Patents Assigned to Northeastern University
  • Patent number: 11753321
    Abstract: Disclosed is an electro-Fenton-like (EFL) platform wherein an electrochemically produced acidic environment supports heterogeneous Fenton-like reaction for high throughput water treatment. The platform enables treatment of contaminated water.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: September 12, 2023
    Assignee: Northeastern University
    Inventors: Akram Alshawabkeh, Long Chen
  • Patent number: 11745236
    Abstract: The present disclosure provides a strip flatness prediction method considering lateral spread during rolling. The method includes: step 1: acquiring strip parameters, roll parameters and rolling process parameters; step 2: introducing a change factor of a lateral thickness difference before and after rolling and a lateral spread factor by considering lateral metal flow, and constructing a strip flatness prediction model based on the coupling of flatness, crown and lateral spread; step 3: constructing a three-dimensional (3D) finite element model (FEM) of a rolling mill and a strip, simulating strip rolling by the 3D FEM, extracting lateral displacement and thickness data of the strip during a stable rolling stage, calculating parameters of the strip flatness prediction model based on the coupling of flatness, crown and lateral spread; and step 4: predicting the flatness of the strip by the strip flatness prediction model based on the coupling of flatness, crown and lateral spread.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: September 5, 2023
    Assignee: Northeastern University
    Inventors: Jie Sun, Qinglong Wang, Pengfei Shan, Zhen Wei, Wen Peng, Jingguo Ding, Dianhua Zhang
  • Patent number: 11732337
    Abstract: The present disclosure provides a method for producing a high nitrogen steel by a duplex melting process of a pressurized ladle refining and a pressurized electroslag remelting, which relates to the technical field of high nitrogen steel melting. In the present disclosure, the molten steel is subjected in sequence to a nitrogen alloying, a deep deoxidation and a deep desulfurization by adding a nickel-magnesium alloy and rare earth in the pressurized ladle furnace, and a combination of a blowing nitrogen from the bottom of the pressurized ladle and a pressurized nitriding at the interface of gas and the molten steel is used to achieve a high-efficiency nitrogen alloying, a uniform nitrogen distribution, and a decreased impurity content in the ingot; then the ingot is subjected to a pressurized electroslag remelting to obtain a high nitrogen steel.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: August 22, 2023
    Assignee: Northeastern University
    Inventors: Huabing Li, Zhouhua Jiang, Hao Feng, Lingfeng Xia, Hongchun Zhu, Shucai Zhang, Weichao Jiao
  • Publication number: 20230245754
    Abstract: Aspects of the present disclosure describe systems and methods for predicting an intra-aortic pressure of a patient receiving hemodynamic support from a transvalvular micro-axial heart pump. In some implementations, an intra-aortic pressure time series is derived from measurements of a pressure sensor of the transvalvular micro-axial heart pump and a motor speed time series is derived from a measured back electromotive force of a motor of the transvalvular micro-axial heart pump. Furthermore, in some implementations, machine learning algorithms, such as deep learning, are applied to the intra-aortic pressure and motor speed time series to accurately predict an intra-aortic pressure of the patient. In some implementations, the prediction is short-term (e.g., approximately 5 minutes in advance).
    Type: Application
    Filed: January 13, 2023
    Publication date: August 3, 2023
    Applicants: ABIOMED, Inc., Northeastern University
    Inventors: Ahmad El Katerji, Erik Kroeker, Elise Jortberg, Rose Yu, Rui Wang
  • Patent number: 11705637
    Abstract: Magnetodielectric (MD) metamaterials have a magnetodielectric (MD) substrate of a ferrite composition or composite having a characteristic impedance matching an impedance of free space and at least one frequency selective surface (FSS). The FSS has a plurality of frequency selective surface elements disposed in a pattern and supported on the MD substrate. The FSS has a conducting composition and is configured to permit one or more of transmission, reflection, or absorption at a selected resonant frequency or selected frequency band. Articles incorporating magnetodielectric metamaterials are provided.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: July 18, 2023
    Assignee: Northeastern University
    Inventor: Vincent Harris
  • Patent number: 11702545
    Abstract: Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: July 18, 2023
    Assignees: The General Hospital Corporation, Northeastern University
    Inventors: Hak Soo Choi, Jonghan Kim, Georges El Fakhri
  • Patent number: 11701031
    Abstract: Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.
