Patents Assigned to Keio University
  • Patent number: 8657811
    Abstract: An intravascular diagnostic or therapeutic apparatus capable of removing blood in an intravascular lumen to be observed using a minimally invasive method is provided. The apparatus includes high-intensity pulsed light generating means and high-intensity pulsed light transmitting means for transmitting high-intensity pulsed light, capable of irradiating the interior of a blood vessel with high-intensity pulsed light, producing water-vapor bubbles and temporarily removing the blood in the blood vessel.
    Type: Grant
    Filed: May 6, 2004
    Date of Patent: February 25, 2014
    Assignee: Keio University
    Inventors: Tsunenori Arai, Eriko Suga, Erika Yamashita, Hikaru Futami
  • Patent number: 8660123
    Abstract: A transmitting side (101) transmits broadcast content (100) through a communication network (111) or a broadcast network (110). Transmission through the communication network (111) involves an addition of an IP header (100b) to the broadcast content (100) for packetization as an IP packet (100a) and transmission to a terminal device (112) on a receiving side (102). Transmission through the broadcast network (110) involves encapsulation of the IP packet into a given transmission packet (105) used with a digital broadcast signal for transmission to the terminal device on the receiving side (102).
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: February 25, 2014
    Assignees: KDDI Corporation, Keio University
    Inventors: Jun Murai, Takaaki Ishida, Kotaro Kataoka, Hiroaki Kimura, Shingo Izawa
  • Patent number: 8655350
    Abstract: A pn junction type solar cell is formed in a predetermined region on a substrate made of glass. Light emitted from a light emitting unit reaches an n-type semiconductor layer after it passed through substrate. The solar cell generates electromotive force corresponding to a quantity of the emitted light. A control circuit, a mask ROM, a transmitting circuit and an antenna are formed on an upper side of the solar cell. A surface of a semiconductor storage device is entirely covered with an insulating film to block entry of outside air. The insulating film is typically formed of physicochemically stable glass or silicon dioxide.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: February 18, 2014
    Assignees: Sharp Kabushiki Kaisha, Kyoto University, Keio University
    Inventors: Shigeki Imai, Yukihiro Nakamura, Hiroyuki Ochi, Naohisa Ohta, Sadayasu Ono
  • Patent number: 8648614
    Abstract: The present invention has an object to provide an electronic circuit testing apparatus that is preferable for testing an electronic circuit which carries out communications between substrates based on inductive coupling and is capable of testing the electronic circuit without using test pads, wherein a probe 15 is caused to intervene in a communications channel composed by inductive coupling based on the first and second transmitter coils 21a, 21b; and the first and second receiver coils 23a, 23b, and an LSI is tested by a tester 11, buffers 12 and 13, and a Tx/Rx switch 14. Accordingly, it is not be necessary for that the electronic circuit testing apparatus is provided with a needle that touches pads and leads of the electronic circuit, and the service life there can be lengthened.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: February 11, 2014
    Assignee: KEIO University
    Inventors: Tadahiro Kuroda, Daisuke Mizoguchi, Noriyuki Mirua
  • Patent number: 8623649
    Abstract: The invention relates to methods of selecting a cardiomyocyte from a cell population derived from a whole heart or a differentiated cell population derived from a stem cell without genetic alteration. Specifically, the invention relates to a method of selecting a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration of a cardiomyocyte, on the basis of a relative content of cellular mitochondria and/or a relative mitochondrial transmembrane potential of the cell. The invention also relates to methods of enriching a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration of a cardiomyocyte, producing a cardiomyocyte without genetic alteration of a cardiomyocyte, and evaluating the ratio of a cardiomyocyte in a cardiomyocyte-containing cell mixture.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: January 7, 2014
    Assignees: Daiichi Sankyo Company, Limited, Keio University
    Inventors: Fumiyuki Hattori, Keiichi Fukuda
  • Patent number: 8611816
    Abstract: To provide an electronic circuit capable of easily testing semiconductor chips that are inductively coupled to each other and that communicate with each other, and an inspection method performed in the electronic circuit.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: December 17, 2013
    Assignee: Keio University
    Inventor: Tadahiro Kuroda
  • Patent number: 8611714
    Abstract: [Object] The present invention has the object of providing an optical fiber enabling high-speed communication, that exhibits superior transparency and excellent flexibility, and that includes trichloroethyl methacrylate as a main component of the core portion monomer. [Means for Solving Problem] An optical fiber configured from a core portion and a cladding portion disposed on an outer periphery of the core portion, wherein the core portion is formed by a main constituent component of a polymer of monomers that include at least 70 wt % of trichloroethyl methacrylate (TCEMA), the cladding portion is formed by a main constituent component of a polymer of monomers which include at least 20 wt % of methyl methacrylate (MMA).
