Abstract: The present disclosure relates generally to compositions and methods for treating, preventing, or slowing the rate of development of a disease or condition mediated by a nonsense mutation in the bone morphogenetic protein receptor type II (Bmpr2) in a subject in need thereof. The method entails administering to the subject a compound of the present disclosure, such as GJ103 and a salt thereof.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Text profiles can be leveraged to select and configure models according to some examples described herein. In one example, a system can analyze a reference textual dataset and a target textual dataset using text-mining techniques to generate a first text profile and a second text profile, respectively. The first text profile can contain first metrics characterizing the reference textual dataset and the second text profile can contain second metrics characterizing the target textual dataset. The system can determine a similarity value by comparing the first text profile to the second text profile. The system can also receive a user selection of a model that is to be applied to the target textual dataset. The system can then generate an insight relating to an anticipated accuracy of the model on the target textual dataset based on the similarity value. The system can output the insight to the user.

Abstract: The present application relates to a method of generating a downlink frame. The method of generating the downlink frame includes: generating a first short sequence and a second short sequence indicating cell group information; generating a first scrambling sequence and a second scrambling sequence determined by the primary synchronization signal; generating a third scrambling sequence determined by the first short sequence and a fourth scrambling sequence determined by the second short sequence; scrambling the short sequences with the respective scrambling sequences; and mapping the secondary synchronization signal that includes the first short sequence scrambled with the first scrambling sequence, the second short sequence scrambled with the second scrambling sequence and the third scrambling sequence, the second short sequence scrambled with the first scrambling sequence and the first short sequence scrambled by the second scrambling sequence and the fourth scrambling sequence to a frequency domain.

Abstract: A core-shell nanowire, a method of forming the core-shell nanowire and a stretchable composite comprising the core-shell nanowire are provided. The core-shell nanowire comprises a core comprising a conductive metal and a shell comprising a biocompatible metal. The method of forming the core-shell nanowire comprises a step of forming a core-shell nanowire by carrying out epitaxial growth of a biocompatible metal on a surface of a core comprising a conductive metal. The stretchable composite comprises a first core-shell nanowire/polymer composite comprising first core-shell nanowires and a first polymer, a first insulating layer disposed on the first core-shell nanowire/polymer composite, and a second core-shell nanowire/polymer composite disposed on the first insulating layer and comprising second core-shell nanowires and a second polymer.

Abstract: The present invention is intended to provide an adaptive optics system and an optical device that allow correction of wavefront phase aberration with higher accuracy than before and have a wider correction range than the conventional ones, regardless of the distance between the observation target and the fluctuation layer, and the size of the observation target. An adaptive optics system includes: a wavefront phase modulator that makes aberration correction to incident light and emits the corrected light; and an imaging-conjugated position adjustment mechanism that adjusts freely within a specimen the position of a surface imaging-conjugated with a fluctuation correction surface formed by the wavefront phase modulator. The imaging-conjugated position adjustment mechanism adjusts the fluctuation correction surface to be imaging-conjugated with a fluctuation layer existing in the specimen.

Abstract: A method, apparatus, and system provide the ability to act on cyber risks and reduce cyber attacks. System characteristics and system information for a cyber system are gathered. The system characteristics and system information are pre-processed to identify vulnerabilities that are relevant to the cyber system. A system model of a cyber environment is generated for the cyber system. One or more features are converted from cyber threat reports to one or more semantically relevant queries over the system model. The system model is reasoned over to generate one or more answers relevant to the one or more semantically relevant queries. Attack models are executed over the system model to generate actionable intelligence and reduce cyber attacks.

Abstract: A successive approximation register analog-to-digital converter (SAR ADC) with calibration function and a calibration method thereof are provided. The SAR ADC has at least one capacitor digital-to-analog converter (CDAC), having Nd capacitors corresponding to Nd bits; and a controller. The calibration method includes: coupling the capacitors of an i-th to an (Nd?1)-th bit to a first reference voltage, and generating a first digital code based an operation of the capacitors of an (i?1)-th bit to a 0-th bit; coupling the capacitors of an (i+1)-th bit to the (Nd?1)-th bit to the first reference voltage, coupling the capacitor of the i-th bit to a second reference voltage, and generating a second digital code based on the operation of the capacitors of the (i?1)-th bit to the 0-th bit; generating a capacitor weight of the capacitor of the i-th bit; and calibrating the SAR ADC based on the capacitor weight.