    Type: Grant
    Filed: November 8, 2021
    Date of Patent: July 18, 2023
    Assignee: Northeastern University
    Inventors: Nian Xiang Sun, Shadi Emam, Adam Keith Ekenseair
  • Patent number: 11701046
    Abstract: A portable wireless neuromonitoring device can be used to diagnose and/or treat conditions of the brain and vision system. The device includes a sensor unit mountable on the head of a human subject and capable of recording signals from the brain in EEG and/or EFEG (electric field encephalography) mode, and the device can be used for simultaneous stimulus display and recording with latency of less than 1 millisecond. The device also includes electrodes that allow rapid set-up and measurement with low impedance contact with the scalp. The device can also be used in conjunction with virtual reality or alternate reality environments.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: July 18, 2023
    Assignee: Northeastern University
    Inventors: Srinivas Sridhar, Craig Versek, Peter Bex
  • Patent number: 11677625
    Abstract: A framework for joint computation, caching, and request forwarding in data-centric computing-based networks comprises a virtual control plane, which operates on request counters for computations and data, and an actual plane, which handles computation requests, data requests, data objects and computation results in the physical network. A throughput optimal policy, implemented in the virtual plane, provides a basis for adaptive and distributed computation, caching, and request forwarding in the actual plane. The framework provides superior performance in terms of request satisfaction delay as compared with several baseline policies over multiple network topologies.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: June 13, 2023
    Assignee: Northeastern University
    Inventors: Edmund Meng Yeh, Khashayar Kamran
  • Publication number: 20230175105
    Abstract: A high-strength steel allowing low-temperature welding and high-heat input welding and a production method thereof are provided, which belongs to the technical field of steel production. The high-strength steel includes the following chemical components by mass fraction: 0.03-0.16% of C, 0.05-0.5% of Si, 1.0-1.9% of Mn, 0.002-0.02% of P, 0.001-0.01% of S, 0.005-0.07% of A1, 0.005-0.04% of Ti, 0.1-0.5% of Cr, 0.0005-0.005% of B, 0.002-0.01% of Mg+Zr, 0.001-0.008% of O, 0.004-0.01% of N, and the balance of Fe and residual elements. Magnesium and zirconium are added to form magnesium/zirconium oxide, titanium and boron are added to form titanium/boron nitride, and the two types of precipitates work synergistically to improve the microstructure of a heat-affected zone. The method optimizes the chemical composition and production process of existing high-strength steel.
    Type: Application
    Filed: July 29, 2022
    Publication date: June 8, 2023
    Applicant: Northeastern University
    Inventors: Chao WANG, Junjie HAO, Guo YUAN, Jian KANG, Zhenlei LI, Guodong WANG
  • Patent number: 11657311
    Abstract: A method and corresponding system identify missing interactions in incompletely known datasets represented as complex networks. The method identifies missing connections in a complex network. The method accesses an electronic representation of the network. The network includes nodes and links, the nodes represent entities, and the links represent interactions between the entities. For each pair of nodes not directly connected by a link, the method determines a number of paths connecting the pair of nodes and calculates a prediction score for the pair of nodes based on the number of paths connecting the pair of nodes. The method ranks the pairs of nodes based on the prediction scores, resulting in an ordered list of node pairs, and selects at least a subset of the pairs of nodes based on the ordered list of node pairs. The selected pairs of nodes represent missing connections in the network.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: May 23, 2023
    Assignee: Northeastern University
    Inventor: Istvan Kovacs
  • Patent number: 11648211
    Abstract: Pharmaceutical formulations (nanococktails) include two or more nanoparticulate delivery vehicles each including an active agent. The nanococktails can be formulated at any ratio of active agents by changing the ratio of nanoparticulate delivery vehicles in the nanococktail. The nanoparticulate delivery vehicles can have matched surface potential to prevent aggregation. The nanoparticulate delivery vehicles of the combined formulation are designed to provide each active agent with desired, preferably overlapping therapeutic windows and a specifically selected pharmacokinetic and pharmacodynamic profile when the nanococktail is administered to a subject. Each of the nanoparticulate delivery vehicles can be designed to enhance solubility, duration of action, targeting, stability, and to program release while preventing degradation of an active agent and preventing side effects, toxicity, and tolerability issues in a subject.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: May 16, 2023
    Assignee: Northeastern University
    Inventors: Paige Baldwin, Srinivas Sridhar, Bijay Singh
  • Patent number: 11651526
    Abstract: An apparatus and corresponding method for frontal face synthesis. The apparatus comprises a decoder that synthesizes a high-resolution (HR) frontal-view (FV) image of a face from received features of a low-resolution (LR) non-frontal-view (NFV) image of the face. The HR FV image is of a higher resolution relative to a lower resolution of the LR NFV image. The decoder includes a main path and an auxiliary path. The auxiliary path produces auxiliary-path features from the received features and feeds the auxiliary-path features produced into the main path for synthesizing the HR FV image. The auxiliary-path features represent a HR NFV image of the face at the higher resolution. As such, an HR identity-preserved frontal face can be synthesized from one or many LR faces with various poses and may be used in types of commercial applications, such as video surveillance.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: May 16, 2023
    Assignee: Northeastern University
    Inventors: Yun Fu, Yu Yin
  • Publication number: 20230096977
    Abstract: A preparation method of a granular adsorbent is provided, including the following: adding a pyrrole monomer to an acidic solution, and adding an oxidant as an initiator to allow a polymerization reaction of the pyrrole monomer to produce polypyrrole (PPy), where an adsorption material powder is added to a reaction system before, during, or immediately after the polymerization reaction, and a resulting mixture is thoroughly stirred; after the polymerization reaction is completed, filtering a resulting reaction system to obtain a filter cake, which is the granular adsorbent; or subjecting the resulting reaction system to centrifugal sedimentation to obtain the monolithic adsorbent. In the present disclosure, the pyrrole monomer is subjected to a polymerization reaction to generate PPy; before being tightly stacked, network structures of PPy wrap the adsorption material powder; and the granular adsorbent is formed through sedimentation and stacking.
