Abstract: A needle assembly includes a needle hole having an inside diameter that is greater than an outside diameter of a needle, and by a moving-side guide integrally provided to a needle tip cover being engaged with a fixed-side guide fixedly provided to the needle, a guide mechanism is provided to guide the needle tip cover from a proximal end side towards a distal end side of the needle while maintaining a state of noncontact with the needle, and to guide the needle tip cover to a position where the needle tip cover covers the needle tip while deviating the needle tip cover in a direction in which the needle hole goes away from a center axis of the needle at a position beyond the needle tip, and avoiding contact of the needle tip with the needle hole.

Abstract: The present invention relates to a synapse formation promoter and a brain plasticity promoter comprising CD24-negative mesenchymal stem cells prepared from a patient's own bone marrow aspirate and treatment of dementia, chronic-phase cerebral infarction, chronic-phase spinal cord injury, mental diseases, and the like using the synapse formation promoter and brain plasticity promoter.

Abstract: Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a core particle containing a water-soluble gelling swelling substance; an intermediate layer containing a drug and coating an outside of the core particle; and an outer layer containing a water-insoluble substance and coating an outside of the intermediate layer. In addition, the orally disintegrating tablet includes the above-described pharmaceutical composition particles.

Abstract: An object is to provide a blood purifying device and an access flow rate measuring method enabling easy and accurate measurement of an access flow rate of an access vessel. A blood purifying device includes a flow rate calculating unit calculating the access flow rate of an access vessel based on an initial blood indicator for blood distributed through a vein side circuit and flowing through the access vessel of a patient, the flow rate distributed through measuring means when a pump is reversed to cause the priming solution to flow out from an artery side circuit, and a blood indicator for the blood diluted with the priming solution which is obtained when the pump is reversed to dilute, with the priming solution, the blood distributed through the vein side circuit.

Abstract: Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a drug-containing core particle; an intermediate layer containing a gelling swelling substance and coating an outside of the core particle; and an outermost layer containing a water-insoluble substance and coating an outside of the intermediate layer.

Abstract: A transmitted light intensity measurement unit for measuring a concentration of fluid flowing through a duct comprises: a light source for supplying light into the duct from a light supply part on a surface of the duct; a light receiving element for receiving the light, which has been passed from the light supply part through the duct wall and the fluid inside the duct, at a light receiving part located on an opposite side in a diametrical direction of the duct relative to the light supply part, and outputs a signal indicating an intensity of the light; and a light-transmissive member disposed on at least one light path among a light pass between the light source and the light supply part and a light pass between the light receiving element and the light receiving part, abutting and closely contacting the duct wall by an elastic deformation of the duct wall.

Abstract: A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.

Abstract: A microcapsule contains a biodegradable polymer and risperidone and has a sustained release property. The biodegradable polymer contained in the microcapsule has a molecular weight corresponding to 85% or more of an initial molecular weight (Mw) of the biodegradable polymer. A method of producing the microcapsule is also disclosed. The method of producing a microcapsule has (A) a step of preparing a first phase by mixing a solution of a biodegradable polymer and a solution of risperidone which are prepared separately, (B) a step of, immediately after the preparation of the first phase, mixing the first phase with a second phase being an aqueous phase to prepare an emulsion, and (C) a step of subjecting the resulting emulsion to in-water drying.

Abstract: Provided is new means for reducing risk of cerebral hemorrhage associated with a reperfusion therapy for vessel occlusion (for example, administration of a medicament including a thrombolytic agent, a platelet aggregation inhibitor, and an anticoagulant agent, or physical removal of a blood clot) and treating an ischemic vascular disorder more effectively. The present invention relates to a medicament for treating an ischemic vascular disorder, comprising mesenchymal stem cells, wherein the medicament is used in combination with a reperfusion therapy for vessel occlusion and more specifically, to a medicament for treating an ischemic vascular disorder, wherein the medicament reduces risk of cerebral hemorrhage associated with the reperfusion therapy for vessel occlusion and extends a time window in which the therapy is applicable.

Abstract: To provide a blood treatment filter device capable of efficiently utilizing a blood treatment filter. A blood treatment filter device 20 has a filter sheet 26 through which a specific component among components forming blood is harder to pass than other components and a spacer sheet 27 through which the specific component is easier to pass than through the filter sheet 26. The filter sheet 26 has filter through-holes 39 disposed at intervals. The filter sheet 26 and the spacer sheet 27 are spirally wound in an overlapped state. The filter device 20 has seals 31 sealing both end portions in the longitudinal direction of a wound body 25 formed by the filter sheet 26 and the spacer sheet 27 which are spirally wound in a fluid-tight manner. The outer peripheral surface of the wound body 25 is formed by the filter sheet 26.

