Patents Assigned to Northeastern University
  • Techniques for processing power system network information
    Patent number: 11176289
    Abstract: Techniques and apparatus for parameter error detection in a power system based on state estimation are described. In one embodiment, for example, an efficient process may be used to derive and compute only the necessary subset of the gain matrix and covariance matrix, thus avoiding the computation and storage of large dense matrices. The described efficient process can be applied either to single-scan or multiple-scan schemes. Other embodiments are described.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: November 16, 2021
    Assignee: Northeastern University
    Inventors: Ali Abur, Yuzhang Lin
  • Piezoelectric cross-sectional Lamé mode transformer
    Patent number: 11158783
    Abstract: A transformer including a piezoelectric plate and interdigital electrodes is provided. The interdigitated electrodes includes a plurality of conductive strips disposed over the piezoelectric plate. A cross-sectional Lamé mode resonance is excited in a cross sectional plane of the piezoelectric plate in response to input voltage applied through the interdigitated electrode, producing a voltage gain. A device including the aforementioned transformer is also provided.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: October 26, 2021
    Assignee: Northeastern University
    Inventors: Matteo Rinaldi, Cristian Cassella
  • Damascene template for nanoelement printing fabricated without chemomechanical planarization
    Patent number: 11156914
    Abstract: Methods of fabricating a damascene template for electrophoretic assembly and transfer of patterned nanoelements are provided which do not require chemical mechanical polishing to achieve a uniform surface area. The methods include conductive layer fabrication using a combination of precision lithography techniques using etching or building up the conductive layer to form raised conductive features separated by an insulating layer of equal height.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: October 26, 2021
    Assignee: Northeastern University
    Inventors: Hobin Jeong, Ahmed Busnaina
  • Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates
    Patent number: 11129790
    Abstract: A method is provided for reversibly modifying a protein or peptide on its glutamine residue(s) by performing a reaction, such as a transglutaminase-catalyzed reaction, between the protein or peptide and an amine-containing reagent, whereby the reagent is linked through its amine function to a side chain of the glutamine residue. Subjecting the modified protein to an appropriate stimulus regenerates the protein or peptide in its original form.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: September 28, 2021
    Assignee: Northeastern University
    Inventors: Zhaohui Sunny Zhou, George O'Doherty, Shanshan Liu, Kevin Ryan Moulton, Lincoln Ombelets, Amissi Sadiki
  • Live single-cell bioassay in microdroplets
    Patent number: 11131673
    Abstract: Bioassays are provided for detecting and analyzing responses from single cells and cell pairs suspended in micro-scale droplets (80-200 ?m diameter) generated in microfluidic devices. Cell responses to various stimuli are analyzed. The stimuli are delivered by homotypic or heterotypic cells, small molecule drugs, and therapeutic agents including immunotherapeutics. The bioassays can be used to describe heterogeneity in any given cell population, and can be used in a clinical setting, such as profiling of patient-derived cells, designing personalized treatment strategies, and optimizing drug combinations for immunotherapy of tumors.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: September 28, 2021
    Assignee: Northeastern University
    Inventors: Tania Konry, Saheli Sarkar, Pooja Sabhachandani
  • Device and method for achieving core part press-down technology in continuous casting round billet solidification process
    Patent number: 11123780
    Abstract: A device for achieving a core part press-down technology in a continuous casting round billet solidification process includes a plurality of round billet radial press-down devices distributed along an axial array of round billets outside a press-down interval of the round billets. The press-down interval is an area from 0.65 of a solid phase ratio of the round billets to solidification end points. Each round billet radial press-down device includes a plurality of press-down rollers. A forming hole for extruding the round billets is formed between the press-down rollers. Two adjacent round billet radial press-down devices are arranged in the manner of staggering. The device can effectively solve the defect problems of porosity, segregation and the like in the core of the continuous casting round billets, the yield of the continuous casting round billets is increased, and the production cost is reduced.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: September 21, 2021
    Assignee: Northeastern University
    Inventors: Guo Yuan, Jian Kang, Yan Zheng, Zhenlei Li, Guanglin Jia, Guodong Wang
  • Software-defined implantable ultrasonic device for use in the internet of medical things
    Patent number: 11115475
