Patents Assigned to Nipro Corporation
  • BLOOD CIRCUIT HAVING PRESSURE MEASUREMENT PORTION
    Publication number: 20170319086
    Abstract: A blood circuit having a pressure measurement portion connected to a pressure measurement device includes: a first measurement portion provided downstream of a pumping segment; and a second measurement portion provided upstream of the pumping segment. The first measurement portion includes: a first housing having a tubular shape; and a first flexible membrane having a tubular shape and provided in the first housing. The second measurement portion includes: a second housing having a tubular shape; and a second flexible membrane having a tubular shape and provided in the second housing. A space between the first flexible membrane and the first housing is larger than a space between the second flexible membrane and the second housing in an initial state before permitting the blood to flow.
    Type: Application
    Filed: October 28, 2015
    Publication date: November 9, 2017
    Applicant: NIPRO CORPORATION
    Inventors: Toshiaki MASUDA, Takeshi YAMAGUCHI
  • Exposure-preventing cap
    Patent number: 9808401
    Abstract: Provided is an exposure-preventing cap of a novel and simple structure that, by being mounted on a vial, can more reliably inhibit leaking of drug solution to an outside when pulling out and collecting drug solution in a syringe from the vial. An exposure-preventing cap, which is mounted on a mouth of a vial sealed with a rubber stopper, wherein a puncturing hole is formed in a center part of a cap-shaped housing that is attached to a mouth of the vial, and a rubber membrane is arranged at the puncturing hole so as to form an internal space between facing surfaces of the rubber membrane and the rubber stopper. The rubber membrane has a dome shape that is convex facing the rubber stopper.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: November 7, 2017
    Assignees: KINKI UNIVERSITY, GTO, LTD., NIPRO CORPORATION
    Inventors: Shunji Ishiwata, Atsushi Taga, Shozo Nishida, Ayako Kita, Reiko Sugiura, Hideki Fujita, Mitsuru Hasegawa
  • Needle-less connector
    Patent number: 9764123
    Abstract: A needle-less connector includes a housing having a drug solution flow path, and an elastic valve body. An end surface of the housing on a side of a tip end opening of the drug solution flow path constitutes a protruding support surface whose center section protrudes and slopes in a direction of a foot, and the elastic valve body is superposed onto the protruding support surface in a state of close contact therewith. Insertion of a male luer into a slit of the elastic valve body causes expanding deformation of the elastic valve body along the protruding support surface. A flexion section is formed on a sloped surface of the protruding support surface, and the sloped surface has different tilt angles on a foot section side and on a crest section side of the flexion section.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: September 19, 2017
    Assignee: NIPRO CORPORATION
    Inventors: Yoshihiko Sano, Hiroshi Matsuo, Ken Suzuki
  • PUNCTURE NEEDLE
    Publication number: 20170252520
    Abstract: The present disclosure relates, according to some embodiments, to a puncture needle that can prevent the occurrence of coring. A puncture needle according to the present disclosure includes a cannula provided with a lumen. The cannula has a blade surface. The blade surface has: a sharp region located on a tip side of the blade surface and provided with a sharp edge on inner and outer circumferences of the blade surface; and a blunt region located on a base end side of the blade surface and provided with a blunt edge on the inner and outer circumferences of the blade surface. A tip of the blade surface is provided with a thick portion formed by a boundary between two surfaces, and the boundary forms an edge.
