Abstract: Compounds having anticonsulive activity, of the formula 1 ##STR1## in which X is hydrogen, a C.sub.1-4 -alkyl, C.sub.1-4 alkoxy, trifluoromethyl, or halogen residue, R.sup.1 and R.sup.2 are independently of each other C.sub.1-4 -alkyl, C.sub.2-4 hydroxyalkyl, cycloalkyl or heteroalkyl, or R.sup.1 and R.sup.2 are together a C.sub.2-6 alkylene reside in which a--CH.sub.2 --group is optionally replaced by oxygen, nitrogen or sulfur, m is 0 or 1, and n is 0 or a cardinal number from 1 to 5, and their pharmaceutically acceptable salts. The application also relates to a process for making the compound of formula (I).
Type:
Grant
Filed:
June 9, 1998
Date of Patent:
February 9, 1999
Assignee:
Arzneitmittelwerk Dresden G.m.b.H.
Inventors:
Hans-Joachim Lankau, Manfred Menzer, Klaus Unverferth, Karl Gewald, Harry Schafer, deceased
Abstract: The present invention involves perfluoro compound emulsions including nitric oxide, their preparation and their use. These emulsions provide a new source of nitric oxide. Such nitric oxide-containing emulsions may be used for the administration of nitric oxide to individuals in need thereof. Individuals in need of nitric oxide administration can include those suffering from hypertension, preeclampsia and a number of other situations where an increased blood flow, for example, is desirable. In addition, given the long use of perfluoro compound emulsions as blood substitutes, the present invention provides a relatively safe mode for administering and distributing nitric oxide-without potential negative side effects such as toxicities due to drug metabolites.
Type:
Grant
Filed:
April 17, 1996
Date of Patent:
February 9, 1999
Assignees:
Board of Regents, The University of Texas System, The Texas A&M University System
Inventors:
R. E. Garfield, A. T. Balaban, W. A. Seitz
Abstract: A process for the production of S(+)-ibuprofen-particles having improved flow properties comprises the steps that coarse-crystalline S(+)-ibuprofen is molten and then in a molten condition is finely distributed in a non-solving medium, preferably in cold water, and is chilled therein. This chilling results in a fine-crystalline primary structure that agglomerates to a secondary structure. In this agglomerate form the product is obtained which is filtered out and is dried. Such particles are suitable for direct pressing of tablets, optionally, tableting auxiliary substances being added, also for the production of tablets having a retarded release of the active substance.
Type:
Grant
Filed:
July 12, 1996
Date of Patent:
February 9, 1999
Assignee:
Gebro Borschek Gesellschaft M.B.H.
Inventors:
Torsten Moller, Gerhard Hantich, Ernst Hesse
Abstract: This electrohydraulic actuator comprises a pair of hydraulic rams (12, 13) and a rocker (14) integral in terms of rotation with an input shaft (7) of the barrel, the rams are arranged parallel with one another in such a way as to be able to control the rotation of the rocker to make it adopt predetermined angular positions corresponding to the gears (R, N, 1, 2, . . . ) selected and this actuator also comprises solenoid valves for controlling the rams. The rocker (14) extends transversely to the shaft (7) and its ends are designed to be able to interact with respective pistons (17, 18) of the rams (12, 13), each ram comprises three pistons (24, 25, 17; 26, 27, 18) which are coaxial and have different cross sections, arranged in chambers (28, 29) of corresponding cross sections formed in the body (11). This electrohydraulic actuator permits extremely quick and easy control of gear selection for a structure which is relatively simple and has a modest cost of manufacture.
Type:
Grant
Filed:
January 15, 1997
Date of Patent:
February 9, 1999
Assignee:
S.A.M.M.-Societe D'Applications Des Machines Motrices
Abstract: Keyboard constructions and methods are described which force or provide feedback for finger action that will enhance stability of the carpal tunnel tendons. Methods are described for reducing incidence of carpal tunnel syndrome in a person who operates a keyboard, involving monitoring actuation of switches, measuring a depression characteristic, comparing the depression characteristic with a predetermined value, and creating a signal corresponding to the number of keystrokes executed with a depression characteristic less than the predetermined value. A method is also described for detecting unphysiologic tendon translation denoting tendon instability in the carpal tunnel of a person who engages in repetitive hand motion.
Abstract: A pneumatic retractable syringe in which the needle is retracted into the barrel of the syringe following use by compressed gas that is released from a gas reservoir when the gas reservoir is ruptured by applying force to the plunger after injection is completed.
Abstract: A precipitated silica composition which, when incorporated into a suitable dentifrice composition, the dentifrice composition exhibits an mPCR of about 103 to 124 and an RDA of about 88 to 102. The invention also provides a precipitated silica composition which, when incorporated into a suitable dentifrice composition, the dentifrice composition exhibits an mPCR to RDA ratio of greater than about 1.1.
Abstract: A hot air oven for food preparation, with a housing, with a cooking chamber that is defined by side walls as well as a bottom wall and a covering wall, with a blower for generating a hot air current in the cooking chamber, with a basket for the food, which basket can be inserted into the cooking chamber, wherein the basket can be rotated around a rotational axis and in operation, is penetrated by the hot air current, and is particularly easy to clean because, at least in sections along its circumference, the basket has a wall that is made of sheet metal and is provided with openings in its wall.
Abstract: An intelligent network telecommunications service allows a calling party (22) to provide a voice message which is converted by the service to a text message. The text message is delivered to any of a plurality of types of media formatters (90), which in turn transmit the text message to corresponding types of receiving equipment (100). The text messages can be delivered to a sole called party or to a distribution list of called parties.
