Abstract: A pouch container is provided with sack-like portions provided respectively to upper parts of the front-surface sheet and the rear-surface sheet.

Abstract: Provided is an advanced heart failure treatment material, as a myocardial/cardiovascular regeneration device, that self-assembles, which can improve the universality and be used in an emergency by commercialization with no need of cell-culturing (cell-free) by controlling stem cells, and has a high therapeutic effect on the fundamental treatment of intractable cardiovascular diseases, in particular, advanced heart failure, in which not only the saving of lives but also improving the patient's quality of life (QOL) are urgent issues. The advanced heart failure treatment material includes a pharmaceutical agent, an agent holding for the pharmaceutical agent, and a myocardial support device.

Abstract: A medical connector having a substantially cylindrical shape, a first upper end for receiving a male luer, and a second lower end, and including: a disc shaped valve member arranged at the first upper end and having an uppermost surface and a lowermost surface, a slit formed at a center portion thereof, an upper groove formed in a circumferential edge portion of the uppermost surface, and a lower groove formed in a circumferential edge portion of the lowermost surface; a housing with a pedestal for supporting the disc shaped valve member; a protrusion projecting upwardly from the pedestal and being arranged in the lower groove; and an annular ring member disposed on the circumferential edge portion of the uppermost surface, and having a claw portion projecting downwardly and being arranged in the upper groove on the uppermost surface of the valve member.

Abstract: A method for producing a vial with low alkali elution by removing a deteriorated region caused by processing on an internal surface of a vial is disclosed. The method is for forming vials from borosilicate glass tubes, which includes a first step of forming a mouth of the vial; a second step of forming the borosilicate glass tube into a cup-shaped body to form a bottom of a vial; and a third step of fire-blasting an internal surface of the cup-shaped body with a flame.

Abstract: An atherectomy catheter has a shaft having an opening in the side wall, a cutter which is positioned near the opening in the internal space of the shaft and which can move in the axial direction of the shaft, and a distal end portion connected to the distal end of the shaft. The distal end portion has a blade tube connected to the distal end of the shaft by continuing the internal space, a reduced diameter portion connected to the distal end of the blade tube by continuing the internal space, and a distal end tip whose outer diameter is smaller than the outer diameter of the distal end of the blade tube, whose distal end side is projected outward from the distal end of the reduced diameter portion, and whose proximal end side is extended into the internal space of the blade tube through the internal space of the reduced diameter portion.

Abstract: A filter device has a catheter having a lumen, a shaft extended in the longitudinal direction from the lumen, and a filter capturing an embolus. The filter is connected to the shaft through a slide ring at the distal end thereof. The shaft is inserted into and passed through the ring. The ring is rotatable with respect to the shaft and slidable in the longitudinal direction. When the filter is expanded in a blood vessel, the ring slides on the shaft. The filter is connected to the shaft through another ring on the peripheral edge of an opening. The shaft is inserted into and passed through the ring. The ring is rotatable with respect to the shaft. The ring is held between a pair of stoppers fixed onto the shaft. Therefore, the movement of the ring in the longitudinal direction with respect to the shaft is prevented.

Abstract: A fluid concentration measuring device measures the concentration of a fluid flowing through a duct having a light-transmissive, deformable duct wall. The device includes a light source; a light receiving element which receives the light, which passed through the wall of the duct and the fluid inside the duct, and outputs a signal indicating the intensity of the light; light path distance setting means and fluid concentration output means which obtains a plurality of relational expressions, which indicate the relation between the light intensity and the fluid concentration when the light from the light supply part is received by the light receiving part over each of the light path distances, and obtains the fluid concentration from the light intensity at the light receiving part based on the relational expressions for the plurality of light path distances and outputs the fluid concentration.

Abstract: A pre-filled syringe includes: a cylindrical container, a front end-side gasket; a rear end-side gasket; an intermediate gasket partitioning an inside of the cylindrical container into a front chamber and a rear chamber; a plunger; a medical drug contained in the front chamber, and a liquid drug contained in the rear chamber. In the state where the plunger is pushed in, a bypass portion included in the cylindrical container faces a groove portion provided in the intermediate gasket, thereby allowing communication between the front chamber and the rear chamber therethrough, so that the medical drug and the liquid drug are mixed, and a liquid mixture is discharged. The pre-filled syringe further includes a movement limiting mechanism for limiting movement of the plunger such that a tail end of the rear end-side gasket does not reach the bypass portion.

Abstract: An administration device can discharge a prescribed, equal amount of medicine a number of times by spraying. A spraying device includes a barrel; a gasket provided slidably movable in liquid-tight manner in the barrel; a rod coupled to a base end of the gasket; and a regulating member provided on the barrel, having a projection that can slidably fit with the guide groove. The guide groove includes at least first and second continuous administering grooves. The second administering groove is configured to include a transitional portion extending in the circumferential direction with a groove wall on the base end side aligned with the base end of the first administering portion, and a second administering portion extending from the transitional portion to a base end along the longitudinal direction. An energizing protrusion engageable with the projection is provided at a boundary between the transitional portion and the second administering portion.