    Type: Application
    Filed: March 2, 2016
    Publication date: September 7, 2017
    Applicants: NIPRO CORPORATION, Food and Drug Administration
    Inventors: Yoshio Higaki, Oleg Vesnovsky
  • Vial and method for producing the same
    Patent number: 9751795
    Abstract: A method for producing a vial with low alkali elution by removing a deteriorated region caused by processing on an internal surface of a vial is disclosed. The method involves forming vials from borosilicate glass tubes including a first step of forming a borosilicate glass tube into a cup-shaped body by formation of a bottom of a vial, and a second step of forming the cup-shaped body into the vial by formation of a mouth of the cup-shaped body.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: September 5, 2017
    Assignee: NIPRO CORPORATION
    Inventors: Hideo Kuwabara, Hideki Yamauchi, Yoshitaka Ishimi, Shinichiro Senga
  • Connection device
    Patent number: 9744102
    Abstract: In a connection device, when a cannula holding member is in a use state, a position of an end portion of an outer cylindrical portion on a retracted position side does not protrude to the retracted position side, with respect to a position of an end portion of an inner cylindrical portion on the retracted position side. Thereby, a connection device including a structure capable of holding a vial by holding means irrespective of the size of the vial can be provided.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: August 29, 2017
    Assignee: NIPRO CORPORATION
    Inventor: Tomohiko Kubo
  • Bilirubin excretion enhancer
    Patent number: 9744217
    Abstract: The purpose of the present invention is to establish a novel therapy method for hyperbilirubinemia and therefore, to provide a bilirubin excretion enhancer. The present invention provides a bilirubin excretion enhancer comprising, as an active ingredient, a serum albumin domain II-like protein comprising a serum albumin subdomain IIA. In one embodiment, the serum albumin subdomain IIA has an amino acid sequence of SEQ ID NO: 1. in one embodiment, the serum albumin domain II-like protein is a serum albumin domain II. In one embodiment, the serum albumin domain II comprises the amino acid sequence of SEQ ID NO: 4.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: August 29, 2017
    Assignee: Nipro Corporation
    Inventors: Masaki Otagiri, Toru Maruyama, Yu Ishima, Ai Minomo
  • Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells
    Patent number: 9738861
    Abstract: A culture system has a culture bag for suspending and culturing pluripotent stem cells in a culture medium; a waste liquid container for storing used culture medium that is connected to the culture bag; a fresh medium container for storing a fresh culture medium that is connected to the culture bag; three-way stopcocks for switching flow channels from the culture bag to the waste liquid container or the fresh culture medium container, etc.; a trap portion for trapping the pluripotent stem cells in the culture medium in the flow toward the waste liquid container side; and a filter portion for subculturing that is formed in fourth and fifth flow channels in parallel to a first flow channel. The first flow channel connects the trap part to the culture bag, and has a mesh by which a cell mass of the pluripotent stem cells can be divided. A pump is used to pump the liquid in the individual flow channels.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: August 22, 2017
    Assignees: KYOTO UNIVERSITY, Nipro Corporation
    Inventors: Norio Nakatsuji, Yoshihiro Yoshikawa, Masakatsu Takeuchi, Daiki Tateyama
  • Syringe plunger with one piece hollow gasket and plunger rod
    Patent number: 9731077
    Abstract: A plunger for a syringe, in which a plunger rod can be prevented by a simple structure from unavoidably falling out of place. The plunger for a syringe includes the plunger rod and a gasket. The gasket is closed at its upper end and has an inner space, and an opening having a diameter smaller than the diameter of the inner space is provided in the lower end of the gasket. The plunger rod has a collar installed at the tip of the plunger rod. When the collar is positioned in the inner space of the gasket, the plunger rod and the gasket are freely movably fitted together without intimate contact between them.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: August 15, 2017
    Assignee: NIPRO CORPORATION
    Inventors: Shigeki Tanaka, Masanobu Iwasa, Ryohei Namba, Hidero Kato, Teruhisa Hirobe
  • NEEDLE ASSEMBLY
    Publication number: 20170216534
    Abstract: A needle assembly includes a needle hole having an inside diameter that is greater than an outside diameter of a needle, and by a moving-side guide integrally provided to a needle tip cover being engaged with a fixed-side guide fixedly provided to the needle, a guide mechanism is provided to guide the needle tip cover from a proximal end side towards a distal end side of the needle while maintaining a state of noncontact with the needle, and to guide the needle tip cover to a position where the needle tip cover covers the needle tip while deviating the needle tip cover in a direction in which the needle hole goes away from a center axis of the needle at a position beyond the needle tip, and avoiding contact of the needle tip with the needle hole.