    Abstract: Implantable and wearable devices and system for transmitting signals ultrasonically through biological tissue are implemented based on an Internet of Medical Things (IoMT) platform software and hardware architecture. The devices are size-, energy-, and resource-constrained and implement ultrasonic communication protocols and communicate with each other through ultrasound.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: September 7, 2021
    Assignee: Northeastern University
    Inventors: Tommaso Melodia, Giuseppe Enrico Santagati
  • Brush polymer-assisted compaction of oligonucleotides
    Patent number: 11104901
    Abstract: The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a non-cationic, sterically congested brush polymer and the use of such polymer-oligonucleotide conjugates in antisense gene regulation and as diagnostic agents.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: August 31, 2021
    Assignee: Northeastern University
    Inventors: Ke Zhang, Xueguang Lu
  • Secure and encrypted logging systems and methods with data recovery
    Patent number: 11106549
    Abstract: Secure logging systems and methods using cryptography and/or encryption with crash recovery. In some embodiments, the secure logging system includes an initialization module to initialize cells of a logging database, including inserting a pseudorandom number into each cell of the logging database. In some embodiments, the secure logging system includes an addition module to encrypt new log messages and add them to the logging database in a given number of pseudorandom cells of the logging database. In some embodiments, the secure logging system includes a listing module to determine where in the logging database the log message was stored and then to decrypt the encrypted log messages. These systems and methods improve computer related technology including by improving crash reconstruction, root cause analysis, network systems security, and logging system encryption and security.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: August 31, 2021
    Assignees: Airbus Defence and Space GmbH, Northeastern University
    Inventors: Erik-Oliver Blass, Guevara Noubir
  • Compounds with Antimicrobial Properties
    Publication number: 20210261616
    Abstract: Embodiments of the present invention relate to a novel compound of Formula (I) or stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, for use in treatment of infection caused by Gram-negative bacteria.
    Type: Application
    Filed: May 17, 2019
    Publication date: August 26, 2021
    Applicant: Northeastern University
    Inventors: Kim Lewis, Yu Imai, Quentin Favre-Godal, Akira Iinishi, Kirsten Meyer
  • Electric field encephalography: electric field based brain signal detection and monitoring
    Patent number: 11083401
    Abstract: Systems and methods for measuring brain activity of a subject are disclosed, comprising: positioning a plurality of electric field sensors at multiple positions on the exterior of a skull of the subject; measuring one to three components of a plurality of instantaneous electric field vectors generated by a plurality of electric field sources, the electric field vectors being measured by the plurality of electric field sensors; and determining brain activity of the subject based on the measurement of the plurality of instantaneous electric field vectors.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: August 10, 2021
    Assignee: Northeastern University
    Inventors: Srinivas Sridhar, Yury Petrov, Ozgur Yavuzcetin
  • Nanoscale etching of light absorbing materials using light and an electron donor solvent
    Patent number: 11073764
    Abstract: A method for etching a light absorbing material permits directly writing a pattern of etching of silicon nitride and other light absorbing materials, without the need of a lithographic mask, and allows the creation of etched features of less than one micron in size. The method can be used for etching deposited silicon nitride films, freestanding silicon nitride membranes, and other light absorbing materials, with control over the thickness achieved by optical feedback. The etching is promoted by solvents including electron donor species, such as chloride ions. The method provides the ability to etch silicon nitride and other light absorbing materials, with fine spatial and etch rate control, in mild conditions, including in a biocompatible environment. The method can be used to create nanopores and nanopore arrays.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: July 27, 2021
    Assignee: Northeastern University
    Inventors: Meni Wanunu, Hirohito Yamazaki
  • Colorimetric and multiplexed isothermal RNA-based assay for SARS-CoV-2 and other viral diagnostics and cell analysis
    Patent number: 11066697
    Abstract: Methods, devices, and kits for performing rapid, highly sensitive, high throughput, accurate, and flexible detection and quantification of nucleic acids based on highly optimized rolling circle amplification are provided. The methods, devices, and kits can be used to detect and track an emergent virus or other pathogen, including SARS-CoV-2, to test and diagnose individual patients with respect to a specific pathogen or disease, including COVID-19, and to detect and analyze cellular nucleic acids. The methods and devices also can be used to detect fragments and variants of DNA or RNA, including those present in cancer cells. The methods, devices, and kits are suitable for use in both high throughput screening carried out in centralized testing laboratories and in point-of-care testing devices used in the field, at home, in the workplace, or at public facilities for rapid detection and diagnosis.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: July 20, 2021
