Abstract: Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

Abstract: Embodiments include a unified framework for minimizing congestion-dependent network cost by jointly optimizing forwarding and caching strategies that account for link congestion between neighboring nodes. As caching variables are integer-constrained, the resulting optimization problem is a non-deterministic polynomial time (NP)-hard problem. Embodiments relax the optimization problem, where caching variables are real-valued. Embodiments include optimality conditions for the relaxed problem. Embodiments include an adaptive and distributed joint forwarding and caching method, based on a conditional gradient method. Embodiments elegantly yield feasible routing variables and integer caching variables at each iteration, and can be implemented in a distributed manner with low complexity and overhead. Over a wide range of network topologies, simulation results show that embodiments have significantly better delay performance in the low to moderate request rate regions.

Abstract: Adaptive RF filters based on modulated resonators are provided. The filter architecture is based on time-interleaved commutation of passive RF resonators. The architecture can behave as a two-port filter network, with a fully tunable instantaneous filter bandwidth. The filters are applicable as miniaturized, environment-aware RF signal processing components and can be used in mobile communications.

Abstract: The invention provides a multi-functional true triaxial shear test device and method for hard rocks, the device comprises a hydraulic system, a left-end combination tangential loading oil cylinder, a right-end combination tangential loading oil cylinder, a front-end combination lateral loading oil cylinder, a rear-end combination lateral loading oil cylinder, an upper normal loading oil cylinder, a lower normal loading oil cylinder, an annular framework, a lateral auxiliary push-and-pull framework, an annular framework support platform, a horizontal support platform and a test chamber. The stiffness of the device is improved, and besides, a total section stress covering loading manner of the rock samples in a shear process is guaranteed. Through improving a temperature reduction manner of front ends of the oil cylinders, the situation that high temperature does not enable the temperature of hydraulic oil in the oil cylinders to rise to affect normal motion of the actuator can be guaranteed.

Abstract: Ion-doped two-dimensional nanomaterials are made by inducing electronic carriers (electrons and holes) in a two-dimensional material using a captured ion layer at the surface of the material. The captured ion layer is stabilized using a capping layer. The induction of electronic carriers works in atomically-thin two-dimensional materials, where it induces high carrier density of at least 1014 carriers/cm2. A variety of novel ion-doped nanomaterials and p-n junction-based nanoelectronic devices are made possible by the method.

Abstract: Multi-solid waste activated concretes with high-silicon iron ore tailings and preparation methods thereof are disclosed. In at least some embodiments, the concrete is prepared from raw materials including 360-380 kg/m3 of a cement, 30-40 kg/m3 of fly ash, 30-40 kg/m3 of a modified ultrafine sand of high-silicon iron ore tailings, 930-950 kg/m3 of a waste stone of tailings, 870-930 kg/m3 of a fine sand of tailings, 160-170 kg/m3 of water, and 4-8 kg/m3 of an additive.

Abstract: The invention provides a visualized time sequence pattern matching method based on Hough transformation, and relates to the technical field of data visualization analysis. The method comprises the steps of: firstly, judging whether historical data to be matched is one-dimensional time sequence data or multi-dimensional time sequence data, and if the historical data to be matched is the multi-dimensional time sequence data, performing normalization processing; performing time sequence selection: selecting a time sequence to be matched from the historical data in a time window pattern, and eliminating the selected time sequence from the historical data; converting a time sequence image in original coordinates to Hough space through the Hough transformation, and judging the similarity matching situation of the time sequence through a voting mechanism; and finally, screening the finally-matched results according to the voting results.

Abstract: The invention relates to a rapid rotation opening type high-pressure rock triaxial pressure chamber with a loading structure, a traditional loading frame is omitted, a pressure chamber shell is fixedly connected with an actuator cylinder barrel through high-strength bolts to form a counterforce body loading maximum principal stress, clearance is saved by 50%. An opening manner of up-and-down motion is abandoned, a pressure chamber sealing and spacing sleeve is sleeved outside the pressure chamber shell and can rotate, rock specimen access openings are formed on the pressure chamber shell and the pressure chamber sealing and spacing sleeve, and a dismountable plugging block is arranged in each rock specimen access opening in the pressure chamber shell, so that a rapid rotation opening manner is achieved. As such, a traditional process in which the high-strength bolts need to be disassembled and assembled is omitted.

Abstract: A multiplexed digital detection platform embodiment for molecular species in solution is based on a single-molecule immunochemistry, and/or aptamer chemistry, on color-barcoded beads. Beads that capture molecular species from a complex sample using selective binders are exposed to a test sample, and the captured molecular species is tagged using second affinity probes that are linked to photocleavable nucleic acid particles. In the embodiment, the beads are then introduced to a counter system that comprises a microcavity/nanopore device. Once a bead is captured by the micropore, nucleic acid particles, e.g., reporter nucleic acid nanoparticles (rNANPs), are released using photocleavage, and are detected by the nanopore. Each electrical spike that is uniquely produced by the nucleic acid nanoparticle is counted as a single molecular species, and the total count represents the overall number of molecular species in the sample. Various molecular species can be detected at the same time.

Abstract: Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.