Abstract: A system and method model a time series from missing data by imputing missing values, denoising measured but noisy values, and forecasting future values of a single time series. A time series of potentially noisy, partially-measured values of a physical process is represented as a non-overlapping matrix. For several classes of common model functions, it can be proved that the resulting matrix has a low rank or approximately low rank, allowing a matrix estimation technique, for example singular value thresholding, to be efficiently applied. Applying such a technique produces a mean matrix that estimates latent values, of the physical process at times or intervals corresponding to measurements, with less error than previously known methods. These latent values have been denoised (if noisy) and imputed (if missing). Linear regression of the estimated latent values permits forecasting with an error that decreases as more measurements are made.

Abstract: Disclosed are a human body communication receiver and an operating method thereof, which may effectively remove low frequency noise. The human body communication receiver according to the present disclosure includes a receiving electrode, a virtual electrode, a filter circuit that is connected between the receiving electrode and the virtual electrode, and removes low frequency noise from a signal received through the receiving electrode to generate a high frequency signal, a low frequency reconstruction circuit that is connected to a rear end of the filter circuit and reconstructs a low frequency baseband signal by rectifying the high frequency signal, and an amplifying circuit that is connected to a rear end of the low frequency reconstruction circuit, and amplifies the low frequency baseband signal.

Abstract: A sunlight concentrating device may include a quantum dot layer having a first surface and a second surface opposite to each other, a first glass layer in contact with the first surface of the quantum dot layer, and a second glass layer in contact with the second surface of the quantum dot layer, and further include a low-refractive layer provided in a predetermined region of the first surface and/or the second surface of the quantum dot layer. The low-refractive layer is patterned, and a refractive index of the low-refractive layer is smaller than a refractive index of the quantum dot layer. The low-refractive layer totally reflects photons, being permeated from the quantum dot layer into the glass layer(s), between the glass layer(s) and the quantum dot layer so that the photons can move within a section with no loss of light thereby overcoming the theoretical limit of light concentration.

Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.

Abstract: A device participates in secret sharing-based MPC. Original data can be restored by combining a share of the device with a corresponding share of another device. The device includes means for acquiring random number and means for updating a share of the device on the basis of the acquired random number. A method for updating by the updating means is designed to perform update in a manner that a share of the device updated on the basis of the acquired random number is combined with the corresponding share of the other device updated on the basis of the random number to cancel an influence of the random number and restore the original data.

Abstract: Disclosed are methods and apparatuses for transmitting and receiving control information in a communication system supporting unlicensed band communication. An operation method of a terminal may comprise receiving, from a base station, first configuration information of a CORESET and second configuration information of a search space associated with the CORESET; receiving, from the base station, third configuration information indicating one or more PDCCH monitoring resource sets associated with the CORESET and the search space; and performing a PDCCH monitoring operation on the one or more PDCCH monitoring resource sets. Therefore, the performance of the communication system can be improved.

Abstract: The present invention relates to a method and apparatus for video encoding/decoding by using a geometric modified picture. The encoding method according to the present invention includes: generating a geometric modified picture by geometrically modifying a reference picture; and generating a first prediction block of a current block by performing inter prediction referencing the geometric modified picture.

Abstract: Disclosed is a cold-resistant and lean-type transgenic pig and a preparation method therefor, which relate to the field of genetic engineering. By transferring a mouse uncoupling protein 1 gene into the genome of a pig, a transgenic pig is obtained which can not only resist the cold but also have an increased lean meat rate by reducing fat deposition. Simultaneous improvement of two important production traits of pigs through the site-directed single gene manipulation not only lays a foundation for the application and basic research of genetic editing for big animals, but also provides with breading researchers a new way of thinking for improving traits of livestock.

Abstract: Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.

Abstract: A semiconductor memory device and a device including the same are provided. The semiconductor memory device includes word lines extending in a first direction on a semiconductor substrate; bit line structures extending across the word lines in a second direction crossing the first direction; contact pad structures between the word lines and between the bit line structures; and spacers between the bit line structures and the contact pad structures. The spacers include a boron nitride layer.

Abstract: A device and a method for transferring and storing a deep in-situ core in a sealed and pressure-maintaining manner includes a pressure vessel, a sealed storage vessel, a control system, a pressure regulation system and at least one spherical valve. The pressure vessel includes a first barrel and a first end sealing piston mounted at a first end of the first barrel and being slidable in the pressure vessel. The sealed storage vessel includes a second barrel and a second end sealing piston which is mounted at a first end of the second barrel. At least one spherical valve is connected between the first barrel and the second barrel. The pressure regulation system is configured for regulating an amount of water in the second barrel. The control system includes a first pressure sensor, a second pressure sensor, and a controller.

Abstract: This disclosure provides a new phagocytosis assay to test the function of RPE cells and photoreceptor progenitors using a pH sensitive fluorescent label.