Abstract: Aspects of the present disclosure describe systems and methods for predicting an intra-aortic pressure of a patient receiving hemodynamic support from a transvalvular micro-axial heart pump. In some implementations, an intra-aortic pressure time series is derived from measurements of a pressure sensor of the transvalvular micro-axial heart pump and a motor speed time series is derived from a measured back electromotive force of a motor of the transvalvular micro-axial heart pump. Furthermore, in some implementations, machine learning algorithms, such as deep learning, are applied to the intra-aortic pressure and motor speed time series to accurately predict an intra-aortic pressure of the patient. In some implementations, the prediction is short-term (e.g., approximately 5 minutes in advance).

Abstract: A multi-modal robot capable of legged and aerial locomotion includes a body structure including a plurality of legs, each leg having at least one joint; a plurality of thrusters connected to the body structure; and a plurality of actuators for controlled movement of the legs and thrusters. The plurality of actuators are embedded within composite housing structures in the body structure. The composite housing structures are formed by additive printing of composite material over components of the actuators. The composite housing structures are reinforced by layers of continuous carbon fiber material. A method of constructing an actuator for use in a multi-modal robot is also disclosed. Additionally, a computer-implemented method is disclosed to identify particular locations and sizes of components in multi-modal robots providing the lowest total cost of transport.

Abstract: A radio access network (RAN) intelligent controller (RIC) and corresponding method may be implemented within RAN and in next-generation cellular networks to improve performance. The RIC comprises an interface to a RAN and further comprises a data-driven logic unit. The data-driven logic unit (i) produces, based on data received from the RAN via the interface, a representation describing a state of the RAN and (ii) based on the representation describing the state, instructs an action associated with at least one network element. The interface transmits a message based on the action instructed. The message is to be routed to the at least one network element. The representation is based on a context of the RAN. The message transmitted enabling re-configuration of the at least one network element. The re-configuration improves performance of the at least one network element within the context.

Abstract: Methods and systems are provided for allocating resources to users in a wireless network including a plurality of edge nodes that provide wireless network access and multi-access edge computing functions. Slice requests are received from the users for a type of resource, including one or more of networking resources, storage resources, and computation resources. A set of slice requests to be admitted is determined based on resource availability constraints among one or more of the networking resources, the storage resources, and the computation resources at each edge node.

Abstract: A high throughput microdroplet-based system for single cell assays in microdroplets is provided. The system integrates parallel devices and switches to enable simultaneous analysis of different cells or cell combinations, or different assay conditions, on a single microfluidic chip. Interconnections between the inlets of individual devices on a common chip enable simultaneous screening of the effect of different combinations of drugs on single cells. The use of an oil inlet and microchannels with matched total flow resistance allows the synchronous generation of droplets with the same dimensions and/or volumes.

Abstract: A quantitative, ultrashort time to echo, contrast-enhanced magnetic resonance imaging technique is provided. The technique can be used to accurately measure contrast agent concentration in the blood, to provide clear, high-definition angiograms, and to measure absolute quantities of cerebral blood volume on a voxel-by-voxel basis.

Abstract: A method of delivering a therapeutic agent into the central nervous system through the blood-brain barrier includes implanting an implant within the submucosal space of the olfactory epithelium. The implant can provide sustained drug delivery to the brain. The implant can be placed using a minimally invasive surgical approach.

Abstract: High capacity, low cost devices for use in growing monocultures of novel, previously unknown microbial species contain adhesive layers with wells covered by nanoporous membranes. The devices are placed in natural environments for cultivation of unknown microbial species.

Abstract: A steganographic communication system and method are provided. A covert packet generator can embed a stream of covert data as covert data symbols within primary I/Q symbols of a primary data stream in a covert packet. The covert packet has a data structure having a header, a payload, and a payload error detecting code. The header includes information on how to demodulate the covert packet by a receiver. The covert packet generator can also determine if a number of primary I/Q symbols is large enough to generate the header and can generate displacements in the primary I/Q symbols in a constellation diagram randomly in a plurality of transmissions to mimic channel noise. A transmitter and receiver can provide mutual authentication for covert transmissions.

Abstract: Devices and methods of the present technology utilize wavelength-dependent transmittance of 2D materials to identify the wavelength of an electromagnetic radiation. A wide range of 2D materials can be used, making possible the use of the technology over a large portion of the electromagnetic spectrum, from gamma rays to the far infrared. When combined with appropriate algorithms and artificial intelligence, the technology can identify the wavelength of one or more monochromatic sources, or can identify color through the use of a training set. When applied in an array format, the technology can provide color imaging or spectral imaging using different regions of the electromagnetic spectrum.