Abstract: Heterocrystals of metal dichalcogenides and Bi2S3, Bi2Se3 or Bi2Te3 are presented, in which the metal dichalcogenides and Bi2S3, Bi2Se3 or Bi2Te3 do not largely retain their independent properties. These heterocrystals exhibit electronic and optical changes, which make them attractive for beyond-silicon electronics and optoelectronics. Particularly, these heterocrystals can be re-configured in a manner that allows bit writing and pattern drawing. Embodiments of these heterocrystals, methods of forming these heterocrystals, methods of reconfiguring the heterocrystals, information storage devices, optoelectronic circuits and photonic crystals are presented.

Abstract: The invention provides devices and methods for automatically preparing pure cultures of microbial cells under native environmental conditions. The devices and methods permit the discovery and investigation of novel microorganisms having unknown culture requirements from natural environments and microbiomes. Cultures obtained using the invention lead to the identification and isolation of novel biologically active compounds. The devices utilize a single entry pore in a thin membrane to select a single cell for clonal expansion.

Abstract: A high-voltage electric pulse device for crushing pretreatment of ores includes an ore feeding bin, a pulse insulating barrel body, a supporting frame, a pulsation device, a product collector and a power supply. The pulse insulating barrel body and the pulsation device are assembled together, a pulsation insulating barrel body is connected with an actuating diaphragm, the actuating diaphragm is connected with an ore discharging outlet, a pulsation cone is arranged in the ore discharging outlet, the pulsation cone is hinged to a connecting rod, and the connecting rod is hinged to an eccentric wheel. Expanding and contracting devices are arranged on a cover plate, a copper bar of each expanding and contracting device is connected to a corresponding high-voltage ceramic capacitor through a high-voltage wire in parallel. A high-voltage negative pole is mounted on a screen cloth at the pulse insulating barrel body.

Abstract: Embodiments solve a problem of minimizing routing costs by jointly optimizing caching and routing decisions over an arbitrary network topology. Embodiments solve an equivalent caching gain maximization problem, and consider both source routing and hop-by-hop routing settings. The respective offline problems are non-deterministic polynomial time (NP)-hard. Nevertheless, embodiments show that there exist polynomial time approximation methods producing solutions within a constant approximation from the optimal. Embodiments herein include distributed, adaptive networks, computer methods, systems, and computer program products that provide guarantees of routing cost reduction. Simulation is performed over a broad array of different topologies. Embodiments reduce routing costs by several orders of magnitude compared to existing approaches, including existing approaches optimizing caching under fixed routing.

Abstract: A resonator system is provided in which a combined overtone resonator device is excited with a two-dimensional mode of mechanical vibration in a cross sectional plane of a piezoelectric plate in response to an alternating voltage applied through an interdigitated electrode. The cross sectional plane extends along the width direction and the thickness direction, and the two-dimensional mode of mechanical vibration is a two-dimensional combined overtone mode of second and third order asymmetrical Lamb-wave overtones.

Abstract: A detector and inclusion location method that uses a reconstruction technique to target and localize sparse small-sized but high-contrast objects, such as a tumor inside tissue. The reconstruction technique applied, can dramatically enhance the property contrast of the tumors or abnormal inclusions by ten to one hundred fold. The reconstruction technique enables the use of nonlinear imaging ill-posed techniques that are function-oriented imaging techniques without any need for structural prior knowledge.

Abstract: The invention relates to a method for preparing high-melting-point metal powder through multi-stage deep reduction, and belongs to the technical field of preparation of powder. The method includes the following steps of mixing dried high-melting-point metal oxide powder with magnesium powder and performing a self-propagating reaction, placing an intermediate product into a closed reaction kettle, leaching the intermediate product with hydrochloric acid as a leaching solution so as to obtain a low-valence oxide MexO precursor of the low-valence high-melting-point metal; uniformly mixing the precursor with calcium powder, pressing the mixture, placing the pressed mixture into a vacuum reduction furnace, heating the vacuum reduction furnace to 700-1200° C., performing deep reduction for 1-6 h, leaching a deep reduction product with hydrochloric acid as a leaching solution and performing treatment, so as to obtain the high-melting-point metal powder.

Abstract: A wireless network operating system for communication between a plurality of nodes of a network is provided. The operating system can enable an operator to define a centralized network control problem at a high level, decompose automatically the network control problem into a set of distributed subproblems, each subproblem characterizing a local behavior of a single session or a subset of sessions or a single node or a subset of nodes or a single protocol layer or a subset of protocol layers, to generate in an automated manner a set of solution algorithms, and send the set of solution algorithms to each node for execution at an associated node controller to optimize the parameters of a programmable protocol stack based on local state information at each node. A network device for use at a node in a wireless network, a method of wirelessly communicating between a plurality of nodes in a network, and a method of providing a wireless network operating system are also provided.

Abstract: An ultra-low power sub-threshold gm stage is disclosed where transconductance is very stable with process, temperature, and voltage variations. This technique can be implemented in a differential amplifier with constant gain and a second order biquad filter with constant cut off frequency. The amplifier gain can achieve a small temperature coefficient of 48.6 ppm/° C. and exhibits small sigma of 75 mdB with process. The second order biquad can achieve temperature stability of 69 ppm/° C. and a voltage coefficient of only 49 ppm/mV.

Abstract: A system and method for transmitting data ultrasonically through biological tissue employs a network of a plurality of nodes, at least a portion of the nodes implantable within the biological tissue. At least one implanted node includes a transmitter having an orthogonal frequency division multiplex signal generator to encode an ultrasonic signal for transmission through the biological tissue to an ultrasonic receiver at another node.