Abstract: A connector which is detachably connected to a cylindrical section is prevented from unintentionally disconnecting and breaking. The connector has inner and outer cylinder members. The inner cylinder member has an engagement plate protruding from the inner peripheral surface of an inner cylinder body and engaging with a recess formed in the outer peripheral surface of the cylindrical section, and also has slits arranged radially and extending from the engagement plate to a part of the inner cylinder body. The engagement between the recess and the engagement plate restricts the axial movement of the inner cylinder member relative to the cylindrical section. When the outer cylinder member is mounted on the inner cylinder member, the inner peripheral surface of the outer cylinder member is in contact with the outer peripheral surface of the inner cylinder member, and the displacement of the engagement plate in the diameter expansion direction is restricted.

Abstract: It is an object of this invention to provide a simple measurement method capable of detecting indoxyl sulfuric acid in a sample rapidly and at high sensitivity. By causing sulfatase and tetrazolium salt to act on indoxyl sulfuric acid in a sample to generate a formazan dye, and then calculating the generation amount of the formazan dye, indoxyl sulfuric acid in the sample can be measured more simply, more rapidly, and at higher sensitivity as compared with former methods.

Abstract: A stent (32) configured to be placed in a body lumen and having a tubular shape formed by a structure that is expandable and contractible skeleton (18, 19) in a radial direction, the skeleton (18, 19) having a heteromorphic structure due to changes of a cross section shape thereof in a thickness direction. A stent (10) that is expandable and contractible in the radial direction while being configured to be placed in a body lumen, the stent (10) having a heteromorphic tubular shape, a cross section shape of which changes in a lengthwise direction, and having a metal skeleton (18, 19) formed by at least one of electroforming and etching.

Abstract: The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.

Abstract: Provided is a vial rubber stopper using multiple types of rubber to prevent the vial rubber stopper from being scraped and from sticking to a presser plate. The vial rubber stopper includes: a cap portion having a flange; a piercing area formed to have a recess at a top surface of the cap portion and configured to traverse longitudinally the cap portion in an axial direction from the recess to a bottom surface of the cap portion; and a leg portion formed on the bottom surface of the cap portion in a way of extending downward and located outside the piercing area with respect to an axial center of the cap portion. The piercing area is formed of rubber having rubber hardness from 20 to 35, and the top surface other than the recess of the cap portion is formed of rubber having rubber hardness from 58 to 90.

Abstract: A blood circuit connector includes: a main body having a cylindrical shape and provided with a first opening end and a second opening end; a plug having a bottomed cylindrical shape and detachably attached to the first opening end; and a connection part configured to connect the main body and the plug. The plug includes a side wall loosely fitted to an outer circumferential surface of the first opening end. The connection part includes a curved part expanding in a direction away from the main body. In a state where the plug is attached to the first opening, the curved part is pushed in a direction approaching the outer circumferential surface of the main body such that the curved part extends, thereby cancelling a loosely fitted state between the side wall and the outer circumferential surface, so as to remove the plug from the first opening end.

Abstract: An electrocardiograph measures an electrocardiac signal by processing electric signals detected by bioelectrode pads. The bioelectrode pads each includes a plurality of sheets of electrodes disposed by being stacked on each other; conductive gel sheets disposed alternately with the sheets of electrodes and interposed between the electrodes; and a dynamic pressure stabilizing plate. The electrocardiograph includes a first differential circuit for obtaining an electrocardiac source signal by taking the difference between signals each obtained from any one of the electrodes of each of two bioelectrode pads; a second differential circuit for obtaining a body motion noise signal by taking the difference between signals obtained from any two of the electrodes of each of said two bioelectrode pads; and a body motion noise removing circuit for removing the low frequency components of the body motion noise signal of each of said two bioelectrode pads from the electrocardiac source signal.

Abstract: A blood flow meter capable of measuring the flow rate of the blood flow with high accuracy in a blood vessel of a living body is provided. An element holding body having a tubular shape and having an outer diameter smaller than or equal to the outer diameter of a hollow shaft, which has flexibility and is insertable into a blood vessel, is provided on the distal side of the shaft so as to be coaxial with the shaft. A flow rate sensor is accommodated in the element holding body. The flow rate sensor has a measurement element in which a nickel wire is spirally wound to be formed into a coil shape so that adjacent nickel wires are not in contact with each other and are insulated. A thermal conductive insulating member is provided between the flow rate sensor and the element holding body in the element holding body and the flow rate sensor is fixed in the element holding body by the insulating member.