Abstract: A heat exchanger includes a case, a bottom member and a plurality of heat transfer pipes (a pipe group) loaded in the heat exchanger case, in which blood flows from one end through the bottom member. The bottom member has an annular wall, a bottom surface, and a blood inlet port. The bottom surface is opposed to one end of the heat transfer pipe. The bottom surface includes a groove portion and a raised bottom portion provided on each of opposing end sides of the groove portion. The raised bottom portion is inclined such that a distance between the raised bottom portion on a side where the blood inlet port is provided and one end of the heat transfer pipe is smaller than a distance between the raised bottom portion opposite to the side where the blood inlet port is provided and one end of the heat transfer pipe.

Abstract: A medical connector having a substantially cylindrical shape, a first upper end for receiving a male luer, and a second lower end, and including: a disc shaped valve member arranged at the first upper end and having an uppermost surface and a lowermost surface, a slit formed at a center portion thereof, an upper groove formed in a circumferential edge portion of the uppermost surface, and a lower groove formed in a circumferential edge portion of the lowermost surface; a housing with a pedestal for supporting the disc shaped valve member; a protrusion projecting upwardly from the pedestal and being arranged in the lower groove; and an annular ring member disposed on the circumferential edge portion of the uppermost surface, and having a claw portion projecting downwardly and being arranged in the upper groove on the uppermost surface of the valve member.

Abstract: Proteins respectively having the amino acid sequences represented by SEQ ID NOs: 1, 17 and 32; structural genes respectively encoding the proteins, preferably respectively having the nucleotide sequences represented by SEQ ID NOs: 2, 18 and 33; an antibody capable of specifically binding to feline-derived cystatin C, feline-derived ?2 microglobulin or feline-derived ?1 microglobulin; a kit for diagnosing feline nephropathy, containing the antibody of the present invention; and a method for diagnosing feline nephropathy using the antibody of the present invention.

Abstract: A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.

Abstract: Provided is a means suitable for mass culture of adherent cells and which allows easy and safe collection of the cultured adherent cells. A cell culture kit has a culture bag having flexibility, such a level of hydrophilicity that the culture of adherent cells can be achieved, and permeability into a bag shape and which is filled with a culture medium; a dissociation solution bag filled with a dissociation solution containing a metal chelating agent or ornithine or a derivative thereof, and a solution sending circuit or a derivative thereof, and a solution sending circuit which connects the culture bag and the dissociation solution bag to each other and can send the dissociation solution from the dissociation solution bag to the culture bag.

Abstract: A novel wipe set and a novel wiping method in which the wipe set is used are provided. With the wipe set comprising a first wipe impregnated with 50 to 200 mg of a sodium hypochlorite aqueous solution per gram of the wipe, a second wipe impregnated with 30 to 110 mg of a sodium thiosulfate aqueous solution per gram of the wipe, and a third wipe impregnated with 4 to 110 mg of a sodium hydroxide aqueous solution per gram of the wipe as well as by the wiping method in which the wipe set of the present invention is used, an anticancer agent spilled on a working table, for example, can be removed effectively.

Abstract: A medical connector of improved configuration. Annular grooves are formed in both inner and outer surfaces of an outer peripheral portion of an elastic valve element to form an annular constricted section. An outer peripheral side from the constricted section is made to serve as an annular fixation section. A valve receiving seat is formed at an inner peripheral edge of an aperture portion in a housing, and an annular ring is fixed to the aperture portion to sandwich and support the annular fixation section between the valve receiving seat and the annular ring. Engaging projections formed on mutually facing surfaces of the valve receiving seat and the annular ring are engaged with the annular grooves, and either the engaging projection and/or the engaging projection is divided in a circumferential direction to have a plurality of projection-divisions.

Abstract: There is provided a method for manufacturing a double-chamber container including an agent storage chamber and a solution storage chamber separated from each other by a weak seal portion, the method including the steps of: preparing a first sheet-like member including a first agent storage chamber forming portion and a first solution storage chamber forming portion whose one sides are joined to each other, as well as a second sheet-like member including a second agent storage chamber forming portion and a second solution storage chamber forming portion whose one sides are joined to each other; and forming the agent storage chamber and the solution storage chamber by joining the first and the second sheet-like members. The weak seal portion is formed by joining the one side of the first medical solution storage chamber forming portion and the one side of the second medical solution storage chamber forming portion.

Abstract: A blood reservoir (1) including a venous blood filter (40) and a cardiotomy filter (5). The cardiotomy blood filter includes a first cardiotomy blood filter member (51) and a second cardiotomy blood filter member (52). The filter member (52) is equipped with a first filter portion (52a) and a second filter portion (52b). The first filter portion (52a) forms the wall portion and the second filter portion (52b) forms the bottom portion. Specifications of the first filter portion (52a) and the second filter portion (52b) are different. A guide member (60) of the blood storage tank (1) is made of a foam material. The blood from which bubbles have been removed is guided while permeating the guide member (60). Consequently, the guide member (60) can lead the blood from which bubbles are removed to a predetermined position at a suitable liquid impact speed.

Abstract: A medical tube clamp wherein first and second plate parts including, on opposing surfaces, compressive protrusions for closing a medical tube are provided with a pair of side walls on both sides projecting from one toward an other of the plate parts, and are also provided with a central guide protrusion projecting from the other toward the one of the plate parts. Both sides of a tip portion of the central guide protrusion make sloping guide surfaces projecting toward a center. When the plate parts are displaced relative to each other so as to become closer, lateral displacement of them is corrected by a slide of the pair of side walls and the sloping guide surfaces, and the central guide protrusion is inserted between the pair of side walls.