    Type: Application
    Filed: September 29, 2022
    Publication date: March 30, 2023
    Applicant: Northeastern University
    Inventors: Liying LIU, Zhe WANG, Zhuo LI
  • Patent number: 11611457
    Abstract: A machine learning (ML) agent operates at a transmitter to optimize signals transmitted across a communications channel. A physical signal modifier modifies a physical layer signal prior to transmission as a function of a set of signal modification parameters to produce a modified physical layer signal. The ML agent parses a feedback signal from a receiver across the communications channel, and determines a present tuning status as a function of the signal modification parameters and the feedback signal. The ML agent generates subsequent signal modification parameters based on the present tuning status and a set of stored tuning statuses, thereby updating the physical signal modifier to generate a subsequent modified physical layer signal to be transmitted across the communications channel.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: March 21, 2023
    Assignee: Northeastern University
    Inventors: Salvatore D'Oro, Tommaso Melodia, Francesco Restuccia
  • Patent number: 11610111
    Abstract: Apparatuses and methods for real-time spectrum-driven embedded wireless networking through deep learning are provided. Radio frequency, optical, or acoustic communication apparatus include a programmable logic system having a front-end configuration core, a learning core, and a learning actuation core. The learning core includes a deep learning neural network that receives and processes input in-phase/quadrature (I/Q) input samples through the neural network layers to extract RF, optical, or acoustic spectrum information. A processing system having a learning controller module controls operations of the learning core and the learning actuation core. The processing system and the programmable logic system are operable to configure one or more communication and networking parameters for transmission via the transceiver in response to extracted spectrum information.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: March 21, 2023
    Assignee: Northeastern University
    Inventors: Francesco Restuccia, Tommaso Melodia
  • Publication number: 20230082272
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Application
    Filed: November 14, 2022
    Publication date: March 16, 2023
    Applicants: TargaGenix, Inc., The Research Foundation for the State University of New York, Northeastern University
    Inventors: James E. EGAN, Mansoor M. AMIJI, Iwao OJIMA
  • Patent number: 11599782
    Abstract: An analog computing method includes the steps of: (a) generating a biasing current (IWi) using a constant gm bias circuit operating in the subthreshold region for ultra-low power consumption, wherein gm is generated by PMOS or NMOS transistors, the circuit including a switched capacitor resistor; and (b) multiplying the biasing current by an input voltage using a differential amplifier multiplication circuit to generate an analog voltage output (VOi). In one or more embodiments, the method is used in a vision application, where the biasing current represents a weight in a convolution filter and the input voltage represents a pixel voltage of an acquired image.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: March 7, 2023
    Assignee: Northeastern University
    Inventor: Aatmesh Shrivastava
  • Patent number: 11589749
    Abstract: A flexible head probe and modular head probe system that includes an optical functional near-infrared spectroscopy (fNIRS) system and integrated position sensor. The head probe and modular head probe system determines physiological data based upon the optical information gathered by the fNIRS system and gathers motion and position data from the position sensor. The physiological data and motion and position data are combined to permit topographical and tomographic analyses of a user's brain tissue.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: February 28, 2023
    Assignee: Northeastern University
    Inventors: Morris Dwight Vanegas, Qianqian Fang
  • Publication number: 20230056702
    Abstract: The present disclosure is directed towards a method of treating a disease or condition associated with gut inflammation. The present disclosure comprises administering, to a patient in need thereof, a composition comprising oxygen-scavenging membrane fragments or membrane vesicles. In some embodiments, membrane vesicles are derived from bacteria. In some embodiments, membrane vesicles are derived from the cytoplasmic membranes of Escherichia coli, Salmonella typhimurium, Gluconobacter oxydans, Pseudomonas aeruginosa, or Acetobacter.
    Type: Application
    Filed: August 23, 2022
    Publication date: February 23, 2023
    Applicant: Northeastern University
    Inventors: Kim LEWIS, Norman PITT, Madeleine MORRISSETTE