Abstract: A hybrid radiating element may comprise a dielectric substrate having a thickness, a top surface and a bottom surface, and an electrically conductive patch disposed on the top surface of the dielectric substrate. The hybrid radiating element may further comprise a graphene stub disposed on the top surface of the dielectric substrate. The graphene stub may be contiguous with, and electrically coupled to, the electrically conductive patch. The hybrid radiating element may further comprise an electrically conductive layer disposed on the bottom surface of the dielectric substrate. An array of hybrid radiating elements may be arranged in a grid pattern of M rows and N columns. A codebook set of biasing voltages may be arranged to drive the radiating elements in the array as a phase transformation matrix, thereby manipulating the reflection of an incoming electromagnetic wave.

Abstract: Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

Abstract: An embodiment is a nozzle for use in additive manufacturing and other applications. The nozzle defines a flow path and is configured to generate a supersonic flow of particles or fluid during operation. The embodiment provides at least one auxiliary flow path port that is configured to introduce an auxiliary flow into the nozzle relative to the flow path that protects an internal surface of the nozzle from wear and corrosion, thereby extending the life of the nozzle for extended periods of continuous operation. An embodiment centralizes particle location along its continuous flow path to achieve small footprint material deposition, thereby increasing 3D print resolution for building more intricate components.

Abstract: Embodiments disclosed herein may be implemented in the form of a method or corresponding apparatus for receiving or transmitting network communications carried at acoustic wavelengths via an acoustic medium. The corresponding method or apparatus may include a gate-level digital hardware module communicatively coupled to a communications module and define therein logic blocks configured to perform respective primitive processing functions, sequences of the logic blocks being capable of processing data units in accordance with any of the multiple communications protocols on a data unit-by-data unit basis without reconfiguring.

Abstract: An auxetic structure includes a plurality of polyhedral units arranged adjacent one another to form a three-dimensional structure. Each polyhedral unit has protrusions extending orthogonally from some surfaces thereof and recesses formed in other surfaces thereof. The protrusions of each polyhedral unit are slidingly received in corresponding recesses of adjacent polyhedral units. A plurality of sleeves are positioned around each protrusion and in a corresponding recess. The sleeves are formed from a softer material than the protrusions. An auxetic effect is achieved by shear-induced displacement of the protrusions in corresponding recesses.

Abstract: Functionalized twin base linkers (TBLs) bind to and deactivate viruses by preventing their entry into cells. Functionalization of TBLs allows them to specifically bind to surface proteins of viruses, where they form structures that limit virus entry into cells and prevent viruses from replicating.

Abstract: A solidly mounted resonator (SMR)-based magnetoelectric (ME) antenna comprises a substrate, a Bragg reflector disposed on the substrate, a magnetostrictive/piezoelectric ME composite element disposed on the Bragg reflector, a first electrically conductive contact and a second electrically conductive contact. The first contact is disposed between the Bragg reflector and the magnetostrictive/piezoelectric ME composite element and electrically coupled to a bottom surface of the magnetostrictive/piezoelectric ME composite element. The second contact is disposed on top of the magnetostrictive/piezoelectric ME composite element and electrically coupled to the top of the magnetostrictive/piezoelectric ME composite element. The magnetostrictive/piezoelectric ME composite element comprises a magnetorestrictive multilayer deposited on a piezoelectric layer. The magnetorestrictive multilayer produces an in-plane uniaxial magnetic anisotropy (UMA). The UMA is a twofold UMA that exhibits a symmetric radiation pattern.

Abstract: The technology provides arrays of microwells with reversible shape for culture, analysis, and recovery of individual cells or groups of cells. The microwells are reversibly formed by vacuum-induced deflection of an elastomeric membrane into an array of microwell molds formed in a microwell substrate. The shape of each microwell or groups of microwells can be selectively altered by applying or releasing vacuum to individual microwells. The devices, systems, and methods utilizing the technology enable collection of individual cells for further study or therapeutic use without the need for micromanipulation.

Abstract: The invention provides cell culture chambers and methods of use thereof. In certain embodiments, the cell culture chambers and methods provide for an expansion and stimulation of T-cells using autologous antigen-presented cells to provide a therapeutic T-cell product that can mobilize a patient's own immune system in a manner that selectively targets a patient's tumor.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.