    Type: Grant
    Filed: July 5, 2010
    Date of Patent: December 17, 2013
    Assignees: Sekisui Chemical Co., Ltd., Keio University
    Inventors: Hirotsugu Yoshida, Ryosuke Nakao, Hiroka Inabe, Tazuru Okamoto, Yuki Masabe, Masato Aoyama, Yasuhiro Koike
  • Patent number: 8600210
    Abstract: A GI type optical fiber of the present invention is a GI type optical fiber having a core component and a cladding component disposed around the outer periphery of the core component, the core component includes a polymer containing at least 55 wt % chlorostyrene monomer and a dopant, and the cladding component includes a polymer of a monomer containing at least 35 wt % methyl methacrylate. It is an object of the present invention to provide a GI type optical fiber in which chlorostyrene is used as the predominant component of the monomer that constitutes the core component, and therefore has excellent transparency and good flexibility, and allows high-speed communication.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: December 3, 2013
    Assignees: Sekisui Chemical Co., Ltd., Keio University
    Inventors: Hirotsugu Yoshida, Tazuru Okamoto, Ryosuke Nakao, Hiroka Inabe, Yuki Masabe, Yasuhiro Koike
  • Patent number: 8592781
    Abstract: A first and a second fluorescent dye are mixed into a solution, the first dye being positively ionized in the solution and the second dye being negatively ionized in the solution and having different fluorescence wavelengths from the first dye. The solution is flown onto a measured surface, and the surface is excited with an evanescent wave to produce a fluorescence intensity distribution of two colors. A fluorescence intensity of the surface is measured using a two-dimensional imaging element, the element providing a fluorescence intensity of each color separated from the other colors, thereby calculating a ratio of the fluorescence intensities of the colors. Using an equation expressing a relationship between the ratio of fluorescence intensities and a wall zeta potential, the ratio is converted to a two-dimensional distribution of wall zeta potentials. This achieves visualizing in real time and quantitatively evaluating the two-dimensional distribution of wall zeta potentials, and surface modifications.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: November 26, 2013
    Assignee: Keio University
    Inventors: Yohei Sato, Yutaka Kazoe, Shu Miyakawa
  • Patent number: 8592643
    Abstract: An object of the present invention is to provide a method for introducing a gene into an embryo for production of a human disease model primate animal using a non-human primate animal such as a marmoset. The present invention relates to a method for introducing a foreign gene into an early embryo of a non-human primate animal, which comprises placing early embryos of a non-human primate in a 0.2 M to 0.3 M sucrose solution, so as to increase the volume of the perivitelline spaces, and then injecting a viral vector containing a human foreign gene operably linked to a promoter into the perivitelline spaces of the early embryos.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: November 26, 2013
    Assignees: Central Institute for Experimental Animals, Keio University
    Inventors: Erika Sasaki, Hideyuki Okano
  • Patent number: 8564093
    Abstract: The invention relates to a semiconductor device and a manufacturing method for the same, and makes the rejection rate of the product after chips are stacked and mounted sufficiently low, even when the chips are selected in a conventional, simple and inexpensive wafer test.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: October 22, 2013
    Assignee: Keio University
    Inventor: Tadahiro Kuroda
  • Patent number: 8546113
    Abstract: It is an object of the present invention to provide DNA encoding novel NADH oxidase from a microorganism belonging to the genus Brevibacterium having excellent pH stability and thermostability. The present invention relates to DNA encoding NADH oxidase from a microorganism belonging to the genus Brevibacterium that is the following (a) or (b): (a) NADH oxidase comprising the amino acid sequence of SEQ ID NO: 18; or (b) NADH oxidase comprising an amino acid sequence derived from the amino acid sequence of SEQ ID NO: 18 by deletion, substitution, or addition of 1 or more amino acid(s) and having NADH oxidase activity.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: October 1, 2013
    Assignee: Keio University
    Inventors: Kenji Miyamoto, Hiromichi Ohta
  • Patent number: 8524747
    Abstract: The object of the present invention is to provide a pharmaceutical composition that inhibits expression of iNOS and COX-2 without inhibiting NF-?B. The pharmaceutical composition that inhibits expression of iNOS and COX-2 without inhibiting NF-?B contains DTCM glutarimide of the Formula (I) as an effective ingredient, thereby being able to inhibit nitric oxide (NO) production and prostaglandin production.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: September 3, 2013
    Assignee: Keio University
    Inventors: Kazuo Umezawa, Yuichi Ishikawa, Shigeru Nishiyama, Miyuki Tachibana, Ayumi Kaneda
  • Patent number: 8524250
    Abstract: The present invention is directed to providing a carrier which can transport a compound to a gut-associated lymphoid tissue efficiently without being degraded or digested. For that purpose, the carrier contains a coccoid cell of a gastric mucosa-damaging spiral bacterium. Preferably, the carrier is orally administered. By making this carrier carry an antigen and orally administering it, a local or a systemic immunological reaction to the antigen can be induced.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: September 3, 2013
    Assignee: Keio University
    Inventors: Shigeo Koyasu, Shigenori Nagai, Chihiro Sasakawa, Hitomi Mimuro
  • Patent number: 8518880
    Abstract: Disclosed is a therapeutic agent effective for the fundamental treatment of a spinal cord injury and a demyelinating disease. Specifically disclosed are a therapeutic agent for a spinal cord injury and a therapeutic agent for a demyelinating disease, each of which comprises an HGF protein as an active ingredient.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: August 27, 2013
    Assignees: Keio University, Osaka University, Kringle Pharma Inc.