Abstract: A method for producing a vial with low alkali elution by removing a deteriorated region caused by processing on an internal surface of a vial is disclosed. The method is for forming vials from borosilicate glass tubes with a bottom wherein an internal surface of the tube is fire-blasted with a flame.

Abstract: Provided is a vial rubber stopper using multiple types of rubber to prevent the vial rubber stopper from being scraped and from sticking to a presser plate. The vial rubber stopper includes: a cap portion having a flange; a piercing area formed to have a recess at a top surface of the cap portion and configured to traverse longitudinally the cap portion in an axial direction from the recess to a bottom surface of the cap portion; and a leg portion formed on the bottom surface of said cap portion in a way of extending downward and located outside the piercing area with respect to an axial center of said cap portion. The piercing area is formed of rubber having rubber hardness from 20 to 35, and the top surface other than the recess of the cap portion is formed of rubber having rubber hardness from 58 to 90.

Abstract: A balloon catheter of novel configuration, which is capable of both efficiently heating a heating element by using a laser light and of ensuring durability by avoiding the laser light directly heating members other than the heating element. Provided is a balloon catheter with a balloon disposed in a distal end section of a shaft and wherein: a tightly wound coil shaped heating element is housed and arranged in the balloon; an optical fiber that irradiates a laser light inside the heating element is disposed; and a supply path that supplies a fluid to inside the balloon through an inside of the heating element and a discharge path that discharges the fluid from inside the balloon through a discharge port positioned on an outside of the heating element are disposed.

Abstract: A drug solution transferring device that can suppress dispersion of a toxic drug solution to a surrounding environment is provided. The drug solution transferring device includes a barrel provided with an opening, and a connection tool for connection to the barrel. The barrel includes an elastic member for closing the opening. The elastic member is formed of a plurality of membranes overlaid together. The membrane has a projection projecting into the barrel. The connection tool includes a first needle having a sharp tip end. The first needle has a liquid hole extending in an extending direction of the first needle. When the needle penetrates through the projection of the membrane, an inside and an outside of the barrel are in communication with each other through the liquid hole to allow transference of the drug solution between the barrel and the connection tool.

Abstract: A disposable lancing device including: a lancet housed in a housing and urged by a spring member such that a puncture member provided at a distal end of the lancet is adapted to extend out from the housing so as to carry out a puncturing operation; a locking ring disposed within the housing such that the lancet is allowed to displace in an extension direction through the locking ring; a locking protrusion provided to the lancet and adapted to be engaged by the locking ring so as to hold the lancet in a puncture-ready position located deep in the housing with the spring member being compressed; and an operating member adapted to carry out the puncturing operation by rotating the locking ring so as to disengage the locking protrusion from the locking ring and displace the lancet in the extension direction by means of the spring member.

Abstract: A method for producing a vial with low alkali elution by removing a deteriorated region caused by processing on an internal surface of a vial is disclosed. The method involves forming vials from borosilicate glass tubes including a first step of forming a borosilicate glass tube into a cup-shaped body by formation of a bottom of a vial, and a second step of forming the cup-shaped body into the vial by formation of a mouth of the cup-shaped body.

Abstract: A method for producing a vial with low alkali elution by removing a deteriorated region caused by processing on an internal surface of a vial is disclosed. The method is for forming vials from borosilicate glass tubes, which includes a first step of forming a mouth of the vial; a second step of forming the borosilicate glass tube into a cup-shaped body to form a bottom of a vial; and a third step of fire-blasting an internal surface of the cup-shaped body with a flame.

Abstract: To provide a measure for reducing the leaching values of alkali components defined in ISO4802 and the like as much as possible in a glass container for use in storage or the like of pharmaceuticals or the like. The measure includes a container converting process of processing a glass tube into a container shape having a bottom and an opening to form a vial and a fire blast process of scanning an inner surface of the vial with a flame of a point burner while emitting the flame to an internal space of the vial and applying the flame to the inner surface.

Abstract: A medical hollow needle structured in accordance with the present invention, wherein the puncture resistance of a blade surface over the entire length in the puncture direction can be made substantially equal, and the patient's pain during needle puncture can be relieved due to a reduction in the peak level of puncture pain with the duration of sensory awareness of the puncture pain shortened by the use of the blade surface in a novel shape employing, in combination with each other, first to fourth inclined surfaces having specific inclination directions. Accordingly, the present invention provides a medical hollow needle with a blade surface in a novel shape whereby the puncture pain can be further reduced compared to needles with a conventional structure, and to provide a preferred method of producing such a medical hollow needle.

Abstract: The invention is configured so that pressurized gas from a pressurized gas supply source passes through a pressurized gas channel provided in a main body of a powder spraying device and is sprayed out. A powder container containing powder such as medical agents is provided on the main body. The powder within the powder container is supplied to the pressurized gas channel and is sprayed together with the pressurized gas. An eccentric rotor with a center of gravity deviated from a center of rotation is provided in the main body. When spraying the powder together with the pressurized gas, vibrations are applied to the main body and the powder container by a rotation of the eccentric rotor. The powder can be thereby mixed more evenly with the pressurized gas.