    Type: Application
    Filed: June 24, 2015
    Publication date: August 3, 2017
    Applicant: NIPRO CORPORATION
    Inventors: Minami KAWABE, Tomoe MORITA
  • SYRINGE NEEDLE DISPOSAL CONTAINER
    Publication number: 20170209230
    Abstract: A syringe needle disposal container for disposing of a syringe needle having a needle holder detachably screw-fitted to an end of a syringe body and a needle body, which includes a lid that covers an opening of a container body and a moving member mounted on the lid so as to be slide-movable. A first holding part for holding one side of needle holder is provided at a predetermined part of the lid. The moving member is formed with a second holding part for holding the other side of the needle holder. An open end of the first holding part on the lid side is deviated toward the first holding part with respect to a reference center axis line L that passes through the center P of a syringe needle holding part in the holding position state and that is substantially perpendicular to a slide-moving direction of the moving member.
    Type: Application
    Filed: July 28, 2015
    Publication date: July 27, 2017
    Applicants: NIPRO CORPORATION, FINE PRO CORPORATION
    Inventors: Hiroyuki NAKAGAMI, Takumi MORO
  • Blood sampling device
    Patent number: 9713426
    Abstract: The position of blood vessels can be more appropriately specified by means of appropriately selecting, on the basis of the conditions and components utilized, and angle between a light emitting unit optical axis of a near-infrared light emitting unit and a normal light of an irradiated surface, and angle between an optical axis of a light receiving side lens and the normal line of the irradiated surface, and an angle between a light receiving surface of a photo diode array and the light receiving unit optical axis. Thus, the subcutaneous blood vessel depth in the direction of the normal line from the irradiated surface can be specified based on changes in illumination intensity in a photodiode array. Consequently, the position of subcutaneous blood vessels can be easily specified.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: July 25, 2017
    Assignee: Nipro Corporation
    Inventors: Satoshi Konishi, Taizo Kobayashi, Hiroshi Yoshida, Takashi Wada, Fumihiro Hagiwara, Norihide Takeyama
  • Powder spraying device
    Patent number: 9707359
    Abstract: The invention is configured so that pressurized gas from a pressurized gas supply source passes through a pressurized gas channel provided in a main body of a powder spraying device and is sprayed out. A powder container containing powder such as medical agents is provided on the main body. The powder within the powder container is supplied to the pressurized gas channel and is sprayed together with the pressurized gas. An eccentric rotor with a center of gravity deviated from a center of rotation is provided in the main body. When spraying the powder together with the pressurized gas, vibrations are applied to the main body and the powder container by a rotation of the eccentric rotor. The powder can be thereby mixed more evenly with the pressurized gas.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: July 18, 2017
    Assignee: NIPRO CORPORATION
    Inventor: Tomohiko Kubo
  • LASER-PRINTABLE TABLET, AND METHOD FOR MANUFACTURING THE SAME
    Publication number: 20170196816
    Abstract: A laser-printable tablet has: a tablet containing an optically unstable drug, a first cover layer that covers the tablet and contains a first color change-inducing oxide, and a second cover layer that covers the first cover layer and contains a second color change-inducing oxide, the concentration in which the second color change-inducing oxide is contained in the second cover layer being different from the concentration in which the first color change-inducing oxide is contained in the first cover layer.
    Type: Application
    Filed: June 2, 2015
    Publication date: July 13, 2017
    Applicant: NIPRO CORPORATION
    Inventors: Yohei HOASHI, Shotaro IKUTA
  • BLOOD PURIFIER
    Publication number: 20170157569
    Abstract: A blood purifier comprises hollow fiber membranes allowing a dialysing fluid or a filtrated fluid to flow outside. The membrane has an effective length of 10 mm or more and 150 mm or less. A maximum value of a permeation flux Jv obtained by dividing a volume of a permeate fluid permeating through the membranes by a membrane area of the hollow fiber membranes and time, is represented as Jvmax. A linear velocity of blood flowing in the membrane is represented as uB. A pressure difference between blood flowing inside the membranes and a fluid flowing outside the membranes is represented as TMP. When a filling blood volume into the membranes per unit membrane area is 20 mL/m2 or more and 35 mL/m2 or less and Jvmax/uB has a value of 0.00015 or more and 0.0006 or less, a TMP change rate is 0.95 or more and 1.05 or less.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 8, 2017
    Applicants: UNIVERSITY OF YAMANASHI, SCHOOL JURIDICAL PERSON KITASATO INSTITUTE, NIPRO CORPORATION
    Inventors: Kenichi MATSUDA, Kenichi KOKUBO, Hirosuke KOBAYASHI, Takashi SUNOHARA, Syunsuke NOTAZAWA, Hiroshi FUKUSHIMA
  • BLOOD CIRCUIT CONNECTOR
    Publication number: 20170128711
    Abstract: A blood circuit connector includes: a main body having a cylindrical shape and provided with a first opening end and a second opening end; a plug having a bottomed cylindrical shape and detachably attached to the first opening end; and a connection part configured to connect the main body and the plug. The plug includes a side wall loosely fitted to an outer circumferential surface of the first opening end. The connection part includes a curved part expanding in a direction away from the main body. In a state where the plug is attached to the first opening, the curved part is pushed in a direction approaching the outer circumferential surface of the main body such that the curved part extends, thereby cancelling a loosely fitted state between the side wall and the outer circumferential surface, so as to remove the plug from the first opening end.