Abstract: A new and useful a plastic article, particularly plastic siding, with an accent color pattern incorporated therein, a specially formed accent color pellet which is useful in manufacturing such an article, and a process for producing the article using the pellets are provided. The process contemplates extruding a plastic product from a base material formed of powder-sized particles and specially formed accent color pellets. The accent color pellets are alloyed masses of resins and pigment which are larger than the powder particles of the base material, and have a higher vicat softening point temperature than the base material. The alloyed pellets are designed to melt controllably and to mix controllably with the base material.
Type:
Grant
Filed:
November 6, 1997
Date of Patent:
February 9, 1999
Assignee:
M. A. HannaColor, a division of M. A. Hanna Company
Inventors:
John J. Dorchester, Bobby D. Smith, Ronald M. Harris
Abstract: The invention relates to a new process for the depletion of 7-amino-3-?(E)-1-propen-1-yl!-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-?(Z)-1-propen-1-yl!-3-cephem-4-carboxylic acid and 7-amino-3-?(E)-1-propen-1-yl!-3-cephem-4 carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-?(Z/E)-1-propen-1-yl!-3-cephem-4-carboxylic acid or by adsorption chromatography.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
February 9, 1999
Assignee:
Biochemie Gesellschaft m.b.H.
Inventors:
Johannes Ludescher, Bernhard Prager, Siegfried Wolf
Abstract: The present invention relates to an oil-based drilling fluid, a continuous phase for an oil-based drilling fluid, and additives for an oil-based drilling fluid. The drilling fluid, the continuous phase of the drilling fluid, and the additives for the oil-based drilling fluid are characterized by non-fluorescence (defined as a fluorescence intensity of 800 or less) when exposed to ultraviolet light. The continuous phase of the drilling fluid is composed of synthetic hydrocarbons selected from the group consisting of oligomers synthesized from one or more alphaolefins containing a C.sub.2 to C.sub.14 chain length, wherein the oligomers have an average molecular weight of from 120 to 100, and additives. The additives of the continuous phase include surfactants, wetting agents and/or emulsifiers.
Abstract: A device for introducing gases into liquids in the form of fine bubbles, especially for introducing air into waste water, which device (1) comprises gas distributors (2) consisting of a longitudinal chamber (20) covered by a porous foil (19) arranged beneath the liquid level and to which gas is fed through a supply duct (5) and emerges into the liquid through the foil in the form of fine bubbles. The gas distributors (2) are connected to supply pipes (5) each provided for a group of gas distributors (2). The gas distributors (2) have a base wall (18) of rigidly-stable material, preferably metal, forming one side of the chamber (20) covered with the porous foil (19). Furthermore, it is preferred that the gas distributors (2), in the direction of their longitudinal extension, are mounted on carriers (7, 7a) arranged on the bottom of a basin or container in which the liquid is present.
Abstract: With the objective of simplifying the splicing of optical fibres and obtaining a very high degree of accuracy in the positional setting of the fibre ends prior to splicing the ends together fully automatically, the relative positions of the fibre ends are determined with the aid of laser light diffraction. By illuminating the fibre ends (1, 2) with laser light (3) and studying the image of the diffraction pattern on a display screen (6), which pattern can be related directly to the perpendicular distance between the fibre ends and the relative offset between the geometric axes of the ends, it is possible to determine the distance between the fibre ends by direct image analysis. A suitable splicing distance between the gap between the fibre ends can then be adjusted automatically to a value suitable for splicing, with regard to fibre material and fibre dimensions.
Abstract: The invention refers to a device for dewatering and/or washing suspensions, especially fibre stock suspensions, with two dewatering rolls rotating in opposite directions, where at least a further two guide rolls, especially press rolls, are provided and a woven, especially endless woven, wire or filter belt runs over each combination of one dewatering roll and one further guide roll, by which arrangement the suspension to be dewatered and/or washed is carried in the gap between the two belts and dewatered. The invention is mainly characterised by the two belts forming a vertical gap and by a device to guide the belts being mounted in the region of this vertical gap.
Abstract: The present invention provides a turf board for simulating snowboarding on snowless terrain. The turf board includes a platform, two wheel assemblies and two bindings. Each of the wheel assemblies includes tires independently attached to a bottom surface of the platform by a shock absorber suspension. In a preferred embodiment, each of the wheel assemblies include a unique, three-piece rim which maintains the tire. The two bindings are attached to a top surface of the platform for securing a user to the turf board.
Abstract: The invention relates to ZrB.sub.2 /Cu composites, and more specifically to methods of making ZrB.sub.2 /Cu composite electrodes and methods of using ZrB.sub.2 /Cu composite electrodes. ZrB.sub.2 powder is contacted with a polymer and shaped to a desired form. The polymer is vaporized and the ZrB.sub.2 powder is sintered. The sintered ZrB.sub.2 is contacted with Cu and heated above the melting point of Cu which causes the Cu to infiltrate the ZrB.sub.2, forming the ZrB.sub.2 /Cu composite electrode.
Type:
Grant
Filed:
August 2, 1996
Date of Patent:
February 9, 1999
Assignee:
The Texas A&M University System
Inventors:
Brent E. Stucker, Walter L. Bradley, Philip T. Eubank, Bedri Bozkurt, Somchintana Norasetthekul
Abstract: An asexually reproduced variety of perennial zoysiagrass with a unique combination of characters including an absence of leaf blade hairs, high turf quality, resistance to fall armyworm and a distinct DNA fingerprint.