Abstract: A cellular electric potential measuring container includes a container body and an electrode substrate, the electrode substrate being attached to a lower end of the container body so as to form a plurality of wells, the cellular electric potential measuring container being for measuring cellular electric potential after being mounted on an electric potential measuring device, wherein the container body comprises: a plurality of tubular portions whose upper and lower ends are open. The electrode substrate includes a substrate body, with a plurality of measurement electrodes and a plurality of reference electrodes being disposed on one surface of the substrate body, and the container body is attached to the surface of the substrate body on which the measurement electrodes and the reference electrodes are disposed, and a method for producing a cellular electric potential measuring container.

Abstract: To provide a means capable easily releasing twist of two or more guidewires passed through a guiding catheter without pulling out the guidewires. A twist releasing apparatus has a shaft, a first tube formed at the tip of the shaft and has a first lumen through which two or more guidewires can be passed, a second tube disposed through a gap at the tip side in the axis direction relative to the first tube and has a second lumen through the two or more guidewires can be passed, and a connection portion for connecting the first tube and the second tube so that the two or more guidewires can be passed through the first lumen and the second lumen. The second tube has a slit that is formed in an axis direction and can be elastically deformed. The connection portion can be elastically deformed into a curved shape in the axis direction.

Abstract: It is an object to provide an orally disintegrating tablet produced by dry granulation and compression, having a hardness of 40 N or more, a disintegration time of 30 seconds or shorter, a friability of 0.1% or less, and an excellent feeling upon ingestion, that is capable of disintegrating with a small amount of water, having a rapid disintegration time, and being maintained stably in a tablet form, which could not been achieved by conventional procedures. Disclosed is an orally disintegrating tablet produced by dry granulation which contains a medicinal ingredient with silica, and sugar alcohol or/and sugar.

Abstract: A disposable lancing device including: a lancet housed in a housing and urged by a spring member such that a puncture member provided at a distal end of the lancet is adapted to extend out from the housing so as to carry out a puncturing operation; a locking ring disposed within the housing such that the lancet is allowed to displace in an extension direction through the locking ring; a locking protrusion provided to the lancet and adapted to be engaged by the locking ring so as to hold the lancet in a puncture-ready position located deep in the housing with the spring member being compressed; and an operating member adapted to carry out the puncturing operation by rotating the locking ring so as to disengage the locking protrusion from the locking ring and displace the lancet in the extension direction by means of the spring member.

Abstract: There is provided a winged indwelling needle for reducing the possibility of damaging a blood vessel or the like by a cannula, including a movable unit 1 having the cannula and a hub, a tube 2 connected to the rear portion of the hub, a holder 3, and a fixing wing 4, in which the movable unit 1 is provided on the holder 3 so as to be capable of sliding in the axial direction, is capable of changing in position between a position in use and a stored position which is behind the position in use, and the movable unit 1 is fixed to the position in use so as to be releasable. The holder 3 includes a protecting cylinder 26 which stores only the front portion including a blade point 6A of the cannula 6 in the interior thereof when the movable unit is positioned at the stored position and is provided with the fixing wing 4, and a guide member 27 exposed upward for guiding the sliding movement of the movable unit 1.

Abstract: The prefilled syringe filled with a drug in advance, leaking of liquid from the cap is prevented, gas barrier properties are given to the whole of the barrel filled with the drug and the shoulder section so that degradation of the drug is prevented, permeation of microbial contaminants is prevented to a high extent, and efficiency of packing as a compact container can be increased. The prefilled syringe includes a guard-shaped extension projecting from the outer periphery of a shoulder section of the syringe barrel on the nozzle side, and a range from a part where a gasket of the plunger is positioned on the outer surface of the syringe barrel filled with the drug to the guard-shaped extension is covered with barrier packaging.

Abstract: A package for a cryopreservation container including at least an adhesive fluoropolymer film. The package for a cryopreservation container makes it possible to store blood, rare cells and vital tissues in a very low temperature environment without any damage to the container. Further, the sealing strength resulting from heat sealing after placing a cryopreservation container in the packages is very good. Therefore, liquid nitrogen can be inhibited from entering the inside and thus contamination with bacteria, viruses or the like contained in liquid nitrogen can be avoided and the package can be prevented from being broken by expansion of intruder liquid nitrogen on the occasion of thawing. Also disclosed is a method for packaging a cryopreservation container and a method of producing a package for a cryopreservation container.

Abstract: Provided is a blood storage tank equipped with a filter having a treatment capacity desired by a health worker. A health worker managing a blood storage tank can comprehend the amount of stored blood more accurately. Furthermore, bubbles are prevented from being mixed into blood after bubbles are removed therefrom. A filter member (52) of a blood storage tank (1) is a filter member for removing foreign matters and bubbles from the blood. The filter member (52) is equipped with a first filter portion (52a) and a second filter portion (52b). The first filter portion (52a) forms the wall portion and the second filter portion (52b) forms the bottom portion. Specifications of the first filter portion (52a) and the second filter portion (52b) are different. The guide member (60) of the blood storage tank (1) consists of foaming material. The blood from which bubbles are removed are thereby led in a state where the blood permeated the guide member (60).