    Inventors: Hideyuki Okano, Yoshiaki Toyama, Masaya Nakamura, Akio Iwanami, Kazuya Kitamura, Toshikazu Nakamura, Hiroshi Funakoshi, Keigo Hanada
  • Patent number: 8518651
    Abstract: It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology, and a marker for identification of a tissue-type of epithelial ovarian cancer. A method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type, comprising: subjecting a sample originated from an individual of interest to a treatment for detecting at least one selected from the group consisting of biological molecules specifically showing an upregulation in expression in a specific tissue-type of epithelial ovarian cancer, and/or at least one selected from the group consisting of biological molecules specifically showing a downregulation in expression in a specific tissue-type of epithelial ovarian cancer, and identifying whether or not the significant detection of the protein is achieved, thereby identifying the tissue-type.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: August 27, 2013
    Assignees: Shimadzu Corporation, Keio University
    Inventors: Taka-aki Sato, Atsuhiko Toyama, Takashi Shimada, Tetsuyoshi Sugita, Daisuke Aoki, Atsushi Suzuki, Nobuyuki Susumu, Hiroyuki Nomura
  • Patent number: 8513379
    Abstract: The invention provides a depolymerization method for a polymer containing an ester bond in a main chain, by causing a solid acid catalyst to act on a polymer containing an ester bond in a main chain to depolymerize the polymer, thereby obtaining a re-polymerizable monomer and/or oligomer as a depolymerization product, and a method for producing a polymer containing an ester bond in a main chain, by polymerizing the re-polymerizable monomer and/or oligomer obtained by the depolymerization method.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: August 20, 2013
    Assignee: Keio University
    Inventor: Shuichi Matsumura
  • Patent number: 8503836
    Abstract: To provide a waveguide type wavelength domain optical switch which makes it possible to use a cheap lens, makes it possible to correct aberration of the demultiplexed wavelengths produced in a plurality of waveguide type demultiplexing circuits, a wavelength domain optical switch is provided with: an integrated element formed by laminating three or more waveguide type demultiplexing circuits; a first lens for collecting light emitted from the integrated element; a polarization separation element for separating light emitted from the first lens into X polarization and Y polarization and emitting the X polarization and the Y polarization at different angles; a second lens for collecting the X polarization and the Y polarization; a first reflective optical phase modulator for reflecting the collected X polarization and Y polarization at any angles; a ½-wavelength plate disposed between the second lens and the first reflective optical phase modulator in order to make polarization directions of the X polarization
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: August 6, 2013
    Assignees: National Institute of Advanced Industrial Science and Technology, Hitachi Cable, Ltd, Keio University
    Inventors: Hiroshi Ishikawa, Toshifumi Hasama, Hitoshi Kawashima, Kenji Kintaka, Masahiko Mori, Hisato Uetsuka, Hiroyuki Tsuda, Keisuke Sorimoto
  • Publication number: 20130189786
    Abstract: An object of the present invention is to provide methods for producing iPS cells with low invasivity and high efficiency. The iPS cells can be produced with high efficiency using a method comprising the steps of culturing mononuclear cells derived from peripheral blood for 3 to 14 days in the presence of anti-CD3 antibody, and subjecting the cultured mononuclear cells to dedifferentiation.
    Type: Application
    Filed: April 15, 2011
    Publication date: July 25, 2013
    Applicants: Dnavec Corporation, Keio University
    Inventors: Keiichi Fukuda, Shinsuke Yuasa, Tomohisa Seki, Mamoru Hasegawa
  • Patent number: 8488964
    Abstract: In an access network using optical switches, communications between an OLT and ONUs are established without a photoelectric conversion performed at an optical switching unit. The OLT controls the downlink optical switch SW(DOWN) to sequentially select each ONU in slots arranged in a discrete manner, and transmits a Discovery Gate message. Upon receipt of the Discovery Gate message, each ONU consecutively transmits Register Request messages. The uplink optical switch SW(UP) sequentially switch signals from ONU#1 through ONU#128 in the slots arranged in a discrete manner, and outputs the signals to the OLT, Some of the Register Requests transmitted from the respective ONUs pass through the SW(UP), and reach the OLT. Based on the received Register Requests, the OLT determines the timing of transmission for the ONUS, and notifies the ONUS of the timing of transmission through a Gate message.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: July 16, 2013
    Assignee: Keio University
    Inventors: Naoaki Yamanaka, Yutaka Arakawa, Kazumasa Tokuhashi