    Assignee: Northeastern University
    Inventors: Tania Konry, Ji Won Lim
  • Low noise ultrathin freestanding membranes composed of atomically-thin 2D materials
    Patent number: 11041247
    Abstract: The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal chalcogenides including molybdenum disulfide. The freestanding membranes are directly grown over an aperture by reacting two precursors in a chemical vapor deposition process carried out at atmospheric pressure. Membrane growth is preferentially over apertures in a thin sheet of solid state material. The resulting membranes are one or a few atomic layers thick and essentially free of defects. The membranes are useful for sequencing of biopolymers through nanopores.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: June 22, 2021
    Assignee: Northeastern University
    Inventors: Pradeep Waduge, Swastik Kar, Meni Wanunu, Joseph Larkin, Ismail Bilgin
  • METHOD FOR DETERMINING PARAMETERS OF HIGH-FREQUENCY VIBRATING MILL WITH THREE GRINDING DRUMS
    Publication number: 20210173974
    Abstract: A method for determining parameters of a high-frequency vibrating mill with three grinding drums is disclosed. The mathematic modeling is established by applying the average parameter method and transfer function method; the synchronization-stability capability coefficient curve, and the dimensionless coupling torque maximum value diagram of the system are obtained by the characteristic analysis of synchronization and stability. Finally, the curves of rotational velocity of motors, displacements of mass bodies, and phase difference between exciters are obtained by the simulation, and the correctness of the method is verified by the comparison of characteristic analysis and simulation. The parameters of the high-frequency vibrating mill of the present invention can lower the technical requirements of exciters, reduce the loss of the exciters, increase the service life of the mill.
    Type: Application
    Filed: September 12, 2019
    Publication date: June 10, 2021
    Applicant: Northeastern University
    Inventors: Xueliang ZHANG, Chao LI, Shiju CUI, Zhiguo GAO, Hongliang YUE, Zhenmin LI, Hui MA
  • Biocompatible and conductive hydrogels with tunable physical and electrical properties
    Patent number: 11028211
    Abstract: A biodegradable and biocompatible hydrogel of tunable conductivity is provided. The hydrogel includes a polymer conjugated to a bio-ionic liquid. The mechanical and electrical properties of the hydrogel can be varied by altering the ratio of the polymer to the bio-ionic liquid in the conjugated polymer. These properties can be varied also by changing the percent weight of the conjugated polymer in the hydrogel. A method for preparing the hydrogel is also provided.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: June 8, 2021
    Assignee: Northeastern University
    Inventors: Nasim Annabi, Iman Noshadi
  • Serotonin receptor-targeting compounds and methods
    Patent number: 11021435
    Abstract: This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine derivatives. Accordingly, the present invention provides for compositions and methods that agonize or antagonize one or more serotonin receptors and which find Use in the treatment of various neuropsychiatric diseases or disorders including, without limitation, autism spectrum disorder (ASD) or associated symptoms.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: June 1, 2021
    Assignee: Northeastern University
    Inventor: Raymond G. Booth
  • Ultrasonic network for wearable devices
    Patent number: 11020001
    Abstract: An ultrasonic communication system and method provide a networking framework for wearable devices based on ultrasonic communications. The ultrasonic communication system and method incorporate a set of physical, data link, network and application layer functionalities that can flexibly adapt to application and system requirements to efficiently distribute information between ultrasonic wearable devices.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: June 1, 2021
    Assignee: Northeastern University
    Inventors: Tommaso Melodia, Giuseppe Enrico Santagati
  • Direct write three-dimensional printing of aligned composite materials
    Patent number: 10987941
    Abstract: An apparatus and method for producing a composite part, such as a reinforced composite part, are provided that enable control over the fiber or other particle orientation within each layer of the part during manufacture. The apparatus and method employ a print head including a dispensing tip and a magnetic assembly controllable to apply a magnetic field at a print location adjacent the dispensing tip outlet.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: April 27, 2021
    Assignee: Northeastern University
    Inventors: Scott Goodrich, Andrew Caunter, Daniel Shores, Ryan Pembroke, Amy Den Dulk, Randall Erb
  • Cannabinergic nitrate esters and related analogs
    Patent number: 10968206
    Abstract: The present technology relates to novel cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools and/or biomarkers. The novel cannabinergic nitrate ester compounds provide medicaments useful in treating a variety of diseases and medical disorders.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 6, 2021
    Assignee: Northeastern University
    Inventors: Alexandros Makriyannis, Venkata Kiran Vemuri