Abstract: A medical container comprising a body for containing a medicament, the body of the medical container being formed of a multilayered film comprising (i) a layer formed of a linear polyolefin and (ii) a layer formed of a cyclic polyolefin adjacent to the layer (i), and the layer (i) formed of the linear polyolefin satisfying the following conditions (a) and/or (b): Condition (a): an amount of a liquid component, which remains after Soxhlet's extraction with organic solvents followed by evaporation of the solvents, is 0.2% by weight or less, and Condition (b): a branching degree of a component, which remains after Soxhlet's extraction with n-hexane followed by evaporation of n-hexane, is 50 or less per 1,000 carbon atoms.

Abstract: A medical connector of improved configuration. Annular grooves are formed in both inner and outer surfaces of an outer peripheral portion of an elastic valve element to form an annular constricted section. An outer peripheral side from the constricted section is made to serve as an annular fixation section. A valve receiving seat is formed at an inner peripheral edge of an aperture portion in a housing, and an annular ring is fixed to the aperture portion to sandwich and support the annular fixation section between the valve receiving seat and the annular ring. Engaging projections formed on mutually facing surfaces of the valve receiving seat and the annular ring are engaged with the annular grooves, and either the engaging projection and/or the engaging projection is divided in a circumferential direction to have a plurality of projection-divisions.

Abstract: A balloon catheter including a connecting member, a catheter shaft, a balloon and a heat-generating member. The heat-generating member is in contact with a fluid in a distal portion of the catheter shaft. A method for treating a patient including introducing a low temperature fluid which flows through the balloon, introducing energy into a catheter shaft, and converting the energy into heat by a heat-generating member to heat the fluid, whereby an organ of the patient is heated and cooled. In the method, a portion of a diseased tissue of the organ is (i) heated from 35 to 40° C. to 60 to 80° C. within 30 seconds, (ii) expanded by applying a pressure of 500 kPa or smaller to the balloon, and (iii) cooled to 45° C. or lower within 40 seconds.

Abstract: A needle tip protector is configured in such a manner that a flexible plate is provided to a protector main body over which an action ring is mounted and that the flexible plate undergoes flexural deformation when the action ring is moved to a predetermined position relative to the protector main body. When the flexible plate undergoes flexural deformation, a needle tip of an inner needle to which the protector main body is mounted is protected by a protection part placed at a distal end of the flexible plate. The needle tip protector is also provided with a slip-stop mechanism for preventing the action ring from slipping out of the protector main body in an axial direction of the needle.

Abstract: A prefilled syringe composed of a barrel having a luer tip at one end and an open proximal end, the barrel having at least a three layer structure of an innermost layer, an outermost layer, both made of a polyolefin resin, and an intermediate layer made of a resin with a barrier property and sandwiched by the innermost layer and the outermost layer. The barrel is produced through the sequential steps of: (a) injecting a specific amount of a polyolefin resin inside a cavity; (b) injecting a specific amount of a resin excelling in barrier property; (c) injecting a specific amount of the polyolefin resin again; and (d) separating the luer tip surface and an injection unit by pushing off a valve pin provided inside a valve gate or an inner nozzle of the injection unit, which injects the resin excelling in barrier property, toward the direction of the luer tip surface as desired.

Abstract: A drape for clean operation is a flexible bag-shaped structure for maintaining a substantially closed operating space around an operation site. The bag-shaped structure comprises a bottom wall 1 and a transparent top wall 2 and has a closed proximal end 100a and a closed distal end 100b. The bottom wall 1 is provided with at least one operation site-revealing opening 3 close to the proximal end, and the top wall 2 is provided with at least one pair of hand insertion parts 4 at a position close to the operation site-revealing opening 3 to allow the physician to aseptically insert the hands into the operating space, and a closed, openable and closable medical device supply port 5 for supplying medical devices required for operations at a position away from the operation site-revealing opening 3.

Abstract: To provide a syringe in which a covering member whose engagement has been released automatically moves to a projection movement terminal where it can be prevented from returning, and returning of a projection positioned at the projection movement terminal can be limited.

Abstract: Glycosylated albumin as a drug carrier for a DDS targeting the liver (particularly kupffer's cell) can be provided by mutating a DNA encoding albumin to encode a mutant albumin containing a partial amino acid sequence permitting glycosylation modification by eukaryotic cell, preferably a consensus sequence of N-linked sugar chain, introducing an expression vector containing the mutant DNA into a host eukaryotic cell, preferably a host cell permitting addition of a high-mannose type sugar chain, culturing the obtained transformant, and recovering a glycosylated albumin protein from the obtained culture.

Abstract: Indwelling needle includes a cylindrical body, a needle having a sharp edge at a tip thereof, a cylindrical hub retaining proximal end of needle and moveable along main body, a protective cover moveable along main body and projecting from main body, and a spring elastically installed between hub and protective cover. First engaging portion of actuating lever is provided on body engaged with first projection of protective cover and second through-hole in hub to allow first retention mechanism to retain indwelling needle in a use state. First engaging portion is moved upward to release first retention mechanism. This separates protective cover and hub from each other under elastic force of spring. Protective cover and hub are thus retained in a housed state by second retention mechanism and third retention mechanism, respectively. This configuration reduces length of member contacting patient in the use state.