    Type: Application
    Filed: June 20, 2014
    Publication date: May 11, 2017
    Applicant: NIPRO CORPORATION
    Inventor: Koichi MURAI
  • Electrode pad for use on living organism
    Patent number: 9642548
    Abstract: An electrode pad for use on a living organism can measure an electrocardiographic signal without being hindered by body-motion noise. The electrode pad is attached to the skin of the living organism, detects an electrical signal, and supplies the electrical signal to an electrocardiograph. The electrode pad for use on a living organism is characterized by the provision of a mesh-like electrode that extends along the skin, a conductive gel sheet that is layered on top of the electrode and extends along the surface of the skin, and a soft protective sheet that covers the layered electrode and conductive gel sheet.
    Type: Grant
    Filed: May 28, 2012
    Date of Patent: May 9, 2017
    Assignees: NIPRO CORPORATION, HARADA ELECTRONICS CO., LTD.
    Inventors: Yoshihiko Sano, Masahide Harada
  • SYRINGE AND INJECTION NEEDLE SAFETY INSTRUMENT
    Publication number: 20170119976
    Abstract: A syringe includes a barrel, a plunger, an injection needle, and an injection needle safety instrument. The injection needle safety instrument has a base portion fixed to the barrel, a cover portion which can cover a pointed end of a needle tube of the injection needle, and a hinge portion which pivotably couples the base portion and the cover portion. The cover portion is constructed to be pivotable between a first position at which the cover portion is held to the base portion as a first locked portion is locked by a locking portion of the base portion and a second position at which the cover portion covers the pointed end of the needle tube and is held to the injection needle as a second locked portion is locked to the same. The cover portion is tilted toward the barrel in the first position.
    Type: Application
    Filed: February 12, 2015
    Publication date: May 4, 2017
    Applicant: NIPRO CORPORATION
    Inventor: Mitsuru HASEGAWA
  • MEDICAL VALVE
    Publication number: 20170106182
    Abstract: A medical valve which is able to more reliably support an outer peripheral part of an elastic valve body with respect to a housing, and prevent a problem of the elastic valve body becoming dislodged inward. A medical valve includes an elastic valve body with annular grooves formed thereon and a tubular support part formed at an outer peripheral side of an annular joining part positioned between the annular grooves. Inside and outside holding parts engage the annular grooves provided to the valve inside and outside surfaces of the annular joining part. The outside holding part and inside holding part are provided to an opening member, and with the tubular support part, a part projecting inward in an axial direction is sandwiched and supported between the inside holding part and outside holding part.
    Type: Application
    Filed: April 7, 2015
    Publication date: April 20, 2017
    Applicant: NIPRO CORPORATION
    Inventors: Kiyotaka YOSHIOKA, Hiroyuki NAKAGAMI, Shingo SAKAMOTO
  • Medicine packaging PTP sheet
    Patent number: 9622940
    Abstract: A medicine packaging PTP sheet capable of protecting a pocket from pressurization by external force in a combined state in which the medicine packaging PTP sheet has a first sheet in which a pocket capable of accommodating a medicine and a projecting convex portion each are projected from the upper surface and a second sheet which is attached to the lower surface of the first sheet and blocks an opening of the pocket. A first distance L1 from the upper surface of the first sheet to the projection end of the convex portion is longer than a second distance L2 from the upper surface of the first sheet to the projection end of the pocket.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: April 18, 2017
    Assignee: Nipro Corporation
    Inventor: Kazuaki Uetake