Abstract: [Object] To provide a catheter having a simple structure capable of excising an atheroma in a blood vessel and capable of obtaining ultrasonic images of a blood vessel. [Solution] A catheter 10 has a shaft 11 having an opening 20 in a part of the side wall on the distal end side, a cutter 12 which is located in the vicinity of the opening 20 in the internal space of the shaft 11 and which can move in the axial direction 101 of the shaft 11, a balloon 23 which is disposed on the side opposite to the opening 20 with respect to the axis of the shaft 11 and which outwardly expands from the side wall of the shaft 11, and a phased array ultrasound probe 17 disposed along the circumferential direction 102 of the outer peripheral surface of the side wall in the vicinity of the opening 20 at least on the same side as the side where the opening 20 is provided with respect to the axis of the shaft 11.

Abstract: The present invention provides a hemiacetal ester prodrug of the pyridone carboxylic acid antibacterial drug, wherein the prodrug is characterized in that, (i) it is hydrolyzed promptly after intestinal absorption and regenerates the pyridone carboxylic acid antibacterial drug as a drug substance, (ii) a one-dose package is possible by preventing chelate-formation in intestines in an oral administration, and (iii) the normal bacterial flora of the intestinal bacterial flora is not influenced at all until the ester is absorbed, because the hemiacetal-type esterification is executed on the carboxylic acid which is a center of the antibacterial action, resulting in prevention of the pseudomembranous colitis. The prodrug is an alkoxy carbonyl hemiacetal-type ester represented by the chemical formula (I), which is useful as a prodrug for inhibiting the enteric-bacterium-shift side effect, and can be used in combination with polyvalent metal-containing medicines.

Abstract: An infusion pump has a primary finger with an inclined surface, which is obliquely inclined to an advancing and retracting direction, and a secondary finger with an inclined surface, which is slidable relative to the inclined surface of the primary finger. When the primary finger is advanced, the secondary finger is retracted in proportion to the variation (increasing) in an entire width of an infusion tube, and when the primary finger is retracted, the secondary finger is advanced in proportion the variation (decreasing) in the entire width of the infusion tube. This configuration can suppress the occurrence of any gap between a tip surface of the secondary finger and an outer peripheral surface of the infusion tube in the advancing and retracting process of the primary finger. Consequently, this prevents the infusion tube from meandering, and suppresses the reduction in the accuracy of the rate of infusion.

Abstract: An object of the present invention is to provide a method for preserving pancreatic islet, a container for preserving pancreatic islet and a kit for transplanting pancreatic islet in order to effectively preserve the pancreatic islet. The present invention presents; a method for preserving a liquid including pancreatic islet in a container for preserving pancreatic islet, wherein at least a part of the container wall face consists of a film having an oxygen permeation coefficient of 2500 cm3/m2·day·atm or greater; a method for preserving a liquid including pancreatic islet in a container for preserving pancreatic islet, wherein at least a part of the container wall face consists of a film having a carbon dioxide permeation coefficient of 1000 to 20000 cm3/m2·day·atm; and a container for preserving pancreatic islet for use in the above-described method, and a kit for transplanting pancreatic islet comprising the container for preserving pancreatic islet.

Abstract: An atherectomy device has a drive circuit which rotates a direct-current motor. The drive circuit has a three-terminal regulator having an ADJ terminal. A partial pressure resistor is connected between the ADJ terminal and an output terminal of the three-terminal regulator. Moreover, one end of six variable resistors whose resistances are set to be different from each other is connected to the ADJ terminal. The other end of the six variable resistors is selectively connected to the negative electrode of a battery by a change-over switch which is a rotary switch having six contacts. When the variable resistors are switched by the change-over switch, the output current of the three-terminal regulator becomes large. Thus, the rotation speed of a cutter which is rotated by the direct-current motor becomes high.

Abstract: Provided is a means suitable for mass culture of adherent cells and which allows easy and safe collection of the cultured adherent cells. A cell culture kit has a culture bag having flexibility, such a level of hydrophilicity that the culture of adherent cells can be achieved, and permeability into a bag shape and which is filled with a culture medium; a dissociation solution bag filled with a dissociation solution containing a metal chelating agent or ornithine or a derivative thereof, and a solution sending circuit or a derivative thereof, and a solution sending circuit which connects the culture bag and the dissociation solution bag to each other and can send the dissociation solution from the dissociation solution bag to the culture bag.

Abstract: A connector which is detachably connected to a cylindrical section is prevented from unintentionally disconnecting and breaking. The connector has inner and outer cylinder members. The inner cylinder member has an engagement plate protruding from the inner peripheral surface of an inner cylinder body and engaging with a recess formed in the outer peripheral surface of the cylindrical section, and also has slits arranged radially and extending from the engagement plate to a part of the inner cylinder body. The engagement between the recess and the engagement plate restricts the axial movement of the inner cylinder member relative to the cylindrical section. When the outer cylinder member is mounted on the inner cylinder member, the inner peripheral surface of the outer cylinder member is in contact with the outer peripheral surface of the inner cylinder member, and the displacement of the engagement plate in the diameter expansion direction is restricted.