful to treat various diseases including blood cancers, such as myelodysplastic syndrome and leukemia. A process for preparing the crystalline polymorphs of 5-aza-4?-thio-2?-deoxycytidine is also disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Compositions and methods are provided herein for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The compositions include fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named a PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap which is synthesized by the polymerase of the fusion protein and which becomes incorporated into the target DNA molecule.

Abstract: Provided is a search system that executes a path search in a graph (a material property relationship graph) in which each material property parameter of a material property parameter pair whose relationship is already known is node and a relationship between the material property parameters is an edge, the search method capable of executing various search methods and various search systems. The search system includes a graph searcher that executes a path search in a material property relationship graph, and a search condition extractor that supplies a plurality of search items to the graph searcher based on search conditions to be input. The search condition extractor extracts, based on the input search conditions, a start point or an end point or both a start point and an end point, and a third node different from the start point and the end point or a path length condition and supplies the extracted items to the graph searcher as a search item.

Abstract: In a light deflection device and a lidar device, a parallel operation can be realized with a simple constitution, so as to avoid enlargement or complication of a system. The reflection angle of the light deflection device depends on a wavelength and a refractive index, so that light beams with respective wavelengths different from each other are simultaneously and parallelly deflected in directions of deflection angles each defined by the wavelength and the refractive index. The light beams with the plural wavelengths different from each other are deflected at the different deflection angles each defined by each wavelength and the refractive index, so that they can be deflected simultaneously and parallelly. The plural deflected light beams can be distinguished from each other based on the difference in the wavelength and the deflection angle of the light, even in the simultaneous and parallel operation.

Abstract: It has been discovered that the cyclic peptide EnnA inactivates the Hsp90 chaperone pathway, but without activating an extensive heat shock response and overexpression of anti-apoptotic proteins. Mechanistically distinct, EnnA inhibits Hsp90 and destabilize PDL-1 and IDO, two major immune checkpoints mediating tumor-induced immune suppression. The provided herein show that EnnA profoundly modulates the cytokine signature of cancer cells and promotes a cytokine profile that favors an immune attack on tumor cells. This translates into highly efficacious anti-tumor activity in vivo, which, when combined with a single dose of chemotherapy, completely reduced the tumor burden in experimental animals and instilled highly efficient immune memory against the primary tumor.

Abstract: Disclosed is a friction-reducing and anti-wear composite material for a wading kinematic pair and a method of preparing the same. The friction-reducing and anti-wear composite material is prepared from carbon fiber (CF) among inorganic fillers, polyimide (PI) and polyether ether ketone (PEEK). These three materials are wet-mixed, dried and placed in a mold followed by curing by a heat press. The cured product is cooled and demolded to obtain the CF/PI/PEEK friction-reducing and anti-wear composite material for a wading kinematic pair. Tribological properties of the PEEK material are enhanced due to synergistic effect arising from hybrid organic-inorganic filling. The friction-reducing and anti-wear composite material provided in the invention has significantly reduced friction coefficient and wear volume loss under the seawater environment.

Abstract: Provided is an image recognition device. The image recognition device includes a frame data change detector that sequentially receives a plurality of frame data and detects a difference between two consecutive frame data, an ensemble section controller that sets an ensemble section in the plurality of frame data, based on the detected difference, an image recognizer that sequentially identifies classes respectively corresponding to a plurality of section frame data by applying different neural network classifiers to the plurality of section frame data in the ensemble section, and a recognition result classifier that sequentially identifies ensemble classes respectively corresponding to the plurality of section frame data by combining the classes in the ensemble section.

Abstract: A method for transmitting a discovery burst according to an exemplary embodiment of the present disclosure may comprise performing first channel-sensing with respect to a shared band to transmit the discovery burst through first window of discovery pattern first duration including the first window to N-th window; in case that the shared band is determined to be not-occupied based on the first channel-sensing, transmitting the discovery burst through the first window of the discovery pattern first duration; performing second channel-sensing with respect to the shared band to transmit the discovery burst through second window of discovery pattern second duration including first window to N-th window; and in case that the shared band is determined to be not-occupied based on the second channel-sensing, transmitting the discovery burst through the second window of the discovery pattern second duration.

Abstract: Disclosed herein are an electrolyte for a lithium secondary battery and a lithium secondary battery including the same. The disclosed lithium secondary battery includes: a cathode; an anode; a separator interposed between the cathode and the anode; and an electrolyte, wherein the electrolyte includes: a lithium salt; and a solvent including a perfluorinated ether-based solvent, fluoroethylene carbonate (FEC), and ethylmethyl carbonate (EMC).

Abstract: Provided are an electronic expansion valve, a control system, and a control method, including: a step motor and a Hall sensor; the step motor includes a rotor and a stator; the rotor includes a permanent magnet; the Hall sensor is provided on the outer periphery of the permanent magnet; the Hall sensor and rotor are arranged in the radial direction, and the stator and Hall sensor are arranged in the axial direction; the main-body part of the Hall sensor is used for sensing the magnetic pole change of the permanent magnet; such a structure reduces the effect that an operating environment has on the Hall sensor when detecting a signal.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: Cascaded metasurfaces can control the phase, amplitude and polarization of an electromagnetic beam, shaping it in three dimensional configuration not achievable with other methods. Each cascaded metasurface has dielectric or metallic scatterers arranged in a period array. The shape of the scatterers determines the three dimensional configuration of the output beam and is determined with iterative calculations through computational simulations.

Abstract: A physiological condition assessing method includes: acquiring a driving-time physiological data measured when a subject is driving a vehicle; acquiring a driving-characteristic data indicating driving characteristics; acquiring a period driving-time physiological data, a period driving-characteristic data and period non-driving-time physiological data corresponding to a first period including the measurement time point of the driving-time physiological data and the measurement time point of the driving-characteristic data, and a second period having a different length to the first period; generating a driving-time physiological feature from the driving-time physiological data and the period driving-time physiological data; generating a driving-characteristic feature; generating a non-driving-time physiological feature quantity; and assessing a physiological condition of the subject, from the non-driving-time physiological feature and at least one of the driving-time physiological feature and the driving-char

Abstract: An aspect of authenticating a user via a processing system includes receiving, at an input device of the processing system, an input gesture corresponding to an explicit assertion of user intent with respect to a function to be performed on the processing system; and simultaneously authorizing and authenticating the user, with respect to the function, from data acquired from the input gesture.

Abstract: A coherent, entangled photon source which uses a continuous wave laser to replace pulsed photon excitation sources in multiphoton nonlinear processes. In various embodiments, the device comprises a continuous wave photon laser creating electromagnetic radiation at a specific frequency and narrow linewidth. The emitted beam may be conditioned by an optical fiber to allow for efficient interaction with a nonlinear crystal. The nonlinear material is designed and fabricated in a specific manner, enabling the quantum mechanical process of a single photon with well-defined energy being converted into two or more photons which display quantum correlations. The nonlinear material and subsequent fiber-optic or free space components control the temporal, spatial, and polarization-related quantum correlations such that the entangled photons can create a signal in multiphoton nonlinear processes that is the same or exceeds that of a pulsed photon source but at the average and peak powers of a continuous wave laser.

Abstract: The present invention relates to compositions that are effective in management of inflammatory diseases. The disclosure provides a peptide complex comprising Abeta 1-42 and undercarboxylated osteocalcin which displays anti-inflammatory and immunomodulatory functions. The disclosure further provides with processes for preparing the compositions.

Abstract: Sensing the electric or strain field experienced by a sample containing a crystal host comprising of solid state defects under a zero-bias magnetic field can yield a very sensitive measurement. Sensing is based on the spin states of the solid-state defects. Upon absorption of suitable microwave (and optical) radiation, the solid-state defects emit fluorescence associated with hyperfine transitions. The fluorescence is sensitive to electric and/or strain fields and is used to determine the magnitude and/or direction of the field of interest. The present apparatus is configured to control and modulate the assembly of individual components to maintain a zero-bias magnetic field, generate an Optically Detected Magnetic Resonance (ODMR) spectrum (with or without optical excitation) using appropriate microwave radiation, detect signals based on the hyperfine state transitions that are sensitive to electric/strain fields, and to quantify the magnitude and direction of the field of interest.

Abstract: According to various aspects, a new concept of Steady-State Visually Evoked Potential (SSVEP) based Brain-Computer Interface (BCI) is described where brain-computer communication occurs by capturing SSVEP induced by consciously imperceptible visual stimuli integrated into, for example, a virtual scene. These consciously imperceptible visual stimuli are able to convey subliminal information to a computer. In various embodiments, computer based operations can be mapped to visual elements with associated flickering stimuli, and induced SSVEP can be detected when the user focused upon them. In various embodiments, these visual elements can be introduced into existing display without any perceivable change to content being displayed.

Abstract: Disclosed herein are a gateway-signaling method for Multiple-Input Single-Output (MISO) operation and an apparatus for the same. An apparatus for transmitting a broadcast signal according to an embodiment of the present invention includes a predistortion unit for performing predistortion for decorrelating signals corresponding to transmitters using the number of transmitters used for MISO and a transmitter coefficient index that are identified using a timing and management packet transmitted through a Studio-to-Transmitter Link (STL), thereby generating a pre-distorted signal; and an RF signal generation unit for generating an RF transmission signal using the pre-distorted signal corresponding to the transmitter coefficient index.